Protein Alignment GramD1B and Gramd1b

DIOPT Version :9

• Sequence 1: NP_995623.2
• Gene: GramD1B / 33552
• FlyBaseID: FBgn0085423
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: XP_006243172.1
• Gene: Gramd1b / 300644
• RGDID: 1305443
• Length: 882
• Species: Rattus norvegicus
• Alignment Length: 1172
• Identity: 311/1172 - (26%)
• Similarity: 477/1172 - (40%)
• Gaps: 362/1172 - (30%)

  Fly   138 NSSQSTKL--LTIQEAAGSFEQSSV-SAVST-------------SSKQIASTTAG-GSP--PAAA 183
            |..::.:|  |.:.|..|:.|.|:| |:.||             .:.|..|..|| .:|  |...
  Rat     5 NMMENLQLPALQVPEPQGAPEGSAVWSSSSTPTLRRRRFKMRRMKNVQEQSLEAGLVAPDLPGVL 69

  Fly   184 APGANEFNGSVLRLTQAATSTSPGSISSAGNTATLGAAPS---------INI----VSSESTRDQ 235
            |||........:.:|.::...:|.|     |.:|..|:|.         :.:    ..|||:..|
  Rat    70 APGKEFLQLPSIEITPSSDEDTPWS-----NCSTPSASPRRKRFLLRKWLRVRERKECSESSSQQ 129

  Fly   236 TQQPQSVDPNGVAAPGDSPSSRKSSTSSKGKASQAKLSTSSSGRDEQDISQHRLSDL-----TQH 295
            :.|..|.|.:  ::...||..|:.||:|....|....|.....|......|::..|.     :.|
  Rat   130 SSQQSSHDDD--SSRFLSPRVREESTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDH 192

  Fly   296 ELSLLRVDREQQV-TSSSSTSNEKPAKTSRLSERAKKKSWYNVIYPNYKSRAEDFKKLFKDVPND 359
            .........||.| .|.||.|.....|.|:     |.:|||||:.|.||.|.|||:||||.:|:.
  Rat   193 SSDKSPSTPEQGVQRSCSSQSGRSGGKNSK-----KSQSWYNVLSPTYKQRNEDFRKLFKQLPDT 252

  Fly   360 ERLIVDYSCALQRDILVQGRLYVSQNYVCFHANIFSWETHVSIKWKDVTAITKEKTALVIPNAIS 424
            ||||||||||||||||:|||||:|:|::||::|||.|||.::::.||:.::||||||.:|||||.
  Rat   253 ERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQ 317

  Fly   425 ISSGKDKYFFATFTSRDKSFLMLFRVWQNTLMNKQFSPQEIWQHVHTCYGDELGLTTDDEDYIDP 489
            :.:..:|:||.:|.:||::::|:||:|||.|:.|...|:|:|..||.|||:|||||:|||||:
  Rat   318 VCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYV-- 380

  Fly   490 TLNKTNEPDFDFQTAIDDDSYSQRQSQQSNQSNQSNPLLPQSGNSSASSGGGVRASAPRKSKTKY 554
                  .||.||.|.    .|.:....:.|:.|.|
  Rat   381 ------PPDDDFNTM----GYCEEIPIEENEVNDS------------------------------ 405

  Fly   555 FFNSSKSSANASASGSDNNKTRESSRKLNKKMKQNAKELTLSSVKPTELSVSVTMSAPNVSSSST 619
               |||||.                                 ..||.        ::|.:...|.
  Rat   406 ---SSKSSI---------------------------------ETKPD--------ASPQLPKKSI 426

  Fly   620 AGSTTASSSTIANHTGSGSGSGSLSGSNTAAASGSGSDKMSAEKKVSTASNSAAVAAAEAAQSLA 684
            ..||..|                 :||:.|..|..|   :..|::|
  Rat   427 TNSTLTS-----------------TGSSEAPVSFDG---LPLEEEV------------------- 452

  Fly   685 SASSGSGSLESKMEMKRKLGKMHRQREE----------GKNAAESVPTDVSDSSDSEENNLPFVP 739
              ..|.||||.::.:...:|    ::.|          ..|..|.:||::|||||:.:..
  Rat   453 --MEGDGSLEKELAIDNIIG----EKIEIMAPVTSPSLDFNDNEDIPTELSDSSDTHDEG----- 506

  Fly   740 TTECTSTHE---GRQIVHTILPINVDTLFNLLFSKSKFITDFHAMRKSTDLVLGEWTKNEEGLQV 801
              |..:.:|   |||.|:.:...:||.|::|||:.|.|:.||...|:.:|::...|.|.|.|.|.
  Rat   507 --EVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTTSPFLRDFMEQRRFSDIIFHPWKKEENGNQS 569

  Fly   802 RTVNVTVQLAASVGPKTSKVTEYQTQRECSKPGELYSIDVNSVNAGIPYAESFSVLIHFCLARTV 866
            |.:..|:.|...:.|||:.|.|.||..:.|:..|.|.||...:...:||.:.|..:..:.|.|..
  Rat   570 RVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVA 634

  Fly   867 DDHTMLSIHTQIKYKKSIWGVVKGFIEKNTWAGLEDFFGAQLHALQSETCIPPAKGKGRRPRRGM 931
            .:.:.|.:.|:::|:|..||.||.|||||.|:||||:|    ..|::|.
  Rat   635 RNKSRLRVSTELRYRKQPWGFVKTFIEKNFWSGLEDYF----RHLETEL---------------- 679

  Fly   932 NQQSATSTSTTSITTGALHTAT----STDNDSIQESRHPHQQDQHQHQHLHMHHHHHHHHGSQHH 992
                   |.|.|.....:|..:    :..:.:::..:.|       |.||.:.|
  Rat   680 -------TKTESTYLAEIHRQSPKEKTNKSSAVRRRKRP-------HAHLRVPH----------- 719

  Fly   993 HHDARHSHHHHHQPLLPHHQQQHPHHWHHRKALLQSGRGTATQIRPLEEAVGPAPAVDPLETQML 1057
                                                          |||.:  :|...|.:..:
  Rat   720 ----------------------------------------------LEEVM--SPVTTPTDEDV- 735

  Fly  1058 AAGGIPGAAVGAAAGHPLLLEGGKQQQLHHQQQMHHHHLQPHKQHLQQQQLHLGGGDGQPLASGQ 1122
                          ||.:....|..|..|..:.      .|...|||..
  Rat   736 --------------GHRIKHVAGSTQTRHIPED------TPDGFHLQSV---------------- 764

  Fly  1123 GSQGHRLRHKGLWLLVILLLC----LMLALNVILLLKLWRLEERIDVDLNRRARMPSLAALSELP 1183
                     ..|.|::..::|    |::.||::|..|||.||    ...........|.....||
  Rat   765 ---------SKLLLVISCVICFSLVLLVILNMMLFYKLWMLE----YTTQTLTAWQGLRLQERLP 816

  Fly  1184 STNQEWLELLRDQEMAHENELHKWQQVLQTAIELLKKVSIVCEKITNDS--HLRQSIESMSMAGR 1246
            .:..||.:||..|:..|:.||.:|::::::::.||.::        .||  :|:..|.|......
  Rat   817 QSQTEWAQLLESQQKYHDTELQRWREIIKSSVMLLDQM--------KDSLINLQNGIRSRDYTAE 873

  Fly  1247 TE 1248
            ::
  Rat   874 SD 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	53/92 (58%)
		DUF4782	751..897	CDD:292635	52/145 (36%)
Gramd1b	XP_006243172.1	PH-GRAM_GRAMDC	251..344	CDD:275406	53/92 (58%)
		DUF4782	519..663	CDD:292635	50/143 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348362
Domainoid	1	1.000	153	1.000	Domainoid score	I4193
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2583
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D322809at33208
OrthoFinder	1	1.000	-	-		FOG0000885
OrthoInspector	1	1.000	-	-		otm46070
orthoMCL	1	0.900	-	-		OOG6_101929
Panther	1	1.100	-	-	O	PTHR23319
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X567
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900