Protein Alignment Pgant2 and GALNT8

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_059113.1
• Gene: GALNT8 / 26290
• HGNCID: 4130
• Length: 637
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 177/499 - (35%)
• Similarity: 262/499 - (52%)
• Gaps: 50/499 - (10%)

  Fly   162 EDPYIRNRFNQEASDALPSNRDIPDTRNPMCRTKKYREDLPETSVIITFHNEARSTLLRTIVSVL 226
            :|.:.:..:|...|:.||.||.|||||:..|..|.|...||..|||:.|.|||.|.:.|.|.|::
Human   141 QDLFRKFGYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQLPSLSVILIFVNEALSIIQRAITSII 205

  Fly   227 NRSPEHLIREIVLVDDYSDHPEDGLELAKIDK---------VRVIRNDKREGLVRSRVKGADAAV 282
            ||:|..|::||:||||:|.:.|..:.|.:..|         :::||:.:|:||.::|..|.:||.
Human   206 NRTPSRLLKEIILVDDFSSNGELKVHLDEKIKLYNQKYPGLLKIIRHPERKGLAQARNTGWEAAT 270

  Fly   283 SSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCPVIDVISMDNFQY--IGASADLRGGFDWNLI 345
            :.|:..||:|:|.|..|.||:|.|::||.|.:|.||.|.|..|.|:.  ...:.|   ||:|.|.
Human   271 ADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKLDKYELAVD---GFNWELW 332

  Fly   346 FKWEYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDKAYFNKLGKYDMKMDVWGGENLEISFRVWQ 410
            .:::.| |......| |.|..:::|.|. |:...::.:..::|..|..|.::||||:|:|.||||
Human   333 CRYDAL-PQAWIDLH-DVTAPVKSPSIM-GILAANRHFLGEIGSLDGGMLIYGGENVELSLRVWQ 394

  Fly   411 CGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFARNTRRAAEVWMDDYKQHYYNA--VPLAKN-I 472
            |||.:||:||||:.|:.|...||.....:  ...||..|.||:|||::|...|.|  :||..: |
Human   395 CGGKVEILPCSRIAHLERHHKPYALDLTA--ALKRNALRVAEIWMDEHKHMVYLAWNIPLQNSGI 457

  Fly   473 PFGNIDDRLALKEKLHCKPFKWYLENVYPDLQAPDPQEVGQFRQ----DSTECLDTMGHLIDGTV 533
            .||::..|:||:|||.||.|.|||:|||| |..|....||..|.    |...||| .|.:...|.
Human   458 DFGDVSSRMALREKLKCKTFDWYLKNVYP-LLKPLHTIVGYGRMKNLLDENVCLD-QGPVPGNTP 520

  Fly   534 GIFPCHNTGGNQEWAFTKRGEI---------KHDDLCLTLVTFARGSQVVLKACDDSENQR---- 585
            .::.||.. .:|...:...||:         ...|.|||  ...:..:..|:.|..:...|
Human   521 IMYYCHEF-SSQNVYYHLTGELYVGQLIAEASASDRCLT--DPGKAEKPTLEPCSKAAKNRLHIY 582

  Fly   586 WIMREGGLVRHYKINVCLDSRDQ--SQQGVSAQHCNSALGTQRW 627
            |..:.||.|.:.....||:.:..  ....:..|.|:    ||.|
Human   583 WDFKPGGAVINRDTKRCLEMKKDLLGSHVLVLQTCS----TQVW 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	123/308 (40%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	32/137 (23%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		1/6 (17%)
		GT1 motif	182..298		45/115 (39%)
		pp-GalNAc-T	184..485	CDD:133004	123/308 (40%)
		Gal/GalNAc transferase motif	358..397		15/39 (38%)
		beta-trefoil_Ricin_GALNT8	485..629	CDD:467350	36/147 (24%)