DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant2 and Galnt3

DIOPT Version :9

Sequence 1:	NP_608773.2	Gene:	Pgant2 / 33556	FlyBaseID:	FBgn0031530	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_056551.2	Gene:	Galnt3 / 14425	MGIID:	894695	Length:	633	Species:	Mus musculus

Alignment Length:	498	Identity:	213/498 - (42%)
Similarity:	293/498 - (58%)	Gaps:	52/498 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 FNQEASDALPSNRDI-PDTRNPMCRTKKYRE--DLPETSVIITFHNEARSTLLRTIVSVLNRSPE 231
            ||..|||.:..:||: ||||.|.|..:|::.  .||.|||||.|||||.||||||:.|||..||.
Mouse   150 FNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPA 214

  Fly   232 HLIREIVLVDDYS--DHPEDGLE--LAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSH 292
            .|::||:||||.|  |:..:.||  :.:...|:::|..:|:||:.:|:.||..|.:..|||||:|
Mouse   215 ILLKEIILVDDASVDDYLHEKLEEYIKQFSIVKIVRQQERKGLITARLLGAAVATAETLTFLDAH 279

  Fly   293 VECNEMWLEPLLERVREDPTRVVCPVIDVISMDNFQY-----IGASADLRGGFDWNLIFKWEYLS 352
            .||...||||||.|:.|:.|.||.|.|..|.::.|::     .|::.: ||.|||:|.|.||.|
Mouse   280 CECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSNHN-RGNFDWSLSFGWESL- 342

  Fly   353 PSERAMRHNDPTTAIRTPMIAGGLFVIDKAYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEI 417
            |.....|..|.|..|:||..|||||.|.|.||..:|.||.:|::|||||:|:|||||||||.|||
Mouse   343 PDHEKQRRKDETYPIKTPTFAGGLFSISKKYFEHIGSYDEEMEIWGGENIEMSFRVWQCGGQLEI 407

  Fly   418 IPCSRVGHVFRKRHPYTFPGGSGNVFARNTRRAAEVWMDDYKQHYY----NAVPLAKNIPFGNID 478
            :|||.||||||.:.|:|||.|: .|.|||..|.||||||:||:.:|    :|..:.|...||::.
Mouse   408 MPCSVVGHVFRSKSPHTFPKGT-QVIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKSFGDLS 471

  Fly   479 DRLALKEKLHCKPFKWYLENVYPDLQAPD--P------QEVGQFRQDSTECLDTMGHLIDG--TV 533
            .|..:|::|.||.|.|||..:||:...||  |      :.|||     ..||| :|....|  .:
Mouse   472 KRFEIKKRLQCKNFTWYLNTIYPEAYVPDLNPVISGYIKSVGQ-----PLCLD-VGENNQGGKPL 530

  Fly   534 GIFPCHNTGGNQEWAFTKRGEIKHD---DLCLTLVTFARGSQVVLKACDDSEN-------QRWIM 588
            .::.||..||||.:.::.:.||:|:   :|||    .|....|.||||....:       |.|.:
Mouse   531 ILYTCHGLGGNQYFEYSAQREIRHNIQKELCL----HATQGVVQLKACVYKGHRTIAPGEQIWEI 591

  Fly   589 REGGLVRHYKINVCLDSRDQSQQGVSAQHCNSALGTQRWSFGK 631
            |:..|:.:....:||.|..:....|.   |::....|:|.|.:
Mouse   592 RKDQLLYNPLFKMCLSSNGEHPNLVP---CDATDLLQKWIFSQ 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	WcaA	200..>432	CDD:223539	124/240 (52%)
		pp-GalNAc-T	205..500	CDD:133004	153/307 (50%)
		Ricin_B_lectin	511..627	CDD:279046	36/127 (28%)
		RICIN	513..629	CDD:238092	35/127 (28%)
Galnt3	NP_056551.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..145
		WcaA	184..>302	CDD:223539	60/117 (51%)
		Catalytic subdomain A	184..293		57/108 (53%)
		pp-GalNAc-T	188..493	CDD:133004	153/307 (50%)
		Catalytic subdomain B	356..418		41/61 (67%)
		Ricin_B_lectin	506..627	CDD:279046	36/133 (27%)
		RICIN	507..629	CDD:238092	37/134 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820