Protein Alignment CG15412 and FBXL17

DIOPT Version :9

• Sequence 1: NP_001259996.1
• Gene: CG15412 / 33553
• FlyBaseID: FBgn0031528
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: XP_005272105.1
• Gene: FBXL17 / 64839
• HGNCID: 13615
• Length: 712
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 80/400 - (20%)
• Similarity: 156/400 - (39%)
• Gaps: 105/400 - (26%)

  Fly   145 LVKLYVPYIANDRLLEEIGNC------CTRLQI---LDISGETDITEIGIDLLAKGVCSQSLTVV 200
            |:|::.....::|.|.....|      |...|.   ||:|....:|:   :||.| :.|:|..::
Human   329 LLKIFSNLSLDERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTD---ELLEK-IASRSQNII 389

  Fly   201 DVGMPGEENICYSDIALILEHCP--------QVETLSTYSFVGAS-----LKFIHDNVDDRF--- 249
            ::.:....::..:.:.::...||        :.:.||..|.:..:     |:.:|....|:.
Human   390 EINISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDE 454

  Fly   250 -------KCR-LKYIHDTG-----TDEATLQVIMQTCPRLETLYLDSPK---TGSLRALSTRNLR 298
                   ||| ||.|| .|     :||..: ||.:.|.:|:.:|:...|   ..|::|.: .:..
Human   455 GLKQLGSKCRELKDIH-FGQCYKISDEGMI-VIAKGCLKLQRIYMQENKLVTDQSVKAFA-EHCP 516

  Fly   299 KLKIYKFVVAELLPLLERPIGRNLRHLTMIKGLGNLELGKLARL-----------CPSLIDLD-C 351
            :|:...|:...:       ..:.:.|||.::.|.:|:|..:..|           |.:|..|: |
Human   517 ELQYVGFMGCSV-------TSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLC 574

  Fly   352 --YMIDSLSYGAGHAKFQQLEGLEILSSAILTSSLKAFLCNSTDLKRLAVDTVEFTDDDIMSMFM 414
              ::|:.........:.|.|:.|.::|            |..||...:|:.....|.:.:
Human   575 LNWIINDRCVEVIAKEGQNLKELYLVS------------CKITDYALIAIGRYSMTIETV----- 622

  Fly   415 QHDFKVLEDV-WFTLAPELTVQSVELLMDSCPELQSVGQLNGWSLTPD-------DLALIRGLLK 471
                    || |   ..|:|.|...|:..|...|:.:|.:....:..|       .::::..|:.
Human   623 --------DVGW---CKEITDQGATLIAQSSKSLRYLGLMRCDKVRVDYQVVCFLHISIVNSLMS 676

  Fly   472 SGNSSIVLTP 481
            ...|..:.||
Human   677 YPLSFSISTP 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15412	NP_001259996.1	AMN1	<142..>228	CDD:187754	18/99 (18%)
		leucine-rich repeat	145..168	CDD:275381	6/28 (21%)
		leucine-rich repeat	169..196	CDD:275381	9/29 (31%)
		leucine-rich repeat	197..224	CDD:275381	2/34 (6%)
		leucine-rich repeat	225..252	CDD:275381	7/41 (17%)
		leucine-rich repeat	253..275	CDD:275381	10/26 (38%)
		leucine-rich repeat	369..393	CDD:275381	4/23 (17%)
		leucine-rich repeat	394..416	CDD:275381	2/21 (10%)
FBXL17	XP_005272105.1	F-box-like	321..368	CDD:289689	9/38 (24%)
		leucine-rich repeat	362..387	CDD:275381	9/28 (32%)
		leucine-rich repeat	388..413	CDD:275381	1/24 (4%)
		AMN1	411..573	CDD:187754	38/171 (22%)
		leucine-rich repeat	414..439	CDD:275381	3/24 (13%)
		leucine-rich repeat	440..465	CDD:275381	5/24 (21%)
		leucine-rich repeat	466..491	CDD:275381	10/26 (38%)
		leucine-rich repeat	492..517	CDD:275381	5/25 (20%)
		leucine-rich repeat	518..541	CDD:275381	5/29 (17%)
		leucine-rich repeat	542..567	CDD:275381	5/24 (21%)
		AMN1	547..>652	CDD:187754	26/132 (20%)
		leucine-rich repeat	568..593	CDD:275381	4/24 (17%)
		leucine-rich repeat	594..615	CDD:275381	7/32 (22%)
		leucine-rich repeat	619..641	CDD:275381	7/37 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100