DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GramD1B and Gramd2b

DIOPT Version :9

Sequence 1:	NP_995623.2	Gene:	GramD1B / 33552	FlyBaseID:	FBgn0085423	Length:	1249	Species:	Drosophila melanogaster
Sequence 2:	NP_001014033.1	Gene:	Gramd2b / 307288	RGDID:	1311016	Length:	445	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	94/342 - (27%)
Similarity:	159/342 - (46%)	Gaps:	77/342 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 TSPGSISSAGNTATLGAAPSINIVSSESTRDQTQQPQSVDPNGVAAP---GDSPSSRKSSTSSKG 265
            :||.|.:.|.:::|  .:||...:|||:            .|||...   ..||:::..::|.:.
  Rat    19 SSPKSSAGASHSST--DSPSSVFLSSEA------------ENGVEDRKRFSKSPTAQSPTSSVEA 69

  Fly   266 KASQAKLST---SSSGRDEQDISQHRLSDLTQHELSLLRVDREQQVTSSSSTSNEKPAKTSRLSE 327
            ::...|.|.   |.|..|..::    |||         :.|.:.:..:.|.|..:|.:.:|:
  Rat    70 ESPDQKRSLGLWSKSSFDGSNL----LSD---------KNDCKTESKADSKTERKKSSSSSQ--- 118

  Fly   328 RAKKKSWYNVIYPNYKSRAEDFKKLFKDVPNDERLIVDYSCALQRDILVQGRLYVSQNYVCFHAN 392
                          ||:... |.|||.|||.:|.|...::||||::||.||:|:||:|::|||:.
  Rat   119 --------------YKANMH-FHKLFLDVPTEEPLRQSFTCALQKEILYQGKLFVSENWICFHSK 168

  Fly   393 IFSWETHVSIKWKDVTAITKEKTALVIPNAISISSGKDKYFFATFTSRDKSFLMLFRVWQNTLMN 457
            :|..:|.:||....||.|.|.||||::|||:.|::..|:|.|.:..|||.::.:|
  Rat   169 VFGKDTKISIPAFSVTLIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLL---------- 223

  Fly   458 KQFSPQEIWQHV-HTCYGDELGLTTDDEDYIDPTLNKTNEPD---FDFQTAIDD-DSYSQRQSQQ 517
                 :.|..|: :|..|:....::.:..:      :.:.|.   .||.....| |...|::.|.
  Rat   224 -----KSICGHLENTSVGNSPNPSSAENSF------RADRPSSLRLDFNDEFSDLDGVVQQRRQD 277

  Fly   518 SNQSNQSNPLLPQSGNS 534
            ....:.|....|:|.||
  Rat   278 LEGYSSSGSQTPESENS 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	40/92 (43%)
GramD1B	NP_995623.2	DUF4782	751..897	CDD:292635
Gramd2b	NP_001014033.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		29/143 (20%)
		PH-GRAM_GRAMDC	135..227	CDD:275406	40/106 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..331		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D944155at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750