Protein Alignment Pgant2 and GALNT2

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 352/641 - (54%)
• Similarity: 435/641 - (67%)
• Gaps: 88/641 - (13%)

  Fly     1 MRRNIKLIVFVSIIWMFVMVYYFQSSTEKVENRALRLREVATAMQQYQDDSSSAAAASTARQWAP 65
            |||..::::..:.:|:..:.||..|
Human     1 MRRRSRMLLCFAFLWVLGIAYYMYS---------------------------------------- 25

  Fly    66 AGGGAGPGAAAGAAGSGADDPGGNVILIGSVKDFERNAVHGLK------LNGIVALEETSQGLSG 124
             |||:   |.||.||.||          |..:|:  |.:..:|      .||    ||.:|.:.
Human    26 -GGGS---ALAGGAGGGA----------GRKEDW--NEIDPIKKKDLHHSNG----EEKAQSME- 69

  Fly   125 GTGGPGGRLPVAPSGRGTEVEY--FNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDIPDT 187
             |..||            :|.:  ||:..|:....:|:|:|||.||:|||..||.|..:|.||||
Human    70 -TLPPG------------KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDT 121

  Fly   188 RNPMCRTKKYREDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSDHPEDGLE 252
            |:..|:.|::|.|||.|||:|||||||||.||||:||||.:||.|||:||:||||||:.||||..
Human   122 RHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGAL 186

  Fly   253 LAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCP 317
            |.||:||||:|||:||||:||||:|||||.:.||||||||.||||.|||||||||.||.||||.|
Human   187 LGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSP 251

  Fly   318 VIDVISMDNFQYIGASADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDKA 382
            :||||:||||||:||||||:|||||||:|||:|::|.:|..|..:|...|:||||||||||:||.
Human   252 IIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKF 316

  Fly   383 YFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFARNT 447
            ||.:||||||.||||||||||||||||||||||||||||||||||||:||||||||||.||||||
Human   317 YFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNT 381

  Fly   448 RRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQAPDPQEV- 511
            |||||||||:||..||.|||.|:|:|:|||..||.|::||.|||||||||||||:|:.||.|::
Human   382 RRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIA 446

  Fly   512 -GQFRQDSTECLDTMGHLIDGTVGIFPCHNTGGNQEWAFTKRGEIKHDDLCLTLVTFARGSQVVL 575
             |..:| .|.||||:||..||.||::.|||.|||||||.||...:||.|||||:|..|.||.:.|
Human   447 FGALQQ-GTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKL 510

  Fly   576 KACDDSEN-QRWIMREG-GLVRHYKINVCLDSRDQSQQGVSAQHCNSALGTQRWSF 629
            :.|.:::: |:|...|| ..:||...|:|||||.....|:|.:.|..|| :|:|.|
Human   511 QGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPAL-SQQWKF 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	228/294 (78%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	57/122 (47%)
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		6/26 (23%)
		Catalytic subdomain A	135..240		80/104 (77%)
		pp-GalNAc-T	139..434	CDD:133004	228/294 (78%)
		Catalytic subdomain B	300..362		54/61 (89%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	57/120 (48%)