DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-2 and dnah2

DIOPT Version :9

Sequence 1:	NP_001015505.5	Gene:	kl-2 / 3355181	FlyBaseID:	FBgn0001313	Length:	4459	Species:	Drosophila melanogaster
Sequence 2:	XP_009301399.1	Gene:	dnah2 / 556023	ZFINID:	ZDB-GENE-130530-910	Length:	4506	Species:	Danio rerio

Alignment Length:	4503	Identity:	2085/4503 - (46%)
Similarity:	2954/4503 - (65%)	Gaps:	127/4503 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LVEYVKKITFLYSLDHRDWNAKVINVISIWLINSTELVLTIFYDCDVLTGC---LGFPVAPVIDL 76
            |.|..|:...|..:....|..:....:..::.:|:..:|.:::  |..||.   ...|...|..:
Zfish    73 LREAFKQRLALSGISKESWTEENEQALDKFISDSSVRLLVVYH--DPFTGLYVDYAMPAQVVEQM 135

  Fly    77 CYFIRSSKEIISIHSFHDMVNFGTVQDDVDGCLLKILELIYAPIFRNFMEWGDNVKQRFCTSLDK 141
            .||||:...:|:..||...|.||:|:......||:::..::.|.......|.:..|..:...|.:
Zfish   136 SYFIRAPDSMITEESFRSSVQFGSVRGGAIEGLLRMMNGVHTPQVTLSTTWPETSKNNYSAELHR 200

  Fly   142 FLGILTAIYFKMSGMTVLYVPYVVKEIAKEISSYDREFVKNLECIAVSWATLIRILLNDKTLTSP 206
            ||..||...||:.|.||||:|....:...|.:..::..|:.||.:.:.|...|:.:|:.::::..
Zfish   201 FLTKLTDSRFKLLGSTVLYIPLEALQHRPEEAVKNKNLVQRLEMVVIHWTRQIKAVLSAQSVSDI 265

  Fly   207 NEYISVGDEFEFWLYRFEVLQGLNAQLDQVDVQQIIRVLRSTHSVYIKQIDELIFESTHELMEAM 271
            .:.:...:|..||..|...|..::.||.:..|:.|..:|:...|.||....:|..:.....::|.
Zfish   266 GDTLGPLEEISFWKSRCADLDSISTQLQKPGVRHIQEILQLYTSTYIPPFCKLAKQIQESSLQAQ 330

  Fly   272 ENIKFLHLLMQPCSQLDFSESPTFVSQLIPRTIHLIRFIWLNSEQYNRRDLITGIFRNLSNQIIR 336
            .|:.||.||.:||.:| ....|..::..:...::|||.||:||..:|.||.||.:.|.:||:|||
Zfish   331 SNVTFLSLLKEPCEEL-AQLKPCEIAPKLAHILNLIRVIWVNSSYFNTRDRITALLRKISNEIIR 394

  Fly   337 FCTEKVNVEKILSGSSRFGIKICNMCIDCCLTYKGIYDIMSKTHAKINIRIGWSLDNAMIFNHVD 401
            .|..::::.:|..|.:....:|.|.||.|||.:|.:|...|:.|.|.:.: |||||...||..||
Zfish   395 LCCREISLNRIFQGYAVSSKQILNDCIQCCLAWKELYLHTSQLHHKHSSQ-GWSLDQISIFALVD 458

  Fly   402 AFMERLNDVIDICESMMVFGRLDESESIPKPQFGGTSGTEFEATADNVENEFLVTLTALCTDSKE 466
            :||:|..|:|:|||....|.|.::.|.:|.|.|.|..|:|.......:|..|..:|..|  .|.:
Zfish   459 SFMQRCKDLIEICECQQQFARWEDGERVPLPCFAGRLGSEVTQKLLYIEATFDKSLQVL--QSVQ 521

  Fly   467 IILNVHKNEWYEEVIKYRRTVQSMEETVQRLMSNVFQHICNVEEALESLNVMIFYSYRSTIRKTF 531
            .||:|....|:|:..::|..::.:|..:|.|:::.|:.:..|||.::.|:|....|.|..|::|.
Zfish   522 DILDVRNPSWHEDYSRFRAKLKDLEVMMQNLITSTFEMVNCVEEGVQLLDVFQHLSGREAIKRTI 586

  Fly   532 LRQVSSAWVFFSNEIDSSVHMLMDR-SKMHESWVPYYA-----SRALGYRVHLDRLVWLCNRLNS 590
            .|:....:..|.:|: ..::::|.| |.:....:|.||     ::||..||.....|     |..
Zfish   587 DRKTVDVYNLFHSEL-VEINLVMCRTSSLIPVQMPRYAGQIHWTKALHSRVERSMEV-----LRR 645

  Fly   591 SDWLPNVSEASVVLKKFESVRREFDKEVKKSFDEW----QKNCCSLLLNQKLDRYLLIRSKKKKG 651
            :.:||:|..|..:...:..:.:..|::|::.|.:|    .|.|     :..||:.|:||.|.|.|
Zfish   646 AHFLPHVRSADEMHVIYVKLCQTLDEKVRRIFTDWSQSLSKEC-----HSSLDQPLMIRCKGKTG 705

  Fly   652 LIECNIDRTILTICEQAQHFERLGLGVPGMVRKIYEKHETLRFVYNSVVQVCLNYNHILSALSEQ 716
            |::.|.::.:|.:..:..:::||...:|..|.::|::.|.|..:..:|:.|..:||.|:..|:..
Zfish   706 LLDINFNKNLLKLFNEIHYWDRLQFEIPHFVTEVYQRREELHNLRENVLLVVRDYNRIIKDLNAD 770

  Fly   717 ERKLFRALIQACDRKIAPGVFKLTYGGE-LSDAYIADCAKHTNKLQETMDIYKRAIQNIARFCEK 780
            |..||...|:..|:||.||:.||.:..: ...|:|.||..|.||:|..:|.||.|....::.||:
Zfish   771 ELGLFSERIRFLDKKIQPGLSKLHWSTKGTPSAFINDCRVHANKVQLMVDEYKAANLATSKHCEQ 835

  Fly   781 ICDTPMLKFNFSGAVTISIFE------NHLSSYLRRVSNILRGFYSTITDLIFAVFKEFQAVIED 839
            |.:  :|..:..|.......|      .|..|.:.|:.|.    :..|..::..|:..|.....:
Zfish   836 ISE--LLLVHLDGKTVYRDHEFQEDQQTHQHSQMLRLQNA----HQDIIKIMARVYGTFHLDGPE 894

  Fly   840 MPIEWYGFVNVFDDMLATAFLTSSKNSLNMLTNALHRDPDMAAAPILVMESDVRERCIVLTPD-- 902
            :...|..::...|.||..||..:.|.||..|:.|::.|..::..|:..:|       :||||:
Zfish   895 VQQHWTSYMEKIDQMLEEAFRVNIKRSLQELSKAINGDGKISPNPLFRVE-------VVLTPETA 952

  Fly   903 -----IDV------IANLLSGYIDRIHNILEQFPRIGIKMKLP-----KEHQYESFSKAFLEDSE 951
                 :|.      :|::::....::...:..|.|      ||     ::.|.:.......:|.|
Zfish   953 RSTAQVDFSPSPQKLAHIVNSISSQLIKTISGFKR------LPDLLTRQQSQRKPIHSIIEQDEE 1011

  Fly   952 STQLICNIEAEIN----HEREEIDGYITFWNSHRMLWETTELEFTKRVKATQMTADIFEASIEYY 1012
                ||.|:..|.    .....:..|:..|:.||.:||..:..|.:|.:....|...|:|.|..|
Zfish  1012 ----ICKIQGAIAAGMVTNASYLQTYLKTWDKHREIWEIEKDSFIQRYQRLNPTVTSFDADIARY 1072

  Fly  1013 SAMADDISYVDAITHVYFILMNQNYIKSSILDCIEKWQALNIKILLSHSFSLIRAIYRYMRKNER 1077
            :.:|:::...:.:..|.|:|::.:.:|.|:|....:||:...::|...:.|.::.::.::::|..
Zfish  1073 TEVANNVQKEETLLSVQFVLLDCSPLKFSLLQHCNEWQSKFTQLLSLMASSKLKELHSFLQENAV 1137

  Fly  1078 KMMMVPRTLK---ESLLAKQFFERIINEVPLKQAGFPPTLELFAILDKYQVEIPEEIRVKVIGLE 1139
            ::...|:||.   |||...:..:..:|::   ::..||..|.:|||.||:|.:...:...:..|.
Zfish  1138 RLSQPPQTLTDLGESLKLLETLQADLNKI---ESQIPPIHEQYAILTKYEVAVDPAVLELLEALN 1199

  Fly  1140 AAWHHYLKRLGEADEMLDNNREEFKKILVQQAEKFKIILKEFLDDFFLKLPTSANINPRIALKFL 1204
            |.|..:.:.:.::|.||..:::..|..|:..:|:|:...:.||..|....|..:::.|..||:.:
Zfish  1200 AEWVWFQQVVIDSDIMLKKHKDTMKSGLILSSEEFQKKTQTFLQSFSSNGPFGSSVTPHSALQQV 1264

  Fly  1205 RIIALKIEDCFTFEESLMRDLAVFNVNQPESIDLRKLDFEVRIVKNIWELIFEWQTNWEGWKKGY 1269
            ..:..::|.....|:::...|.:|.:.||.|.|:..|:.:|..::.:||:..:|:..|..||.|:
Zfish  1265 SELRAQLEALKEEEQNICSGLNIFTIEQPASKDILALEKDVDYLQQVWEIARQWEDLWAEWKGGH 1329

  Fly  1270 FWKMNINEMEDTALNLYKEFTTLNKKFYDRHWEMLEATTKNVDSFRRTLPLITALKNPCMRERHW 1334
            ...:....|::||..::|....|::.|.|:|||:::::...::.|::.:||||.|:|..:|||||
Zfish  1330 LASLQTEVMDNTAQTMFKTLHKLSRAFKDKHWEIVDSSKSRIEQFKKIIPLITDLRNSALRERHW 1394

  Fly  1335 NRVRDVIHVNFDENSKNFTLELIINLDFQAFSEDIQDISNPATMELQIENSIKNIATIWKKQSFE 1399
            |::|..:...||.:|.:||||.|:.|.....:|.|.|||..|:.||.||.:::.|...||:.|.:
Zfish  1395 NQIRQEVQQTFDPSSADFTLEKIVALGLDHHAESISDISGAASKELSIEQTLEGIMKTWKEMSLD 1459

  Fly  1400 MAFYHD-GIYRIKNVEDCFQLLEEHMVQISAMKATRFVEPFITIVDYWEKTLSYISETLEKGLTV 1463
            :..:.| |.::::..::.||.||::.|.:|.:||:|||:.|...||:||:.||.:.|.:|..|||
Zfish  1460 ITPHKDKGHHKLRGTDEVFQALEDNQVTLSVIKASRFVKAFEKEVDHWERCLSLVLEVIEMILTV 1524

  Fly  1464 QRQWLYLENIFQGDDIRKQLPEEAKRFATITEEFRTISSKMFQAKTAVKATNLRPPPFLLNRFSR 1528
            ||||:||||||..|||||||..|...|..:|..::.|..::.:.|.|::.|:   .|.||.:.|.
Zfish  1525 QRQWMYLENIFLADDIRKQLVRETAEFDAVTSSWKIIMERLDKDKNALRGTH---HPGLLEKLSE 1586

  Fly  1529 MDERLELIQRALEIYLEAKRQLFPRFYFISNDDLLEILGNSKRPDLVQTHLKKLFDNLYKLELKR 1593
            |:.:||.||::|::|||.|||:||||||:||||||||||.|:.|:.||.||||.|||:..|.:.:
Zfish  1587 MNTKLEEIQKSLDMYLETKRQIFPRFYFLSNDDLLEILGQSRNPEAVQPHLKKCFDNIKSLRINK 1651

  Fly  1594 VGKTLSRWQASGMHSDDGEYVEFMMVIYIDGPSERWLKQVEEYMLVVMKEMLKLTRGSLKKLVGN 1658
            || |.::.:||||.|.|||:|:|...:.::||.|.||..||..|...:|:.|:....:|||:.|.
Zfish  1652 VG-TGNKSEASGMFSADGEFVDFTHPVLLEGPVEAWLCDVERTMRWTLKDSLRNCSMALKKMPGK 1715

  Fly  1659 REKWISLWPGQMVLTTAQIQWTTECTRSLIHCSMVDQKKPLRKLKKKQIKVLSKLSEMSRKDLTK 1723
            |.||:..|||||::|.:||||||:.||:|:.......|..|:.|||||:.:|::.||..|.:|||
Zfish  1716 RGKWVRDWPGQMLITASQIQWTTDVTRALMTSKERADKSALKSLKKKQVSMLNQYSEAIRGNLTK 1780

  Fly  1724 TMRLKVNTLITLEIHGRDVIERMYKSNCKDTGHFEWFSQLRFYWHRESELCVIRQTNTEHWYGYE 1788
            .:|||:..|:|:|:|.||||.::.|..|.|...|:|..|||.||.::.:.|:||||||...||||
Zfish  1781 ILRLKIVALVTVEVHARDVISKLAKGGCCDVNAFDWLCQLRLYWEKDVDDCIIRQTNTHFRYGYE 1845

  Fly  1789 YTGNSGRLVITPLTDRCYITLTTALHLHRGGSPKGPAGTGKTETVKDLGKALGIWVIVTNCSEGL 1853
            |.||||||||||||||||:|||||||||||||||||||||||||||||||:||::|||.||||||
Zfish  1846 YLGNSGRLVITPLTDRCYMTLTTALHLHRGGSPKGPAGTGKTETVKDLGKSLGMYVIVVNCSEGL 1910

  Fly  1854 DYKSIGKNFSGLAQSGCWGCFDEFNRINIEVLSVVAQQIMSIMAALSTKALELMFEGQMIKLKHT 1918
            |:||:|:.:|||||:|.||||||||||||||||||||||:||::|||.......|||:.|.|..:
Zfish  1911 DFKSMGRMYSGLAQTGAWGCFDEFNRINIEVLSVVAQQILSILSALSAGLNNFSFEGRQINLIWS 1975

  Fly  1919 VGLFITMNPGYAGRTELPDNLKSMFRPISMMVPDNIIIAENLLFSDGFTNTRNLARKVYTLYELA 1983
            .|:|||||||||||||||||||||||||||:|||:.:|||..||::||.|.:.||:||:|||.||
Zfish  1976 CGIFITMNPGYAGRTELPDNLKSMFRPISMVVPDSTLIAEITLFAEGFNNCKVLAKKVFTLYSLA 2040

  Fly  1984 KQQLSKQYHYDFGLRSMVALLRYAGRKRRQLPNTTEEEIVYLAMKDMNVARLTANDLPLFNGIMS 2048
            .||||||.|||||||::.:||||||:|||..|:..:|||:.::|||||:|:|::.||||||||:.
Zfish  2041 VQQLSKQDHYDFGLRALTSLLRYAGKKRRARPDIVDEEILLMSMKDMNIAKLSSIDLPLFNGIIQ 2105

  Fly  2049 DIFPGVSLPTIDYSEFNIAIYEEFREAGLQPITIAVKKVIELFETKNSRHSVMIIGDTGTAKSVT 2113
            |:||.|..|||||.:...|:..|.|::|||.|...|.|||:|:||||||||.||:|.||:.|:||
Zfish  2106 DLFPAVETPTIDYGKLKEAVEAELRQSGLQVIPFTVTKVIQLYETKNSRHSTMIVGKTGSGKTVT 2170

  Fly  2114 WRTLQNCFYRMNSQRFSGWEAVTVYPVNPKALNLAELYGEYNLSTGEWLDGVLSSIMRIICGDEE 2178
            ||||||....::.....|:..:...|:||||::|.||||||||||.||.||||||:||:.|.||:
Zfish  2171 WRTLQNTLSTLHRNGEPGFNLIRECPLNPKAVSLGELYGEYNLSTNEWTDGVLSSLMRMACADEK 2235

  Fly  2179 PTQKWLLFDGPVDAVWIENMNSVMDDNKLLTLVNSERITMPVQVSLLFEVGDLAVASPATVSRCG 2243
            |.:||::||||||.:|||:|||||||||:|||:|.|||:||.||||||||.||:|||||||||||
Zfish  2236 PDEKWIVFDGPVDTLWIESMNSVMDDNKVLTLINGERISMPEQVSLLFEVEDLSVASPATVSRCG 2300

  Fly  2244 MVYNDYNDWGWKPFVNSWLQRLRIKEFADFLRIHFDYMVPKILDFKRMRCKEPVRTNELNGVVSL 2308
            |||:||:|.||||:|.||::: |.|...|.|...|:..:.|.|.||:..|||.|...|||||.||
Zfish  2301 MVYSDYSDLGWKPYVQSWMEK-RQKVETDLLWQLFERYIDKTLAFKKTHCKELVAITELNGVASL 2364

  Fly  2309 CKLLEIFGTKVNGINPINLELLEEMTRLWFMFCLVWSICSSVDEDSRQRLDSFIRELESCFPIKD 2373
            |:|.:...|..||:.|.:.|....|..|||:|.|:||:|:||||:.|:::|:|:||:|..||.||
Zfish  2365 CRLYQSLATAENGVKPADSENYGRMVELWFIFSLIWSVCASVDEEGRKKIDTFLREIEGSFPNKD 2429

  Fly  2374 TVFDYFVDPNERTFLPWDSKLLSSWKCDFESPFYKIIVPTGDTVRYEYVVSKLLAEEYPVMLVGN 2438
            |:::|:||...:|:..::.||...|:....:|||||:|||.|||||.|:|..|::.::||:|.|.
Zfish  2430 TIYEYYVDTKNKTWASFEDKLPKGWRYASNAPFYKIMVPTVDTVRYHYLVKALVSTQHPVLLTGP 2494

  Fly  2439 VGTGKTSTAISVMEACDKNKFCILAVNMSAQTTAAGLQESIENRTEKRTKTQFVPIGGKRMICFM 2503
            |||||||.|.||:::.|...:..|.||||:||::..:||.||:|.|||.|..:||:|||:|:.|:
Zfish  2495 VGTGKTSVAQSVLQSLDNITWATLTVNMSSQTSSNNVQEIIESRVEKRIKGVYVPVGGKKMVVFL 2559

  Fly  2504 DDFNMPAKDIYGSQPPLELIRQWIDYKYWFNRKTQQKIYVQNTLLMAAMGPPGGGRQTISSRTQS 2568
            ||.||||.|.:||||||||:|.||||.:|::|:.|...|:::..|:.:||||||||..||.|.||
Zfish  2560 DDLNMPAVDNFGSQPPLELLRLWIDYGFWYDRQKQTLKYIKDLFLLGSMGPPGGGRTHISGRLQS 2624

  Fly  2569 RFVLLNLTFPSQETIIRIFGTMLCQKLESYPNEVREMWLPITLCTINLYVSMISKMLPTPNKSHY 2633
            ||.|:|:|||::..|.||:|||:.|||:.:..||:.:...:|..|:.||.::.|:.||||.|.||
Zfish  2625 RFNLINMTFPTESQIKRIYGTMISQKLQEFEEEVKPIGGILTQATLELYHAITSRFLPTPAKIHY 2689

  Fly  2634 LFNLRDISKVFQGLLRSEKELQNKKNFFLRLWVHECFRVFSDRLVDDSDQFWFVNTINDILGKHF 2698
            ||||||||||||||||:.|:..:.|....|||:|||||||||||||.:|...||..:::.|..||
Zfish  2690 LFNLRDISKVFQGLLRAHKDFHDTKQSITRLWIHECFRVFSDRLVDHADMETFVGVLSEKLASHF 2754

  Fly  2699 EVTFHSLCPSKVPPFFGDFAHPQGFYEDLQVDF--LRTFMKNQLEEYNNFPGMTRMNLVFFREAI 2761
            :|.||::||:|.||.||||......|||| :||  |:..|:||||:||..||:..|:||.||:||
Zfish  2755 DVPFHTICPNKQPPLFGDFLRESQIYEDL-LDFKALKVHMENQLEDYNLTPGVVPMSLVLFRDAI 2818

  Fly  2762 EHIVRILRVISQPRGHILNMGIGGSGRQVLTKLAAFILEMAVFQIEVTKKYKTGDFREDLKNLYK 2826
            :|:.|::|||||.||::|.:||||||||.||:|||:|....|||:||||:|:..:||||:|.||:
Zfish  2819 DHVTRLVRVISQLRGNMLLVGIGGSGRQSLTRLAAYICRFTVFQVEVTKQYRKQEFREDIKKLYR 2883

  Fly  2827 VTGIKQRLTIFIFSSDQIAEVSFLEITNNMLSTGEI-NLFKSDEFDELKPELERPAKKNGVLLTT 2890
            :||::.:.|:|:|:..||.:.||||..||:||:||: ||:|:||.||::..|...|:|:.:|.|.
Zfish  2884 LTGVENKPTVFLFNDTQIVDESFLEDINNILSSGEVPNLYKADELDEIQSALSDSARKDNILETP 2948

  Fly  2891 EALYSYFILNVRDFLHVALCFSPIGENFRSYIRQYPALLSSTTPNWFRFWPQEALLEVASHFLIG 2955
            :|:::|.|..||:.||:.||.||:|:.||:.|||||||::.||.:||..||::||||||...|.|
Zfish  2949 DAMFNYLIERVRNNLHIVLCMSPVGDPFRNRIRQYPALVNCTTIDWFSEWPRDALLEVAERCLDG 3013

  Fly  2956 FPLNVVVSGKEDEKHRESLVISTEAILQRDIAYVFSVIHSSVAKMSENMYAEVKRYNYVTSPNYL 3020
            ..|     |.:|.             :|..:|.:|..:|.|||:.|..|..|:||:||||..|||
Zfish  3014 LSL-----GSDDG-------------IQTKVASIFVTVHQSVAQFSHRMKVELKRHNYVTPTNYL 3060

  Fly  3021 QLVSGFKKLLEKKRLEVSTASNRLRNGLSKISETQEKVSLMSEELKASSEQVKILARECEDFISM 3085
            :||||:||||.:||.|:....::|||||.||.:|:.||..||.||:.:.::|....::||:::.:
Zfish  3061 ELVSGYKKLLSEKRDELGEQVSKLRNGLFKIDDTRTKVEAMSVELEEAKKKVAEFQKQCEEYLVV 3125

  Fly  3086 IEIQKSEATEQKEKVDAEAVLIRRDEIICLELAATARADLEVVMPMIDAAVKALDALNKKDISEV 3150
            |..||.||.||::.|.|.:..|..:||.|..:|..|:.||:..:|.::.|:|||::|||||::|:
Zfish  3126 IVQQKREADEQQKAVGAHSEKIEAEEIKCKAMAENAQRDLDEALPALEEAMKALESLNKKDMTEI 3190

  Fly  3151 KSYGRPPMKIEKVMEAVLILLGKEPTWENAKKVLSESTFLNDLKNFDRDHISDKTLKRIAIYTKN 3215
            |||||||..:|.||:||:||.|.||||..||:.|.|..|:..|.|||:|:|||:.||.|..|...
Zfish  3191 KSYGRPPALVETVMQAVMILRGCEPTWAEAKRQLGEGNFIKQLVNFDKDNISDRVLKTIGQYCTQ 3255

  Fly  3216 PELEPDKVAVVSLACKSLMQWIMAIENYGKVYRIVAPKQEKLDSAMKSLEEKQAALAAAKKKLEE 3280
            |:.:|:.:..||||.|||..|:.|:|.||:::|:|.||:.:|..||..|.|||||||.|:.||.|
Zfish  3256 PDFQPEIIGRVSLAAKSLCMWVRAMEVYGRIFRVVEPKRARLHGAMTQLAEKQAALAEAQGKLRE 3320

  Fly  3281 LQVVIEELYRQLEEKTNLLNELRAKEERLRKQLERAIILVESLSGERERWIETVNQLDLSFEKLP 3345
            :...::.|.||.:||.....|||.|.|.:..:|:||..||..|:|||.||.|||:.|:.:...|.
Zfish  3321 VGEKLDHLKRQYDEKLAQKEELRRKSEDMELKLDRAGKLVSGLAGERVRWKETVDGLEKNMSCLV 3385

  Fly  3346 GDCLLSVAFMSYLGAFDTKYREELLVK-WSLLIKDLLIPATLELKVTYFLVDAVSIREWNIQGLP 3409
            |||||:.||:||:|.|.:.:|:||:.. |...:::|.:|.:.......||....::|||||||||
Zfish  3386 GDCLLAAAFLSYMGPFLSNHRDELVTDIWMKQVRELEVPCSPGFSFAVFLSKPTAVREWNIQGLP 3450

  Fly  3410 ADDLSTENGVIVTQGSRWPLIIDPQMQANNWIKNMEERNQLMTLDFGMADYLRQLERALKEGLPV 3474
            :|..|||||||||:|:||||::|||.||..||||||.:..|..:|..|.|:||.||.|::.|.||
Zfish  3451 SDAFSTENGVIVTRGNRWPLMVDPQGQALKWIKNMEFKQGLKVIDLQMPDFLRILENAVQFGSPV 3515

  Fly  3475 LLQNVGEYLDQAINPILRQSFTIQSGERLLKFNDKYISYNNSFRFYITTKISNPHYPPEISSKTT 3539
            |||||.|.||.::.|||.:|.|...|..|||..||.|.|:..||||:|||:|||||.||||||||
Zfish  3516 LLQNVQEELDPSLAPILNKSLTRVGGRFLLKLGDKEIEYSPEFRFYMTTKLSNPHYTPEISSKTT 3580

  Fly  3540 IVNFALKQDGLEAQLLGIIVRKEKPALEEQKDELVMTIARNKRTLIDLDNEILRLLNESRGSLLD 3604
            |||||:|:.|||||||||:||||:|.||||||.||:.||..||.|.:|::||||||||:.|||||
Zfish  3581 IVNFAVKEQGLEAQLLGIVVRKERPELEEQKDSLVINIASGKRKLQELEDEILRLLNEATGSLLD 3645

  Fly  3605 DDELFSTLQKSRQTSVLVKESLSIAEVTEVEIDAARQEYKPASERASILFFVLMDMSKIDPMYVF 3669
            |.:|.:|||.|:.|:..|.|.|.|:|:||.:||.||:.|:|.::|||||||||.|:..|||||.|
Zfish  3646 DVQLVNTLQTSKVTATEVAEQLEISELTESQIDTAREAYRPCAQRASILFFVLNDLGCIDPMYQF 3710

  Fly  3670 SLAAYILLFTQSIERSPRNQLVHERIQNINEYHSYAVYRNTCRGLFERHKLLFSIHMTAKILSNA 3734
            ||.|||.||..|||.|||:..:.|||.|:|.:|:|||||.|||||||.||||||.||.||||..:
Zfish  3711 SLDAYINLFILSIESSPRSHKLEERINNLNRHHTYAVYRYTCRGLFECHKLLFSFHMCAKILEAS 3775

  Fly  3735 GKLLEEEYDFILKGGIVLDKLGQAPNPAPWWISEQNWDNITELDKVSGFHGIIDSFEQHYKAWNG 3799
            |||..:||:|.|:||:|||...|..||...|:|:.||||||||||::.||.::.||||:.:.|:.
Zfish  3776 GKLNMDEYNFFLRGGLVLDTKKQMDNPCSHWLSDSNWDNITELDKLTNFHELMASFEQYPRDWHH 3840

  Fly  3800 WYATTFPEQEDLVGEWNDKLTDFQKICVLRSLRPDRISFCLTQFIITKLGPRYVDPPVLDLKATF 3864
            ||....||:..|.|||.:...:.||:.::||||.||:|.|:|.|:|..||.::|:||:||:||..
Zfish  3841 WYTNPEPEKAPLPGEWENSCNELQKMLIVRSLRQDRVSLCVTAFVINNLGSQFVEPPILDMKAVV 3905

  Fly  3865 DESISQTPLIFVLSPGVDPAQSLISLSESVKMAQRMYSLSLGQGQAPIATKLIMDGIKDGNWVFL 3929
            .:|.::|||||||||||||..:|:.|:|:..|.||.::||||||||||||:||.:|:.:|:||||
Zfish  3906 ADSTTRTPLIFVLSPGVDPTAALLQLAETSGMGQRFFALSLGQGQAPIATRLIKEGVANGHWVFL 3970

  Fly  3930 ANCHLSLSWMPTLDKMIATMQSMKLHKKFRLWLSSSPHPDFPISILQTSIKMTTEPPRGIKSNMK 3994
            ||||||||||..|||::..:|..:.|..|||||||||||:|||:||||.||:|||||||:|.|||
Zfish  3971 ANCHLSLSWMCELDKLVDELQVQECHPDFRLWLSSSPHPEFPIAILQTGIKITTEPPRGVKWNMK 4035

  Fly  3995 RLYNNINEANMENCSEPSKYKKLLFALCFFHTVLLERKKFLELGWNVIYSFNDSDFEVSEILLLL 4059
            |||..::|.....||.|..|:||||:|||||:|:|||:|||:||||:|||||||||||||.||.|
Zfish  4036 RLYQRVSETQFLRCSRPLLYRKLLFSLCFFHSVILERRKFLQLGWNIIYSFNDSDFEVSENLLSL 4100

  Fly  4060 YLNEYEDTPWGALKYLIAGVNYGGHITDDWDRRLLITYINQFFCDQALQTRKFRLSTLPNYFIPD 4124
            ||:|||:.||.|||:||||:|||||:|||||||||.|||||:||...:.|..|::|:|.:|::|.
Zfish  4101 YLDEYEEIPWDALKFLIAGINYGGHVTDDWDRRLLTTYINQYFCPAVIDTPFFKVSSLVSYYVPR 4165

  Fly  4125 DGDVQSYLDQIQMFPNFDKPDAFGQHSNADIASLIGETRMLFEALLSMQVQ---TNSTSSNENGE 4186
            ||...||:|.|...|..:.|:.|||:.||||||.|.|.|.||..|||:|.|   |::||:..:.|
Zfish  4166 DGSQSSYVDYISQLPALEHPELFGQNPNADIASQITEARTLFHTLLSLQPQVTSTDTTSAGASRE 4230

  Fly  4187 TKVFDLAKEILMNTPDEINYEQTAKIIGINRTPLEVVLLQEIERYNKLLVDMSTQLRDLRRGIQG 4251
            .||.:|:.::|...|.||:||.|.|::..:.:||.|||||||:|||.||..:...|.:|.:||:|
Zfish  4231 DKVLELSADVLQKIPAEIDYEGTRKLLKDDLSPLNVVLLQEIQRYNTLLHTIRLSLLELEKGIKG 4295

  Fly  4252 LVVMSSDLEDIYLAVSEGRVPLQWLKAYNSLKPLAAWARDLIHRVGHFNSWAKTLRPPILFWLAA 4316
            ||||||.||:.:..:.:.|||..|.|||.||||||:|.|||..||..|..||:|.|||:||||:.
Zfish  4296 LVVMSSSLEETFNCIHDARVPPLWEKAYPSLKPLASWTRDLCQRVEQFARWAETARPPVLFWLSG 4360

  Fly  4317 YTFPTGFVTAVLQTSARATKTPIDELSWDFYVFVEEDTAAARIIREGGGVYIRSLFLEGGGWLRK 4381
            :||||||:|||||:|||.....:|.|||:|.|...||...  :.....||.|:.|||||.||.:|
Zfish  4361 FTFPTGFLTAVLQSSARQNNVSVDTLSWEFSVTTVEDNNL--LFPPKDGVLIQGLFLEGAGWDKK 4423

  Fly  4382 NQCLQDPLPMELICPLPVIHFKPVENLKKRCRGVYQCPAYYYPVRSG-----SFVIAVDLKSGNE 4441
            ..||.:..||:|:||:|.|||||||:.|:..:.:|.||.||||||||     |||:|||||||..
Zfish  4424 ASCLVEAEPMQLVCPMPTIHFKPVESRKRLAKNMYSCPCYYYPVRSGSSGRQSFVVAVDLKSGAV 4488

  Fly  4442 KADYWIKRGTALLLSLAN 4459
            ..|:|||||||||:||.|
Zfish  4489 PYDHWIKRGTALLMSLDN 4506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-2	NP_001015505.5	DHC_N1	178..749	CDD:285571	173/581 (30%)
		DHC_N2	1244..1646	CDD:285579	170/402 (42%)
		P-loop_NTPase	1785..2015	CDD:304359	175/229 (76%)
		P-loop_NTPase	2099..2242	CDD:304359	93/142 (65%)
		P-loop_NTPase	2401..2668	CDD:304359	143/266 (54%)
		P-loop_NTPase	2752..3030	CDD:304359	138/278 (50%)
		MT	3043..3373	CDD:289543	154/330 (47%)
		AAA_9	3402..3618	CDD:289547	140/215 (65%)
		Dynein_heavy	3760..4447	CDD:281078	392/694 (56%)
dnah2	XP_009301399.1	DHC_N1	237..799	CDD:285571	173/576 (30%)
		DHC_N2	1301..1705	CDD:285579	172/407 (42%)
		P-loop_NTPase	1842..2072	CDD:304359	175/229 (76%)
		P-loop_NTPase	2158..2299	CDD:304359	92/140 (66%)
		P-loop_NTPase	2461..2724	CDD:304359	143/262 (55%)
		P-loop_NTPase	2809..3070	CDD:304359	138/278 (50%)
		MT	3083..3415	CDD:289543	154/331 (47%)
		AAA_9	3443..3659	CDD:289547	140/215 (65%)
		Dynein_heavy	3801..4494	CDD:281078	392/694 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588119
Domainoid	1	1.000	475	1.000	Domainoid score	I416
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H72110
Inparanoid	1	1.050	3814	1.000	Inparanoid score	I6
OMA	1	1.010	-	-		QHG56318
OrthoDB	1	1.010	-	-		D1492at2759
OrthoFinder	1	1.000	-	-		FOG0000396
OrthoInspector	1	1.000	-	-		oto39655
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	1	1.100	-	-	LDO	PTHR10676
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5075
SonicParanoid	1	1.000	-	-		X7125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940