Protein Alignment Pgant2 and GALNT9

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001116108.1
• Gene: GALNT9 / 50614
• HGNCID: 4131
• Length: 603
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 212/575 - (36%)
• Similarity: 305/575 - (53%)
• Gaps: 76/575 - (13%)

  Fly    93 IGSVKDFERNAVHGLKLNGIVALEETSQGLSGGTGGPGGRLPVAPSGRGTEVEYFNEAGYIRAGA 157
            :|::.|  |.|:    |..:..|||.......|...|.| |...|.|.|       :.|.  |..
Human    54 VGTLGD--REAI----LQRLDHLEEVVYNQLNGLAKPIG-LVEGPGGLG-------QGGL--AAT 102

  Fly   158 LRN----GEDPYIRNRFNQEASDALPSNRDIPDTRNPMCRTKKYREDLPETSVIITFHNEARSTL 218
            ||:    .|..|....:|.:.||.:..:|.|||.|...||...|.:|||:.||:..|.|||.|.:
Human   103 LRDDGQEAEGKYEEYGYNAQLSDRISLDRSIPDYRPRKCRQMSYAQDLPQVSVVFIFVNEALSVI 167

  Fly   219 LRTIVSVLNRSPEHLIREIVLVDDYSDHPEDGLELAK-IDK-----VRVIRNDKREGLVRSRVKG 277
            ||::.||:|.:|..|::|::||||.||:.|....|.: ::|     |:::||.:||||:|:|::|
Human   168 LRSVHSVVNHTPSQLLKEVILVDDNSDNVELKFNLDQYVNKRYPGLVKIVRNSRREGLIRARLQG 232

  Fly   278 ADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCPVIDVISMDNF---QYIGASADLRGG 339
            ..||.:.|:.|.|:|||.|..|.||.|.|:|||..|:|.|.||.|....|   ||..|:    .|
Human   233 WKAATAPVVGFFDAHVEFNTGWAEPALSRIREDRRRIVLPAIDNIKYSTFEVQQYANAA----HG 293

  Fly   340 FDWNLIFKW-EYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDKAYFNKLGKYDMKMDVWGGENLE 403
            ::|.|   | .|:.|.:..:...|.:..||||.:.|..||:|:.||..:|..|..|:|:||||:|
Human   294 YNWGL---WCMYIIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGGENVE 355

  Fly   404 ISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFA-RNTRRAAEVWMDDYKQHYYNA-- 465
            :..||||||||:|::|||||.|:.|.|.||   ....:.:| ||..|||||||||:|.|.|.|
Human   356 LGMRVWQCGGSMEVLPCSRVAHIERTRKPY---NNDIDYYAKRNALRAAEVWMDDFKSHVYMAWN 417

  Fly   466 VPLAK-NIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQA-PDPQEVGQFRQD--STECLDTMG 526
            :|::. .:.||::.:||||:::|.|:.||||||||||:::. .:....|:.|..  |..|||...
Human   418 IPMSNPGVDFGDVSERLALRQRLKCRSFKWYLENVYPEMRVYNNTLTYGEVRNSKASAYCLDQGA 482

  Fly   527 HLIDGTVGI-FPCHNTGGNQEWAFTKRGEIK----------HDDLCLTLVTFARGSQVVLKACDD 580
            .  ||...| :|||.. .:|...::..|.::          .|..|  ||....|....||.|:|
Human   483 E--DGDRAILYPCHGM-SSQLVRYSADGLLQLGPLGSTAFLPDSKC--LVDDGTGRMPTLKKCED 542

  Fly   581 --SENQR-WIMREGGLVRHYKINVCLD---SRDQSQQGVS--AQHCNSALGTQRW 627
              ...|| |...:.|.:.......||:   |:| :..|:.  .|.|:.    |:|
Human   543 VARPTQRLWDFTQSGPIVSRATGRCLEVEMSKD-ANFGLRLVVQRCSG----QKW 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	138/308 (45%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	36/139 (26%)
GALNT9	NP_001116108.1	Catalytic subdomain A	150..261		49/110 (45%)
		pp-GalNAc-T	154..453	CDD:133004	138/308 (45%)
		Catalytic subdomain B	318..380		34/61 (56%)
		beta-trefoil_Ricin_GALNT9	456..600	CDD:467351	36/147 (24%)