Protein Alignment GramD1B and Gramd1a

DIOPT Version :9

• Sequence 1: NP_995623.2
• Gene: GramD1B / 33552
• FlyBaseID: FBgn0085423
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: XP_006228894.1
• Gene: Gramd1a / 361550
• RGDID: 1311022
• Length: 811
• Species: Rattus norvegicus
• Alignment Length: 1145
• Identity: 295/1145 - (25%)
• Similarity: 453/1145 - (39%)
• Gaps: 397/1145 - (34%)

  Fly   115 APGSNAGDRRDSITEEITITSTTNSSQSTKLLTIQE-AAGSFEQSSVSAVSTSSKQIASTTAGGS 178
            ||....|..:||        |.:.:.|.|:...:|: :..|:....|.|:     .|..::.|.|
  Rat    11 APQGAQGANQDS--------SGSPTEQQTQDDNVQDLSPKSWRLLGVPAI-----HITPSSDGES 62

  Fly   179 PPAAAAPGANEFNGSVLRLTQAATSTSPGSISSAGNTATLG-AAPSINIVSSESTRDQTQ----- 237
            ||  ..|....|        |:..:..|..:|....|...| ::||    ||.|.|.:.|
  Rat    63 PP--GTPNTPRF--------QSLKTPDPECLSQDSTTPHSGRSSPS----SSPSLRKRLQLLPPS 113

  Fly   238 QPQSV---DPNGVAAPGDSPSSRKSSTSSKGKASQAKLSTSSSGRDEQDISQHRLSDLTQHELSL 299
            :|.|.   :|..:...|...||.||..|       ..|||.|.|
  Rat   114 RPPSAPEPEPGTMVEKGSDSSSEKSGVS-------GTLSTQSLG--------------------- 150

  Fly   300 LRVDREQQVTSSSSTSNEKPAKTSRLSERAKKKSWYNVIYPNYKSRAEDFKKLFKDVPNDERLIV 364
                      |.:...|.|           |.:|||:::.|.||.|.|||:|||..:|..|||||
  Rat   151 ----------SRNFIRNSK-----------KMQSWYSMLCPTYKQRNEDFRKLFSKLPEAERLIV 194

  Fly   365 DYSCALQRDILVQGRLYVSQNYVCFHANIFSWETHVSIKWKDVTAITKEKTALVIPNAISISSGK 429
            ||||||||:||:|||||:|:|::||::|||.|||.:||:.|:||.:.|||||.:|||||.|.:..
  Rat   195 DYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTES 259

  Fly   430 DKYFFATFTSRDKSFLMLFRVWQNTLMNKQFSPQEIWQHVHTCYGDELGLTTDDEDYIDP-TLNK 493
            :|:||.:|.:||:.||::||:|||.|:.|..||:|:|..||.|||.|||||::||||:.| .||.
  Rat   260 EKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVCPLQLNG 324

  Fly   494 TNEP-DFDFQTAIDDDSYSQRQSQQSNQSNQSNPLLPQSGNSSASSGGGVRASAPRKSKTKYFFN 557
            ...| :.....|:.|.|    .|..:::|.:.:|:..:.|..:.                    |
  Rat   325 LGSPKEVGDVIALSDIS----PSGAADRSQEPSPVGSRCGRVTP--------------------N 365

  Fly   558 SSKSSANASASGSDNNKTRESSRKLNKKMKQNAKELTLSSVKPTELSVSVTMSAPNVSSSSTAGS 622
            .|::|::|. .|::.:|..::..:|:....|        :|.|....:|...:.|:
  Rat   366 LSRASSDAD-HGAEEDKEDQTDSQLDASSSQ--------TVTPVAEPLSAEPAPPD--------- 412

  Fly   623 TTASSSTIANHTGSGSGSGSLSGSNTAAASGSGSDKMSAEKKVSTASNSAAVAAAEAAQSLASAS 687
                        |..|..|.|             |.:|.|:.::..|||             |:|
  Rat   413 ------------GPTSNLGPL-------------DLLSREELLTDTSNS-------------SSS 439

  Fly   688 SGSGSLESKMEMKRKLGKMHRQREEGKNAAESVPTDVSDSSDSEENNLPFVPTTECTSTHEGRQI 752
            :|                     |||..||  :..|:|                       ||.:
  Rat   440 TG---------------------EEGDLAA--LLPDLS-----------------------GRLL 458

  Fly   753 VHTILPINVDTLFNLLFSKSKFITDFHAMRKSTDLVLGEWTKNEEGLQVRTVNVTVQLAASVGPK 817
            ::::..:..:.|..:|||.|.|:..|...||.||:.|..|:.:.:..|.|.:..|:.::..:|||
  Rat   459 INSVFHVGAERLQQMLFSDSPFLQGFLQQRKFTDVTLSPWSSDSKCHQRRVLTYTIPISNQLGPK 523

  Fly   818 TSKVTEYQTQ-RECSKPGELYSIDVNSVNAGIPYAESFSVLIHFCLARTVDDHTMLSIHTQIKYK 881
            ::.|.|.||. |...:.|... :|...:..||||.:.|.....:|:.....:...|.:.::|:|:
  Rat   524 SASVVETQTLFRRGPQAGGCV-VDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYR 587

  Fly   882 KSIWGVVKGFIEKNTWAGLEDFFGAQLHALQSETCIPPAKG------KGRRPRRGMNQQSATSTS 940
            |..|.:||..|||::|.|:||:|    |.|..|.    ||.      :|.:..||:
  Rat   588 KQPWSLVKSLIEKSSWTGIEDYF----HHLDREL----AKAEKVSLEEGGKDARGL--------- 635

  Fly   941 TTSITTGALHTATSTDNDSIQESRHPHQQDQHQHQHLHMHHHHHHHHGSQHHHHDARHSHHHHHQ 1005
                                                                             
  Rat   636 ----------------------------------------------------------------- 635

  Fly  1006 PLLPHHQQQHPHHWH-HRKALLQSGRGTATQIRPLEEAVGPA-PAVDP-LETQMLAAGGIPGAAV 1067
             |....:::.|..|. ||.                    ||. |..|| .:|.|..:|.:
  Rat   636 -LSGLRRRKRPLSWRGHRD--------------------GPQHPDPDPCTQTSMHTSGSL----- 674

  Fly  1068 GAAAGHPLLLEGGKQQQLHHQQQMHHHHLQPHKQHLQQQQLHLGGGDGQPLASGQGSQGHRLRHK 1132
                                            .....:..:..|.|.|.|.|
  Rat   675 --------------------------------SSRFSEPSVDQGPGAGIPSA------------- 694

  Fly  1133 GLWLLVILLLC----LMLALNVILLLKLWRLEERIDVDLNRRAR----MPSLA-ALSELPSTNQE 1188
              .:|:.:::|    :::|||.:|..:||.||        |.|.    ..||| |..:.|.|..|
  Rat   695 --LVLISIVICVSLIVLIALNALLFYRLWSLE--------RTAHTFESWHSLALAKGKFPQTATE 749

  Fly  1189 WLELLRDQEMAHENELHKWQQVLQTAIELLKKVSIVCEKI 1228
            |.|:|..|:..|..|:|||:|:|:.::|||.::....||:
  Rat   750 WAEILALQKHFHSVEVHKWRQILRASVELLDEMKFSLEKL 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	56/92 (61%)
		DUF4782	751..897	CDD:292635	42/146 (29%)
Gramd1a	XP_006228894.1	PH-GRAM_GRAMDC	188..281	CDD:275406	56/92 (61%)
		DUF4782	457..603	CDD:292635	42/146 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348359
Domainoid	1	1.000	153	1.000	Domainoid score	I4193
eggNOG	1	0.900	-	-		E1_KOG1032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2583
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D322809at33208
OrthoFinder	1	1.000	-	-		FOG0000885
OrthoInspector	1	1.000	-	-		otm46070
orthoMCL	1	0.900	-	-		OOG6_101929
Panther	1	1.100	-	-	LDO	PTHR23319
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X567
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760