DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15412 and Fbxl22

DIOPT Version :9

Sequence 1:	NP_001259996.1	Gene:	CG15412 / 33553	FlyBaseID:	FBgn0031528	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_780415.1	Gene:	Fbxl22 / 74165	MGIID:	1921415	Length:	236	Species:	Mus musculus

Alignment Length:	226	Identity:	45/226 - (19%)
Similarity:	76/226 - (33%)	Gaps:	88/226 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 HMHYMYDIVRKCKQLVKLYVPYIANDRL---LEEIGNC--CTRLQILDISGETDITEIGIDLLAK 190
            |.|.:.::.:.             |.||   |..:..|  .:|:|:..|.....      ..|.:
Mouse    47 HFHSLAELKKD-------------NFRLSPALRSLSICWHSSRVQVCSIEDWLK------SALQR 92

  Fly   191 GVCSQSLTVVDVGMPGEENICYSDIAL-ILEHCPQVE--TLSTYSFVGASLKFIHDNVDDRFKCR 252
            .:|||..::|            :|..| :...||.:.  |||....|
Mouse    93 SICSQHESLV------------NDFLLQVCNRCPNLTSVTLSGCGHV------------------ 127

  Fly   253 LKYIHDTGTDEATLQVIMQTCPRLETLYLDSPKTGSLRALSTRNLRKLKIYKFVVAELLPLLERP 317
                    ||:...:::: :||||.||.|::....:.|.|:.           |.|.
Mouse   128 --------TDDCLARLLL-SCPRLRTLRLENCARVTNRTLAA-----------VAAH-------- 164

  Fly   318 IGRNLR--HLTMIKGLGNLELGKLARLCPSL 346
             ||.|:  |:...:.:....|.:|...||:|
Mouse   165 -GRALQTLHVDFCRNVSAAGLLRLRAACPNL 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15412	NP_001259996.1	AMN1	<142..>228	CDD:187754	17/93 (18%)
		leucine-rich repeat	145..168	CDD:275381	5/27 (19%)
		leucine-rich repeat	169..196	CDD:275381	5/26 (19%)
		leucine-rich repeat	197..224	CDD:275381	4/27 (15%)
		leucine-rich repeat	225..252	CDD:275381	4/28 (14%)
		leucine-rich repeat	253..275	CDD:275381	3/21 (14%)
		leucine-rich repeat	369..393	CDD:275381
		leucine-rich repeat	394..416	CDD:275381
Fbxl22	NP_780415.1	F-box-like	3..43	CDD:403981
		LRR 1	15..40
		LRR 2	43..72		6/37 (16%)
		AMN1	45..>200	CDD:187754	45/226 (20%)
		LRR 3	98..123		7/36 (19%)
		leucine-rich repeat	116..141	CDD:275381	7/51 (14%)
		LRR 4	124..149		10/51 (20%)
		leucine-rich repeat	142..167	CDD:275381	9/44 (20%)
		LRR 5	150..175		8/44 (18%)
		leucine-rich repeat	168..193	CDD:275381	5/24 (21%)
		LRR 6	176..201		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100