Protein Alignment GramD1B and Gramd1a

DIOPT Version :10

• Sequence 1: NP_995623.2
• Gene: GramD1B / 33552
• FlyBaseID: FBgn0085423
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_001386565.1
• Gene: Gramd1a / 361550
• RGDID: 1311022
• Length: 807
• Species: Rattus norvegicus
• Alignment Length: 1141
• Identity: 295/1141 - (25%)
• Similarity: 452/1141 - (39%)
• Gaps: 393/1141 - (34%)

  Fly   115 APGSNAGDRRDSITEEITITSTTNSSQSTKLLTIQE-AAGSFEQSSVSAVSTSSKQIASTTAGGS 178
            ||....|..:||        |.:.:.|.|:...:|: :..|:....|.|:     .|..::.|.|
  Rat    11 APQGAQGANQDS--------SGSPTEQQTQDDNVQDLSPKSWRLLGVPAI-----HITPSSDGES 62

  Fly   179 PPAAAAPGANEFNGSVLRLTQAATSTSPGSISSAGNTATLG-AAPSINIVSSESTRDQTQ----- 237
            ||  ..|....|        |:..:..|..:|....|...| ::||    ||.|.|.:.|
  Rat    63 PP--GTPNTPRF--------QSLKTPDPECLSQDSTTPHSGRSSPS----SSPSLRKRLQLLPPS 113

  Fly   238 QPQSV---DPNGVAAPGDSPSSRKSSTSSKGKASQAKLSTSSSGRDEQDISQHRLSDLTQHELSL 299
            :|.|.   :|..:...|...||.||..|       ..|||.|.|
  Rat   114 RPPSAPEPEPGTMVEKGSDSSSEKSGVS-------GTLSTQSLG--------------------- 150

  Fly   300 LRVDREQQVTSSSSTSNEKPAKTSRLSERAKKKSWYNVIYPNYKSRAEDFKKLFKDVPNDERLIV 364
                      |.:...|.|           |.:|||:::.|.||.|.|||:|||..:|..|||||
  Rat   151 ----------SRNFIRNSK-----------KMQSWYSMLCPTYKQRNEDFRKLFSKLPEAERLIV 194

  Fly   365 DYSCALQRDILVQGRLYVSQNYVCFHANIFSWETHVSIKWKDVTAITKEKTALVIPNAISISSGK 429
            ||||||||:||:|||||:|:|::||::|||.|||.:||:.|:||.:.|||||.:|||||.|.:..
  Rat   195 DYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTES 259

  Fly   430 DKYFFATFTSRDKSFLMLFRVWQNTLMNKQFSPQEIWQHVHTCYGDELGLTTDDEDYIDP-TLNK 493
            :|:||.:|.:||:.||::||:|||.|:.|..||:|:|..||.|||.|||||::||||:.| .||.
  Rat   260 EKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVCPLQLNG 324

  Fly   494 TNEP-DFDFQTAIDDDSYSQRQSQQSNQSNQSNPLLPQSGNSSASSGGGVRASAPRKSKTKYFFN 557
            ...| :.....|:.|.|    .|..:::|.:.:|:..:.|..:.                    |
  Rat   325 LGSPKEVGDVIALSDIS----PSGAADRSQEPSPVGSRCGRVTP--------------------N 365

  Fly   558 SSKSSANASASGSDNNKTRESSRKLNKKMKQNAKELTLSSVKPTELSVSVTMSAPNVSSSSTAGS 622
            .|::|::|. .|::.:|..::..:|:....|        :|.|....:|...:.|:
  Rat   366 LSRASSDAD-HGAEEDKEDQTDSQLDASSSQ--------TVTPVAEPLSAEPAPPD--------- 412

  Fly   623 TTASSSTIANHTGSGSGSGSLSGSNTAAASGSGSDKMSAEKKVSTASNSAAVAAAEAAQSLASAS 687
                        |..|..|.|             |.:|.|:.::..|||             |:|
  Rat   413 ------------GPTSNLGPL-------------DLLSREELLTDTSNS-------------SSS 439

  Fly   688 SGSGSLESKMEMKRKLGKMHRQREEGKNAAESVPTDVSDSSDSEENNLPFVPTTECTSTHEGRQI 752
            :|                     |||..||  :..|:|                       ||.:
  Rat   440 TG---------------------EEGDLAA--LLPDLS-----------------------GRLL 458

  Fly   753 VHTILPINVDTLFNLLFSKSKFITDFHAMRKSTDLVLGEWTKNEEGLQVRTVNVTVQLAASVGPK 817
            ::::..:..:.|..:|||.|.|:..|...||.||:.|..|:.:.:..|.|.:..|:.::..:|||
  Rat   459 INSVFHVGAERLQQMLFSDSPFLQGFLQQRKFTDVTLSPWSSDSKCHQRRVLTYTIPISNQLGPK 523

  Fly   818 TSKVTEYQTQ-RECSKPGELYSIDVNSVNAGIPYAESFSVLIHFCLARTVDDHTMLSIHTQIKYK 881
            ::.|.|.||. |...:.|... :|...:..||||.:.|.....:|:.....:...|.:.::|:|:
  Rat   524 SASVVETQTLFRRGPQAGGCV-VDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYR 587

  Fly   882 KSIWGVVKGFIEKNTWAGLEDFFGAQLHALQSETCIPPAKG------KGRRPRRGMNQQSATSTS 940
            |..|.:||..|||::|.|:||:|    |.|..|.    ||.      :|.:..||:
  Rat   588 KQPWSLVKSLIEKSSWTGIEDYF----HHLDREL----AKAEKVSLEEGGKDARGL--------- 635

  Fly   941 TTSITTGALHTATSTDNDSIQESRHPHQQDQHQHQHLHMHHHHHHHHGSQHHHHDARHSHHHHHQ 1005
                                                                             
  Rat   636 ----------------------------------------------------------------- 635

  Fly  1006 PLLPHHQQQHPHHWH-HRKALLQSGRGTATQIRPLEEAVGPA-PAVDP-LETQMLAAGGIPGAAV 1067
             |....:::.|..|. ||.                    ||. |..|| .:|.|..:|.:
  Rat   636 -LSGLRRRKRPLSWRGHRD--------------------GPQHPDPDPCTQTSMHTSGSL----- 674

  Fly  1068 GAAAGHPLLLEGGKQQQLHHQQQMHHHHLQPHKQHLQQQQLHLGGGDGQPLASGQGSQGHRLRHK 1132
                                            .....:..:..|.|.|.|.|
  Rat   675 --------------------------------SSRFSEPSVDQGPGAGIPSA------------- 694

  Fly  1133 GLWLLVILLLCLMLALNVILLLKLWRLEERIDVDLNRRAR----MPSLA-ALSELPSTNQEWLEL 1192
              .:|:.::|.:::|||.:|..:||.||        |.|.    ..||| |..:.|.|..||.|:
  Rat   695 --LVLISIVLIVLIALNALLFYRLWSLE--------RTAHTFESWHSLALAKGKFPQTATEWAEI 749

  Fly  1193 LRDQEMAHENELHKWQQVLQTAIELLKKVSIVCEKI 1228
            |..|:..|..|:|||:|:|:.::|||.::....||:
  Rat   750 LALQKHFHSVEVHKWRQILRASVELLDEMKFSLEKL 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	56/92 (61%)
		VASt	751..899	CDD:464975	43/148 (29%)
Gramd1a	NP_001386565.1	PH-GRAM_GRAMDC	188..281	CDD:275406	56/92 (61%)
		VASt	457..605	CDD:464975	43/148 (29%)