Protein Alignment Pgant2 and GALNTL6

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: XP_016863733.1
• Gene: GALNTL6 / 442117
• HGNCID: 33844
• Length: 609
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 198/537 - (36%)
• Similarity: 295/537 - (54%)
• Gaps: 57/537 - (10%)

  Fly   120 QGLSGGTGGPGGRLPVAPSGRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDI 184
            :.:..|.|..|...|:      ||.::.:.|              |..|.||...|:.:...|.:
Human    86 EAMRSGKGEHGKPYPL------TEEDHDDSA--------------YRENGFNIFVSNNIALERSL 130

  Fly   185 PDTRNPMCRTKKYREDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYS--DHP 247
            ||.|:..|:.|.|.|.||.||:||.||||..::|||||.|::||:|..||.||:||||:|  :|.
Human   131 PDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPGSLIAEIILVDDFSEREHL 195

  Fly   248 EDGLE--LAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVRED 310
            :|.||  :|:..|||::|..|||||:|:|:.||..|...||||||||.|.|..||.|||.::..:
Human   196 KDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALN 260

  Fly   311 PTRVVCPVIDVISMDNFQYIGASAD-LRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAG 374
            ...:|||:||||..::|.|...:.| :||.|||.:.:|...:.|.   ::..||:....:|::||
Human   261 HKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPE---LQRADPSDPFESPVMAG 322

  Fly   375 GLFVIDKAYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGS 439
            |||.:|:.:|.:||.||..:::||||..||||:||.|||.:..:|||||||::||..||..|  |
Human   323 GLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVP--S 385

  Fly   440 GNVFARNTRRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENV----- 499
            |...|||.:|.||.|||::.::.|...|..:::..|:|..:..|:::|.||.|||::..|
Human   386 GTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVP 450

  Fly   500 --YPDLQAPDPQEVGQFRQDSTE-CLDTMGHLIDGT-VGIFPCHNTGGNQEWA----FT------ 550
              ||.:: |.|...|:.|..:.. |:|:. |...|| :.:..|...|..:.|:    ||
Human   451 KYYPPVE-PPPAAWGEIRNVAANLCVDSK-HGATGTELRLDICVKDGSERTWSHEQLFTFGWRED 513

  Fly   551 -KRGEIKHD-DLCLTLVTFARGSQVVLKACDDSE-NQRWIMREGGLVRHYKINVCLDSRDQSQQG 612
             :.||..|. ..|...:  :..|.|.|..|...: ||.|..|:...:.|...|.|:|. :.:::.
Human   514 IRPGEPLHTRKFCFDAI--SHNSPVTLYDCHGMKGNQLWGYRKDRTLFHPVSNSCMDC-NPAEKK 575

  Fly   613 VSAQHCNSALGTQRWSF 629
            :....|:....||:|.|
Human   576 IFMARCDPLSETQQWIF 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	138/306 (45%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	32/133 (24%)
GALNTL6	XP_016863733.1	pp-GalNAc-T	151..446	CDD:133004	137/299 (46%)
		beta-trefoil_Ricin_GALNTL6	457..604	CDD:467355	35/141 (25%)