DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant2 and GALNT13

DIOPT Version :9

Sequence 1:	NP_608773.2	Gene:	Pgant2 / 33556	FlyBaseID:	FBgn0031530	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_001363332.1	Gene:	GALNT13 / 114805	HGNCID:	23242	Length:	571	Species:	Homo sapiens

Alignment Length:	653	Identity:	255/653 - (39%)
Similarity:	343/653 - (52%)	Gaps:	121/653 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRRNI--KLIVFVSIIWMFVMVY---YFQSSTEKVENRALR-----LREVATAMQQYQDDSSSAA 55
            |||.:  |:::..|::|:.|.|:   || |...|.:::..|     ||.|.:..|:
Human     1 MRRFVYCKVVLATSLMWVLVDVFLLLYF-SECNKCDDKKERSLLPALRAVISRNQE--------- 55

  Fly    56 AASTARQWAPAGGGAGPGAAAGAAGSGADDPGGNVILIGSVKDFERNAVHGLKLNGIVALEETSQ 120
                           |||..            |..:||  .||.:.......|:
Human    56 ---------------GPGEM------------GKAVLI--PKDDQEKMKELFKI----------- 80

  Fly   121 GLSGGTGGPGGRLPVAPSGRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDIP 185
                                                           |:||..|||.:..||.:|
Human    81 -----------------------------------------------NQFNLMASDLIALNRSLP 98

  Fly   186 DTRNPMCRTKKYREDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSDHPEDG 250
            |.|...|:||.|.::||.|||:|.|||||.||||||:.||:||||.:|:.|::||||.|:.....
Human    99 DVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLK 163

  Fly   251 LELAKIDK-----VRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVRED 310
            |.|....|     |::||.::|.||:|:|::||.|:...|:||||:|.||...||||||.|::||
Human   164 LTLENYVKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKED 228

  Fly   311 PTRVVCPVIDVISMDNFQYIGASADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAGG 375
            ...||||:|||||.|.|:|:..|....|||:|.|.|:|..:...|...|..|.|..:|||.:|||
Human   229 RKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGG 293

  Fly   376 LFVIDKAYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSG 440
            ||.||:.||.::|.||..||:|||||||:|||:|||||||||:.||.|||||||..|||||||:|
Human   294 LFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTG 358

  Fly   441 NVFARNTRRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQA 505
            :|..:|.||.||||||::|..:|...|....:.:|::..|..|:|.|.||||.|||||:|||.|.
Human   359 HVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQI 423

  Fly   506 PDP-QEVGQFRQ-DSTECLDTMGHLIDGTVGIFPCHNTGGNQEWAFTKRGEIKHDDLCLTLVTFA 568
            |.. ..:|:.|. ::.:|||.||...:..||||.||..||||.:::|...||:.|||||. |:..
Human   424 PRRYYSLGEIRNVETNQCLDNMGRKENEKVGIFNCHGMGGNQVFSYTADKEIRTDDLCLD-VSRL 487

  Fly   569 RGSQVVLKACDDSENQRW-IMREGGLVRHYKINVCLDSR---DQSQQGVSAQHCNSALGTQRWSF 629
            .|..::||......||.| ...|...:.|.....||...   |.||. .:.:.||.:. .|:|..
Human   488 NGPVIMLKCHHMRGNQLWEYDAETHTLLHIITQSCLSVNKVADGSQH-PTVETCNDST-LQKWLL 550

  Fly   630 GKY 632
            ..|
Human   551 RNY 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	WcaA	200..>432	CDD:223539	130/236 (55%)
		pp-GalNAc-T	205..500	CDD:133004	162/299 (54%)
		Ricin_B_lectin	511..627	CDD:279046	42/120 (35%)
		RICIN	513..629	CDD:238092	42/120 (35%)
GALNT13	NP_001363332.1	pp-GalNAc-T	118..418	CDD:133004	162/299 (54%)
GALNT13	NP_001363332.1	Ricin_B_lectin	431..548	CDD:395527	42/119 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820