DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-2 and Dnhd1

DIOPT Version :9

Sequence 1:	NP_001015505.5	Gene:	kl-2 / 3355181	FlyBaseID:	FBgn0001313	Length:	4459	Species:	Drosophila melanogaster
Sequence 2:	NP_001357732.1	Gene:	Dnhd1 / 77505	MGIID:	1924755	Length:	4749	Species:	Mus musculus

Alignment Length:	4881	Identity:	961/4881 - (19%)
Similarity:	1702/4881 - (34%)	Gaps:	1469/4881 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   468 ILNVHKNE---------WYEEVIKYRRTVQSMEETVQRLMSNVFQHICNVEEALE--SLNVMIFY 521
            ||::|..|         |:.:...:|.        :||:   .|...|.:.:||.  ..||.:..
Mouse   368 ILHIHPVEGSEAMTLGTWHRDCALWRE--------LQRI---PFFKNCLLRKALTCWKKNVRLCG 421

  Fly   522 SYRSTIRKTFLRQVSSAWVFFSNEIDSSVHMLMDRSKMHESWVPYYASRALGYRVHLDRLVWLCN 586
            .:|.   :|||:                .|:|        |.:|::.:..|    |::||:   .
Mouse   422 LHRI---QTFLK----------------THLL--------SAIPHFGAGML----HINRLL---Q 452

  Fly   587 RLNSSDWLPNVSEASVVLKKFESVRREFDKEVKKSFDEWQKNCCSLLLNQKLDRYLLIRSKKKKG 651
            ...|..|||...:.|     :|.|  :..|.:.|.             |.|..|.|
Mouse   453 EFRSVSWLPKEPDRS-----YELV--DLQKAIAKE-------------NHKALRVL--------- 488

  Fly   652 LIECNIDRTILTICEQAQHFERLGLGVPGMVRKIYEKHETLRFVYNSVVQVCLNYNHILSALSEQ 716
                         |    ||..|...:..::      ||....:...:.:...|:|.|
Mouse   489 -------------C----HFLNLCTSILQLI------HEDTYQMQQGLQERVQNWNRI------- 523

  Fly   717 ERK------LFRALIQACDRKIAPG---VFKLTYGGELSDAYIADCAKHTNKLQETMDIYKRAIQ 772
             ||      |.|.|.:..::|:...   :.||.....|.|..|  |....:.|::.:..:
Mouse   524 -RKGQGSIYLQRTLCRHLEKKLKQAETWLLKLGKFARLIDYMI--CQNLVSILEDEISSF----- 580

  Fly   773 NIARFCEKICDTPMLKFNFSGAVTISIF-ENHLSSYLRRVSNILRGFYSTITDLIFAVFKEFQAV 836
             ||...:.....|.|       ::..:| :|...|.:.||.:|::|...::..:..:..|..|:
Mouse   581 -IANTLQAPRQNPFL-------LSQLVFDDNGQLSPMPRVESIIQGLIKSLQSIKTSALKVLQS- 636

  Fly   837 IEDMPIEWYGFVNVFDDMLATAFLTSSKNSLNMLTNALHRDPDMAAAPILV----MESD-VRERC 896
                                    |..:.|.::|.:..::|.|..|..::.    ..|| ||..|
Mouse   637 ------------------------TDLRTSRDLLYSEDNKDQDSNAEFLMPKFHGKASDAVRLFC 677

  Fly   897 ------------IVLTPDIDVIANLLSGYI-----DRIHNILEQFPRIGIKMKLP---------- 934
                        ..:|..::|..:.|.|..     |.:...|::  ..||:..|.
Mouse   678 GPNVGYVWPWKSHAITDVLEVRGHKLRGQFLHPNYDHVQEDLDK--NAGIQQALAVQQSLLEDMR 740

  Fly   935 -------KEHQ-----YESFSKAF----LEDSESTQL----------------ICNIEAEI---- 963
                   .:|:     || |.||:    |||...:.:                :.|:..|:
Mouse   741 QEVQEFCNKHKWVEGIYE-FLKAWSSQKLEDLRGSPINNYVNLVIQLKKWQERVSNMSVELLTKG 804

  Fly   964 ------NHE-REEIDGYIT-------------FWNSHRMLWETTELEFTKRVKAT---------Q 999
                  .|: :||:...:.             .|:.::.|  .|||....||..|         |
Mouse   805 KLLFLSGHDVQEELGSKLNNMRKNILEQAQNECWSRNQQL--MTELTEFLRVFQTISSDIHAIAQ 867

  Fly  1000 MTADIFEASIEYYSAMADDISYVDAI-----THVYFILMNQNYIKSSILDCIEKWQALNI----- 1054
            .:..:.||: |.|..:.:.:.||.::     .|....:.....:..::||.   |:|...
Mouse   868 CSQKLSEAN-EQYCQLEERVEYVRSLHDLIRNHCALFIAENETLDIALLDL---WEAFQFERSQV 928

  Fly  1055 -KILLSHSFSLIRAIYRYMRKNERKMMMVPRTLKESLLAKQF----------------------- 1095
             :.|||...:::..:        :::|.......|.||||..
Mouse   929 SEFLLSKQHAIVPRL--------QQLMAAALAELEGLLAKALSGPFMDPSQEQRSTEQQLGALEH 985

  Fly  1096 -FERIINEVPLKQAGFPPTLELFAILDKYQ--VEIPEEIRVKVIGLEAAWHHYLKRLGEADEMLD 1157
             |..|:|       .|......:.....|:  :..|......::..:..|..|        .::.
Mouse   986 QFLNILN-------NFNALCNAYCTFTGYKKPMSPPASGNRPIVLQQRIWRLY--------RIIS 1035

  Fly  1158 NNREEFKKILVQQAEKFKIILKEFLDDFFL----KLPTSANINPRIALKFLRIIA---------- 1208
            .|..|:|.:..   .||.:.:.....|.:|    :|.|:..:...:..:.:|::.
Mouse  1036 ENLGEWKCVAF---SKFNLSMAREKTDAWLTEAVRLSTALGLQSPVLQRCMRMLEEFRAYLPLLI 1097

  Fly  1209 ----LKIEDCFTFEESLMRDLAVFNVNQPESIDLRK------LDFEVRIVKNIW----------E 1253
                |:::|..|  :||:|.|.:.::...:.:.|.:      |:|..|| ..:|          |
Mouse  1098 KLGNLQLQDLNT--QSLLRALGLGSLRSLDLLTLGQMLNYPLLEFAERI-NQVWQYDKERIHAQE 1159

  Fly  1254 LIFEWQTNWEGWKKGYFWKMNINEMEDTALNLYKEFTTLNKKFYDRHWEMLEATTKNVDSFRRTL 1318
            ::.:.|..|||                      ::...||        .:|....|...|.|.
Mouse  1160 ILQQMQQYWEG----------------------RQLRLLN--------FILHVPYKPPTSERS-- 1192

  Fly  1319 PLITALKNPCMRERHWNRVRDVIHVNFDENSKNFTLELIINLDFQAFSEDIQDISNPATMELQIE 1383
                  |.|.:|...|..|        .::|..|.|.     |:.:..:.||
Mouse  1193 ------KRPALRSPQWELV--------GKDSGTFLLS-----DYSSLQDAIQ------------- 1225

  Fly  1384 NSIKNIATIWKKQSFEMAFYHDGIYRIKNVEDCFQLLEEHMVQISAMKATRFVEPFITIVDYWEK 1448
            ||::                  .:::|..::...||   |.:.:.                 |..
Mouse  1226 NSLQ------------------ALFKILAIQKSGQL---HKIALE-----------------WVA 1252

  Fly  1449 TLSYISETLEKGLTVQRQWLYLENIFQGDDIRKQLPEEAKRFATITEEFRT---ISSKMFQAKTA 1510
            .:..:...||..:..|::|::|..:.....|....||...||..:.:::||   ||.......:.
Mouse  1253 IMYGLGALLEVWVAFQQKWIFLNKVLHEMKIEFPAPELNARFKAMDDQYRTLMRISVADPMVLSL 1317

  Fly  1511 VKATNLRPPPFLLNRFSRM----DERLELIQRALEIYLEAKRQLFPRFYFISNDDLLEILGNSKR 1571
            :.....|.|.|......:|    ...||.|..|||..|......|||.:|:|:.:|:.:|.....
Mouse  1318 ILPNTKRSPYFQGQHLQQMLKAGSGELEAIIMALEDVLYGVCANFPRLFFLSDSELVALLAAPLD 1382

  Fly  1572 PDLVQTHLKKLFDNLYKLEL--KRVGKTLSRWQASGMHSDD--------GEYVEFM--MVIYIDG 1624
            ....|...::.|.::..:..  |...|.:::..:|...|.:        ||.|:..  :.::.|.
Mouse  1383 TREAQLWAQRCFPHIKAVNFRSKSTKKKINQDSSSSTESAETIAVLAAGGEEVKLQEPLPLHTDL 1447

  Fly  1625 PSERWLKQVEEYMLVVMKEML------KLTRG-----SLKKLVGNR--------EKW---ISLWP 1667
            |  :||..:|:.:..::..:|      :|.:|     :||.:...|        :.|   :.::|
Mouse  1448 P--KWLASLEKCLRFIIVNLLQSCVATRLAQGPSLIKALKAMPQQRQMPMQVYVQHWLDAVQVFP 1510

  Fly  1668 GQMVLTTAQIQWTTECTRSLIHCSMVDQKKPLRKLKKKQIKVL-----SKLSEMSRKDLTKTMRL 1727
            .|.:|...::.|..|...:|:.    .:...:|.:....::||     |:.|....|.|....:.
Mouse  1511 WQCILVAEEVVWRAEMEEALLE----SRTMHMRSVHVHNLEVLVQFIRSQRSSQDGKSLPSVRQT 1571

  Fly  1728 KV-NTLITLEIHGRDVIERMYKSNCKDTGHFEWFSQLRFYW---H---RESELCVIRQTNTEH-- 1783
            .: :||:...:..||:.:.:.|:...|...|.|..||:::.   |   :....|:....:||.
Mouse  1572 SLFSTLLVKAVTHRDIAQLLEKNQVSDLTDFHWVRQLKYHLGSSHLNLKSPVQCLTTIASTEPSV 1636

  Fly  1784 -----W---------YGYEYTGNSGRLVITPLTDRCYITLTTALHLHRGGSPKGPAGTGKTETVK 1834
                 |         |.|||.|.....:.:.:.:|....|..||.....|:..|..|.||.|||.
Mouse  1637 SPAACWIDVLGRSFMYNYEYMGPKLGPLPSLMHERQVFILLMALDEVAYGAILGRDGLGKAETVN 1701

  Fly  1835 DLGKALGIWVIVTNCSEGLDYKSIGKNFSGLAQSGCWGCFDEFNRINIEVLSVVAQQI------- 1892
            .|...||..:::..|...::::.:....:|..|||.|...:..|::...:||.:.|::
Mouse  1702 SLAWTLGRQLVIMPCLPQIEFQCLRNYLNGALQSGAWLLLENVNQLPSSLLSALGQRLDELHYLY 1766

  Fly  1893 --------MSIMAALSTKALEL---MFEGQMIKLKHTVGLFITMNPGYAGRTELPDNLKSMFRPI 1946
                    .:|.....||.|.|   .||...:.::...|.|:|:   ::...::|.||..:.||:
Mouse  1767 APLYQKASKNISTINPTKPLLLGGGFFEKHQVSMRLGFGCFLTL---HSLGPDIPANLHLLLRPV 1828

  Fly  1947 SMMVPDNIIIAENLLFSDGFTNTRNLARKVYTLYELAKQQLS----------KQYHYDFGLRSMV 2001
            ::.:||...:||..|...|..:...:|.::..|:.|.::.:|          ||.     |...:
Mouse  1829 ALALPDLQRVAELNLLGAGVQDASQMASRLSKLFSLERELVSGNLPCRLPLLKQV-----LEHTI 1888

  Fly  2002 ALLRYAGRKRRQL---PNTTEEEIVYLAMKDMNVARLTANDLPLFN-----------GIMSDIFP 2052
            ..|..:..|:.|.   |..:||..:..|:...          |||:           .::..|||
Mouse  1889 QTLNTSQEKKSQQPYDPAASEEAALLRALLHS----------PLFSILDGLRLQKLQELLCGIFP 1943

  Fly  2053 GVS---LPTIDYSEFNIAIYEEFREAGLQPITIAVKKVIELFETKNSRHSVMIIGDTGTAKSVTW 2114
            ..|   ...:.:......:.||.::.||.|.:..|..:.:|.:..:....::::|..|:.||..|
Mouse  1944 NASHVLAEPVSHRLIKSVVVEELQQLGLFPASNTVTSLEQLSQALSRASGILLLGPAGSGKSTCW 2008

  Fly  2115 RTL---QNCFYRMNSQRFSGWEAVTVYPVNPKALNLAELYGEYNLSTG-EWLDGVLSSIMRI--I 2173
            |:|   ||....|......|:::|.:..:.|..||..|..|   .|.| .|..|:...::..  .
Mouse  2009 RSLFKIQNRLAAMEHTSTKGFQSVEIVHLYPSVLNSKEYLG---WSEGPSWHYGIFPKLLHAAPY 2070

  Fly  2174 C---GDEEPTQK------WLLFDGPVDAVWIENMNSVMDDNKLLTLVNSERITMPVQVSLLFEVG 2229
            |   |.|||::|      |::.||..:..|.:::..::.|...|:|.|.::|..|:....|.||.
Mouse  2071 CKSVGSEEPSEKFTGIQQWIICDGAPNHAWTDSVTCLLRDPPQLSLPNGQQIARPLGTFFLIEVA 2135

  Fly  2230 DLAVASPATVSRCGMVYNDYNDWGWKPFVNSW----------------LQRLRIKEFADFLRIHF 2278
            :.|..||..:.||.:|        |.....:|                ||:..|.|| ::|.
Mouse  2136 EAAGMSPTVLGRCALV--------WCSGEQTWHSMLSVLMASLPHEYHLQQETITEF-NYLA--- 2188

  Fly  2279 DYMVPKILDF-KRMRCKEPVRTN----------ELNGVVSLCK-----LLEIFG-----TK--VN 2320
            :.:||.:|.| .|:.....::.:          |:..:|.:.:     ||.:|.     ||  .:
Mouse  2189 EVLVPSVLRFLTRIGASSQLQVHGHQAVCPGVAEVTSLVRILRALLDPLLHLFEEEKSYTKEDFS 2253

  Fly  2321 GINPINLELLEEMTRLW-------------------FMFCLVWSICSSVDEDSRQRLDSFIRELE 2366
            |.:.:........||:.                   |:|.::||..:.:........|.|:::..
Mouse  2254 GSDLVTQNFKSSKTRVQSDRVNVNKKQRRHLLAISSFLFAIIWSFGAHLPSRHWPLFDDFMKKSI 2318

  Fly  2367 SCF------PIKDTVFDYFVDPNERTFLPWDSKLLSSW-KCDFESPFYKIIVPTGDTVRYEYVVS 2424
            |..      |....|||..|:..:.|.:|:..:.||:. |.:..|     ..|:..|.:..|||.
Mouse  2319 SSLPNYPEPPPSALVFDLHVNFEDGTLVPFTGQYLSTHVKGNLGS-----FQPSSQTEQLLYVVD 2378

  Fly  2425 KLLAEEYPVMLVGNVGTGKTSTAISVMEACDKNKFCILAVNMSAQTTAAGLQESIENRTEKRTKT 2489
            .||:...||:|.|.:.|||:    :.:|...|..:.::...:.....:..|:..:......:|:.
Mouse  2379 LLLSNGQPVLLAGEIATGKS----AFVEVLVKPNYPVIHSPIHPALNSTHLRHLLSRGVHGQTQA 2439

  Fly  2490 QFVP---IGGKRMICF-MDDFNM----PAKDIYGSQPPLELIRQWIDYKYWFNRKTQQKIYVQNT 2546
            ..:|   ...|..|.| |:|.::    |.|:   .||.||.:||          ..:..||..||
Mouse  2440 SSIPGHHQDSKGSILFLMEDLHLATFDPEKN---CQPVLETLRQ----------AMEGTIYAHNT 2491

  Fly  2547 L----------LMAAMGPPGGGRQTISSRTQSRFVLLNLTFPSQETIIRIFGTMLCQKLESYPNE 2601
            |          .:|....||...:.:..|....|.:|.|...:|:|::......:...||.:|:.
Mouse  2492 LELQTLQTTVNFLATATVPGYSERPLCPRLYRLFTVLALNSMTQDTLLSRHVPSIQAWLERFPSV 2556

  Fly  2602 VREMWLPITL--CTINLYVSMISKMLPTPNKSHYLFNLRDISKVF-------------------- 2644
            .||..|...|  .::..:.::....:|:|.:.||.|:...:|.:.
Mouse  2557 EREHTLARALVRASVEAWEAVCKCFMPSPLRPHYRFSPHSVSHILGSLQLLPTRMGSRGFAETFH 2621

  Fly  2645 --------QGLLRSEKELQNKKNFFLRLWVHECFRVFSDRLVDDSDQFWFVNTINDI-------- 2693
                    .||..:...:.......:|||:||..|.|.|||..|.::......:.::
Mouse  2622 HQEYLRRVSGLRGTRLTIMMSMRVMVRLWLHEAQRTFCDRLDSDRERSHCAKLLLEVAQNVFCGG 2686

  Fly  2694 -----LGKHFE-----------------------------------------------VTFHSLC 2706
                 |.|..|                                               ::.:||.
Mouse  2687 PGSESLAKDCEEEEVEEEKVPEVESEEEIAQWETLSNSDSGSEEEEDPYGLQATTGSFLSENSLA 2751

  Fly  2707 P--------------------------------SKVPPFFGDFA----------------HPQGF 2723
            |                                ||.|......|                :||..
Mouse  2752 PFPRKSVNKENTENVSQMAEQEEDIRDSSSKLQSKTPKHEWQMAPQMDLSLPLLLPVLLFYPQES 2816

  Fly  2724 YEDLQVDFLRT----------FMKNQLEEYNNFPGMT----RMNLVFFR--EAIEHIVRILRVIS 2772
            ..||......|          :::.|.|........|    :||..|.:  ..::|:..::||::
Mouse  2817 PSDLVFSLELTLGSNFESPNLYLERQWENLEKQLVATAVRLKMNSGFSQCPVMVQHVAHLVRVLA 2881

  Fly  2773 QPRGHILNMG-IGGSGRQVLTKLAAFIL-----------EMAVFQIEVTKKYKTGDFREDLKNLY 2825
            :|:.|.|.:. ..|:||.....||:.|.           |.|:||......:..|...:.:..|
Mouse  2882 RPQQHALLLSEFRGTGRYTAIILASSICQAHLHYLSVESEEAIFQCLRDASWHAGLLNQPVALL- 2945

  Fly  2826 KVTGIKQRLTIFIFS-----------SDQIAEVSFLEITNNMLSTGEINLFKSDEFDELKPELER 2879
                :.:.:.:.||.           .||..|...                  |..:|..|: |.
Mouse  2946 ----VPEGVNVAIFCRLLALATSGSFPDQYTEADL------------------DNIEEHFPK-EN 2987

  Fly  2880 PAKKNGVLLTTEALYSYFILNVRDFLHVALCFSPIGENFRSYIRQYPA----LLSSTTPNWFRF- 2939
            .|.|:.:  ..:.:.:.|...|.:.||:   |..:|:| ::..:..|.    ||..|..:..|:
Mouse  2988 IANKHAI--KRDTILNRFYQQVCNNLHM---FFMVGDN-QAQNQLAPTLFLNLLQLTIASVERYE 3046

  Fly  2940 -WPQEALLEVASHFL---IGFPLNVVVSGKEDEKHRESLVISTEAILQRDIAYVFSVIHSSVAKM 3000
             |.|.:|:.:|...|   ...||:.......|.||           |..::|.:.:.||.|.|..
Mouse  3047 PWDQASLVRIAQFCLENDHSLPLDDGSLKYPDFKH-----------LIPNVANIMARIHVSSACY 3100

  Fly  3001 SENMYAEVKRYNYVTSPNYLQLVSGFKKLLEKKRLEVSTASNRLRNGLSKISETQEK----VSLM 3061
            .::|...:.   .||...:...:..|.:..::..|::...::|::..|..:....|:    .||:
Mouse  3101 HKHMCPALP---LVTPKTFQDFLDMFLQQQQQMVLQMRMRASRIQTALKTLRLMVERHSTQTSLL 3162

  Fly  3062 SE---ELKAS----------SEQVKILARECEDFISMIEIQKSEATEQKEKVDAEAVLIRRDEII 3113
            ::   :||.|          .||.||:.|:     .|||.|..|:..:.        |:|:.:.:
Mouse  3163 TDLEAQLKGSYKSVGICQGQLEQSKIMYRQ-----KMIECQHQESLIEN--------LVRQHDAL 3214

  Fly  3114 CLELAATARADLEVVMPMIDAA-VKALDALNKKDISEVKSYGRPPMKIEKVMEAVLILLGKEPTW 3177
                    :|..||.:..:..| |..|..|...|..|::||..||..:.||.:|:..|..:|..|
Mouse  3215 --------KAQQEVFLEQMGKAFVGPLSQLRVADFEEIRSYRAPPESVVKVTDALCDLFHQETGW 3271

  Fly  3178 ENAKKVLSESTFLNDLKNFDRDHISDKTLKRIAIYTKNPELEPDKVAVVSLACKSLMQWIMAIEN 3242
            .:||::|....|..:|..|.::.::|..|.::....:.|.:....:..||:...:|..|:.|:..
Mouse  3272 SSAKQLLCTEDFYQELVFFPKEKLTDSELVKLNEALRAPGMSDAALRSVSIPAANLAVWLWAVLR 3336

  Fly  3243 YGKVYRIVAPKQEKLDSAMKSLEEKQAALAAAKKKLEELQVVIEELYRQLEEKTNLLNELRAKEE 3307
            ||...|...|       ....|.:..|.||..:.:|.:.|....:|..|....|..|.:.:....
Mouse  3337 YGLAQRRGLP-------TGLLLRQVDATLAREQARLGQFQFQAHDLLEQTRSLTKKLEDAQVSHN 3394

  Fly  3308 RLRKQLERAII-------LVESLSGERERWIETVNQLDLSFEKLPGDCLLSVAFMSYLGAFDTKY 3365
            .:.:.|.:|..       :..:|......|...:.:|....:.:.||.||..|.:.|||.|..:.
Mouse  3395 HVMETLNQAQCGNFQKWPMESALLTPMHMWTTQLQKLQEQAKTVFGDALLCSAAIIYLGPFPPQR 3459

  Fly  3366 REELLVKWSLLI------------------------KDLLIPATLELKVTYFLVDAVSIREWNIQ 3406
            |:|||.||..|.                        |:.|:|......:...|.....:.:|:..
Mouse  3460 RQELLEKWLSLCQGSEEALDPDDVARALRQKSVGVPKNPLLPTRTPFSILTLLSYGSELHQWDRD 3524

  Fly  3407 GLPADDLSTENGVIVT-----QGSRWPLIIDPQMQANNWI---------------KNMEERNQLM 3451
            ..|....:...|:::.     ..|||||:|||..||..|:               |..:|:..:.
Mouse  3525 LKPQAKSARLLGLLLRSHIHFSSSRWPLLIDPSNQAIMWLNPLPPKQNRSLEPSPKESKEKFHVT 3589

  Fly  3452 TLDFG--MADYLR---------------------------------------------------- 3462
            ..|.|  ..|.|.
Mouse  3590 KQDSGDNTEDELEDENNEEEDEANEQRKEQKAEENKIQGENEQEVQETEKENEPESSGSHSSLPS 3654

  Fly  3463 ---------------------QLERALKEGLPVLLQNVGEYL---------------DQAINP-- 3489
                                 ||..|...||||||.||...|               ..::.|
Mouse  3655 ETQSLPSCLTVLSGTDPELGPQLLEAAANGLPVLLTNVELSLGCQELQWLLSKKNLSPPSVQPGF 3719

  Fly  3490 --ILRQSFTIQSGERLLKFNDKYISYNNSFRFYITTKISNPHYPPEISSKTTIVNFALKQDGLEA 3552
              .|..:|.|.:..|:|.|                          |:.....:::..|..:.||.
Mouse  3720 CLFLSTTFPIHALSRVLGF--------------------------EMLKGLNVLDLGLNMEILEE 3758

  Fly  3553 QLLGIIVRKEKPALEEQKDELVMTIARNKRTLIDLDNEILRLLNESRGSLLDDDELFSTL----Q 3613
            |:|..|:.:|:|.||.:..:|.                 :|..:.......|:::|..||    |
Mouse  3759 QMLHEILCRERPELETRWQDLK-----------------IRAADTYEAMKADEEQLLVTLLRQNQ 3806

  Fly  3614 KSRQTSVLVKESL-SIAEVTEV-----EIDAARQE-------YKPASERASILFFVLMDMSKIDP 3665
            |.::.|..:::.: :.|::.::     |::..:||       |:|.:.....:...|..:..:.|
Mouse  3807 KRQKPSKFLRKMVRTQAKICQLNAQMEELEDQKQEVVALWAPYRPVAYHGMAMVEALSPLQNLLP 3871

  Fly  3666 MYVFSLAAYILLFTQSIERSPRNQLVHERIQNINEYHSYAVYRNTCRGL-FERHKLLFSIHMTAK 3729
            .:..:...::.:..::|:             ::..|.||       ||. ...|.|...||:..:
Mouse  3872 SFCMTSENWLAVIRRAID-------------SMKSYDSY-------RGEDLPSHLLRLKIHLARQ 3916

  Fly  3730 ILSNAGKLLEEEYDFILKGGIV----------------------LDKL----GQAPNPA------ 3762
            :|:|.          ::..|::                      |::|    |.:.:|:
Mouse  3917 LLTNT----------VVALGLIQTPLVGAFGALAMLQVTTKTPKLERLALWPGLSASPSSGHNMQ 3971

  Fly  3763 ------PWWISEQNWDNITELDKVSGFHGIIDSFEQHYKAWNGWYATTFPEQEDLVGEWNDKLTD 3821
                  |.|:|.:.|:....|:.:..|.|:.:|...|...|..:.:.:........|..::.|:.
Mouse  3972 IPGVIRPAWLSSKAWEECGALELLPPFAGLCESLAGHSGVWQDYLSLSSTVLGPAPGPNSEPLSL 4036

  Fly  3822 FQKICVLRSLRPDRISFCLTQFIITKLGPRYVDPPVLDLKATFDESISQTPLIFVLSPGVDPAQS 3886
            |||:.:.|.||||.::..|.....:.|| |.:|..:......|:......|::.:|.|...|..:
Mouse  4037 FQKLILWRVLRPDCLAGALADLTTSLLG-RPLDENLGAPTMIFEHIQPTQPILILLPPPGHPTAT 4100

  Fly  3887 LISLSESVKMA------QRMYSLSLG-QGQAPIAT--KLIMDGIKDGNWVFLANCHLSLSWMPTL 3942
            |..::...|:|      |.::.::|| :...|::|  ..:...:..|:|:.|.||||...|...|
Mouse  4101 LHPVTVIRKLAANHEKPQHLHVIALGSEDWDPVSTVVNTLCQAMLQGHWLVLDNCHLMPFWPREL 4165

  Fly  3943 ----------------DKMIATMQS---MKLHKKFRLWLSSSPHPDFPISILQTSIKMTTEPPRG 3988
                            .:::|..:|   :.:|:.|||||           |:.|... |:.|...
Mouse  4166 LQPLQGLLDRARVVSDSELLAEPESRSVVTVHRDFRLWL-----------IVPTEAS-TSLPGML 4218

  Fly  3989 IKSNMKRLYNN--------INEANMEN--CSEPSKYKKLLFALCFFHTVLLERKKF-LEL----- 4037
            .:|:|...:|.        |:..:.:.  |::|......||   |.|.:||.|:.: |:|
Mouse  4219 TQSSMPVFWNQSLELGRILIDSLDSQQGLCTQPLTQTLPLF---FLHGLLLHRQLYGLKLQAHRG 4280

  Fly  4038 GWNVIYSFNDSDFEVSEILLLLYLNEYED------TPWGALKYLIAGVNYGGHITDDWDRRLLI- 4095
            .|             |::.|...|...|.      .|..||..|.|.|.|||.:.|..||..|:
Mouse  4281 RW-------------SQVTLTRALQIQEQLWASLGNPSAALLELTASVLYGGSLGDLEDREALVS 4332

  Fly  4096 ---TYIN--QFFCDQALQTRKFRLSTL-PNYFIPDDGDVQSYLD---QIQMFPNFDKPDAFGQHS 4151
               |.:|  ....||. .|.::.|:|| |:   |:.|::.:..|   |:.:.|...:|...|.:.
Mouse  4333 LTRTCLNPRNMNWDQP-HTPQYLLATLMPS---PELGELDARTDCKAQMHLLPTPPEPRTCGLNE 4393

  Fly  4152 NADIASLIGETRMLFEALLSMQVQTNSTSSNENGETKVFDL------AKEIL-----MNTPDEIN 4205
            ......:..::|:|..||.........|......:.|...|      ||:.|     :.|.:.|.
Mouse  4394 APQAWLMRRQSRVLLNALQKCSSTWVPTVCGGIAQRKERQLQQRLAQAKKRLVALQALLTNNRIR 4458

  Fly  4206 YEQTA---KIIGIN-RTPLEVVLLQEI----ERYNKLLVDMSTQLRDLRRGIQGLVVMSSDLEDI 4262
            ..|..   .::|.| |.|||..|..|:    .....||.|:...|:.|:.|..   ..||....:
Mouse  4459 SGQCVTPWAVLGPNARRPLEGFLETEVLELKHLVGTLLCDLDCLLQQLKGGTP---CTSSRCAKV 4520

  Fly  4263 YLAVSEGRVPLQWLK---AYNSLKPLAAWARDLIHRVGHF-------NSWAKTLRPPILFWLAAY 4317
            ..|:..|.:|..|..   |.:.|..|  |.|.|..| ||.       .......:|..:|.|:|:
Mouse  4521 AQALWAGHLPQPWRSHALAGSQLPWL--WLRQLSRR-GHLLIRYLDSGMSENANKPERIFHLSAF 4582

  Fly  4318 TFPTGFV-----TAVLQTSARATKTP--IDELS------WDFYVFVEEDTAAARIIREGG----- 4364
            ..|...:     .|||:.|......|  .|.:|      |.     |.......|..|.|
Mouse  4583 RHPGRLLLALRWEAVLENSVHNPNLPGHQDSISGSLPPKWQ-----ELSNHPLHIWVENGPNPKV 4642

  Fly  4365 ---GVYIRSLFLEGGGWLRKNQCLQDPLPMELICPLPVIHFKPVENLKKRCR-----------GV 4415
               |:.:..|.|:...|.:.:..|||....: .||||     || ::..:.|           |:
Mouse  4643 PKMGLLLTGLQLQHAEWDQTDGALQDSFSSQ-PCPLP-----PV-SISTQARRGKDAPVSAGLGM 4700

  Fly  4416 YQCPAY 4421
            |.||.|
Mouse  4701 YSCPVY 4706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-2	NP_001015505.5	DHC_N1	178..749	CDD:285571	58/300 (19%)
		DHC_N2	1244..1646	CDD:285579	79/436 (18%)
		P-loop_NTPase	1785..2015	CDD:304359	61/260 (23%)
		P-loop_NTPase	2099..2242	CDD:304359	43/157 (27%)
		P-loop_NTPase	2401..2668	CDD:304359	65/314 (21%)
		P-loop_NTPase	2752..3030	CDD:304359	64/311 (21%)
		MT	3043..3373	CDD:289543	85/354 (24%)
		AAA_9	3402..3618	CDD:289547	58/333 (17%)
		Dynein_heavy	3760..4447	CDD:281078	187/795 (24%)
Dnhd1	NP_001357732.1	DHC_N2	1021..1469	CDD:369852	101/565 (18%)
		AAA_6	1652..2005	CDD:372306	81/370 (22%)
		Dynein_AAA_lid	2187..2347	CDD:375381	29/162 (18%)
		P-loop_NTPase	2366..2533	CDD:393355	44/183 (24%)
		P-loop_NTPase	2869..3119	CDD:393355	60/293 (20%)
		MT	<3198..3468	CDD:289543	70/292 (24%)
		AAA_9	<3663..3801	CDD:372311	34/180 (19%)
		Dynein_heavy	4103..4222	CDD:367303	28/130 (22%)
		Dynein_C	<4519..4744	CDD:375627	49/203 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910