DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GramD1B and LAM5

DIOPT Version :9

Sequence 1:	NP_995623.2	Gene:	GramD1B / 33552	FlyBaseID:	FBgn0085423	Length:	1249	Species:	Drosophila melanogaster
Sequence 2:	NP_116611.1	Gene:	LAM5 / 850501	SGDID:	S000001852	Length:	674	Species:	Saccharomyces cerevisiae

Alignment Length:	772	Identity:	168/772 - (21%)
Similarity:	292/772 - (37%)	Gaps:	223/772 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 QENPEHLQQQSQPEEELQAEAPGSNAGDRRDSITEEITITSTTNS-SQSTKLLTIQEAAG----- 153
            :::.:.::|...|.|.   .:...||||......:|:.:.:.||. .::..::|.|.||.
Yeast    14 EDSTDSVKQLGPPFEH---ASNNDNAGDTEAESLQEVPLNTETNDVRKNLVVITNQSAADEHPTE 75

  Fly   154 -SFEQSSVSAVSTSSKQIASTTAGGSPPAAAAPGANEFNGSVLRLTQAATSTSPGSISSAGNTAT 217
             ..:||..|:.|:....:.|:.....|    :|           ::::.|.|||
Yeast    76 IKHDQSRTSSTSSFFSGMISSFKSNVP----SP-----------VSRSTTPTSP----------- 114

  Fly   218 LGAAPSINIVSSESTRDQTQQPQSVDPNGVAAPGDSPSSRKSSTSSKGKASQAKLSTSSSGRDEQ 282
                                         |:.|......|:.|..||.::|:
Yeast   115 -----------------------------VSQPSIISHRREPSMGSKRRSSR------------- 137

  Fly   283 DISQHRLSDLTQHELS--LLRVDREQQVTSSSSTSNEKPAKTSRLSERAKKKSWYNVIYPNYKS- 344
                 |:|:.|..|:.  |.:|::..:|.:..:.|..|......  .|..::.:.:..| :|.|
Yeast   138 -----RISNATIAEIGSPLQQVEKPDEVKTRLTPSQMKEDNYDH--RRFVEERYMDTPY-HYASE 194

  Fly   345 -RAEDFKKLFKDVPNDERLIVDYSCALQRDILVQGRLYVSQNYVCFHANIFSWETHVSIKWKDVT 408
             |.:||.:.||.||.|:||:.|::|.|.|::|.||:||:::.::||::|:..|...|.|.::|||
Yeast   195 QRNKDFHETFKSVPKDDRLLDDFNCGLNRELLYQGKLYITETHLCFNSNVLGWIAKVLIAFEDVT 259

  Fly   409 AITKEKTALVIPNAISISSGKDKYFFATFTSRDKSFLMLFRVWQNTLMNKQFSPQEIWQHVHTCY 473
            .:.|...|.:.|:||||.:...|..|..|.|||.:|.::..||..||:.|..:.:.|     ...
Yeast   260 FMEKTSAAGLFPSAISIETKMGKTLFNGFISRDAAFGLMKEVWSRTLLQKDMASENI-----NTK 319

  Fly   474 GDELGLTTDDEDYIDPTLNKTNEPDFDFQTAIDDDSYSQRQSQQSNQSNQSNPLLPQSGNSSASS 538
            .::.|...:.:|.|:....:.|:.|     |.|:|  :.....::..:|::.|      ||::||
Yeast   320 AEKSGNGKEIDDAINSIDEENNDKD-----ANDND--TNENDDENISTNETTP------NSTSSS 371

  Fly   539 GGGVRASAPRKSKTK-YFFNSSKS----------SANASASGSDNNKTRESSRKLNKKM------ 586
                    |.|.|.| |...:..|          |.:..|....||:.      :.|::
Yeast   372 --------PDKEKEKAYKLRADSSYQYDGPIYHHSTSFPAEPMANNEF------VLKELPFDCAP 422

  Fly   587 ----------KQNAKELTLSSVKPTELSVSVTMSAPNVS----SSST--------------AG-- 621
                      :||  |..|..::..|.|...|:  ||.:    ||.|              ||
Yeast   423 GILFEIMFNSEQN--EFLLDFLRGQEGSQITTI--PNFTSIDGSSMTLKREYSYEKALHFPAGPK 483

  Fly   622 STTASSSTIANHTGSGSGSGSLSGSNTAAASGSGS------------DKMSAEKKVS-----TAS 669
            |||...:.:.......:....:|...|......||            |:::...:||     |.|
Yeast   484 STTCYVAEVIKRKDPDTYYEVISSIRTPNVPSGGSFSTKTRYLIRWNDEITCLLRVSFWVEWTGS 548

  Fly   670 NSAAVAAAEAAQSLASASSGSGSLESKMEMKRKLGKMHRQREEGKNAAESVPTDVS----DSSDS 730
            :        ..:.:......:|.||:...|:|.|.|..      ||..|.....:|    :..|.
Yeast   549 S--------WIKGMVENGCKNGQLEAAQLMERILSKFI------KNNVEECQITISKEEEEQDDK 599

  Fly   731 EENN----------LPFVPTTECTSTHEGRQI-----VHTILPINVDTLFNLLFSKS 772
            |..|          ...|.|....:..:|.::     :...|.:.|..||||.:.:|
Yeast   600 EVKNKLKEVDLEQPREAVVTAPAIAEQQGLKVTMETWLFLYLIVVVLLLFNLFYIRS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	35/92 (38%)
GramD1B	NP_995623.2	DUF4782	751..897	CDD:292635	7/27 (26%)
LAM5	NP_116611.1	PH-GRAM_GRAMDC	209..302	CDD:275406	35/92 (38%)
LAM5	NP_116611.1	DUF4782	418..562	CDD:406424	26/155 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000885
OrthoInspector	1	1.000	-	-		otm46922
orthoMCL	1	0.900	-	-		OOG6_101929
Panther	1	1.100	-	-	O	PTHR23319
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1861
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840