Protein Alignment GramD1B and Gramd1b

DIOPT Version :9

• Sequence 1: NP_995623.2
• Gene: GramD1B / 33552
• FlyBaseID: FBgn0085423
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: XP_017168808.1
• Gene: Gramd1b / 235283
• MGIID: 1925037
• Length: 897
• Species: Mus musculus
• Alignment Length: 1182
• Identity: 312/1182 - (26%)
• Similarity: 482/1182 - (40%)
• Gaps: 367/1182 - (31%)

  Fly   138 NSSQSTKL--LTIQEAAGSFEQSSV-SAVST-------------SSKQIASTTAG-GSP--PAAA 183
            |..::.:|  |.:.|..|:.|.|:| |:.||             .:.|..|..|| .:|  |...
Mouse     5 NMMENLQLPALQVPEPQGAPEGSAVWSSSSTPTLRRRRFKMRRMKNVQEQSLEAGLVAPDLPGVL 69

  Fly   184 APGANEFNGSVLRLTQAATSTSPGSISSAGNTATLGAAPS---------INI----VSSESTRDQ 235
            |||........:.:|.::...:|.|     |.:|..|:|.         :.:    ..|||:..|
Mouse    70 APGKEFLQLPSIEITPSSDEDTPWS-----NCSTPSASPRRKRFLLRKWLRVRERKECSESSSQQ 129

  Fly   236 TQQPQSVDPNGVAAPGDSPSSRKSSTSSKGKASQAKLSTSSSGRDEQDISQHRLSDL-----TQH 295
            :.|..|.|.:  ::...||..|..||:|....|....|.....|......|::..|.     :.|
Mouse   130 SSQQSSHDDD--SSRFLSPRVRDESTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDH 192

  Fly   296 ELSLLRVDREQQVTSS-----------SSTSNEKPAKTSRLSERAKKKSWYNVIYPNYKSRAEDF 349
            .........||.|..|           :|.|:::.:|..||:...|.:|||||:.|.||.|.|||
Mouse   193 SSDKSPSTPEQGVQRSCSSQSGRSGGKNSKSHKRLSKYDRLNLIKKSQSWYNVLSPTYKQRNEDF 257

  Fly   350 KKLFKDVPNDERLIVDYSCALQRDILVQGRLYVSQNYVCFHANIFSWETHVSIKWKDVTAITKEK 414
            :||||.:|:.||||||||||||||||:|||||:|:|::||::|||.|||.::::.||:.::||||
Mouse   258 RKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEK 322

  Fly   415 TALVIPNAISISSGKDKYFFATFTSRDKSFLMLFRVWQNTLMNKQFSPQEIWQHVHTCYGDELGL 479
            ||.:|||||.:.:..:|:||.:|.:||::::|:||:|||.|:.|...|:|:|..||.|||:||||
Mouse   323 TARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGL 387

  Fly   480 TTDDEDYIDPTLNKTNEPDFDFQTAIDDDSYSQRQSQQSNQSNQSNPLLPQSGNSSASSGGGVRA 544
            |:|||||:        .||.||.|.    .|.:....:.|:.|.|
Mouse   388 TSDDEDYV--------PPDDDFNTM----GYCEEIPIEENEVNDS-------------------- 420

  Fly   545 SAPRKSKTKYFFNSSKSSANASASGSDNNKTRESSRKLNKKMKQNAKELTLSSVKPTELSVSVTM 609
                         |||||.                                 ..||.
Mouse   421 -------------SSKSSI---------------------------------ETKPD-------- 431

  Fly   610 SAPNVSSSSTAGSTTASSSTIANHTGSGSGSGSLSGSNTAAASGSGSDKMSAEKKVSTASNSAAV 674
            ::|.:...|...||..|                 :||:.|..|..|   :..|::|
Mouse   432 ASPQLPKKSITNSTLTS-----------------TGSSEAPVSFDG---LPLEEEV--------- 467

  Fly   675 AAAEAAQSLASASSGSGSLESKMEMKRKLGKMHRQREE----------GKNAAESVPTDVSDSSD 729
                        ..|.||||.::.:...:|    ::.|          ..|..|.:||::|||||
Mouse   468 ------------MEGDGSLEKELAIDNIIG----EKIEIMAPVTSPSLDFNDNEDIPTELSDSSD 516

  Fly   730 SEENNLPFVPTTECTSTHE---GRQIVHTILPINVDTLFNLLFSKSKFITDFHAMRKSTDLVLGE 791
            :.:..       |..:.:|   |||.|:.:...:||.|::|||:.|.|:.||...|:.:|::...
Mouse   517 THDEG-------EVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFLRDFMEQRRFSDIIFHP 574

  Fly   792 WTKNEEGLQVRTVNVTVQLAASVGPKTSKVTEYQTQRECSKPGELYSIDVNSVNAGIPYAESFSV 856
            |.|.|.|.|.|.:..|:.|...:.|||:.|.|.||..:.|:..|.|.||...:...:||.:.|..
Mouse   575 WKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYT 639

  Fly   857 LIHFCLARTVDDHTMLSIHTQIKYKKSIWGVVKGFIEKNTWAGLEDFFGAQLHALQSETCIPPAK 921
            :..:.|.|...:.:.|.:.|:::|:|..||.||.|||||.|:||||:|    ..|::|.
Mouse   640 INRYTLTRVARNKSRLRVSTELRYRKQPWGFVKTFIEKNFWSGLEDYF----RHLETEL------ 694

  Fly   922 GKGRRPRRGMNQQSATSTSTTSITTGALHTAT----STDNDSIQESRHPHQQDQHQHQHLHMHHH 982
                             |.|.|.....:|..:    ::.:.:::..:.|       |.||.:.|
Mouse   695 -----------------TKTESTYLAEIHRQSPKEKASKSSAVRRRKRP-------HAHLRVPH- 734

  Fly   983 HHHHHGSQHHHHDARHSHHHHHQPLLPHHQQQHPHHWHHRKALLQSGRGTATQIRPLEEAVGPAP 1047
                                                                    |||.:  :|
Mouse   735 --------------------------------------------------------LEEVM--SP 741

  Fly  1048 AVDPLETQMLAAGGIPGAAVGAAAGHPLLLEGGKQQQLHHQQQMHHHHLQPHKQHLQQQQLHLGG 1112
            ...|.:..:               ||.:....|..|..|..:.      .|...|||..
Mouse   742 VTTPTDEDV---------------GHRIKHVAGSTQTRHIPED------TPDGFHLQSV------ 779

  Fly  1113 GDGQPLASGQGSQGHRLRHKGLWLLVILLLC----LMLALNVILLLKLWRLEERIDVDLNRRARM 1173
                               ..|.|::..::|    |::.||::|..|||.||    .........
Mouse   780 -------------------SKLLLVISCVICFSLVLLVVLNMMLFYKLWMLE----YTTQTLTAW 821

  Fly  1174 PSLAALSELPSTNQEWLELLRDQEMAHENELHKWQQVLQTAIELLKKVSIVCEKITNDS--HLRQ 1236
            ..|.....||.:..||.:||..|:..|:.||.||::::::::.||.::        .||  :|:.
Mouse   822 QGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVLLLDQM--------KDSLINLQN 878

  Fly  1237 SIESMSMAGRTE 1248
            .|.|......::
Mouse   879 GIRSRDYTAESD 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	53/92 (58%)
		DUF4782	751..897	CDD:292635	52/145 (36%)
Gramd1b	XP_017168808.1	PH-GRAM_GRAMDC	266..359	CDD:275406	53/92 (58%)
		DUF4782	538..682	CDD:374299	51/143 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844894
Domainoid	1	1.000	153	1.000	Domainoid score	I4273
eggNOG	1	0.900	-	-		E1_KOG1032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2744
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D322809at33208
OrthoFinder	1	1.000	-	-		FOG0000885
OrthoInspector	1	1.000	-	-		otm43980
orthoMCL	1	0.900	-	-		OOG6_101929
Panther	1	1.100	-	-	O	PTHR23319
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1861
SonicParanoid	1	1.000	-	-		X567
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790