Protein Alignment Pgant2 and Galnt2

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_644678.2
• Gene: Galnt2 / 108148
• MGIID: 894694
• Length: 570
• Species: Mus musculus
• Alignment Length: 637
• Identity: 349/637 - (54%)
• Similarity: 433/637 - (67%)
• Gaps: 81/637 - (12%)

  Fly     1 MRRNIKLIVFVSIIWMFVMVYYFQSSTEKVENRALRLREVATAMQQYQDDSSSAAAASTARQWAP 65
            |||..::::..:::|:..:.||..|
Mouse     1 MRRRSRMLLCFALLWVLGIAYYMYS---------------------------------------- 25

  Fly    66 AGGGAGPGAAAGAAGSGAD--DPGGNVILIGSVKDFERNAVHGLKLNGIVALEETSQGLSGGTGG 128
             |||:...|..|.||...|  |       |.|:|..:.:...|         :|.:||:.  |..
Mouse    26 -GGGSALAAGGGGAGRKGDWND-------IDSIKKKDLHHSRG---------DEKAQGVE--TLP 71

  Fly   129 PGGRLPVAPSGRGTEVEY--FNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDIPDTRNPM 191
            ||            :|.:  ||:..|:....:|:|:|||.||:|||..||.|..:|.|||||:..
Mouse    72 PG------------KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLHMDRGIPDTRHDQ 124

  Fly   192 CRTKKYREDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSDHPEDGLELAKI 256
            |:.|::|.|||.|||:|||||||||.||||:||||.|||.|||:||:||||||:.||||..|.||
Mouse   125 CQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKRSPPHLIKEIILVDDYSNDPEDGALLGKI 189

  Fly   257 DKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCPVIDV 321
            :||||:|||:||||:||||:|||||.:.||||||||.||||.|||||||||.||.||||.|:|||
Mouse   190 EKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNERWLEPLLERVAEDRTRVVSPIIDV 254

  Fly   322 ISMDNFQYIGASADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDKAYFNK 386
            |:||||||:||||||:|||||||:|||:|::|.:|..|..:|...|:||||||||||:||.||.:
Mouse   255 INMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKLYFEE 319

  Fly   387 LGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFARNTRRAA 451
            ||||||.||||||||||||||||||||||||||||||||||||:||||||||||.||||||||||
Mouse   320 LGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAA 384

  Fly   452 EVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQAPDPQEV--GQF 514
            |||||:||..||.|||.|:|:|:|||..||.|::||.||||||||:||||:|:.||.|::  |..
Mouse   385 EVWMDEYKHFYYAAVPSARNVPYGNIQSRLELRKKLGCKPFKWYLDNVYPELRVPDHQDIAFGAL 449

  Fly   515 RQDSTECLDTMGHLIDGTVGIFPCHNTGGNQEWAFTKRGEIKHDDLCLTLVTFARGSQVVLKACD 579
            :| .|.||||:||..||.|||:.|||.|||||||.||...:||.|||||:|..:.||.:.|:.|.
Mouse   450 QQ-GTNCLDTLGHFADGVVGIYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRSPGSLIRLQGCR 513

  Fly   580 DSEN-QRWIMREG-GLVRHYKINVCLDSRDQSQQGVSAQHCNSALGTQRWSF 629
            :::: |:|...|| ..:||...|:|||||.....|:|.:.|..|| :|:|.|
Mouse   514 ENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPAL-SQQWKF 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	228/294 (78%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	57/122 (47%)
Galnt2	NP_644678.2	Catalytic subdomain A	134..239		81/104 (78%)
		pp-GalNAc-T	138..433	CDD:133004	228/294 (78%)
		Catalytic subdomain B	299..361		54/61 (89%)
		beta-trefoil_Ricin_GALNT2	445..564	CDD:467312	57/120 (48%)