Protein Alignment GramD1B and LAM4

DIOPT Version :10

• Sequence 1: NP_995623.2
• Gene: GramD1B / 33552
• FlyBaseID: FBgn0085423
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_011948.1
• Gene: LAM4 / 856480
• SGDID: S000001122
• Length: 1345
• Species: Saccharomyces cerevisiae
• Alignment Length: 1181
• Identity: 242/1181 - (20%)
• Similarity: 417/1181 - (35%)
• Gaps: 346/1181 - (29%)

  Fly    15 NVDAKKAKRKKMIKDSDKINPTTSSVNITVTTAESSSSCKNPANANMIPETTQPDQLQSQTQTQA 79
            |.:......|...:|.:..:.:..|:::.....|...|.|...::|...|.| ||.....|..:.
Yeast   108 NTNLTAGSLKGRFQDGNSNSNSVPSLSVQALEKEKLQSGKREGSSNQAEEKT-PDGHDEHTAFET 171

  Fly    80 QLQPQSQSPSQCQQ--AQENPEHLQQQSQPEEELQAEAPGSNAGDRRDSITEEITITSTTNSSQS 142
            .|.....:.|...:  .|:.......:::|::..:      |:.:...:::|..|....|:|:
Yeast   172 FLSFAHNAVSHIPKINVQDADNGTISRNEPKDRKK------NSSNISGALSENSTNNKNTSST-- 228

  Fly   143 TKLLTIQEAAGSFEQS-----SVSAVSTSSKQIASTTAGGS---PPAAAAPGANEFNGSVLRLTQ 199
                  :|:.|.|.::     :.|..||.|.|..:||..||   |.:.:........|.:...:.
Yeast   229 ------KESDGPFLKNLDNILAASKSSTPSNQQLNTTEAGSKSKPSSLSRLAFGNLKGHIHSNSH 287

  Fly   200 AATSTSPGSISSAGNT---------------------------------------ATLGAAPSIN 225
            ::::...|..:|..:|                                       |||   ..:.
Yeast   288 SSSNAISGDDTSLDDTRKMTDDMARKVVFEPIRHSHDKPTPGVGNLKLEHFDDSQATL---EGLE 349

  Fly   226 IVSSES--------TRDQTQQ-------------------PQSVDPNGVAAPGDSPSSRKSSTSS 263
            .:|:||        :|...||                   ...|.|...|....|..:.|.:|||
Yeast   350 AMSAESLPEADHLDSRGPVQQSNLERKTVPSKWSVVSSSTTDGVKPRRRAKSMISAMADKQNTSS 414

  Fly   264 KG-KASQAKLSTSSSG-----------RDEQDISQHRLS----------------DLTQHELSLL 300
            .. :..:.:||.:||.           |:.:::|:..|:                ..|..:.||.
Yeast   415 DVLQDCKKRLSFNSSNGLTNNDPEYEDREPREMSKKFLNRRSFSPGSISMGMKVLPSTALKYSLN 479

  Fly   301 RVDREQQVTSS----SSTSNEKPAKTSRLSERAKKKSW----YNVIYPN---------------Y 342
            :|.....:.|:    .|.||.:|:...|   |:..||:    .|:|.|:               |
Yeast   480 KVKNSTDIASTIIPRPSMSNGRPSSGLR---RSSSKSFSSTPVNIIEPSEENGRQSSIRIKGVEY 541

  Fly   343 KSRAED--FKKLFKD--VPNDERLIVDYSCALQRDILVQGRLYVSQNYVCFHANIFSWETHVSIK 403
            .|..:|  |..:|||  |..:||||:|:||||.||||:|||:|:|..::.|::||..|.:.|.|.
Yeast   542 ASEKKDAEFHAIFKDSGVSPNERLILDHSCALSRDILLQGRMYISDQHIGFYSNILGWVSTVFIP 606

  Fly   404 WKDVTAITKEKTALVIPNAISISSGKDKYFFATFTSRDKSFLMLFRVWQNTLMNKQF-------- 460
            :|.:..|.|..||.:.||.|.|.:...||.||:|||||.::.::..||...::.|:|
Yeast   607 FKTIVQIEKRATAGIFPNGIVIDTLHTKYTFASFTSRDATYDLITEVWNQIILGKRFRSNSNNTN 671

  Fly   461 -SPQEIWQHVHTCYGDELGLTTDDE--DYIDPTLNKTNEPDFDFQTAIDDDSYSQRQSQQSNQSN 522
             |...|               :|||  ||.|         |:|.....|||.|     ..||..:
Yeast   672 SSSNSI---------------SDDENDDYDD---------DYDDYGDDDDDLY-----DNSNNIS 707

  Fly   523 QSNPL-----------LPQSGNSSASSGGGVRASAPR---KSKTKYFFNSSKSSANASASGSDNN 573
            .|..:           ||....:....|.|:....|:   .::|.|     |.:.|....   |.
Yeast   708 DSTDMTSSVSIGKPEDLPMPLQTDTPYGTGIPPLGPKIHSPTETVY-----KPAPNEKLV---NE 764

  Fly   574 KTRESS--RKLNKKMKQNAKEL--TLSSVKPTELS-VSVTMSAPNVSSSST-------------- 619
            .|..:|  |.:|....::...:  .|.:.|.:::| :.|.:.:|.||....
Yeast   765 STIHASLGRVVNILFGKDVSYIMAILKAQKNSDISPIPVLVDSPTVSEGKKRDYSYVKTTPGAIG 829

  Fly   620 AGSTTASSSTIANHTGSGSGSGSLSGSNTAAASGSGSDKMSAEKKVSTASNSAA-----VAAAEA 679
            .|.|....:....|.........|..:.|.......|..:.....:|.|:|:..     |:....
Yeast   830 PGKTKCMITETIQHFNLEEYVQVLQTTKTPDVPSGNSFYVRTVYLLSWANNNETKLKLYVSVEWT 894

  Fly   680 AQSLASASSGSGSLESKME------------MKRKLGKMHRQREEGKNAAESVP----------- 721
            .:||..:....|:.:...:            :.|...|..|..:|......::|
Yeast   895 GKSLIKSPIEKGTFDGVTDATKILVEELGNILTRSATKRKRSSKENTVTVSTLPKMEPSSHAPTE 959

  Fly   722 ----TDVSDSSDSEENNLPFVPTTECTSTHEGRQIVHTILPINVDTLFNLLFSKSKFITDFHAMR 782
                .|..||...|..|:|                    .|:.  |:..|||..:   |::  |:
Yeast   960 PDIQKDKDDSIIRENENIP--------------------APLG--TVVQLLFGSN---TEY--MQ 997

  Fly   783 KSTDLVLGEWTKNEEGLQVRTV---------------NVTVQLAASVGPKTSKVTEYQTQRECSK 832
            |..       |:::..:.|.|:               ..|.:|..|:|||         |.:|..
Yeast   998 KVI-------TRDKNNVNVETIPKFTPSLVEGGSRHYEYTKKLNNSIGPK---------QTKCLL 1046

  Fly   833 PGELYSIDVNSV--------NAGIPYAESFSVLIHFCLARTVDDHTMLSIHTQIKY-KKSIWGVV 888
            ...:..:|:|:.        ...:|...:|:|.....|.....|.|.:::.|:|.: .||.   :
Yeast  1047 TESIEHMDINNYVLVTQTTKTPDVPSGSNFAVESKIFLFWGQHDTTNMTVITKINWTSKSF---L 1108

  Fly   889 KGFIEKNTWAGLE---DFFGAQLHALQSETCIPPAKGKGRRP-RRGMNQQSATSTSTTSITTGAL 949
            ||.|||.:..|.:   |:..::|..:.|       :.|.::| ::.|..........:.:...:.
Yeast  1109 KGAIEKGSVEGQKVSVDYMLSELRDIIS-------RAKSKKPVKKVMKSHDKHRPFHSKVEQKSS 1166

  Fly   950 HTATSTDNDSI 960
            .:..|.||..|
Yeast  1167 ESRKSDDNKDI 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	42/92 (46%)
		VASt	751..899	CDD:464975	36/171 (21%)
LAM4	NP_011948.1	PH-GRAM_GRAMDC	561..654	CDD:275406	42/92 (46%)
		VASt	761..910	CDD:464975	25/151 (17%)
		VASt	974..1119	CDD:464975	38/190 (20%)