Protein Alignment Pgant2 and Galnt18

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_776100.2
• Gene: Galnt18 / 233733
• MGIID: 2446239
• Length: 622
• Species: Mus musculus
• Alignment Length: 545
• Identity: 186/545 - (34%)
• Similarity: 279/545 - (51%)
• Gaps: 88/545 - (16%)

  Fly   135 VAPSGRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDIPDTRNPMCRTKKYRE 199
            ::|.||...::.|...||                  |...||.||.:|.:||.|...||...:.:
Mouse   105 LSPEGRRVALKQFQYYGY------------------NAYLSDRLPLDRPLPDLRPSGCRNLSFPD 151

  Fly   200 DLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSDHPEDGLELAK-IDKV---- 259
            .|||.|::..|.|||.|.|||:|.|.:.|:|.||::||:||||.|.:.|...:|.: :|||
Mouse   152 SLPEVSIVFIFVNEALSVLLRSIHSAMERTPSHLLKEIILVDDNSSNEELKEKLTEYVDKVNGQK 216

  Fly   260 ----RVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCPVID 320
                :|:|:.|:|||:||||.|..||.:.|:...|:|||.|..|.||:|.|::|:..|::.|..|
Mouse   217 PGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFD 281

  Fly   321 VISMDNF---QYIGASADLRGGFDWNLIFKW-EYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDK 381
            .|..|||   :|..|:.    ||||.|   | .||:|.:...:..:.|..||:|.:. |.|::|:
Mouse   282 NIKYDNFEIEEYPLAAQ----GFDWEL---WCRYLNPPKAWWKLENSTAPIRSPALI-GCFIVDR 338

  Fly   382 AYFNKLGKYDMKMDVWGGENLEISFR---------------VWQCGGSLEIIPCSRVGHVFRKRH 431
            .||.::|..|..|:|:||||:|:..|               |||||||:|::||||:.|:.|...
Mouse   339 QYFEEIGLLDEGMEVYGGENVELGIRVSEISHTGLSSAPMMVWQCGGSVEVLPCSRIAHIERAHK 403

  Fly   432 PYTFPGGSGNVFARNTRRAAEVWMDDYKQHYYNAVPLAKNIP-------FGNIDDRLALKEKLHC 489
            ||| ...:.:| .||..|.||||||::|.|.|    :|.|||       .|:|..|.||:::|.|
Mouse   404 PYT-EDLTAHV-RRNALRVAEVWMDEFKSHVY----MAWNIPQEDSGIDIGDITARKALRKQLQC 462

  Fly   490 KPFKWYLENVYPDLQAPDPQEVGQFRQDSTE---CLDTMGHLIDGTVGIFPCHN-TGGNQEWAFT 550
            |.|:|||.:|||:::...........|:|.:   ||| .|...:....::.||. |..|..:..:
Mouse   463 KTFRWYLVSVYPEMRMYSDIIAYGVLQNSLKTDLCLD-QGPDTENVPIVYICHGMTPQNVYYTSS 526

  Fly   551 KRGEI--------KHDDLCLTLVTFARGSQVVLKACDDSENQR----WIMREGGLVRHYKINVCL 603
            ::..:        ..|:.||..|    .|:..|..|..::.:|    |...:||.:::.|...||
Mouse   527 QQIHVGILSPTVDDDDNRCLVDV----NSRPRLIECSYAKAKRMKLHWQFSQGGSIQNRKSKRCL 587

  Fly   604 DSRDQSQQGVSAQHCNSALGTQRWS 628
            :.::.|......|........|.|:
Mouse   588 ELQENSDMEFGFQLVLQKCSGQHWT 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	135/329 (41%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	28/135 (21%)
Galnt18	NP_776100.2	Catalytic subdomain A	153..267		53/113 (47%)
		pp-GalNAc-T	157..473	CDD:133004	135/329 (41%)
		Catalytic subdomain B	324..400		31/76 (41%)
		beta-trefoil_Ricin_GALNT18	476..617	CDD:467353	28/142 (20%)