DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15412 and FBXL18

DIOPT Version :10

Sequence 1:NP_001259996.1 Gene:CG15412 / 33553 FlyBaseID:FBgn0031528 Length:486 Species:Drosophila melanogaster
Sequence 2:NP_001308142.1 Gene:FBXL18 / 80028 HGNCID:21874 Length:801 Species:Homo sapiens


Alignment Length:581 Identity:111/581 - (19%)
Similarity:194/581 - (33%) Gaps:206/581 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 LGATPNIYQDLLRVILSSDYLDANMRFTCLQMLLNC-GVTFLMTEVFPFSYY---EKILQVIAAQ 113
            ||.:..|...:|..:.|:| |..|:|.||.::...| ..:.:.|.:....|.   :|:.|::...
Human    29 LGFSDEILLHILSHVPSTD-LILNVRRTCRKLAALCLDKSLIHTVLLQKDYQASEDKVRQLVKEI 92

  Fly   114 GAGLRVLNIKG-IWVKEEHMHYMYDIVRKCKQLVKL-----YVPYIANDRLLEEIGN-------- 164
            |..::.|::.| .|:....:.:    |.:|:.|||:     ::..:...::|..:.:        
Human    93 GREIQQLSMAGCYWLPGSTVEH----VARCRSLVKVNLSGCHLTSLRLSKMLSALQHLRSLAIDV 153

  Fly   165 ------------------------------------CCTRL-------QILD-------ISGETD 179
                                                |||.|       :|||       :||:..
Human   154 SPGFDASQLSSECKATLSRVRELKQTLFTPSYGVVPCCTSLEKLLLYFEILDRTREGAILSGQLM 218

  Fly   180 ITEIGID----------LLAKGVCSQS-----LTVVD-----------VGMPGE----------- 207
            :.:..:.          .||.|..:|.     |.|:.           :.:||.           
Human   219 VGQSNVPHYQNLRVFYARLAPGYINQEVVRLYLAVLSDRTPQNLHAFLISVPGSFAESGATKNLL 283

  Fly   208 ----ENICYSDIAL---------ILEHC----PQVETLSTYSFVGASL--KFIHDNVDDRFKCRL 253
                .|:....:.|         :|:|.    |...:.|..:..|..|  :.|:...|.|....|
Human   284 DSMARNVVLDALQLPKSWLNGSSLLQHMKFNNPFYFSFSRCTLSGGHLIQQVINGGKDLRSLASL 348

  Fly   254 KY---IH-----------DTGTDEATLQVIMQTCPRLETLYLDSPKTGSLRALS---------TR 295
            ..   :|           :...|.:.|:.::.:|..|..|.|.:....|...|.         .|
Human   349 NLSGCVHCLSPDSLLRKAEDDIDSSILETLVASCCNLRHLNLSAAHHHSSEGLGRHLCQLLARLR 413

  Fly   296 NLRKLKIYKFVVAELLPLLERPIGRNLRHLTMIKGLG-NLELGKLARLCPSLIDLDCYMIDSLSY 359
            :||.|.:....||:..|..:|...:...| .:.:|.| .:.:|  .:.|||..            
Human   414 HLRSLSLPVCSVADSAPRADRAPAQPAMH-AVPRGFGKKVRVG--VQSCPSPF------------ 463

  Fly   360 GAGHAKFQQLEGLEILSSAILTSSLKAFLCNSTDLKRLAVDTVEFTDDDIMSMFMQHDFKVLEDV 424
             :|.|..|        .|::..|.||    |...|:.|.:....|      |..|..:...:.: 
Human   464 -SGQACPQ--------PSSVFWSLLK----NLPFLEHLELIGSNF------SSAMPRNEPAIRN- 508

  Fly   425 WFTLAPELTVQSVELLMDSCPELQSVGQLNGWSLTPDDLALIRGLLKSGNSSIVLTPNGFL 485
              :|.|....|||.   ||  |:.::||          ||.:|.|..:...| |||.:|.:
Human   509 --SLPPCSRAQSVG---DS--EVAAIGQ----------LAFLRHLTLAQLPS-VLTGSGLV 551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15412NP_001259996.1 AMN1 <142..>228 CDD:187754 27/202 (13%)
leucine-rich repeat 145..168 CDD:275381 6/71 (8%)
leucine-rich repeat 169..196 CDD:275381 9/50 (18%)
leucine-rich repeat 197..224 CDD:275381 8/65 (12%)
leucine-rich repeat 225..252 CDD:275381 6/28 (21%)
leucine-rich repeat 253..275 CDD:275381 5/35 (14%)
leucine-rich repeat 369..393 CDD:275381 5/23 (22%)
leucine-rich repeat 394..416 CDD:275381 5/21 (24%)
FBXL18NP_001308142.1 F-box_FBXL18 28..71 CDD:438900 12/42 (29%)
FBXL18_LRR 85..678 CDD:466163 96/524 (18%)
leucine-rich repeat 345..384 CDD:275381 5/38 (13%)
leucine-rich repeat 385..414 CDD:275381 5/28 (18%)
leucine-rich repeat 415..484 CDD:275381 22/96 (23%)
leucine-rich repeat 451..476 CDD:275381 8/47 (17%)
leucine-rich repeat 485..532 CDD:275381 16/70 (23%)
leucine-rich repeat 533..559 CDD:275381 7/20 (35%)
leucine-rich repeat 560..589 CDD:275381
leucine-rich repeat 590..615 CDD:275381
leucine-rich repeat 616..640 CDD:275381
Blue background indicates that the domain is not in the aligned region.

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