DRSC/TRiP Functional Genomics Resources

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Protein Alignment kl-2 and dhc-4

DIOPT Version :10

Sequence 1:NP_001015505.5 Gene:kl-2 / 3355181 FlyBaseID:FBgn0001313 Length:4459 Species:Drosophila melanogaster
Sequence 2:NP_001338793.1 Gene:dhc-4 / 189209 WormBaseID:WBGene00012272 Length:2727 Species:Caenorhabditis elegans


Alignment Length:3316 Identity:596/3316 - (17%)
Similarity:1157/3316 - (34%) Gaps:975/3316 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   686 YEKHETLRFVYNSVVQVC----LNYNHILSALSEQE-RKLFRALIQACDRKIAPGVFKLTYGGEL 745
            ||  :.||.....:.::|    |.::     :.:|| :|.||.|.:. :|..:..|.||.|    
 Worm    35 YE--DRLRRESRKIPKICRKQFLKWH-----VEQQEAKKKFRRLREK-NRDESIYVAKLWY---- 87

  Fly   746 SDAYIADCAKH-----------------------TNKLQETMDIYKR--AIQNIARFCEKICDTP 785
               |:  ..||                       ..:|:|.||..:|  .|:|:|...:|.....
 Worm    88 ---YV--LKKHPLKPRVEWSFQRVHKLSPKNERIAQELEELMDCAERYALIENVADGYQKRVKDE 147

  Fly   786 MLKFNFSGAVTISIFENHLSS---YLRRVSNI----LRGFYSTITDLIFAVFKEFQAVIEDMPIE 843
            :.:.|     .|..:.:|:.:   .|.|..::    :|.|:.....|||.|.:.....:.::||:
 Worm   148 LARLN-----KIEKYHHHVKNNREILLRSQSLAAMKIRIFFENRKGLIFEVNELIDPEVGNIPIK 207

  Fly   844 WYGFVNV-----FDDMLATAFLTSS---KNSLNMLTNALHRDPDMAA-APILVMESDVRERCIVL 899
            .:..|.:     |...:....|..:   :...|::.|.:.::...|| ..|......:|.:...|
 Worm   208 KFREVTLTKVLEFSQEINMKLLKKNWRDEKKRNIVQNCIVQETTNAAFGTIQAYLKTLRNKPAFL 272

  Fly   900 TPDIDVIANLLSGYIDRIHNILEQFPRIGIKMKLPKEHQYESFSKAFLEDSESTQ---LICNIEA 961
            :.|..::...|....::|..:|::  .|.:...|..       .:...||.|:.|   :|| :|.
 Worm   273 SIDCMIVDRKLWVNSEQIRLLLKE--PISVMCALEN-------VRMSTEDCETWQEEAMIC-VEV 327

  Fly   962 EINHE----REEIDGYITFWNSHRMLWETTELEFTKRVKATQMTADIFEASIEYYSAMADDISYV 1022
             ::||    ...|..|....:.:::..:.||.|..|                     |.||.:::
 Worm   328 -LSHELIVHHPFIQPYAFLIDDYKVSPKLTEEELIK---------------------MYDDSTHL 370

  Fly  1023 D-AITHVYFILMNQNYIKSSILDCIEKWQALN---------IKILLSHSF-SLIRAIYRYMRKNE 1076
            . .:|....:|.    |:..:|.....|..::         :|:.:...| :|:..:....||.:
 Worm   371 QIRLTKAVKLLT----IRCFVLRLESVWSEVDRRIRSFRNQLKMAIRRKFTTLLNKLLHDFRKYD 431

  Fly  1077 RKM--------MMVPRTLKESLL--------AKQFFE------RIINEVPLKQAGFPPTLELFAI 1119
            |.:        ||:....:..|:        .:||.|      .|...:.|..:.....|:|.::
 Worm   432 RALQYRSIDPSMMLSNKAQVDLMLQNEIGDSVRQFVEVYDKVFEITQHISLDTSQLDTLLQLASL 496

  Fly  1120 LDKYQVEIPEEIRVKVIGLEAAWHHYLKRLGEADEMLDNNREEFKKILVQQAEKFKIIL----KE 1180
                ::.:|:.|....       |.:.||:......:...:.:....:.:..||.||:.    .:
 Worm   497 ----RLSLPQCINDHA-------HFFQKRISTFLHFVTKKQSKVMSNVQKAMEKLKIVQTMGNPQ 550

  Fly  1181 FLDDFFLKLPTSANINPRIALKFLRIIALKIEDCFTFEESLMRDLAVFNVNQPESIDLRKLDFEV 1245
            .:|::..::   |.:.|     .|..:..:|||...||.::  |:.|.:|.:     :|....|:
 Worm   551 EVDNYLTQM---AKLRP-----MLDNLITEIEDLNKFETAV--DIQVSDVTK-----MRHFVGEI 600

  Fly  1246 RIVKNIWELIFEWQTNWEGWKKGYFWKMN---------INEMEDTALNLYKEFT--------TLN 1293
            ..:::::|.           ..||:..:|         :|  .|.:.|...:||        :|.
 Worm   601 GSLQSLFEA-----------TSGYYKHVNAFFESRRTLVN--IDASRNFIDQFTIQLSIFESSLT 652

  Fly  1294 KKFYDRHWEMLEATTKNVDSFRRTLPLITALKNPCMRERHWNRVRDVIHVNFDENS-KNFTLELI 1357
            .....:|:  :......||:|::...:...:....:.:.||.|:.::  |.||... .|.::..|
 Worm   653 THRAAKHF--IAYARNEVDAFKKNFAVAEVMSCRRLLDAHWLRMSEI--VGFDLTPYANSSIAQI 713

  Fly  1358 INLDFQAFSEDIQDISNPATMELQIENSIKNIATIWKKQSFEMAFY--------------HDGIY 1408
            ..|..:|..:.::.|:..|..|....:.:..|.|.|.::..||..|              |   :
 Worm   714 CELGLEAHLQQLKPIAFSAEREATAADQLHAIVTFWSQEPLEMRCYVQWKLSLALKLSELH---H 775

  Fly  1409 RIKNVEDCFQLLEEHMV---QISAMKATRFVEPFITIVDYW----EKTLSYISETLEKGLTVQRQ 1466
            |::|  |...|  :||.   ||:.....:::|        |    ||.|....||       |::
 Worm   776 RVQN--DINTL--KHMTNVEQITDDSLPQWIE--------WTARAEKILKAWCET-------QQK 821

  Fly  1467 WLYLENIFQGDDIRKQLPEEAKRFATITEEFRTISSKMFQAKTAVKATNLRPPPFLLNRFSRMDE 1531
            |:.:.|||.  ..|..|.:|.:...|..:.|..|...:.:.:|..:...|...|..:.:.:.|  
 Worm   822 WMRVANIFV--TCRDTLQKEYELLRTCAKYFIKIERNVLKDETIYRVMQLPHLPCWIQKINSM-- 882

  Fly  1532 RLELIQRALEIYLEAKRQLFPRFYFISNDDLLEILGNSKRPDLVQTHLKKLFDNLYKLELKRVGK 1596
             :.:|.:.:...|:..|....|....|...||.:...:.    ::|.||.|..:.:.        
 Worm   883 -VSIIIQGVRGLLDGMRMNNARLCLSSEVHLLNLFSTTS----IETRLKLLLKDCFP-------- 934

  Fly  1597 TLSRWQASGMHSDDGEYVEFMMVIYIDGPSERWLKQVEEYMLVVMKEMLKLTRGSLKKLVGNREK 1661
                                                                  ||::|..||..
 Worm   935 ------------------------------------------------------SLRRLCFNRRN 945

  Fly  1662 WISLWPGQMVLTTAQIQWTTECTRSLIHCSMVDQKKPLRKLKKKQIKVLSKLSEM---SRKDLTK 1723
            .:.:      :...:.:.|.:.|:     |.::.::|...::..:....|||:::   .|:|.:|
 Worm   946 QLEM------VDLLEEKVTVDLTK-----SEIESQEPCELIRSIEQAFASKLTDIITYERQDRSK 999

  Fly  1724 TMRLKVNTLITLEIHGRDVIERMYKSNCKDTGHFEWFSQLRFYWHRESELCV-----------IR 1777
            ... :|...:...|..|..::.::.|..:.|.:.:..|.     .|:|.|.|           |.
 Worm  1000 AAS-RVGANVAELIETRQTLDPLFLSRVEKTYYIQHRSV-----QRQSLLTVDFVYSTEINRFIP 1058

  Fly  1778 QTNTEHWYGYEYTGNSGRLVI---TPLTDRCYI-----TLTTALHLHRGGSPKGPAGTGKTETVK 1834
            ::..:.|       :||.:|:   ...:.|.::     .:.:.|.:........||...:...  
 Worm  1059 RSLADSW-------SSGHIVLLIGEMCSTRSFVLRLANCMCSNLRIVNSHQLLEPAFLERVTK-- 1114

  Fly  1835 DLGKALGIWVIVTNCSEGLDYKSIGKNFSGLAQSGCWGCFDEFNRINIEVLSVVAQQIMSIMAAL 1899
              |.|:..|.::....:.||.:.|.|.|..||..     ...|.|:.:.....:..|:.:.:|  
 Worm  1115 --GIAMSSWFVLLENVDLLDSQLIFKLFKILASQ-----VTSFPRLFLSSTDEIKNQLPTNIA-- 1170

  Fly  1900 STKALELMFEGQMIKLKHTVGLFITMNPGYAGRT------------ELPDNLKSMFRPISMMVPD 1952
             .:.|.:..|            |:.::|.:...|            :||..|.|..:|.|.  |.
 Worm  1171 -VEHLGVFHE------------FVEVSPAFKFETSPLSSVRTSSIPKLPAQLVSTGQPPSS--PH 1220

  Fly  1953 NIIIAENLLFSDGFTNTRNLARKVYT------LYELAKQQLSKQYHYDFGLRSMVALLRYAGRKR 2011
            ::::             ..:..|:..      :..|||:.|                       :
 Worm  1221 SVLL-------------EKIGAKIRNREISGCVGSLAKETL-----------------------K 1249

  Fly  2012 RQLPNTTEEEI-VY--LAMKDMNVARLTANDLPLFNGIMSDIFPGVSLPTIDYSEFNIAIYEEFR 2073
            ..|.|..|:.| ||  :.::|..|.|             ||.|.......:    |.:       
 Worm  1250 ETLQNFPEKIIWVYTDVFVRDQMVTR-------------SDEFAATQSGIL----FEV------- 1290

  Fly  2074 EAGLQPITIAVKKVIELFETKNSRHSVMIIGDTGTAKSVTWRTLQNCFYRMNSQRFSGWEAVTVY 2138
               |.|.|.....    .:::.|.||      |.:..|||..|:. .||..:       |...::
 Worm  1291 ---LSPATTGNGG----SDSERSYHS------TISTSSVTINTIV-VFYGFS-------EFWNIF 1334

  Fly  2139 P-VNPKALNLAELYGEYNLSTGEWL---DGVL----SSIMRIIC-GDEE----PTQKWLLFDGPV 2190
            | ::|..|.    ...|:..|..:|   ||..    .::..::| .|||    .|.|  .||.|.
 Worm  1335 PFISPLFLK----KDGYSAQTPPFLTLDDGSTYWPQENVQFLMCIPDEEGFHLNTVK--KFDIPF 1393

  Fly  2191 DAVWIENMNSVMD---------DNKLLTLVNSERITMPVQVSLLFEVGDLAVAS----------- 2235
            ..|   |.|..||         ..|...|.|  :|::   |.::.|:.|..::.           
 Worm  1394 HVV---NENLKMDVARSWRKVWHKKYTELFN--KISL---VEIMDELVDRILSPMASHFKSTFLW 1450

  Fly  2236 PATVSRCGMVYNDYNDWGWKPFVNSWLQRLRIKEFADFLRIHFDYMVPKILDFKRMRCKEPVRTN 2300
            |:|:.:  ::|:|         :...:...||....|.|||                        
 Worm  1451 PSTLFQ--VIYHD---------LTEVIPTSRITSVNDTLRI------------------------ 1480

  Fly  2301 ELNGVVSLCKLLEIFGTKVNGINPINLELLEEMTRLWFMFCLVWSICSSVDEDSRQRLDSF---- 2361
              ..|::....:.||.                                    |.:.:::.:    
 Worm  1481 --TVVLATANFISIFA------------------------------------DDQGKVEKYMGRA 1507

  Fly  2362 ---IRELESCFPIKDTVFDYFVDPNERT-FLPWDSKLLSSWKCDFESPFYKIIVPTGDTVRYEYV 2422
               |||..| ..:.|.:.::.:...:.| .:.|:.:.......|.:|....|::.|.:..|..:.
 Worm  1508 LGAIREKLS-IQMPDDICNWKISYQDATKLVRWEDEPFCQSSIDKDSAIGNIMIVTPNMDRLLFY 1571

  Fly  2423 VSKLLAEEYPVMLVGNVGTGKTSTAISVMEACDKNKFCILAV-NMSAQTTAAGLQESIENRTEKR 2486
            ..:|||..:.:::.|...:.||.....:      :||....| :::.:......:..:.|...::
 Worm  1572 SIRLLASGHNILVHGPPYSRKTMFVKMI------SKFLSSTVGDLTVEFLWLDGKSRVGNDVAQK 1630

  Fly  2487 TKTQFVPIGG--------KRMICFMDDFNMPAKDIYGSQPPLELIRQWIDYK-YWFNRK------ 2536
               :|..:.|        |::...:|.|:.       ::|.|.:|..::|:| ||.:.|      
 Worm  1631 ---KFADVVGTCERAHQSKQLYIVIDRFSF-------TEPLLPIIEFFVDHKTYWKDGKLCNSDA 1685

  Fly  2537 -------TQQKIY--VQNTLLMAAMGPPGGGRQTISSRTQSRFVLL----NLTFPSQETIIRIFG 2588
                   |.::.|  :..|..:|                 |.||.:    :..|..|:.:::   
 Worm  1686 QIRMIIITDEEDYAWLHKTKALA-----------------STFVGIAMPASTKFKDQKPLVQ--- 1730

  Fly  2589 TMLCQKL--ESYPNEVREMWLPITLCTINL----YVSMISKM-LPTPNKSHYLFNLRDISKVFQG 2646
            :::....  :|:.:|...:....:.|.:.:    ||..:|.| |.|.....:.|...|...    
 Worm  1731 SLIAANFTAKSFSSEYHHILESFSSCIVEIVRKPYVENLSSMALATRLAKSFFFAFPDNCP---- 1791

  Fly  2647 LLRSEKELQNKKNFFLRLWVHECFRVFSDRLVDDSDQFWFVNTINDILGKHFEVTFHS------- 2704
                      ..:..|||::||..||..| .:|...:..|......::.::|...|.:       
 Worm  1792 ----------DPDALLRLFIHESARVIGD-AIDPIHRATFAQQFETLIDENFNTAFQAILKHIAQ 1845

  Fly  2705 -----------------------LCPSKVPPFFGDFAHP--QGF-YEDL--QVDFLRTFMKNQLE 2741
                                   |..|:|.      ||.  .|. ||.:  :|.|.|: ::|.|.
 Worm  1846 ISEEEEEEEGVEKRMTASLDMFDLIYSEVD------AHDVVDGLAYEPVVDRVQFQRS-IENFLF 1903

  Fly  2742 EYNNFPGMTRMNLVFFREAIEHIVRILRVISQPRGHILNMGIGGSGRQVLTKLAAFILEMAVFQI 2806
            |::......|:.|....|....:.|::|||.|...|::......|||..:.|.|.......:..:
 Worm  1904 EHHRNHTKDRVRLFVDWETSGWVQRVMRVIRQASEHMVLTAPPNSGRTQVVKAACVACNATMMHM 1968

  Fly  2807 EVTKK-YKTGDFREDL---KNLYKVTGIKQRLTIFI---FSSDQIAEVSFLE---------ITNN 2855
            :|... |.|...|.:.   :.:..:....|.:.|.:   |..::: |..::|         .|.:
 Worm  1969 QVDATCYDTFISRWEYALSRAINIIANTNQHVVILVHLDFCYEKV-EPRWMEQIKLWIECPNTQH 2032

  Fly  2856 MLSTGEINLFKSDEFDELKPELERPAKKNGVLLTTEALYSYF-------------ILNVR--DFL 2905
            ::|..:::.. .::..|.:..|....:..|:.|..:.:..|.             :|..|  |.|
 Worm  2033 LVSDEQLHTM-GEQLIECEKNLATQMQTIGLRLPGQRMCKYLPVETLKEPQALRKVLEARIFDAL 2096

  Fly  2906 HVALCFSPIGENFRSY--IRQYPALLSSTTPNWFRFWPQEALLEVASHFLIGFPLNVVVSGKEDE 2968
            ||.....|..:...|:  |...|.:..|           |.|.:|:         .::...|.||
 Worm  2097 HVMFLVDPQFKTDFSWCTIFHVPTIEKS-----------ELLSKVS---------KIISDCKVDE 2141

  Fly  2969 KHRESLVISTEAILQRDIAYVFSVIHSSVAKMSENMYAEVKRYNYVTSPNYLQLVSGFKKLLEKK 3033
              ...:::||..|:::   |:.|:              .:..|..|.| ...::...|:.:..::
 Worm  2142 --AAQIIVSTFFIVKK---YLQSI--------------GIALYGTVFS-QLFEVADCFQIVFREQ 2186

  Fly  3034 RLEVSTASNRLRNGLSKISETQEKVSLMSEELKASSEQVKILARECEDFISMIEIQKSEATEQKE 3098
            :.|:.....||...| ...|..||::.|.:|:...:.|.:|:  |.|..:|.:..:::....:.|
 Worm  2187 KKELVAEGTRLNEAL-HTCEQIEKLAEMGKEVDIEAVQRRIV--EKETMLSKMNRERNTKGARME 2248

  Fly  3099 KVDAEAVLIRRDEIICLELAATARADLEVVMPMIDAAVKA-----------LDALNKKDISEVKS 3152
             |.:|.|.::...:      .|.||:...:...::|.|.|           |...:..||..:..
 Worm  2249 -VLSELVAVKATNL------ETMRAEEAALKTTVEAMVSAPQEEFRKCVEELLKFSNTDIKTLSK 2306

  Fly  3153 YGRPPMKIEKVMEAVLILLGKEP----------TWENAKKVLSESTFLNDLKNFDRDHISDKTLK 3207
            ..:|.:.|....|.:..:.  ||          .|..:.|.:|:..|...|...|.|.::...:|
 Worm  2307 ITKPSVGIRLCCEMLRTIF--EPNFKPKRHAAEAWTESLKFVSDKAFFIKLATCDADILTVDQMK 2369

  Fly  3208 RIAIYTKNPELEPDKVAVVSLACKSLMQWIMAIENYGKVYRIVAPKQEKLDSAMKSLEEKQAALA 3272
            .:..|....|...:|:...|:.|..|.:||.|........|::..:.|:.....:.:.:.:....
 Worm  2370 VLKKYVDRAEFNANKIEHESVVCACLCRWIGAFLELACTLRVMEEQVEESKELREHIRQTEVRFE 2434

  Fly  3273 AAKKKLEELQVVIEELYRQLEEKTNLL-NELRAKEERLRKQLERAIILVESLSGERERWIETVNQ 3336
            ....::::|:..:|:|...:.|...:| |:.|..:.|||..     .|:.:|...|:||...:.|
 Worm  2435 NESSEMQQLKSDVEKLTVLIRENEQVLANDRRLCDYRLRSG-----DLLAALEPHRKRWKSQLKQ 2494

  Fly  3337 LDLSFEKLPGDCLLSVAFMSYLGAFDTKYREELLVKWSLLIKDLLIPATLELKVTYFLVDAVS-- 3399
            .:...::|.|:.||...           :|..||.:              |..||...|...:  
 Worm  2495 NEKKQKELVGNTLLFAI-----------HRAHLLCQ--------------EKAVTLICVSMCTSH 2534

  Fly  3400 IREWNIQGLPADDLSTENGVIVTQGSRWPLIIDPQMQANNWIKNMEERNQLMTLDFGMADYLRQL 3464
            :...|:|.  ...:::.:.||                  |.|....:.::...|.....|.|.|.
 Worm  2535 LTSQNVQF--DSSMASSSNVI------------------NRILRTLKSSRRFCLFLSTTDSLLQN 2579

  Fly  3465 ERALKEGLPVLLQNVGEYLDQAINPIL-----RQSFTIQSGERLLKFNDKYISYNNSFRFYITTK 3524
            .|::..|        ..|||  |:|.|     :.:.::|          |::.......||..|:
 Worm  2580 VRSVLPG--------ATYLD--ISPPLTWKEPQMAVSLQ----------KHVYSIVPTVFYNLTE 2624

  Fly  3525 ISNPHYPPEISSKTTIVNFALKQDGLEAQLLGIIVRKEKPALEEQKDELVMTIARNKRTLIDLDN 3589
            :.    |||      :....:|.:..|      :....|| ||...|.|.:.:|:|   |..:.:
 Worm  2625 VP----PPE------MYEILMKSEEKE------VCYHNKP-LELPDDILFVFVAKN---LGHIPD 2669

  Fly  3590 EILRLLNESRGSL----LDDDELFSTLQKSRQTSVLVKESLSIAEVTEVEIDAARQEYKPASERA 3650
            :|.:|:.....|:    ::|.|   .::::..:|:|       .|.|..:|..:|...:.|.:.|
 Worm  2670 QIRKLMEVIVVSIPLEPIEDRE---KIERNELSSLL-------GEFTAADILESRDLTRKAMQIA 2724

  Fly  3651 S 3651
            |
 Worm  2725 S 2725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kl-2NP_001015505.5 DHC_N1 180..749 CDD:462457 17/67 (25%)
DHC_N2 1238..1646 CDD:462462 77/446 (17%)
DYN1 <1478..4135 CDD:227570 422/2395 (18%)
AAA_6 1785..2111 CDD:463697 58/354 (16%)
Dynein_C 4161..4455 CDD:465677
dhc-4NP_001338793.1 DHC_N2 599..992 CDD:462462 88/513 (17%)
Blue background indicates that the domain is not in the aligned region.

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