Protein Alignment Pgant2 and GALNT16

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_065743.2
• Gene: GALNT16 / 57452
• HGNCID: 23233
• Length: 558
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 271/527 - (51%)
• Similarity: 357/527 - (67%)
• Gaps: 31/527 - (5%)

  Fly   123 SGGTGGP-GGR----------LPVAPSGRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASD 176
            |||.|.. .||          :|:..:  ||..:.|:|..|:.|..|:.|||||.::.|||..||
Human    35 SGGRGAQRAGRRSEQLREDRTIPLIVT--GTPSKGFDEKAYLSAKQLKAGEDPYRQHAFNQLESD 97

  Fly   177 ALPSNRDIPDTRNPMCRTKKYREDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVD 241
            .|..:|.|.|||:..|.:..|..|||.||||||||||||||||||:.|||||:|.:||:||:|||
Human    98 KLSPDRPIRDTRHYSCPSVSYSSDLPATSVIITFHNEARSTLLRTVKSVLNRTPANLIQEIILVD 162

  Fly   242 DYSDHPEDGLELAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLER 306
            |:|..|||.|.|.:|.||:.:|||:||||:||||:|||.|.::||||||||.|.|..||.|:|:|
Human   163 DFSSDPEDCLLLTRIPKVKCLRNDRREGLIRSRVRGADVAAATVLTFLDSHCEVNTEWLPPMLQR 227

  Fly   307 VREDPTRVVCPVIDVISMDNFQYIGASADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPM 371
            |:||.||||.|:|||||:|||.|:.|||||||||||:|.||||.: |.|:.|...|||..||||:
Human   228 VKEDHTRVVSPIIDVISLDNFAYLAASADLRGGFDWSLHFKWEQI-PLEQKMTRTDPTRPIRTPV 291

  Fly   372 IAGGLFVIDKAYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFP 436
            ||||:|||||::||.|||||.:||:|||||.|:|||||.|||||||:|||||||||||||||.||
Human   292 IAGGIFVIDKSWFNHLGKYDAQMDIWGGENFELSFRVWMCGGSLEIVPCSRVGHVFRKRHPYNFP 356

  Fly   437 GGSGNVFARNTRRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYP 501
            .|:...:.|||:|.||||||:|||:||.|.|.|....||::..|:..::|::||.|:||||||||
Human   357 EGNALTYIRNTKRTAEVWMDEYKQYYYEARPSAIGKAFGSVATRIEQRKKMNCKSFRWYLENVYP 421

  Fly   502 DLQAPDPQEVGQFRQDSTECLDTMGHLIDG--TVGIFPCHNTGGN----QEWAFTKRGEIKHDDL 560
            :|..|..:.:....:....||::.|....|  .:|:..|..:..|    |.|.|:.. .|:....
Human   422 ELTVPVKEALPGIIKQGVNCLESQGQNTAGDFLLGMGICRGSAKNPQPAQAWLFSDH-LIQQQGK 485

  Fly   561 CL----TLVTFARGSQVVLKACDDSE-NQRWIMREGGLVRHYKINVCLDSRDQSQQGVSAQHCNS 620
            ||    ||:: :.||.|:|:.|:..| .|:| .|:|..::|....:||:::  ..|.|::: |.:
Human   486 CLAATSTLMS-SPGSPVILQMCNPREGKQKW-RRKGSFIQHSVSGLCLETK--PAQLVTSK-CQA 545

  Fly   621 ALGTQRW 627
            ....|:|
Human   546 DAQAQQW 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	197/294 (67%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	33/129 (26%)
GALNT16	NP_065743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..54		6/18 (33%)
		Catalytic subdomain A	122..227		72/104 (69%)
		pp-GalNAc-T	126..420	CDD:133004	197/294 (67%)
		Catalytic subdomain B	286..348		48/61 (79%)
		beta-trefoil_Ricin_GALNT16	426..557	CDD:467357	34/133 (26%)