DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GramD1B and gramd1c

DIOPT Version :9

Sequence 1:	NP_995623.2	Gene:	GramD1B / 33552	FlyBaseID:	FBgn0085423	Length:	1249	Species:	Drosophila melanogaster
Sequence 2:	XP_005162786.1	Gene:	gramd1c / 563054	ZFINID:	ZDB-GENE-050506-88	Length:	692	Species:	Danio rerio

Alignment Length:	1006	Identity:	238/1006 - (23%)
Similarity:	375/1006 - (37%)	Gaps:	356/1006 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 TQQPQSVDPNGVAAP-GDSPSSRKSSTSSKGKASQAKLSTSSSGRDEQDISQHRLSDLTQHELSL 299
            |:.|:.:..|.:|.. |.|...|.||                   :||:     :..:||
Zfish     2 TETPKPLMGNELAQENGQSGEVRGSS-------------------EEQE-----MKGITQ----- 37

  Fly   300 LRVDREQQVTSSSSTSN--EKPAKTSRLSERAKKKSWYNVIYPNYKSRAEDFKKLFKDVPNDERL 362
               ..:|.:..::...|  |:.|....:...|..:|..::.|.:||.|:::|:||||:||..|:|
Zfish    38 ---TPKQPMGKATDGKNPEEQEALEVTVQFTAAPQSTDSLYYTSYKQRSDEFRKLFKEVPEHEKL 99

  Fly   363 IVDYSCALQRDILVQGRLYVSQNYVCFHANIFSWETHVSIKWKDVTAITKEKTALVIPNAISISS 427
            :|||:||||:|||:|||:|.::|.:||::::|. .|.:.:..||:.:::|||||..|||||.||:
Zfish   100 VVDYTCALQKDILLQGRIYFTENCLCFYSHVFR-GTKIMVNMKDIISVSKEKTAKWIPNAIQIST 163

  Fly   428 GKDKYFFATFTSRDKSFLMLFRVWQNTLMNKQFSPQEIWQHVHTCYGDELGLTTDDEDYIDPTLN 492
            ..:|.||::|::|:||:..:||:|||.||.|:.:..|:.|.|...||::|||:.|:.:
Zfish   164 NSEKLFFSSFSTREKSYQSIFRLWQNVLMEKKLTKLELLQMVRQHYGNDLGLSHDEME------- 221

  Fly   493 KTNEPDFDFQTAIDDDSYSQRQSQQSNQSNQSNPLLPQSGNSSASSGGGVRASAPRKSKTKYFFN 557
                   .|||::|                ...|.||
Zfish   222 -------SFQTSVD----------------TITPTLP---------------------------- 235

  Fly   558 SSKSSANASASGSDNNKTRESSRKLNKKMKQNAKELTLSSVKPTELSVSVTMSAPNVSSSSTAGS 622
                                       .:....::.|....:||.|.:      |:...:|...|
Zfish   236 ---------------------------SLNMRGEDYTGRPERPTSLRL------PHGELNSYEAS 267

  Fly   623 TTASSSTIANHTGSGSGSGSLSGSNTAAASGSGSDKMSAEKKVSTASNSAAVAAAEAAQSLASAS 687
            |.           .|..:.|..|.::..::..|.|.:      ||.|:       :.:.:|:...
Zfish   268 TP-----------QGDDTQSSVGLHSVLSANGGDDSL------STPSH-------QLSPNLSLNR 308

  Fly   688 SGSGSLESKMEMKRKLGKMHRQREEGKNAAESVPTDVSDSSDSEENNLPFVPTTECTS-THEGRQ 751
            |||..:..:......|           ||.|...:|.|.|...||     |...|..| ..:||.
Zfish   309 SGSERVSKRSSFSLDL-----------NANEDQLSDNSRSDSLEE-----VEERETASPVSQGRL 357

  Fly   752 IVHTILPINVDTLFNLLFSKSKFITDFHAMRKSTDLVLGEWTKNEEGLQVRTVNVTVQLAASVGP 816
            .|:.:..|:.:.:||||||.|.|...|..:||.|.:....|.|...|...||:|.|:.:...:..
Zfish   358 FVNRVFHISAEKMFNLLFSDSSFTRRFMDIRKITGITATPWKKEASGCMKRTLNYTITINNPLVG 422

  Fly   817 KTSKVTEYQTQRECSKPGELYSIDVNSVNAGIPYAESFSVLIHFCLARTVDDHTMLSIHTQIKYK 881
            |.|..||.||..:.|:.|:.|.||.......:||.:.|.....:|:.|.......|.|:|.:|||
Zfish   423 KFSTATETQTLYKESREGQYYMIDSEVYTHDVPYHDYFYTQNRYCIIRNSKHKCRLRIYTDVKYK 487

  Fly   882 KSIWGVVKGFIEKNTWAGLEDFFGAQLHALQSETCIPPAKGKGRRPRRGMNQQSATSTSTTSITT 946
            |..||:||.||.||:|:||||:|    ..|::|.....|:              .|..|..:..|
Zfish   488 KQPWGLVKSFITKNSWSGLEDYF----RHLEAELLDEEAE--------------LTQGSGDAGKT 534

  Fly   947 GALHTATSTDNDSIQESRHPHQQDQHQHQHLHMHHHHHHHHGSQHHHHDARHSHHHHHQ---PLL 1008
            |||.....|.:.::||...|.:                           |::|.....|   .:.
Zfish   535 GALRRRRRTYSRTLQEHMKPAK---------------------------AQYSTDSEQQRTGTMG 572

  Fly  1009 PHHQQQHPHHWHHRKALLQSGRGTATQIRPLEEAVGPAPAVDPLETQMLAAGGIPGAAVGAAAGH 1073
            |...:..||.|:                                         |.....|.:
Zfish   573 PMDIKNTPHRWN-----------------------------------------ITSVVFGMS--- 593

  Fly  1074 PLLLEGGKQQQLHHQQQMHHHHLQPHKQHLQQQQLHLGGGDGQPLASGQGSQGHRLRHKGLWLLV 1138

Zfish   594 ----------------------------------------------------------------- 593

  Fly  1139 ILLLCLMLALNVILLLKLWRLEERIDVD----LNRRARM---------PSLAALSELPSTNQEWL 1190
             |:|.:::.||:.|..|||.:|   ||.    ||.:.||         |.|.....:|..:||
Zfish   594 -LILFVLVVLNLGLFFKLWAME---DVAHRMYLNTKHRMKERVESSLPPDLGPRHGMPHRSQE-- 652

  Fly  1191 ELLRDQEMAHENELHKWQQVLQTAIELLKKV 1221
                        |:|..:.|||.:|.||:::
Zfish   653 ------------EVHLLRAVLQDSINLLEQL 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	44/92 (48%)
GramD1B	NP_995623.2	DUF4782	751..897	CDD:292635	52/145 (36%)
gramd1c	XP_005162786.1	PH-GRAM_GRAMDC	97..187	CDD:275406	44/90 (49%)
gramd1c	XP_005162786.1	DUF4782	357..503	CDD:292635	52/145 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589815
Domainoid	1	1.000	120	1.000	Domainoid score	I5706
eggNOG	1	0.900	-	-		E1_KOG1032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D322809at33208
OrthoFinder	1	1.000	-	-		FOG0000885
OrthoInspector	1	1.000	-	-		otm24894
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23319
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X567
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.850