Protein Alignment Pgant2 and Galnt12

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_766281.1
• Gene: Galnt12 / 230145
• MGIID: 2444664
• Length: 576
• Species: Mus musculus
• Alignment Length: 535
• Identity: 229/535 - (42%)
• Similarity: 320/535 - (59%)
• Gaps: 50/535 - (9%)

  Fly   129 PGGRLPVAP---------SGRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDI 184
            ||...||.|         ...|..|..     .::...||..|:...:::.|...||.:..:|.:
Mouse    53 PGRHEPVLPRPPLPADALGAHGEAVRL-----QLQGEELRLQEESVKQHQINIYLSDRISLHRRL 112

  Fly   185 PDTRNPMCRTKKYRED-LPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSD--H 246
            |:..||:||..||..| ||:|||:|.|:|||.||||||:.|||..||:.|:.|::|||||||  |
Mouse   113 PERWNPLCREVKYDYDNLPKTSVVIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREH 177

  Fly   247 PEDGL--ELAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVRE 309
            .::.|  ||:::.|||:||..:||||||:|:.||.||...||||||.|.||:|.||||||:|:.|
Mouse   178 LKERLANELSQLPKVRLIRASRREGLVRARLLGASAARGEVLTFLDCHCECHEGWLEPLLQRIHE 242

  Fly   310 DPTRVVCPVIDVISMDNFQYIGASADLR-GGFDWNLIFKWEYLSPSER-AMRHNDPTTAIRTPMI 372
            ..:.|||||||||..:.|:|:|.|.:.: |||||.|:|.|..:...|| :||  .|...||:|.:
Mouse   243 KESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHVVPQRERQSMR--SPIDVIRSPTM 305

  Fly   373 AGGLFVIDKAYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPG 437
            |||||.:.|.||:.||.||..|:||||||||.|||:|||||:||..|||.|||||.|:.||
Mouse   306 AGGLFAVSKRYFDYLGSYDTGMEVWGGENLEFSFRIWQCGGTLETHPCSHVGHVFPKQAPY---- 366

  Fly   438 GSGNVFARNTRRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPD 502
             |.:....|:.||||||||::|:.||:..|.|:..|||::.:|..|:.||.||.|||:|:.|||:
Mouse   367 -SRSKALANSVRAAEVWMDEFKELYYHRNPQARLEPFGDVTERKKLRAKLQCKDFKWFLDTVYPE 430

  Fly   503 LQAPD--PQEVGQFRQDSTE--CLD----TMGHLIDGTVGIFPCHNTGGNQEWAFTKRGEIKHD- 558
            |..|:  |...|..:.....  |||    ...|:....|.::.||..|.||.:.:|.|.||:::
Mouse   431 LHVPEDRPGFFGMLQNRGLRGYCLDYNPPNENHVEGHQVLLYLCHGMGQNQFFEYTTRKEIRYNT 495

  Fly   559 ---DLCLTLVTFARGSQ-VVLKACDDS--ENQRWIMREGGLVRHYKINVCLDSRDQSQQGVSAQH 617
               :.|:|:   ..|.. :|:..|.::  |||.:|::|.|.:.|.....|:::.::......|.:
Mouse   496 RQPEACITV---EDGKDTLVMDLCRETVPENQEFILQEDGTLVHKHSRKCVEATEKVLDNGFAPY 557

  Fly   618 ---CNSALGTQRWSF 629
               |.:: ..|||.|
Mouse   558 LRDCTNS-DNQRWFF 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	164/300 (55%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	33/134 (25%)
Galnt12	NP_766281.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..58		2/4 (50%)
		Catalytic subdomain A	130..239		66/108 (61%)
		pp-GalNAc-T	134..428	CDD:133004	164/300 (55%)
		Catalytic subdomain B	299..361		41/61 (67%)
		beta-trefoil_Ricin-like	438..574	CDD:483949	35/138 (25%)