Protein Alignment GramD1B and gramd1a

DIOPT Version :9

• Sequence 1: NP_995623.2
• Gene: GramD1B / 33552
• FlyBaseID: FBgn0085423
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: XP_005158319.1
• Gene: gramd1a / 555994
• ZFINID: ZDB-GENE-060503-688
• Length: 907
• Species: Danio rerio
• Alignment Length: 1200
• Identity: 322/1200 - (26%)
• Similarity: 488/1200 - (40%)
• Gaps: 362/1200 - (30%)

  Fly    65 TTQPDQLQSQ---------TQTQAQLQPQSQSPSQCQQAQENPEHLQQQSQPEEELQAEA----- 115
            ||.|:.|.::         ....:..:..|:|||        |...:.:|:..|:.:|:|
Zfish    11 TTPPEILIAEPISIPILNILPPSSDTESWSRSPS--------PRAHRYRSRSREKRKAKAQQEDK 67

  Fly   116 PGSNAGDRRDSITEEITITSTTNSSQSTKLLTIQEAAGSFEQSSVSAVSTSSKQIAST--TAGGS 178
            .|:...|:|                           .|..|:|. |..|.||..:.:.  ...|:
Zfish    68 SGAKHCDKR---------------------------KGELERSP-SHASASSSMVCNVDDEEQGN 104

  Fly   179 PPAAAAPGANEFNGSVLRLTQAATSTSPGSISSAGNTATLGAAPSINIVSSESTRDQTQQPQSVD 243
            |.....|.:..::.|     .:.:..|..||.|..|..:          ..:|:...:..|:|
Zfish   105 PCVLLLPPSRSWSRS-----SSLSRRSRWSIRSLLNKDS----------DCDSSSTASNSPRS-- 152

  Fly   244 PNGVAAPGDSPSSRKSSTSSKGKASQAKLSTSSSGRDEQDISQHRLSDLTQHELSLLRVDREQQV 308
                 .||.|||.|:....  |:||:.:.:...||...                     |.....
Zfish   153 -----TPGSSPSLRRRVLG--GRASEGETAGEKSGGGS---------------------DSPLPP 189

  Fly   309 TSSSSTSNEKPAKTSRLSERAKK-KSWYNVIYPNYKSRAEDFKKLFKDVPNDERLIVDYSCALQR 372
            |.|||||: .|......:..||| :|||||:.|.||.|.|||:||||.:|:.||||||||||||:
Zfish   190 TPSSSTSS-YPLAARHFTRNAKKMQSWYNVLSPTYKQRNEDFRKLFKKLPDTERLIVDYSCALQK 253

  Fly   373 DILVQGRLYVSQNYVCFHANIFSWETHVSIKWKDVTAITKEKTALVIPNAISISSGKDKYFFATF 437
            |||:|||||:|:|::||::|||.|||.::|..||||.:||||||.:|||||.||:..:|:||.:|
Zfish   254 DILLQGRLYLSENWLCFYSNIFRWETTITILLKDVTNLTKEKTAKLIPNAIQISTENEKHFFTSF 318

  Fly   438 TSRDKSFLMLFRVWQNTLMNKQFSPQEIWQHVHTCYGDELGLTTDDEDYIDPTLNKTN-----EP 497
            .:||:|::|:||:|||.||:|..||:|:|..||.|||.|||||::|:||:.||....|     |.
Zfish   319 GARDRSYMMIFRLWQNALMDKTLSPKELWHIVHQCYGTELGLTSEDDDYVSPTAEHMNGLLPGEE 383

  Fly   498 DFDFQTAIDDDSYSQRQSQQSNQSNQSNPLLPQSGNSSASSGGGVRASAPRKSKTKYFFNSSKSS 562
            .......:|..|.               |:.|.|             |:|          .|.:|
Zfish   384 PVSVTDLLDLGSV---------------PVAPAS-------------SSP----------PSSAS 410

  Fly   563 ANASASGSDNNKTRESSRKLNKKMKQNAKELTLSSVKPTELSVSVTMSAPNVSSSSTAGSTTASS 627
            ....||||                                       |.|:.||||......:..
Zfish   411 VLPCASGS---------------------------------------SPPSSSSSSQPVEVPSIR 436

  Fly   628 STIANHTGSGSGSGSLSG-SNTAAASGSGSDKMSAEKKVSTASNSAAVAAAEAAQSLASASSGSG 691
            ::|.......|...||.. :||.|...|...|...:.:..:|::|        .||..|.....|
Zfish   437 ASIDPEPSPPSSQSSLPPVTNTGAVPASVILKEGGDSQSESANHS--------LQSPPSIPHNLG 493

  Fly   692 SLESKMEMKRKLGKMHRQREEGKNAAESVPTDVSDSSDSEENNLPFVPTTECTSTHEGRQIVHTI 756
            :| |.::|...               |.:|||.|:|||::|.:   ...:.|...: ||..::|:
Zfish   494 NL-SSLDMTND---------------EDLPTDPSNSSDTQEES---EVESFCADLN-GRLHINTV 538

  Fly   757 LPINVDTLFNLLFSKSKFITDFHAMRKSTDLVLGEWTK-NEEGLQVRTVNVTVQLAASVGPKTSK 820
            :.:.||.|.:||||.:.||....:.|..|||.:.||.: :..|...|.::.|:.:...:||||:.
Zfish   539 VRMGVDKLHDLLFSDTHFIQHLFSQRHFTDLSVHEWQQDSSSGSSSRVLSYTIAINNPLGPKTAP 603

  Fly   821 VTEYQTQRECSKPGELYSIDVNSVNAGIPYAESFSVLIHFCLARTVDDHTMLSIHTQIKYKKSIW 885
            |.|.||..:.|...|.|.:|...:.:||||.:.|..:..:||.......:.|.:.:.|.|:|..|
Zfish   604 VVETQTLHKSSSRSECYVVDSEVITSGIPYQDYFYTVHRYCLTSVNKHKSRLRVSSDICYRKQPW 668

  Fly   886 GVVKGFIEKNTWAGLEDFFGAQLHALQSETCIPPAKGKGRRPRRGMNQQSATSTSTTSITTGALH 950
            .:||..||||||:|:|:::    ..|:.|.|               ..::...|..|.::.|.:.
Zfish   669 SLVKALIEKNTWSGIEEYY----RHLEMEVC---------------KLETLLQTEVTVVSAGEMP 714

  Fly   951 TATSTDNDSIQESRHPHQQDQHQHQHLHMHHHHHHHHGSQHHHHDARHSHHHHHQPLLPHHQQQH 1015
            :..||                                                          :.
Zfish   715 SPDST----------------------------------------------------------KT 721

  Fly  1016 PHHWHHRKALLQSGRGTATQIRPLEEAVGPAPAVDPL--ETQMLAAGGIPGAAVGAAAGHPLLLE 1078
            |.....||.......|...:.|   ||.|.....|.:  |.....|||
Zfish   722 PPGLRRRKRTCPRRAGERDRDR---EAAGGGERGDRITDERDRREAGG----------------- 766

  Fly  1079 GGKQQQLHHQQQMHHHHLQPHKQHLQQQQLHLGGGDGQPLASGQGSQGHRLRHKGLWLLVILLLC 1143
                                       |.:.|    |:...:|.||..:.:  ..:.|:|..::|
Zfish   767 ---------------------------QYMKL----GERWRAGGGSNNNSI--STILLIVSFMIC 798

  Fly  1144 ----LMLALNVILLLKLWRLEERIDVDLNRRA------RMPSLAALSELPSTNQEWLELLRDQEM 1198
                :::|||::|..|||.||        |.|      ...||.. |.||.:..||.::|:.|..
Zfish   799 VSLVVLVALNMMLFYKLWALE--------RAAHTLETWHSYSLTD-SPLPQSAGEWAQVLQLQRQ 854

  Fly  1199 AHENELHKWQQVLQTAIELLKKVSIVCEKI 1228
            .|:.:::||||:||:::.||.::....||:
Zfish   855 FHQAQMNKWQQILQSSVTLLDQMKQSLEKL 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	58/92 (63%)
		DUF4782	751..897	CDD:292635	49/146 (34%)
gramd1a	XP_005158319.1	PH-GRAM_GRAMDC	239..332	CDD:275406	58/92 (63%)
		DUF4782	535..682	CDD:318273	51/146 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589814
Domainoid	1	1.000	156	1.000	Domainoid score	I4141
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1628
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D322809at33208
OrthoFinder	1	1.000	-	-		FOG0000885
OrthoInspector	1	1.000	-	-		otm24894
orthoMCL	1	0.900	-	-		OOG6_101929
Panther	1	1.100	-	-	LDO	PTHR23319
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1861
SonicParanoid	1	1.000	-	-		X567
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.930