DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant2 and POC1B-GALNT4

DIOPT Version :9

Sequence 1:	NP_608773.2	Gene:	Pgant2 / 33556	FlyBaseID:	FBgn0031530	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_001186710.1	Gene:	POC1B-GALNT4 / 100528030	HGNCID:	42957	Length:	575	Species:	Homo sapiens

Alignment Length:	609	Identity:	246/609 - (40%)
Similarity:	332/609 - (54%)	Gaps:	85/609 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AASTARQWAPAGGGAGPGAAAGAAGSGADDPGGNVILIGS--VKDFERNAVHGLKLNGIVALEET 118
            ||.|:...:|.|...|.|.|..               :||  :.|.::|.            |:.
Human    19 AAITSLDLSPNGKQLGAGRARE---------------LGSRRLSDLQKNT------------EDL 56

  Fly   119 SQGLSGGTGGPGGRLPVAPS------GRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASDA 177
            |:        |..:.|.|.|      |:.:::: .||      ..|:..|:...|...|...||.
Human    57 SR--------PLYKKPPADSRALGEWGKASKLQ-LNE------DELKQQEELIERYAINIYLSDR 106

  Fly   178 LPSNRDIPDTRNPMCRTKKYR-EDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVD 241
            :..:|.|.|.|...|:::|:. ..||.|||||.|:|||.|||||||.|||..||..|::||:|||
Human   107 ISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVD 171

  Fly   242 DYSD--HPEDGLE--LAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEP 302
            |.||  :.:..||  ::.:|:||:||.:|||||||:|:.||..|...||||||.|.|||..||||
Human   172 DLSDRVYLKTQLETYISNLDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEP 236

  Fly   303 LLERVREDPTRVVCPVIDVISMDNFQ-YIGASADLRGGFDWNLIFKWEYLSPSERAMRHN--DPT 364
            ||||:..|.|.|||||||.|..:.|: |:.....:.|||||.|.|:|..:...||..|.:  ||
Human   237 LLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDP- 300

  Fly   365 TAIRTPMIAGGLFVIDKAYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRK 429
              ||:|.:|||||.:.|.||..||.||..|:||||||||:|||||||||.|||.|||.|||||.|
Human   301 --IRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPK 363

  Fly   430 RHPYTFPGGSGNVFARNTRRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKW 494
            |.||..|.     |.:||.||||||||:||:|:||..|.|:...:|:|.:|..|:|:|.||.|.|
Human   364 RAPYARPN-----FLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDISERKLLRERLRCKSFDW 423

  Fly   495 YLENVYPDLQAPD--PQEVGQFRQD--STECLD---TMGHLIDGTVGIFPCHNTGGNQEWAFTKR 552
            ||:||:|:|..|:  |...|..|..  |:||||   ...:.....:.:|.||..||||.:.:|..
Human   424 YLKNVFPNLHVPEDRPGWHGAIRSRGISSECLDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSN 488

  Fly   553 GEIKHD---DLCLTLVTFARGSQVVLKACDDS-----ENQRWIMREGGLVRHYKINVCLDS--RD 607
            .||:.:   :||..:.  .:.:.|.::.|...     .|..|..:|.|.:.|....:||.:  ..
Human   489 KEIRFNSVTELCAEVP--EQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTP 551

  Fly   608 QSQQGVSAQHCNSALGTQRWSFGK 631
            :.:..|..:.|::....|.|||.|
Human   552 EGRPDVQMRTCDALDKNQIWSFEK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	WcaA	200..>432	CDD:223539	139/238 (58%)
		pp-GalNAc-T	205..500	CDD:133004	170/301 (56%)
		Ricin_B_lectin	511..627	CDD:279046	31/130 (24%)
		RICIN	513..629	CDD:238092	31/130 (24%)
POC1B-GALNT4	NP_001186710.1	WcaA	131..427	CDD:223539	172/303 (57%)
		pp-GalNAc-T	135..429	CDD:133004	170/301 (56%)
		RICIN	443..573	CDD:238092	32/131 (24%)
		Ricin_B_lectin	443..571	CDD:279046	31/129 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810