DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GramD1B and GRAMD2A

DIOPT Version :9

Sequence 1:	NP_995623.2	Gene:	GramD1B / 33552	FlyBaseID:	FBgn0085423	Length:	1249	Species:	Drosophila melanogaster
Sequence 2:	NP_001012660.1	Gene:	GRAMD2A / 196996	HGNCID:	27287	Length:	354	Species:	Homo sapiens

Alignment Length:	297	Identity:	80/297 - (26%)
Similarity:	128/297 - (43%)	Gaps:	57/297 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 RVDREQQVTSSSSTSNEKPAKTSR------------LSERAKKKSWYNVIYPNYKSRAEDFKKLF 353
            ::.|:....:|..:..|||.:...            ..|..||.....:....|.   :.:.|||
Human    17 QMHRKTASLNSPVSCKEKPDRVEEPPDYSLHWPEGLKGEEIKKCGREGITLNKYN---QQYHKLF 78

  Fly   354 KDVPNDERLIVDYSCALQRDILVQGRLYVSQNYVCFHANIFSWETHVSIKWKDVTAITKEKTALV 418
            ||||.:|.::...|||||||.|:|||||:|.|::||||::|..:..|.|....|..|.|.|.|.:
Human    79 KDVPLEEVVLKVCSCALQRDFLLQGRLYISPNWLCFHASLFGKDIKVVIPVVSVQMIKKHKMARL 143

  Fly   419 IPNAISISSG-KDKYFFATFTSRDKSFLMLFRVW-------QNTLMNKQFS----------PQEI 465
            :||.::|::. ..||.|.:..|||..:.:|.||.       :.:|..::||          |:..
Human   144 LPNGLAITTNTSQKYIFVSLLSRDSVYDLLRRVCTHLQPSSKKSLSVREFSGEPESLEVLIPEMK 208

  Fly   466 WQHVHTCYGDELGLTTDDEDYIDPTLNKTNEPDFDFQTAID--DDSYSQRQSQQSNQSNQSNPLL 528
            |:.|  |.........|:...|.|             :::|  |..:..|:...|.:|...  :.
Human   209 WRKV--CPSSRSLSLPDNIPCIPP-------------SSVDSTDSFFPSRKPPMSEKSRAQ--VA 256

  Fly   529 PQSGNSSASSGGGVRASAPRKSKTKYFFNSSKSSANA 565
            .::|...|....|...:.|:|..     |.|.::.||
Human   257 SENGGRWAWPMPGWGPACPKKMP-----NCSPTAKNA 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GramD1B	NP_995623.2	PH-GRAM_GRAMDC	358..451	CDD:275406	39/93 (42%)
GramD1B	NP_995623.2	DUF4782	751..897	CDD:292635
GRAMD2A	NP_001012660.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		5/28 (18%)
GRAMD2A	NP_001012660.1	PH-GRAM_GRAMDC	84..177	CDD:275406	39/92 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D944155at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750