DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-2 and CG14651

DIOPT Version :9

Sequence 1:	NP_001015505.5	Gene:	kl-2 / 3355181	FlyBaseID:	FBgn0001313	Length:	4459	Species:	Drosophila melanogaster
Sequence 2:	NP_649475.3	Gene:	CG14651 / 40568	FlyBaseID:	FBgn0037254	Length:	1079	Species:	Drosophila melanogaster

Alignment Length:	1070	Identity:	188/1070 - (17%)
Similarity:	367/1070 - (34%)	Gaps:	364/1070 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 PTFVSQLI----------PRTIHLIRFIWLNSEQYNRRDLITGIFR-NLSNQIIRFCTEKVNVEK 346
            ||.:.::|          |:.:.:.|    ...||.:.:|:..:.: .|::.:::...|:.||..
  Fly    97 PTILPKVIQTRYVPKRHLPKDVEVDR----RRRQYQKINLVNELAKAGLTDDVLQPTEEQYNVMS 157

  Fly   347 ILS----------GSSRFGIKICNMCIDCCLTYKGIYDIMSKTHAKIN---IRIGWSLDNAMIFN 398
            ..:          ..|.|.|.......:..:.....|.:.:|.:...|   :...|.: .|:..:
  Fly   158 EFAFPHKFPLSYFDDSNFDINSPAAWFELGVVGDAHYPLPAKAYLPYNQSLLNCQWGM-AAVTAH 221

  Fly   399 HVDAFMERLNDVIDICESMMVFGRLDESESIPKPQFGGTSGTEFE-------ATADNVENEFLVT 456
            |.|:.:..|..:.|.|           :.::||.||...:....:       |..:..:.|.|:.
  Fly   222 HEDSDLWTLLSLEDGC-----------TYTVPKLQFMFMAEDPHKYIKRLQAAVHERHKGEQLML 275

  Fly   457 LTALCTDSKEIILNVHKNEWYEEVIKYR-RTVQSM-------EETVQRLMSN---VFQHICNVEE 510
            :        |:|::...:|..|..:.|. :.::|:       |:..:||.|.   ||:.:..:.|
  Fly   276 M--------ELIVDCVLHEDIESTVFYSFKPIESVLQAAKVSEQCKRRLRSEVNLVFERLMALYE 332

  Fly   511 ALESLNVMI---FYSYRSTIRKTFLRQVSSAWVFFSNEIDSSVHMLMDRSKMHESWVPYYASRAL 572
             ||...:.:   |..:|:...|.||.:..:..|.....::.....:..:.|.::     |...:|
  Fly   333 -LEQFILKMPKEFPQFRNINLKEFLPRSFAVDVSGKERLELQALGITMQEKRYD-----YLKASL 391

  Fly   573 GYRV--------------HLDRL-VWLCN---RLNSSDWLPNVSEA-----SVVLK-----KFES 609
            .|.|              :::.| :::|:   .|...|:| ...||     :..||     :..:
  Fly   392 FYCVGGIEAMAGVAIECQYIETLSIFICSFSKPLALVDFL-QAQEAHSDNVATFLKVYWPQQLTT 455

  Fly   610 VRREFDKEVKKSFDEWQKNCCSLLLNQKLDRYLLIRSKKKKGLIECNIDRTILT----ICEQAQH 670
            |.....:.:.|.:.:...|..::.|..|:.|::|....:.:..:|..::.:::.    :|:....
  Fly   456 VITVVLRALGKGWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETSLMNFSHFVCDPCLQ 520

  Fly   671 FERL------------------------GLGV----------------PGMV---RKIYEKHETL 692
            |..|                        .||:                ||:|   :|..||...:
  Fly   521 FLELKSNYKWTNNYIDTEFPFQKPVFAMTLGISEDRKVFYSTDPDEFQPGLVEIFKKCLEKSSGV 585

  Fly   693 RFVYNSVVQVCLNYNHILSALSEQERKLFRALIQACDRKIAPGVFKLTYGGELSDAYIADCAKHT 757
            |.:..||:...                           |.||.::.||.  ||    |.|.....
  Fly   586 RCIDGSVMSFL---------------------------KFAPNLYILTV--EL----IEDRFLRE 617

  Fly   758 NKLQETMDIYKRAI---QNIARFCEKICDTPMLKFNF-----------SGAVTISIFENHLSSYL 808
            |:|.:  :.|.:|:   :..||..|:..|..:|..|.           |..|...|.||
  Fly   618 NELLK--NCYAKAVLPLRAYARLYERFIDFYLLNVNTYMQAYAQAHKPSSEVKRDILEN------ 674

  Fly   809 RRVSNILRGFYSTITDLIFAVFKEFQAVIEDMPIEWYGFVNVFDDMLATAFLTSSKNSLNMLTNA 873
            :|:...||                     |.:|                ||:|.....:|:.|
  Fly   675 KRLKEELR---------------------EILP----------------AFITIGPFYINVDT-- 700

  Fly   874 LHRDPDMAAAPILVMESDVRERCIVLTPDIDVIANLLSGYIDRIH--------NILEQFPRIGIK 930
                         :.:..:::|       |:|:..:...|:||::        ..||.|.||. :
  Fly   701 -------------MKQFMIKKR-------IEVVRRIFEYYVDRMYETNEVLLDRCLEMFRRIA-E 744

  Fly   931 MKLPKEHQYESFSKAFLEDSEST--QLICNIEAEIN---HEREEIDGYITFWNSHR--MLW---- 984
            ..:..||.||      :.|...|  .|:..::|:|.   .|.:.:|.:....:.|:  |.|
  Fly   745 RPISIEHLYE------IRDFAQTVPDLVDELKADIQVMWLEYDLLDSFFYNLSDHQFAMKWNVYA 803

  Fly   985 ---------------ETTELEFTKRVKATQMTADIFEASIEYYSAMADDISYVDAITHVYFILMN 1034
                           :..::|...|:.|::..|  ||..:|   ::.|::       ..|.:..|
  Fly   804 WPHQIMVRLSTLKDEQKVDIEDFLRLHASECQA--FEERLE---SLNDEV-------QAYSLAFN 856

  Fly  1035 QNYIKSSILDCIEKWQALNIKILLSHSFSLIRAIYRYMRKNERKMMMVPRTLKESLLAKQFFERI 1099
            .|..:.:.:|..:.|                 |:.:.:.|..:.:.......:...|:.:|.|.|
  Fly   857 TNRAQETSVDIKKTW-----------------ALIKELEKVSQTLQFRQELFELEPLSVEFLESI 904

  Fly  1100 INEVPLKQAGFPPTLEL------FAILDKYQVEIPEEIRVKVIGLEAAWHHYLKRLGEADEMLDN 1158
            |       |.|.|...|      |..|:...:..|    :..:.||..|::.::...|.:|.:
  Fly   905 I-------ASFTPYKNLWYGCANFLKLEDATLGNP----IAQLDLEDVWNNLMRLRDELNESM-- 956

  Fly  1159 NREEFKKILVQQAEKFKIILKEF---LDDF 1185
                  ||..::.| ...:.|.|   :|||
  Fly   957 ------KIFHEKVE-IMDVAKTFIAKIDDF 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-2	NP_001015505.5	DHC_N1	178..749	CDD:285571	96/575 (17%)
		DHC_N2	1244..1646	CDD:285579
		P-loop_NTPase	1785..2015	CDD:304359
		P-loop_NTPase	2099..2242	CDD:304359
		P-loop_NTPase	2401..2668	CDD:304359
		P-loop_NTPase	2752..3030	CDD:304359
		MT	3043..3373	CDD:289543
		AAA_9	3402..3618	CDD:289547
		Dynein_heavy	3760..4447	CDD:281078
CG14651	NP_649475.3	DHC_N2	904..>1042	CDD:285579	22/96 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930