DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-2 and kl-5

DIOPT Version :9

Sequence 1:	NP_001015505.5	Gene:	kl-2 / 3355181	FlyBaseID:	FBgn0001313	Length:	4459	Species:	Drosophila melanogaster
Sequence 2:	NP_001015499.4	Gene:	kl-5 / 26067054	FlyBaseID:	FBgn0267433	Length:	4559	Species:	Drosophila melanogaster

Alignment Length:	4732	Identity:	1422/4732 - (30%)
Similarity:	2330/4732 - (49%)	Gaps:	592/4732 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 FPVAPVIDLCYFIRSSKEIISIH-SFHDMVNFGTVQDDVDGCL--LKIL-ELIYAPIFRNFME-- 126
            |||.|...:.||||   .:..:| :..:|:|...:.|.:...|  |.|| :.::.|:..|.:.
  Fly    74 FPVRPRYKVAYFIR---YLTPLHLTDENMLNSLLIGDLLPNPLANLSILCDEVFFPLLNNTVNQV 135

  Fly   127 -WGDNVKQRFCT-SLDKFLGILTAIYFKMSGM----TVLYVPYVVKEIAK--------EISSYDR 177
             |.:.:.....| |.:...||.     :|.|:    |:..:|..:.|:.:        :||..:.
  Fly   136 GWTNVIANDMKTESQEMRNGIA-----QMKGLVINRTIFPLPICMDEVMQAAPAIAMGDISVVNP 195

  Fly   178 EFVKNLECIAVSWATLIRILLNDKT---LTSPNEYISVGDEFEFWLYRFEVLQGLNAQLDQVDVQ 239
            ....:||.:.|.|...:..|:|.|.   :.|...:......|.||..|.|.|:.|..||....::
  Fly   196 LMKHSLEFMVVKWLDSVEDLVNIKAGEKIYSKENFPLPEAIFSFWESRLENLENLAEQLGDRRIK 260

  Fly   240 QIIRVLRSTHSVY---IKQIDELIFESTHELMEAMENIKFLHLLMQPCSQLDFSESPTFVSQLIP 301
            .|..||....|::   .::|.||:.||   |.||.:..|.|..|.:...:.:.::.....|.:.|
  Fly   261 TIGFVLEKIQSIFEHSYRRIVELVLES---LAEARDITKCLSPLKRKMDKFETNDMDENRSDIRP 322

  Fly   302 RTIHLIRFIWLNSEQYNRRDLITGIFRNLSNQIIRFCTEKVNVEKILSGSSRFGIKICNMCIDCC 366
            ..: .|..:|.:|..::..:.:|..|....|.:|......|..:.|..|......|..::.:...
  Fly   323 LML-TIGLVWGHSRYFHTLNNMTLFFNLFHNSLIDCVNRTVEPDSIFQGDVDEAYKKLDINMQHL 386

  Fly   367 LTYKGIYDIMSKTHAKINIRIG-------WSLDNAMIFNHVDAFMERLNDVIDICESMMVFGRLD 424
            ..||.||:....:..|  .:||       |:.....||..:|.|:.||.::.|:..::..|.:|:
  Fly   387 EYYKLIYNECRNSLKK--FKIGTTFNSQDWTWHQDEIFGRLDKFLVRLEELKDLFNTVRDFQKLE 449

  Fly   425 ESESIPKPQFGGTSGTEFEATADNVENEFLVTLTALCTDSKEIILNVHKNEWYEEVIKY------ 483
                  |...||..|.:.....:.:..|:                |....||..  |:|
  Fly   450 ------KIVMGGLKGRQITFALEKILEEY----------------NSIYREWTN--IQYNPIDPD 490

  Fly   484 ---------RRTVQSMEETVQRLMSNVFQHICNVEEALESLNVMIFYSYRSTIRKTFLRQVSSAW 539
                     |.:.::..:.::|::|..|      |:.||..:.::...      ...||.:
  Fly   491 AENSLFQRDRLSFKAKTDVMERMVSFQF------EKGLEDTHDLLLAG------SLLLRPI---- 539

  Fly   540 VFFSNEIDSSVHMLMDRSK-----MHESWVPY-YASRALGYRVHLDRLVWLCNRLNSSDWLPNVS 598
              ....::..:|:::|..:     :.:.::.: ....|||           .|.|.:.|..|.||
  Fly   540 --IKKHVEPLMHVIVDDFEEEIMCVKKEFINFKNVFTALG-----------LNELPTDDCFPKVS 591

  Fly   599 EASVVLKK-------------------FESVR------------REFDKEVKKSFDEWQKNCCSL 632
            .|...|||                   |::.|            :|.|...|...|:|...|...
  Fly   592 GAISFLKKLRHRIIGLHKEHELYEYPLFDNERGGYVSDIFNIMVQEIDDFTKMLLDKWTVECWQG 656

  Fly   633 LLNQKLDRYLLIRSKKKKGLIECNIDRTILTICEQAQHFERLGLGVPGMVRKIYEKHETLRFVYN 697
            :   :.|..|.:..|.:...:..|....::...:..:....||..|...:.|.:.:.:.|.....
  Fly   657 I---QQDITLTLIEKDEANELRVNFTERLIFALKDIKVVRLLGCDVSVNLTKFFCREDELWQARV 718

  Fly   698 SVVQVCLNYNHILSALSEQERKLFRALIQACDRKIAP----------------GVFKLT-YGGEL 745
            .::::...||.........|::|..|.:...:.::.|                .:||:. |   |
  Fly   719 KLMRIAEWYNDTFERAHPTEKRLIAAEMILIEEQMKPLLDFIKWNAFSQRFIVMIFKMVKY---L 780

  Fly   746 SDAYIADCAKHTNKLQETMDIYKRAIQN---IARFCEKICD----------TPMLKFNFSGA--- 794
            .|..:|        .||.::..|.:|::   :..|..|..:          .|:|....:.|
  Fly   781 HDRLVA--------AQENLEAIKESIRSWGKVPLFQRKDLNPALLLHTDPREPILSIRAANAADT 837

  Fly   795 ---------VTISIF------------------------------------------------EN 802
                     |.:.:|                                                |:
  Fly   838 QRLIDLLMYVNLKLFFDIPRRYSLPPGEHGEEDEESDGIWPPIISLSVMTSVKFKKKREVIDEED 902

  Fly   803 HLSSYLRRVS----NILRGF--YSTITDLI---FAVFKEFQAVIEDMPIEWYGFVNVFDDMLATA 858
            .|..:....|    .|:..|  |..:..|.   .|:|:|::..::::..|     |:.|.::
  Fly   903 DLEEFEEEQSESEEEIITPFHRYELLKGLSQEERALFREYEIYVDEIIAE-----NLVDSVI--- 959

  Fly   859 FLTSSKNSLNMLTNALHRDPDMAAAPILVMESDVRERCIVLTPDIDV-----IANLLSGYIDRIH 918
               :|...|.|..:..:.:    ..||..:..:::|..:|...::|.     .|..:...:|.::
  Fly   960 ---TSSTYLRMEVDNRYEN----NTPIFEIFMELQEPNVVYFRNLDTSSKTGFAFFIETILDDMN 1017

  Fly   919 NILEQFPRIG-----IKMKLPKEHQYESFSKAFLEDSESTQLICNIEAEINHEREEIDGYITF-- 976
            |::....|:.     :....|.....|...|:.| |.:..:::..|:..:...|....|::.|
  Fly  1018 NMMSLLKRVAQDPTEVTNMNPYSFYDELQDKSEL-DKQRVEIMNKIKLALQAVRVHGKGFMEFSS 1081

  Fly   977 ---WNSHRMLWET---------------TELEFTKRVKATQM---TADIFEASIEYYSAMADDI- 1019
               |:....|.|.               .:||.:..||...:   ...:::..::.:..:.|.|
  Fly  1082 LWIWDKSTYLSEVKKFGRNLTLDERDAEADLEGSSGVKLLGLEYPPLSVYKEQLDKFIELQDQIR 1146

  Fly  1020 ---SYVDAITHVYFILMNQNYIKSSILDCIEKWQALNIKILLSHSFSLIRAIYRYMRKNERKMMM 1081
               :|.|...   |:.:|....|.::|..:.:|.:|....|::...:.::.:..::  :|..:::
  Fly  1147 TWETYEDFFV---FLRLNMTGFKVAVLSQVGQWISLFKLDLINRVKNSLKELQDFV--DEANIVL 1206

  Fly  1082 VPRTLKESLLAKQFFE------RIINEVPLKQ----AGFPPTLELFAILDKYQVEIPEEIRVKVI 1136
                  :..|.|..||      .::|::..||    :.|.|..|:..:|.:|..|..:....::.
  Fly  1207 ------KIELQKDDFEGLVKILSVLNQINEKQCIYDSMFDPLKEIIDLLRQYNYEFKDTELAQIN 1265

  Fly  1137 GLEAAWHHYLKRLGEADEMLDNNREEFKKILVQQAEKFKIIL---------KEFLDDFFLKLPTS 1192
            .|..||.. :|||....:.|....:.::..|:::    :|:|         |:||...|..:| .
  Fly  1266 ELPDAWMK-VKRLAATTKQLIAPIQSYQVDLIEK----RILLCDNMANTYRKKFLSKKFFFVP-C 1324

  Fly  1193 ANINPRIALKFLRIIALKIEDCFTFEESLMRDLAVFNVNQPESIDLRKLDFEVRIVKNIWELIFE 1257
            .:....|....|.::||:..     :.||.....:|.:..|:.:.:....|::::||.:|:....
  Fly  1325 LSCYELIDESDLELVALEER-----QRSLAESAVLFELQGPDPVKIELCRFDLKLVKIMWDFAIT 1384

  Fly  1258 WQTNWEGWKKGYFWKMNINEMEDTALNLYKEFTTLNKKFYDRHWE---MLEATTKNVDSFRRTLP 1319
            .|:....|||..:.|::|..|:.......:|...|:|..  |.||   .:||:.||:   ..:|.
  Fly  1385 IQSTINDWKKTPWKKIDIENMDQECKKFGRELRGLDKAM--RTWEPFIFMEASLKNL---MTSLR 1444

  Fly  1320 LITALKNPCMRERHWNRVRDVIHVNFDENSKNFTLELIINLDFQAFSEDIQDISNPATMELQIEN 1384
            .:|.|:||.:|:|||..:.....|.|..:... ||:.:|:|:...:.|::::|.:.:..|:.:|.
  Fly  1445 AVTELQNPAIRDRHWIELMQTTKVKFSMDDST-TLKDLIDLNLHEYEEEVKNIVDKSVKEMAMEK 1508

  Fly  1385 SIKNIATIWKKQSFEMAFYHD--GIYRIKNVEDCFQLLEEHMVQISAMKATRFVEPFITIVDYWE 1447
            .:::|||.|....|.... ||  .|..:|..|:..:.||:|..|:..|.:::::..|...|..|:
  Fly  1509 QLRDIATAWGTMEFGTDI-HDRTSIKLLKASEELIETLEDHQGQLQNMASSKYIAFFEHEVRLWQ 1572

  Fly  1448 KTLSYISETLEKGLTVQRQWLYLENIFQG-DDIRKQLPEEAKRFATITEEFRTISSKMFQAKTAV 1511
            ..||...:.:.....|||:|.|||:||.| :|||.||||:::||..|.:||:.:.::|...:..|
  Fly  1573 NRLSNADQIIGSWFEVQRKWQYLESIFIGSEDIRSQLPEDSRRFDYIDKEFKALLAQMNADRNVV 1637

  Fly  1512 KATNLRPPPFLLNRFSRMDERLELI-------QRALEIYLEAKRQLFPRFYFISNDDLLEILGNS 1569
            ::||        ...|::.|.||::       ::||..|||.||..:|||||:|:.|||:||.|.
  Fly  1638 RSTN--------RSGSKLYEHLEILLKMLLLCEKALNDYLETKRLSYPRFYFVSSADLLDILSNG 1694

  Fly  1570 KRPDLVQTHLKKLFDNLYKLELKRVGKTLSRWQASGMHSDD-GEYVEFMMVIYIDGPSERWLKQV 1633
            ..|.||..||.||:|::.||.|....|     .|:||.:.: .|||.|:......|..|.||.::
  Fly  1695 NNPALVARHLTKLYDSMGKLNLISGSK-----NAAGMVAKELEEYVPFLENCDCSGKVEVWLNRI 1754

  Fly  1634 EEYMLVVMKEMLK--LTRGSLKKLVGNREKWISLWPGQMVLTTAQIQWTTECTRSLIHCSMVDQK 1696
            .:.|...:::.||  ||....|.    |..||..||.|..|...||.||||...:.   :.|.|:
  Fly  1755 TDKMRDTLRDQLKRSLTFYDHKP----RHVWIFEWPAQPALVGTQIMWTTETNDAF---AKVQQR 1812

  Fly  1697 --KPLRKLKKKQIKVLSKLSEMSRKDLTKTMRLKVNTLITLEIHGRDVIERMYKSNCKDTGHFEW 1759
              ..|:...||||..|:.|..:...|||...|.|:.|:.|:::|.|||:..:.....:....|:|
  Fly  1813 YENALKDYNKKQITQLNNLIILLLGDLTAAERQKIMTICTIDVHSRDVVGTIIAKKVEVQTAFQW 1877

  Fly  1760 FSQLRFYWHRESELCVIRQTNTEHWYGYEYTGNSGRLVITPLTDRCYITLTTALHLHRGGSPKGP 1824
            .||||..|..:.:.|.....:.:..|.|||.||:.||||||||||||||||.:|||..||:|.||
  Fly  1878 QSQLRHRWDPKIDDCFANICDAQFRYDYEYLGNTPRLVITPLTDRCYITLTQSLHLVMGGAPAGP 1942

  Fly  1825 AGTGKTETVKDLGKALGIWVIVTNCSEGLDYKSIGKNFSGLAQSGCWGCFDEFNRINIEVLSVVA 1889
            ||||||||.||||:|||:.|.|.||||.:||||||....||||:|.||||||||||::|||||||
  Fly  1943 AGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGDIHKGLAQTGAWGCFDEFNRISVEVLSVVA 2007

  Fly  1890 QQIMSIMAALSTKALELMFEGQMIKLKHTVGLFITMNPGYAGRTELPDNLKSMFRPISMMVPDNI 1954
            .|:..|..|:.:|.....|.|:.|.|:.|||:|||||||||||.|||:|||:::||.:|:|||..
  Fly  2008 VQVKCIQDAIKSKKQTFSFLGEHIALRTTVGVFITMNPGYAGRAELPENLKALYRPCAMVVPDFA 2072

  Fly  1955 IIAENLLFSDGFTNTRNLARKVYTLYELAKQQLSKQYHYDFGLRSMVALLRYAGRKRRQLPNTTE 2019
            :|:|.:|.::||...|.||||..|||.|.|:.||||.|||:|||::.::|..||..||......|
  Fly  2073 LISEIMLVAEGFQEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGALRRDDRQRPE 2137

  Fly  2020 EEIVYLAMKDMNVARLTANDLPLFNGIMSDIFPGVSLPTIDYSEFNIAIYEEFREAGLQPITIAV 2084
            ::::..|::|.|:.::..:|:|:|.|::.|:||.:.:|.....||...|.....:..|||....:
  Fly  2138 DQVLMRALRDFNIPKIVTDDVPVFMGLIGDLFPALDVPRKRNPEFEAVIKRSALDLKLQPEDGFI 2202

  Fly  2085 KKVIELFETKNSRHSVMIIGDTGTAKSVTWRTLQNCFYRMNSQRFSGWEAVTVYPVNPKALNLAE 2149
            .|:::|.|....||||.|||..||.||..|:||...:  .|.:|...:.     .:||||:...|
  Fly  2203 LKIVQLEELFAVRHSVFIIGFAGTGKSEVWKTLNKTY--QNQKRKPHYN-----DLNPKAVTNDE 2260

  Fly  2150 LYGEYNLSTGEWLDGVLSSIMR--IICGDEEPTQKWLLFDGPVDAVWIENMNSVMDDNKLLTLVN 2212
            |:|..|.||.||.||:.|.:||  ...|...|  ||::.||.:|.:|||::|:||||||:|||.:
  Fly  2261 LFGIVNPSTREWKDGLFSILMRDQANLGGTGP--KWIVLDGDIDPMWIESLNTVMDDNKVLTLAS 2323

  Fly  2213 SERITMPVQVSLLFEVGDLAVASPATVSRCGMVYNDYNDWGWKPFVNSWLQRLRIKEFADFLRIH 2277
            :|||.:..::.||||:..|..|:||||||.|::|.:..|.||.||:.|||...........|.:.
  Fly  2324 NERIALTKEMRLLFEIASLRTATPATVSRAGILYINPQDLGWTPFIQSWLGTRTNSSEVSMLNVL 2388

  Fly  2278 FDYMVPKILDFKRMRCKEPVRTNELNGVVSLCKLLEIFGTKVNGINPINLELLEEMTRLWFMFCL 2342
            ||..||.:||..|.|.:.....:::..:...|.||:...|..|..|    :..::...::|:||:
  Fly  2389 FDKYVPPLLDIFRTRLRSITPISDIARLQMTCYLLDSMLTPQNVPN----DCPKDWYEIYFVFCI 2449

  Fly  2343 VWSICSSVDED-----SRQRLDSFIRELESC-FPIKDTVFDYFVDPNERTFLPWDSKLLSSWKCD 2401
            ||...||:.:|     |.:....|:.|.::. ||:..|:|.:::|...:.|.|| :.|:..::.|
  Fly  2450 VWGFGSSLFQDQIIDWSNEFSKWFLNEYKAVKFPLSGTIFSFYIDHETKKFFPW-TNLVPQFELD 2513

  Fly  2402 FESPFYKIIVPTGDTVRYEYVVSKLLAEEYPVMLVGNVGTGKTSTAISVMEACDKNKFCILAVNM 2466
            .:.|....:|.|.:|.|..:.:..|:..::|:||:|..|:|||....:.:.|...:|:.:..|..
  Fly  2514 MDLPLQSNLVNTAETTRLRFFMDTLIEADHPLMLIGPSGSGKTILMNAKLSALPSDKYSVTNVPF 2578

  Fly  2467 SAQTTAAGLQESIENRTEKRTKTQFVPIGGKRMICFMDDFNMPAKDIYGSQPPLELIRQWIDYKY 2531
            :..||:..||..:|...||:....:.|||.||||.|:||.|||..|.|.:..|..||||::||.:
  Fly  2579 NFYTTSEMLQRILEKPLEKKAGRNYGPIGNKRMIYFVDDMNMPEVDKYFTVQPHTLIRQFMDYHH 2643

  Fly  2532 WFNRKTQQKIYVQNTLLMAAMGPPGGGRQTISSRTQSRFVLLNLTFPSQETIIRIFGTMLCQKLE 2596
            |::|:......:....::|.|. |..|..||..|.|..|....:..|||:.:..|..::|.|.::
  Fly  2644 WYDRQKMTLRDIHKCNIVACMN-PSAGSFTIDPRLQRHFCSFAVNPPSQDALFHILNSILSQHMD 2707

  Fly  2597 S----YPNEVREMWLPITLCTINLYVSMISKMLPTPNKSHYLFNLRDISKVFQGLLRSEKELQNK 2657
            :    :...|.::...:....|.|::.::|..|||..|.||.||||||:.:|.|:|.|..|....
  Fly  2708 NPIQKFDKAVIKLCENMVTTAITLHLKVVSSFLPTAIKFHYNFNLRDIANIFTGVLYSNSETCPN 2772

  Fly  2658 KNFFLRLWVHECFRVFSDRLVDDSDQFWFVNTINDILGKHFEVTFHSLCPSKVPPFFGDFAHPQG 2722
            .|..:|||:|||:||:.|:|||.:|...|...::||:.|..|.....:..:: |..:..||  :|
  Fly  2773 SNQMIRLWIHECYRVYGDKLVDYTDINSFKKIVSDIVRKGIEGVNDDVVYAQ-PLIYCHFA--KG 2834

  Fly  2723 FYEDLQV------DFLRTFMKNQLEEYNNFPGMTRMNLVFFREAIEHIVRILRVISQPRGHILNM 2781
            . .|::.      |.|::.:....:.||::.|  .||||.|.:|:.|:.||.|::...||:.|.:
  Fly  2835 L-TDIKYMPISGWDRLKSLLDEAQDRYNDYIG--AMNLVLFDDAMSHVCRISRILESSRGYALLI 2896

  Fly  2782 GIGGSGRQVLTKLAAFILEMAVFQIEVTKKYKTGDFREDLKNLYKVTGIKQRLTIFIFSSDQIAE 2846
            |:||||:|.||:||:||..:.||||::||.|...|.:.::..||...|:|.....|:.:..::|.
  Fly  2897 GVGGSGKQSLTRLASFISSLDVFQIQLTKDYSVSDLKANIATLYMKAGVKTSACCFLMTDSEVAR 2961

  Fly  2847 VSFLEITNNMLSTGEIN-LFKSDEFDELKPELERPAKKNGVLLTTEALYSYFILNVRDFLHVALC 2910
            ..||.:.|::|::|:|: ||..||.:.:...:....|:.|::...|..:.|||..||..|.|.||
  Fly  2962 EQFLVLVNDLLASGDIHELFPDDEVENIVNAVRNEVKQLGIVDNRENCWKYFIEKVRSLLKVVLC 3026

  Fly  2911 FSPIGENFRSYIRQYPALLSSTTPNWFRFWPQEALLEVASHFLIGFPLNVVVSGKEDEKHRESLV 2975
            |||:|...|...|::|||::.||.:||..|||:||..|:..||    ..:.|..||
  Fly  3027 FSPVGATLRVRSRKFPALVNCTTIDWFHEWPQQALESVSLRFL----SEITVLPKE--------- 3078

  Fly  2976 ISTEAILQRDIAYVFSVIHSSVAKMSENMYAEVKRYNYVTSPNYLQLVSGFKKLLEKKRLEVSTA 3040
                  |...::...:.:|.:|..:|:...|..|||||.|..::|:|::.:.|||.:|.......
  Fly  3079 ------LALPVSNFMAFVHKTVNDISKLYLANAKRYNYTTPKSFLELIALYSKLLHEKVKANLDR 3137

  Fly  3041 SNRLRNGLSKISETQEKVSLMSEELKASSEQVKILARECEDFISMIEIQKSEATEQKEKVDAEAV 3105
            ..||.|||.|::...::|..:.:.||....::||..:|.::.|.::      .|| .|||..|..
  Fly  3138 RLRLENGLIKLASCTKEVDALQDVLKVQEVELKIKNQEADNLIIVV------GTE-NEKVSKERA 3195

  Fly  3106 LIRRDE--IICLELAATARA-----DLEVVMPMIDAAVKALDALNKKDISEVKSYGRPPMKIEKV 3163
            ...::|  :..:|...||:|     |.....|.:.||.:||:.|||.:::|:||:|.||..:..|
  Fly  3196 FASKEEKNVRQIEEDVTAKAKLCEEDFLKAQPALIAAQEALNTLNKNNLTELKSFGSPPDAVVSV 3260

  Fly  3164 MEAVLILL---GKEP---TWENAKKVLSE-STFLNDLKNFDRDHISDKTLKRIAIYTKNPELEPD 3221
            ..|||:|.   ||.|   :|:..:..:.. ..||::|.|:|:.||....:|.:..|..:.|..|:
  Fly  3261 CGAVLVLFSSKGKIPKDRSWKACRAFMGNVDKFLDNLINYDKKHIHPDVIKALQPYILDAEFSPE 3325

  Fly  3222 KVAVVSLACKSLMQWIMAIENYGKVYRIVAPKQEKLDSAMKSLEEKQAALAAAKKKLEELQVVIE 3286
            |:...|.|...|..|::.|..:..||.:|.||:..|..:.|.:::.:..|.|...:|.|
  Fly  3326 KILAKSSAAAGLCSWVININRFYDVYLVVEPKERALLESEKEVKDARDKLTALNLRLTE------ 3384

  Fly  3287 ELYRQLEEKTNLL----NELRAKEERLRKQLERAII-------LVESLSGERERWIETVNQLDLS 3340
                 |||:.|.|    :|..||:::.:.:..:...       |:..|:.|:.||:|:|..|...
  Fly  3385 -----LEEQLNALQMEYDEALAKKQKCQDEASKTAFTIDIANRLIGGLATEKIRWMESVKVLTFG 3444

  Fly  3341 FEKLPGDCLLSVAFMSYLGAFDTKYREELLVK-WSLLIKDLL--IPATLELKVTYFLVDAVSIRE 3402
            .::||||.|:...|:||:|.|...||:||..| |....|:..  ||:|..:.....:.|...|.|
  Fly  3445 IQQLPGDILIISCFISYVGCFTRAYRQELQEKLWMPAFKNSQPPIPSTDGVDPFEMICDDAQIAE 3509

  Fly  3403 WNIQGLPADDLSTENGVIVTQGSRWPLIIDPQMQANNWIKNMEERNQLMTLDFGMADYLRQLERA 3467
            ||.||||:|.:|.||..|:.|..|:||:||||:|...|:|. :....|:.|.....:||.|:|||
  Fly  3510 WNNQGLPSDRMSAENAAILVQSERYPLMIDPQLQGIKWVKT-KYGTGLVVLRLSQRNYLDQVERA 3573

  Fly  3468 LKEGLPVLLQNVGEYLDQAINPILRQSFTIQSGERLLKFNDKYISYNNSFRFYITTKISNPHYPP 3532
            :..|..:|::|:||.:|..:||:|.:.. |:.| .:||..|:.|.:|:.||..:.||::||||.|
  Fly  3574 VSNGSVLLIENIGENIDPVLNPLLGRQL-IKKG-TVLKIGDREIDFNSRFRLILHTKLANPHYKP 3636

  Fly  3533 EISSKTTIVNFALKQDGLEAQLLGIIVRKEKPALEEQKDELVMTIARNKRTLIDLDNEILRLLNE 3597
            |:.::||::||.:.:||||.|||..:|:.|:|.||..:..|.......|.||..|::::|..|:.
  Fly  3637 EMQAQTTLINFTVTRDGLEDQLLAEVVKVERPDLEAMRTRLTQQQNHFKITLKFLEDDLLARLSS 3701

  Fly  3598 SRGSLLDDDELFSTLQKSRQTSVLVKESLSIAEVTEVEIDAARQEYKPASERASILFFVLMDMSK 3662
            :..::|:|..|...|:|:::|:..::..::.|::|.|:||:||:.|:||:|||||::|:|.|:.|
  Fly  3702 AGDNVLEDVTLVMNLEKTKKTADEIEVKVAEAKITGVQIDSAREAYRPAAERASIIYFILNDLFK 3766

  Fly  3663 IDPMYVFSLAAYILLFTQSIERSPRNQLVHERIQNINEYHSYAVYRNTCRGLFERHKLLFSIHMT 3727
            |:|:|.|||.|:.::|..::.::...:.:.:|::|:.:..::..:..|.|||||:.||:|...:.
  Fly  3767 INPIYQFSLKAFTVVFNNAMLKAMAAEKLKDRVENLIDSITFCSFVYTSRGLFEQDKLIFLTQLC 3831

  Fly  3728 AKILSNAGKLLEEEYDFILKGGIVLDKLGQAPNPAP--WWISEQNWDNITELDKVSGFHGIIDSF 3790
            .:||.|.|::...|.||:|       :....||...  .|::...|..|..|:..:.|.|:....
  Fly  3832 IQILVNLGEVEPTELDFLL-------RFPYMPNQTSNFTWLTHVGWGGIRALNNQAVFKGLEKDI 3889

  Fly  3791 EQHYKAWNGWYATTFPEQEDLVGEWNDKLTDFQKICVLRSLRPDRISFCLTQFIITKLGPRYVDP 3855
            |..:|.|..:..:..||.|...|||..| :..|::|::|.:||||:|:.:..||..|||.:|:|.
  Fly  3890 EGSHKRWKKFVDSESPENEKFPGEWKGK-SAIQRLCIMRCIRPDRMSYAMRSFIEEKLGSKYIDA 3953

  Fly  3856 PVLDLKATFDESISQTPLIFVLSPGVDPAQSLISLSESVKMA---QRMYSLSLGQGQAPIATKLI 3917
            ..::...||:||..:|.:.|||||||||.:.:..|.:|:..:   :..:|:||||||..:|...|
  Fly  3954 RSMEFSRTFEESSPETHIFFVLSPGVDPLKDVEKLGKSLGFSFDHENFHSVSLGQGQEIVAENAI 4018

  Fly  3918 MDGIKDGNWVFLANCHLSLSWMPTLDKMIATMQSMKLHKKFRLWLSSSPHPD-----FPISILQT 3977
            ....:.|:||.|.|.||...|:|:|:|.:.:..| .:|..:||:||:.|..|     .|..||::
  Fly  4019 EIASQYGHWVILQNIHLVARWLPSLEKKMESSLS-NVHTSYRLFLSAEPAGDPAAHILPQGILES 4082

  Fly  3978 SIKMTTEPPRGIKSNMKRLYNNINEANMENCSEPSKYKKLLFALCFFHTVLLERKKFLELGWNVI 4042
            :||:|.|||.|:.:|:.:..:|.::..:|.||:.:::|.:||:||:||.|:.||:||...|||..
  Fly  4083 AIKITNEPPTGMMANIHKALDNFSDETLEMCSKETEFKAILFSLCYFHAVVAERRKFGPQGWNRS 4147

  Fly  4043 YSFNDSDFEVSEILLLLYLNEYEDTPWGALKYLIAGVNYGGHITDDWDRRLLITYINQFFCDQAL 4107
            |.||..|..:|..:|..||......||..|:||...:.|||||||||||||..||:.:|...:.:
  Fly  4148 YPFNVGDLTISVYVLYNYLEANTRVPWEDLRYLFGEIMYGGHITDDWDRRLCRTYLEEFMQPELI 4212

  Fly  4108 QTRKFRLSTLPNYFIPDDGDVQSYLDQIQMFP-----------NF-------DKPDAFGQHSNAD 4154
                             ||:    |:..|.||           |:       :.|..:|.||||:
  Fly  4213 -----------------DGE----LEYCQGFPAPGILKYTGYHNYIDDNLPSESPSLYGLHSNAE 4256

  Fly  4155 IASLIGETRMLFEALLSMQVQTNSTSSNENGETK-----VFDLAKEILMNTPDEINYEQTAKIIG 4214
            |..|...:..||.  :..::|...|..:..|||.     :.::.::||..||...|   ..:::|
  Fly  4257 IGFLTTVSERLFR--IVFELQPRMTGGSSGGETVSQEDIIKNIIEDILDKTPTPFN---ILELMG 4316

  Fly  4215 --INRTPLEVVLLQEIERYNKLLVDMSTQLRDLRRGIQGLVVMSSDLEDIYLAVSEGRVPLQWLK 4277
              .:|:|..:|..||.||.|.|:.::...|.:|..|::|.:.:||.:||:.:.:...:||.||.|
  Fly  4317 RVEDRSPYIIVAFQECERMNNLMTELKRSLNELDLGLKGELTISSVMEDLMVCLYMDQVPEQWTK 4381

  Fly  4278 -AYNSLKPLAAWARDLIHRVGHFNSWAKTLRPPILFWLAAYTFPTGFVTAVLQTSARATKTPIDE 4341
             ||.|:..|.:|..||:.|:.....|....|.|...|||.:..|...:||::|.:||..:.|:|.
  Fly  4382 LAYPSMLGLQSWFSDLMLRLRELEGWVADFRMPSSIWLAGFFNPQSLLTAIMQQTARKNEWPLDR 4446

  Fly  4342 LSWDFYV---FVEEDTAAARIIREGGGVYIRSLFLEGGGWLRKNQCLQDPLPMELICPLPVIHFK 4403
            :..:..|   :.||.|.|.|     .|.||..||:||..|..|...:.|....||...:||::.|
  Fly  4447 MCLNCDVTKKWKEELTTAPR-----EGAYINGLFMEGARWDMKMGTIADAFLKELFPAMPVLYIK 4506

  Fly  4404 PVENLKKRCRGVYQCPAYYYPVRSGSFVIAVDLKSGNEKADYWIKRGTALLL 4455
            .|...|:..:.||:||.|...:|..:||...:||| .|:|..|...|..|||
  Fly  4507 AVTQDKQDIKNVYECPVYKIRLRGPTFVWTFNLKS-RERASKWTLAGVCLLL 4557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-2	NP_001015505.5	DHC_N1	178..749	CDD:285571	124/652 (19%)
		DHC_N2	1244..1646	CDD:285579	132/415 (32%)
		P-loop_NTPase	1785..2015	CDD:304359	143/229 (62%)
		P-loop_NTPase	2099..2242	CDD:304359	65/144 (45%)
		P-loop_NTPase	2401..2668	CDD:304359	89/270 (33%)
		P-loop_NTPase	2752..3030	CDD:304359	99/278 (36%)
		MT	3043..3373	CDD:289543	107/355 (30%)
		AAA_9	3402..3618	CDD:289547	85/215 (40%)
		Dynein_heavy	3760..4447	CDD:281078	243/725 (34%)
kl-5	NP_001015499.4	DHC_N1	197..763	CDD:285571	119/627 (19%)
		DHC_N2	1368..1770	CDD:285579	135/421 (32%)
		P-loop_NTPase	1903..2132	CDD:304359	143/228 (63%)
		P-loop_NTPase	2217..2352	CDD:304359	64/143 (45%)
		P-loop_NTPase	2510..2783	CDD:304359	89/273 (33%)
		P-loop_NTPase	2860..3127	CDD:304359	102/287 (36%)
		MT	3140..3480	CDD:289543	108/357 (30%)
		AAA_9	3509..3722	CDD:289547	85/215 (40%)
		Dynein_heavy	3864..4549	CDD:281078	242/718 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450557
Domainoid	1	1.000	84	1.000	Domainoid score	I5259
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1492at2759
OrthoFinder	1	1.000	-	-		FOG0000396
OrthoInspector	1	1.000	-	-		otm47047
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.750