DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant2 and GALNTL6

DIOPT Version :9

Sequence 1:	NP_608773.2	Gene:	Pgant2 / 33556	FlyBaseID:	FBgn0031530	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	XP_016863733.1	Gene:	GALNTL6 / 442117	HGNCID:	33844	Length:	609	Species:	Homo sapiens

Alignment Length:	537	Identity:	198/537 - (36%)
Similarity:	295/537 - (54%)	Gaps:	57/537 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 QGLSGGTGGPGGRLPVAPSGRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDI 184
            :.:..|.|..|...|:      ||.::.:.|              |..|.||...|:.:...|.:
Human    86 EAMRSGKGEHGKPYPL------TEEDHDDSA--------------YRENGFNIFVSNNIALERSL 130

  Fly   185 PDTRNPMCRTKKYREDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYS--DHP 247
            ||.|:..|:.|.|.|.||.||:||.||||..::|||||.|::||:|..||.||:||||:|  :|.
Human   131 PDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPGSLIAEIILVDDFSEREHL 195

  Fly   248 EDGLE--LAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVRED 310
            :|.||  :|:..|||::|..|||||:|:|:.||..|...||||||||.|.|..||.|||.::..:
Human   196 KDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALN 260

  Fly   311 PTRVVCPVIDVISMDNFQYIGASAD-LRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAG 374
            ...:|||:||||..::|.|...:.| :||.|||.:.:|...:.|.   ::..||:....:|::||
Human   261 HKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPE---LQRADPSDPFESPVMAG 322

  Fly   375 GLFVIDKAYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGS 439
            |||.:|:.:|.:||.||..:::||||..||||:||.|||.:..:|||||||::||..||..|  |
Human   323 GLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVP--S 385

  Fly   440 GNVFARNTRRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENV----- 499
            |...|||.:|.||.|||::.::.|...|..:::..|:|..:..|:::|.||.|||::..|
Human   386 GTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVP 450

  Fly   500 --YPDLQAPDPQEVGQFRQDSTE-CLDTMGHLIDGT-VGIFPCHNTGGNQEWA----FT------ 550
              ||.:: |.|...|:.|..:.. |:|:. |...|| :.:..|...|..:.|:    ||
Human   451 KYYPPVE-PPPAAWGEIRNVAANLCVDSK-HGATGTELRLDICVKDGSERTWSHEQLFTFGWRED 513

  Fly   551 -KRGEIKHD-DLCLTLVTFARGSQVVLKACDDSE-NQRWIMREGGLVRHYKINVCLDSRDQSQQG 612
             :.||..|. ..|...:  :..|.|.|..|...: ||.|..|:...:.|...|.|:|. :.:::.
Human   514 IRPGEPLHTRKFCFDAI--SHNSPVTLYDCHGMKGNQLWGYRKDRTLFHPVSNSCMDC-NPAEKK 575

  Fly   613 VSAQHCNSALGTQRWSF 629
            :....|:....||:|.|
Human   576 IFMARCDPLSETQQWIF 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	WcaA	200..>432	CDD:223539	115/236 (49%)
		pp-GalNAc-T	205..500	CDD:133004	138/306 (45%)
		Ricin_B_lectin	511..627	CDD:279046	31/130 (24%)
		RICIN	513..629	CDD:238092	31/130 (24%)
GALNTL6	XP_016863733.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810