DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant2 and Galnt11

DIOPT Version :9

Sequence 1:	NP_608773.2	Gene:	Pgant2 / 33556	FlyBaseID:	FBgn0031530	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_001346819.1	Gene:	Galnt11 / 231050	MGIID:	2444392	Length:	608	Species:	Mus musculus

Alignment Length:	645	Identity:	254/645 - (39%)
Similarity:	337/645 - (52%)	Gaps:	114/645 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VFVSIIWMFVMVYYFQSS--TEKVENRALRLREVATAMQQYQDDSSSAAAASTARQWAPAGGGAG 71
            :|.|..|..::..||..|  |:.:.|..::               .|.......:::.|. ...|
Mouse    14 LFTSATWTVLLFIYFNFSEVTQPLRNVPIK---------------GSGPHGPFPKKFYPR-FTRG 62

  Fly    72 PGAAAGAAGSGADDPGGNVILIGSVKDFERNAVHGLKLNGIVALEETSQGLSGGTGGPGGRLPVA 136
            ||...        ||           .|:.|.:..|..|.|   |:..:|||..:...|
Mouse    63 PGRVL--------DP-----------QFKANRIDRLMNNHI---EDPDKGLSKSSSELG------ 99

  Fly   137 PSGRGTEVEYFNEAGYIRAGALRN-GEDPYIRNRFNQEASDALPSNRDIPDTRNPMCRTKKYRED 200
                    ..|||    |...||: |   |.::.||...|:.|..:||:|||||..||.|.|..|
Mouse   100 --------MIFNE----RDQELRDLG---YQKHAFNMLISNRLGYHRDVPDTRNAECRRKSYPTD 149

  Fly   201 LPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSDHPEDGLELAKID-------- 257
            ||..|::|.|:|||.|.||||:.||::|:|.||:.||:||||.||.  |.|: .::|
Mouse   150 LPTASIVICFYNEAFSALLRTVHSVVDRTPAHLLHEIILVDDSSDF--DDLK-GELDEYIQRYLP 211

  Fly   258 -KVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCPVIDV 321
             ||:||||.|||||:|.|:.||..|...||.|||||.|.|.|||:|||..:.|||..|||||||:
Mouse   212 AKVKVIRNMKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAIILEDPHTVVCPVIDI 276

  Fly   322 ISMDNFQYIGASADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTA-IRTPMIAGGLFVIDKAYFN 385
            ||.|...| .:|..:||||:|.|.|||:.:..||  :...|..|| ||:|.:|||||.:::.|||
Mouse   277 ISADTLAY-SSSPVVRGGFNWGLHFKWDLVPVSE--LGGPDGATAPIRSPTMAGGLFAMNRQYFN 338

  Fly   386 KLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFARNTRRA 450
            .||:||..||:|||||||||||:|.|||.|.|:|||||||:||||.||..|.|. :....|:.|.
Mouse   339 DLGQYDSGMDIWGGENLEISFRIWMCGGKLFILPCSRVGHIFRKRRPYGSPEGQ-DTMTHNSLRL 402

  Fly   451 AEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQAPDPQEVGQFR 515
            |.||:|:||:.|::..|..||..||||.:|:.|::||.|:.|||||:|:||::|.|.|....|
Mouse   403 AHVWLDEYKEQYFSLRPDLKNKSFGNISERVELRKKLGCQSFKWYLDNIYPEMQIPGPNAKPQ-- 465

  Fly   516 QDSTECLDTMGHLIDGTVGIFPCHNTGGNQEWAFTKRGEIKHDDLCLTLVTFARGSQ----VVLK 576
                                .|.....|.:.....:||.:.|......||...|.||    |:||
Mouse   466 --------------------QPVLINRGPKRPRVLQRGRLYHLQTNKCLVAQGRSSQKGGLVLLK 510

  Fly   577 ACDDSE-NQRWIMREGGLVRHYKI---NVCLD-SRDQSQQGVSAQHCNSALGTQRWSFGK 631
            .||..: .|.||..|.    |..|   .:||| |..:|........|:.:.|:|:|:|||
Mouse   511 TCDYGDPTQVWIYNED----HELILNNLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGK 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	WcaA	200..>432	CDD:223539	136/241 (56%)
		pp-GalNAc-T	205..500	CDD:133004	164/304 (54%)
		Ricin_B_lectin	511..627	CDD:279046	30/124 (24%)
		RICIN	513..629	CDD:238092	31/124 (25%)
Galnt11	NP_001346819.1	Catalytic subdomain A	150..261		61/113 (54%)
		pp-GalNAc-T	154..452	CDD:133004	164/304 (54%)
		Catalytic subdomain B	319..381		41/61 (67%)
		Ricin_B_lectin	483..604	CDD:306998	30/88 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820