DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant2 and Galnt16

DIOPT Version :9

Sequence 1:	NP_608773.2	Gene:	Pgant2 / 33556	FlyBaseID:	FBgn0031530	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_001074890.1	Gene:	Galnt16 / 108760	MGIID:	1917754	Length:	558	Species:	Mus musculus

Alignment Length:	631	Identity:	282/631 - (44%)
Similarity:	375/631 - (59%)	Gaps:	98/631 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IVFVSIIWMFVMVYYFQSSTEKVENRALRLREVATAMQQYQDDSSSAAAASTARQWAPAGGGAGP 72
            |..:::.|:....||.                       :||:.:.||::|
Mouse     9 IAILTVAWILGTFYYL-----------------------WQDNRAHAASSS-------------- 36

  Fly    73 GAAAGAAGSGADDPGGNVILIGSVKDFERNAVHGLKLNGIVALEETSQGLSGGTGGPGGRLPVAP 137
                   |.||...||.              ...|:.:..:.|..|
Mouse    37 -------GRGAQRAGGR--------------PEQLREDRTIPLIVT------------------- 61

  Fly   138 SGRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDIPDTRNPMCRTKKYREDLP 202
               ||..:.|:|..|:.|..|:.|||||.::.|||..||.|.|:|.|.|||:..|.:..|..|||
Mouse    62 ---GTPSKGFDEKAYLSAKQLKPGEDPYRQHAFNQLESDKLSSDRPIRDTRHYSCPSLSYSSDLP 123

  Fly   203 ETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSDHPEDGLELAKIDKVRVIRNDKR 267
            .||||||||||||||||||:.|||||:|..||:||:||||:|..|||.|.|.:|.||:.:|||||
Mouse   124 ATSVIITFHNEARSTLLRTVKSVLNRTPASLIQEIILVDDFSSDPEDCLLLTRIPKVKCLRNDKR 188

  Fly   268 EGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCPVIDVISMDNFQYIGA 332
            |||:||||:|||.|.::||||||||.|.|..||:|:|:||.||.||||.|:|||||:|||.|:.|
Mouse   189 EGLIRSRVRGADVAGATVLTFLDSHCEVNVEWLQPMLQRVMEDHTRVVSPIIDVISLDNFAYLAA 253

  Fly   333 SADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDKAYFNKLGKYDMKMDVW 397
            ||||||||||:|.||||.: |.|:.|...|||..||||:||||:|||||::||.|||||.:||:|
Mouse   254 SADLRGGFDWSLHFKWEQI-PLEQKMTRTDPTKPIRTPVIAGGIFVIDKSWFNHLGKYDAQMDIW 317

  Fly   398 GGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFARNTRRAAEVWMDDYKQHY 462
            ||||.|:|||||.|||||||:|||||||||||||||.||.|:...:.|||:|.||||||:|||:|
Mouse   318 GGENFELSFRVWMCGGSLEIVPCSRVGHVFRKRHPYNFPEGNALTYIRNTKRTAEVWMDEYKQYY 382

  Fly   463 YNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQAPDPQEVGQFRQDSTECLDTMGH 527
            |.|.|.|....||::..|:..::|:.||.|:||||||||:|..|..:.:....:....||::.|.
Mouse   383 YEARPSAIGKAFGSVATRIEQRKKMDCKSFRWYLENVYPELTVPVKEVLPGVIKQGVNCLESQGQ 447

  Fly   528 LIDG--TVGIFPCHNTGGN----QEWAFTKRGEIKHDDLCL----TLVTFARGSQVVLKACDDSE 582
            ...|  .:|:..|..:..:    |.|.|:.. .|:....||    ||:: :.||.|:|:.|:..|
Mouse   448 NTAGDLLLGMGICRGSAKSPPPAQAWLFSDH-LIQQQGKCLAATSTLMS-SPGSPVILQTCNPKE 510

  Fly   583 -NQRWIMREGGLVRHYKINVCLDSRDQSQQGVSAQHCNSALGTQRW 627
             .|:| .|:|..::|....:||:::  ..|.|::: |.:....|:|
Mouse   511 GKQKW-RRKGSFIQHSVSGLCLETK--PAQLVTSK-CQTDAQAQQW 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	WcaA	200..>432	CDD:223539	166/231 (72%)
		pp-GalNAc-T	205..500	CDD:133004	198/294 (67%)
		Ricin_B_lectin	511..627	CDD:279046	31/126 (25%)
		RICIN	513..629	CDD:238092	32/126 (25%)
Galnt16	NP_001074890.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..53		7/53 (13%)
		Catalytic subdomain A	122..227		73/104 (70%)
		pp-GalNAc-T	126..420	CDD:133004	198/294 (67%)
		Catalytic subdomain B	286..348		48/61 (79%)
		Ricin_B_lectin	441..552	CDD:306998	31/116 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351893at33208
OrthoFinder	1	1.000	-	-		FOG0001204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2085
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820