Protein Alignment Pgant2 and Galnt1

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_038842.3
• Gene: Galnt1 / 14423
• MGIID: 894693
• Length: 559
• Species: Mus musculus
• Alignment Length: 533
• Identity: 242/533 - (45%)
• Similarity: 318/533 - (59%)
• Gaps: 41/533 - (7%)

  Fly   116 EETSQGLSGGT---------GGPG--GRLPVAPSGRGTEVEYFNEAGYIRAGALRNGEDPYIRNR 169
            |:..:||..|.         .|||  |:..|.|.   .:.|...|...|              |:
Mouse    36 EKQERGLPAGDVLELVQKPHEGPGEMGKPVVIPK---EDQEKMKEMFKI--------------NQ 83

  Fly   170 FNQEASDALPSNRDIPDTRNPMCRTKKYREDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLI 234
            ||..||:.:..||.:||.|...|:||.|.::||.|||:|.|||||.||||||:.||:||||.|:|
Mouse    84 FNLMASEMIALNRSLPDVRLEGCKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMI 148

  Fly   235 REIVLVDDYSDHP------EDGLELAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHV 293
            .|||||||.|:..      |..::..|: .|.|||.::|.||:|:|:|||..:...|:||||:|.
Mouse   149 EEIVLVDDASERDFLKRPLESYVKKLKV-PVHVIRMEQRSGLIRARLKGAAVSRGQVITFLDAHC 212

  Fly   294 ECNEMWLEPLLERVREDPTRVVCPVIDVISMDNFQYIGASADLRGGFDWNLIFKWEYLSPSERAM 358
            ||...||||||.|::.|...||||:|||||.|.|:|:..|....|||:|.|.|:|..:...|...
Mouse   213 ECTAGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDR 277

  Fly   359 RHNDPTTAIRTPMIAGGLFVIDKAYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRV 423
            |..|.|..:|||.:|||||.||:.||.::|.||..||:|||||||||||:|||||:|||:.||.|
Mouse   278 RKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHV 342

  Fly   424 GHVFRKRHPYTFPGGSGNVFARNTRRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLH 488
            ||||||..|||||||:|.:..:|.||.||||||::|..:|...|....:.:|:|..||.|:.||.
Mouse   343 GHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRLGLRRKLQ 407

  Fly   489 CKPFKWYLENVYPDLQAPDPQ-EVGQFRQ-DSTECLDTMGHLIDGTVGIFPCHNTGGNQEWAFTK 551
            ||||.|||||:|||.|.|... .:|:.|. ::.:|||.|....:..||||.||..||||.:::|.
Mouse   408 CKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQVFSYTA 472

  Fly   552 RGEIKHDDLCLTLVTFARGSQVVLKACDDSENQRWIMREGGL-VRHYKINVCLD-SRDQSQQGVS 614
            ..||:.|||||. |:...|...:||......||.|......| ::|...|.||| :.::..|..|
Mouse   473 NKEIRTDDLCLD-VSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDSQVPS 536

  Fly   615 AQHCNSALGTQRW 627
            .:.|..: .:|:|
Mouse   537 IRDCTGS-RSQQW 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	165/300 (55%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	42/121 (35%)
Galnt1	NP_038842.3	Catalytic subdomain A. /evidence=ECO:0000305|PubMed:10037781	115..225		61/110 (55%)
		pp-GalNAc-T	119..419	CDD:133004	165/300 (55%)
		Catalytic subdomain B. /evidence=ECO:0000305|PubMed:10037781	285..347		42/61 (69%)
		beta-trefoil_Ricin_GALNT1	426..552	CDD:467344	42/125 (34%)