DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant2 and GALNT6

DIOPT Version :9

Sequence 1:	NP_608773.2	Gene:	Pgant2 / 33556	FlyBaseID:	FBgn0031530	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_009141.2	Gene:	GALNT6 / 11226	HGNCID:	4128	Length:	622	Species:	Homo sapiens

Alignment Length:	539	Identity:	224/539 - (41%)
Similarity:	312/539 - (57%)	Gaps:	63/539 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 RLPVAPSGRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDI-PDTRNPMCRTK 195
            |.|..|:..|.:.:.|.::.:... ..:..|:.|.::.||..|||.:...|.: ||||.|.|..:
Human   105 RPPQDPNAPGADGKAFQKSKWTPL-ETQEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQ 168

  Fly   196 KYRE--DLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYS--DHPEDGLE--LA 254
            |:|.  .|..|||||.|||||.||||||:.|||:.:|..|::||:||||.|  :|.::.||  :.
Human   169 KFRRCPPLATTSVIIVFHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDASTEEHLKEKLEQYVK 233

  Fly   255 KIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCPVI 319
            ::..|||:|.::|:||:.:|:.||..|.:.||||||:|.||...||||||.|:.||.|.||.|.|
Human   234 QLQVVRVVRQEERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTVVVSPDI 298

  Fly   320 DVISMDNFQYI----GASADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAGGLFVID 380
            ..|.::.|::.    ......||.|||:|.|.||.|.|.|: .|..|.|..|::|..|||||.|.
Human   299 VTIDLNTFEFAKPVQRGRVHSRGNFDWSLTFGWETLPPHEK-QRRKDETYPIKSPTFAGGLFSIS 362

  Fly   381 KAYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFAR 445
            |:||..:|.||.:|::|||||:|:|||||||||.|||||||.||||||.:.|:|||.|: :|.||
Human   363 KSYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGT-SVIAR 426

  Fly   446 NTRRAAEVWMDDYKQHYY----NAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQAP 506
            |..|.||||||.||:.:|    .|..:|:...||:|.:||.|:|:|||..|.|||.||||::..|
Human   427 NQVRLAEVWMDSYKKIFYRRNLQAAKMAQEKSFGDISERLQLREQLHCHNFSWYLHNVYPEMFVP 491

  Fly   507 D--PQEVGQFRQDST-ECLDTMGHLIDGTVG----------IFPCHNTGGNQEWAFTKRGEIKHD 558
            |  |...|..:...| :|||         ||          ::.||..||||.:.:|.:.:::|:
Human   492 DLTPTFYGAIKNLGTNQCLD---------VGENNRGGKPLIMYSCHGLGGNQYFEYTTQRDLRHN 547

  Fly   559 ---DLCLTLVTFARG----------SQVVLKACDDSENQRWIMREGGLVRHYKINVCLDSRDQSQ 610
               .|||.:...|.|          |||       .:::.|.:.:..|:|:.....||.|:|:..
Human   548 IAKQLCLHVSKGALGLGSCHFTGKNSQV-------PKDEEWELAQDQLIRNSGSGTCLTSQDKKP 605

  Fly   611 QGVSAQHCNSALGTQRWSF 629
               :...||.:...|.|.|
Human   606 ---AMAPCNPSDPHQLWLF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	WcaA	200..>432	CDD:223539	126/239 (53%)
		pp-GalNAc-T	205..500	CDD:133004	160/306 (52%)
		Ricin_B_lectin	511..627	CDD:279046	33/139 (24%)
		RICIN	513..629	CDD:238092	33/139 (24%)
GALNT6	NP_009141.2	Catalytic subdomain A	176..285		58/108 (54%)
		pp-GalNAc-T	180..485	CDD:133004	160/306 (52%)
		Catalytic subdomain B	348..410		41/61 (67%)
		Ricin_B_lectin	497..619	CDD:306998	33/140 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920