DRSC/TRiP Functional Genomics Resources

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Protein Alignment kl-2 and DYNC1H1

DIOPT Version :9

Sequence 1:NP_001015505.5 Gene:kl-2 / 3355181 FlyBaseID:FBgn0001313 Length:4459 Species:Drosophila melanogaster
Sequence 2:NP_001367.2 Gene:DYNC1H1 / 1778 HGNCID:2961 Length:4646 Species:Homo sapiens


Alignment Length:4819 Identity:1183/4819 - (24%)
Similarity:2140/4819 - (44%) Gaps:775/4819 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TDRGSEI----------AGLVEYVKKITFLYSLDHRDWNAKVINVISIWL------------INS 48
            ||.|.::          :|:..::::|..:..||....:...:..||.||            ..|
Human   230 TDFGDKVEDPTFLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRES 294

  Fly    49 TELVLTIFYDCDVLTGCLGFPVAPVIDLCYFIRSSKEIISIHSFHDMVNFGTVQDDVDGCLLKIL 113
            .|::||:    |:|                  :..|.      ||..|:|     |.|..|.:.|
Human   295 PEVLLTL----DIL------------------KHGKR------FHATVSF-----DTDTGLKQAL 326

  Fly   114 ELI--YAPIFRNFMEWGDNVKQRFCTSLDKFLGILTAIYFKMSGMTVLYVPY-----VVKEIAKE 171
            |.:  |.|:.::| ...|.:.   .|.|||....|.||:..:..:.....|.     :|:.|:::
Human   327 ETVNDYNPLMKDF-PLNDLLS---ATELDKIRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRD 387

  Fly   172 ISSYDREFVKNLECIAVSWATLIRILLNDKTLTSPNEYISVGDEFEFWLYRFEVLQGLNAQLDQV 236
            :||...:.:...:.:.|::....:::            ::..:.|:.|...:|.||.|...:.:.
Human   388 LSSQLLKVLGTRKLMHVAYEEFEKVM------------VACFEVFQTWDDEYEKLQVLLRDIVKR 440

  Fly   237 DVQQIIRV---LRSTHSVYIKQIDEL-IFESTHELMEAMENIKFLHLLMQPCSQLDFSESPTFVS 297
            ..::.:::   :...|.....::|:: .|...||.:.|:                          
Human   441 KREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAV-------------------------- 479

  Fly   298 QLIPRTIHLIRFIWLNSEQYNRRDLITGIFRNLSNQIIRFCTEKVNVEKILSGSSRFGIKICNMC 362
                    ::|.:         |..:|.:.:....::..  .:.:.|.::|     |.....|..
Human   480 --------IVRVL---------RPQVTAVAQQNQGEVPE--PQDMKVAEVL-----FDAADANAI 520

  Fly   363 IDCCLTYKGIYDI----MSKTHAKINIRIGWSLDNAMIFNHVDAFMERLNDVIDICESMMVFGRL 423
            .:..|.|:.:.::    :||...:     .|           :|.|:|.::.||..|: .:..||
Human   521 EEVNLAYENVKEVDGLDVSKEGTE-----AW-----------EAAMKRYDERIDRVET-RITARL 568

  Fly   424 DESESIPKPQFGGTSGTEFEATADNVENEFLVTLTALCTDSKEIILNVHKNEWYEEVIKYRRTVQ 488
                   :.|.|         ||.|....|     .:.:....:.:..|          .|..::
Human   569 -------RDQLG---------TAKNANEMF-----RIFSRFNALFVRPH----------IRGAIR 602

  Fly   489 SME-ETVQRLMSNVFQHICNVEEALESLN--VMIFYSYRSTIRKTFLRQVS--SAWVFFSNEIDS 548
            ..: :.:||           |::.:|||:  ..:.|......:.:.:|.:.  |..:.::.:||.
Human   603 EYQTQLIQR-----------VKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDR 656

  Fly   549 SVHMLMDRSK--MHESWVPYYASRALGYRVHLDRLVWLCNRLNSSDWLPNVSEASVVLKKFESVR 611
            .:...|.|.:  :.:.|                               .|..|...:.:..:|.|
Human   657 QLTAYMKRVEDVLGKGW-------------------------------ENHVEGQKLKQDGDSFR 690

  Fly   612 REFDKEVKKSFDEWQKNCCSLLLNQKLDRYLLIRSKKKKG------LIECNIDRTILTICEQAQH 670
            .:.:  .::.||:|.:......|... .|...|.|.:.:|      .::.|....|:|:.::.::
Human   691 MKLN--TQEIFDDWARKVQQRNLGVS-GRIFTIESTRVRGRTGNVLKLKVNFLPEIITLSKEVRN 752

  Fly   671 FERLGLGVP-GMVRKIYEKHETLRFVYNSVVQVCLNYNHILSALSEQERKLFRALIQACDRK--- 731
            .:.||..|| .:|.|.::.::...|.. |:::....|......:  :||.....|:....::   
Human   753 LKWLGFRVPLAIVNKAHQANQLYPFAI-SLIESVRTYERTCEKV--EERNTISLLVAGLKKEVQA 814

  Fly   732 -IAPGVFKLTYGGELSDAYIADCAKHTNKLQETMDIYKRAIQNIARFCEKICDTPMLKFNFSGAV 795
             ||.|: .|.:.....|.|:                 :|..:.:..|.||:.|            
Human   815 LIAEGI-ALVWESYKLDPYV-----------------QRLAETVFNFQEKVDD------------ 849

  Fly   796 TISIFENHLSSYLRRVSNILRGFYSTITDLIFAVFKEFQAVIEDMPIEWYG----FVNVFDDMLA 856
             :.|.|..:...:|.:...:.. :.|.::::..|    |..::|:.:..|.    :||..|..:.
Human   850 -LLIIEEKIDLEVRSLETCMYD-HKTFSEILNRV----QKAVDDLNLHSYSNLPIWVNKLDMEIE 908

  Fly   857 --------------TAFL---TSSKNSLNMLTNALHRDPDMAAAP-------ILVMESDVRERCI 897
                          |..|   ...|..::|.|:|    |.::..|       .:|.|..:..:.|
Human   909 RILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDA----PQVSHKPGGEPKIKNVVHELRITNQVI 969

  Fly   898 VLTPDIDVIANLLSGYIDRIHNILEQFPRI-------GIKMKLPKEHQYESFSKAFLED-----S 950
            .|.|.|:.....|...:.....::...|||       |:..:|.:|.::...:...:.|     .
Human   970 YLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRMPDGPVALE 1034

  Fly   951 ESTQLICNIEAEINHEREEIDGYITFWNSHRMLWETTELEFTKRVKATQMTADIFEASIEYYSAM 1015
            ||...:..|.:       |::.|:..|..::.||:              |.|:      ..|:.:
Human  1035 ESYSAVMGIVS-------EVEQYVKVWLQYQCLWD--------------MQAE------NIYNRL 1072

  Fly  1016 ADDI---------------SYVDAITHVYF--ILMNQNYIKSSILDCIEKW---------QALNI 1054
            .:|:               ::.:|.|...|  ::::...::|.:....:.|         |.|..
Human  1073 GEDLNKWQALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGS 1137

  Fly  1055 KILLSHS-FSLIR-----------------AIYRYMRKNERKMMMVPRTLK-----ESLLAKQFF 1096
            .:...|| .|..|                 ....|::..:||:....:.::     :.||.||.|
Human  1138 NMTEFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQRF 1202

  Fly  1097 ERIINEVPLKQAGFPPTLELFAILDKYQVEIPEEIRVKVIGLEAAWHHYLKRLGEADEMLDNNRE 1161
            :            |||:   :..:|               .:|..|..:...:...|..:.....
Human  1203 Q------------FPPS---WLYID---------------NIEGEWGAFNDIMRRKDSAIQQQVA 1237

  Fly  1162 EFKKILVQQAEKFKIILKEFLDDFFLKLPTSANINPRIALKFLRIIALKI-------EDCFTFEE 1219
            ..:..:||:....:....:.|.|:....|.:.|:.|..||:.|.|...|.       |.|...:|
Human  1238 NLQMKIVQEDRAVESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKE 1302

  Fly  1220 SL-MRDLAVFNVNQPESIDLRKLDFEVRIVKNIW-ELIFEW----QTNWEGWKKGYFWKMNINEM 1278
            :| :.|..:.:.:: |.:.: .|: |::.:|.:| ||...|    |...:.|......|:..|  
Human  1303 ALELTDTGLLSGSE-ERVQV-ALE-ELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQN-- 1362

  Fly  1279 EDTALNLYKEFTTLNKKFYDRHWEMLEATTKNVDSFRRTLPLITALKNPCMRERHWNRVRDVIHV 1343
            .|..||..|.|....:::  ..:|.::...|   .:.:...|:..||:..:::|||.::...:||
Human  1363 LDALLNQLKSFPARLRQY--ASYEFVQRLLK---GYMKINMLVIELKSEALKDRHWKQLMKRLHV 1422

  Fly  1344 NFDENSKNFTLELIINLDFQAFSEDIQDISNPATMELQIENSIKNIATIWKKQSFEMAFYHDGIY 1408
            |:..:  ..||..|.::|.|.....::|:...|..|:.:|..:|.|..:|.....::..|.:...
Human  1423 NWVVS--ELTLGQIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCR 1485

  Fly  1409 RIKNVEDCFQLLEEHMVQISAMKATRFVEPFITIVDYWEKTLSYISETLEKGLTVQRQWLYLENI 1473
            .|:..:|.|..::||:..:||||.:.:.:.|......||..|:.|....:..:.|||:|:|||.|
Human  1486 LIRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGI 1550

  Fly  1474 FQGD-DIRKQLPEEAKRFATITEEFRTISSKMFQAKTAVKATNLRPPPFLLNRFSRMDERLELIQ 1537
            |.|. ||:..||.|.:||.:|:.||..:..|:.::...:...|::.   :.....|:.:.|..||
Human  1551 FTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQG---VQRSLERLADLLGKIQ 1612

  Fly  1538 RALEIYLEAKRQLFPRFYFISNDDLLEILGNSKRPDLVQTHLKKLFDNLYKLELKRVGKTLSRWQ 1602
            :||..|||.:|..||||||:.::|||||:||||....:|.|.||:|..:..:.|......:    
Human  1613 KALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVV---- 1673

  Fly  1603 ASGMHSDDGEYVEFMMVIYI-DGPS-ERWLKQVEEYMLVVMKEML--KLTR----GSLKKLVGNR 1659
             .|:.|.:||.|.|...:.| :.|. ..||..||:.|.|.:.::|  .:|.    |....:..|.
Human  1674 -LGISSREGEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNT 1737

  Fly  1660 E-KWISLWPGQMVLTTAQIQWTTECTRSLIHCSMVDQKKPLRKLKKKQIKVLSKLSEMSRKDLTK 1723
            . .||..:..|:|:.:|||.|:.....:|..........||..:.......|:.|::....:...
Human  1738 YITWIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQPP 1802

  Fly  1724 TMRLKVNTLITLEIHGRDVIERMYKSNCKDTGHFEWFSQLRFYWHRES----ELCVIRQTNTEHW 1784
            ..|.|:..|||..:|.|||...:.||...:...|||.||:|||:..:.    :...|:..|.:..
Human  1803 LRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMANAKFN 1867

  Fly  1785 YGYEYTGNSGRLVITPLTDRCYITLTTALHLHRGGSPKGPAGTGKTETVKDLGKALGIWVIVTNC 1849
            ||:||.|...:||.||||||||:|:|.||....||||.|||||||||:||.||..||.:|:|.||
Human  1868 YGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFVLVFNC 1932

  Fly  1850 SEGLDYKSIGKNFSGLAQSGCWGCFDEFNRINIEVLSVVAQQIMSIMAAL---------STKA-- 1903
            .|..|::::|:.|.||.|.|.|||||||||:...:||.|:||:..|..||         .|.|  
Human  1933 DETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNPNYDKTSAPI 1997

  Fly  1904 -LELMFEGQMIKLKHTVGLFITMNPGYAGRTELPDNLKSMFRPISMMVPDNIIIAENLLFSDGFT 1967
             .||:  .:.:|:...:.:|||||||||||:.||||||.:||.::|..||..:||:.:|:|.||.
Human  1998 TCELL--NKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFR 2060

  Fly  1968 NTRNLARKVYTLYELAKQQLSKQYHYDFGLRSMVALLRYAGRKRRQ------------------- 2013
            ....||.|:...::|..:|||.|.|||||||::.::|..||..:|:                   
Human  2061 TAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERGEAVDEG 2125

  Fly  2014 --LPNTTEEEIVYLAMKDMNVARLTANDLPLFNGIMSDIFPGVSLPTIDYSEFNIAIYEEFREA- 2075
              ..|..|:||:..::.:..|.:|.|.|:||...::||:||||.....:.:    |:.||.::. 
Human  2126 EIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMT----ALREELKKVC 2186

  Fly  2076 ---------GLQPITIAVKKVIELFETKNSRHSVMIIGDTGTAKSVTWRTLQNCFYRMNSQRFSG 2131
                     |.:...:.|:||::|::.....|.:|::|.:|:.||:.||.|....     :|..|
Human  2187 QEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKAL-----ERLEG 2246

  Fly  2132 WEAVTVYPVNPKALNLAELYGEYNLSTGEWLDGVLSSIMRIICGD---EEPTQKWLLFDGPVDAV 2193
            .|.| .:.::|||::...|||..:.:|.||.||:.:.::|.|...   |...::|::|||.||..
Human  2247 VEGV-AHIIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQWIVFDGDVDPE 2310

  Fly  2194 WIENMNSVMDDNKLLTLVNSERITMPVQVSLLFEVGDLAVASPATVSRCGMVYNDYNDWGWKPFV 2258
            |:||:|||:||||||||.|.||:::|..|.::|||.||..|:.|||||||||:...:........
Human  2311 WVENLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIF 2375

  Fly  2259 NSWLQRLR---IKEFAD-------------------FLRIHFD---------------------- 2279
            |::|.|||   :.|..|                   .|:|..|                      
Human  2376 NNFLARLRSIPLDEGEDEAQRRRKGKEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHA 2440

  Fly  2280 YMVPKILDFKRMRCKEPVRTNELNGVVSLCKLLEIFGTKVNGIN------PINLELLEEMTRLWF 2338
            :.:..|:|..|:||           :.||..:|......|...|      |:.:|.||...:.:.
Human  2441 FQLEHIMDLTRLRC-----------LGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQRYL 2494

  Fly  2339 MFCLVWSICSSVDEDSRQRLDSFIRELESCFPIKDT----VFDYFVDPNERTFLPWDSKLLSSWK 2399
            ::.::||:........|..|..:||.: :..|:...    :.||.|..:.. :.||.:|:     
Human  2495 VYAILWSLSGDSRLKMRAELGEYIRRI-TTVPLPTAPNIPIIDYEVSISGE-WSPWQAKV----- 2552

  Fly  2400 CDFESPFYK-----IIVPTGDTVRYEYVVSKLLAEEYPVMLVGNVGTGKTSTAISVMEACDKNKF 2459
            ...|...:|     ::|||.||||:|.::...|||..|::|.|..|:|||.|..|.:.|....: 
Human  2553 PQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDME- 2616

  Fly  2460 CILAVNMSAQTTAAGLQESIENRTE-KRTKTQFV--PIG-GKRMICFMDDFNMPAKDIYGSQPPL 2520
             ::.:|.|:.||...|.::.::..| :||....|  |:. ||.::.|.|:.|:|..|.||:|..:
Human  2617 -VVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVI 2680

  Fly  2521 ELIRQWIDYKYWFNRKTQQKIYVQNTLLMAAMGPP-GGGRQTISSRTQSRFVLLNLTFPSQETII 2584
            ..|||.:::..::....|..:.::....:.|..|| ..||:.:|.|......::.:.:|...::.
Human  2681 SFIRQMVEHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLT 2745

  Fly  2585 RIFGTMLCQKLESYPNEVREMWLPITLCTINLYVSMISKMLPTPNKSHYLFNLRDISKVFQGLLR 2649
            :|:||.....|...|: :|....|:|...:..| :|..:......:.||:::.|::::..:|:..
Human  2746 QIYGTFNRAMLRLIPS-LRTYAEPLTAAMVEFY-TMSQERFTQDTQPHYIYSPREMTRWVRGIFE 2808

  Fly  2650 SEKELQN-KKNFFLRLWVHECFRVFSDRLVDDSDQFWFVNTINDILGKHFEVTFHSLCPSKVPPF 2713
            :.:.|:. .....:|:|.||..|:|.||||:|.::.|....|:.:..|||.........|: |..
Human  2809 ALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSR-PIL 2872

  Fly  2714 FGDFAHPQGFYEDLQVDFLRTFMKNQL----EEYNNFPGMTRMNLVFFREAIEHIVRILRVISQP 2774
            :.::....  |..:..:.||.::|.:|    ||..:.|      ||.|.|.::|::||.|:..||
Human  2873 YSNWLSKD--YIPVDQEELRDYVKARLKVFYEEELDVP------LVLFNEVLDHVLRIDRIFRQP 2929

  Fly  2775 RGHILNMGIGGSGRQVLTKLAAFILEMAVFQIEVTKKYKTGDFREDLKNLYKVTGIKQRLTIFIF 2839
            :||:|.:|:.|:|:..|::..|::..::|:||:|.:||...||.|||:.:.:.:|.|.....||.
Human  2930 QGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIM 2994

  Fly  2840 SSDQIAEVSFLEITNNMLSTGEI-NLFKSDEFDELKPELERPAKKNGVLLTT-EALYSYFILNVR 2902
            ....:.:..|||..|.:|:.||: .||:.||:..|..:.:..|:|.|::|.: |.||.:|...|.
Human  2995 DESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVI 3059

  Fly  2903 DFLHVALCFSPIGENFRSYIRQYPALLSSTTPNWFRFWPQEALLEVASHFLIGFPL---NVVVSG 2964
            ..|||....:|..|..:......|||.:....|||..|..|||.:|...|.....|   |.:|..
Human  3060 RNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNYIVPD 3124

  Fly  2965 ---------KEDEKHRESLVISTEAILQRDIAYVFSVIHSSVAKMSENMYAEVKRYNYVTSPNYL 3020
                     .:...|||::|.|        ..:|...:|.:.|::::    ...|...:|..:||
Human  3125 YMPVVYDKLPQPPSHREAIVNS--------CVFVHQTLHQANARLAK----RGGRTMAITPRHYL 3177

  Fly  3021 QLVSGFKKLLEKKRLEVSTASNRLRNGLSKISETQEKVSLMSEELKASSEQVKILARECEDFISM 3085
            ..::.:..|..:||.|:......|..||.||.||.::|..:..:|:..|:::::......|.:..
Human  3178 DFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKK 3242

  Fly  3086 IEIQKSEATEQKEKVDAEAV---LIRRDEIICLELAATARADLEVVMPMIDAAVKALDALNKKDI 3147
            :...:.||  :|:||.::.:   |.::.|:|. :...:.:.||:.|.|.:..|..|:.::.|:.:
Human  3243 MVKDQQEA--EKKKVMSQEIQEQLHKQQEVIA-DKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHL 3304

  Fly  3148 SEVKSYGRPPMKIEKVMEAVLILLGKEPT-WENAKKVLSESTFLNDLKNFDRDHISDKTLKRI-A 3210
            .||:|...||..::..:|::.:|||:..| |:..:.::....|:..:.||..:.|||...::: .
Human  3305 VEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEISDAIREKMKK 3369

  Fly  3211 IYTKNPELEPDKVAVVSLACKSLMQWIMAIENYGKVYRIVAPKQEKLDSAMKSLEEKQAALAAAK 3275
            .|..||....:.|...||||..:::|.:|..||..:.:.|.|.:.:|.......::.|       
Human  3370 NYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLEDDAKDNQ------- 3427

  Fly  3276 KKLEELQVVIEEL----YRQLEEKTNLLNE---LRAKEERLRKQLERAIILVESLSGERERWIET 3333
            :|..|::.:|.:|    .|..||...|::|   ::|....:..::.|:..|::|||.|||||.:|
Human  3428 QKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKT 3492

  Fly  3334 VNQLDLSFEKLPGDCLLSVAFMSYLGAFDTKYREELLVKWSLLIKDLLIPATLELKVTYFLVDAV 3398
            ..........:.||||||.||::|.|.||.:.|:.|...||..::...|....::..|.:|.:|.
Human  3493 SETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIARTEYLSNAD 3557

  Fly  3399 SIREWNIQGLPADDLSTENGVIVTQGSRWPLIIDPQMQANNWIKNMEERNQLMTLDFGMADYLRQ 3463
            ....|....||||||.|||.:::.:.:|:||||||..||..:|.|..:..::....|....:.:.
Human  3558 ERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKN 3622

  Fly  3464 LERALKEGLPVLLQNVGEYLDQAINPILRQSFTIQSGERLLKFNDKYISYNNSFRFYITTKISNP 3528
            ||.||:.|.|:|:|:|..| |..:||:|.:......|..|:...|:.|..:.||..:::|:....
Human  3623 LESALRFGNPLLVQDVESY-DPVLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTV 3686

  Fly  3529 HYPPEISSKTTIVNFALKQDGLEAQLLGIIVRKEKPALEEQKDELVMTIARNKRTLIDLDNEILR 3593
            .:||::.|:.|.|||.:.:..|::|.|..:::.|:|.::|::.:|:......:..|..|:..:|:
Human  3687 EFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQ 3751

  Fly  3594 LLNESRGSLLDDDELFSTLQKSRQTSVLVKESLSIAEVTEVEIDAARQEYKPASERASILFFVLM 3658
            .|||.:|.:||||.:.:||:..::.:..|...:...::...|::...|:|.|.|...|.::|.:.
Human  3752 ALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTME 3816

  Fly  3659 DMSKIDPMYVFSLAAYILLFTQSIERSPRNQLV--H-ERIQNINEYHSYAVYRNTCRGLFERHKL 3720
            .:.:|..:|.:||..::.::...:..:|..:.|  | :|:..|.:......:....||:..:..:
Human  3817 SLKQIHFLYQYSLQFFLDIYHNVLYENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHI 3881

  Fly  3721 LFSIHMT-AKILSNAGK-LLEEEYDFILKGGIVLDKLGQAPNPAPWWISEQNWDNITELDKVSGF 3783
            .|::.:. .|:....|: ..:.|:...|:|..::...|..|...  .::.:..:.:..|..:..|
Human  3882 TFAMLLARIKLKGTVGEPTYDAEFQHFLRGNEIVLSAGSTPRIQ--GLTVEQAEAVVRLSCLPAF 3944

  Fly  3784 HGIIDSFEQHYKAWNGWYATTFPEQEDLVGEWNDKL------TDFQKICVLRSLRPDRISFCLTQ 3842
            ..:|... |..:.:..|..::.||| .:...|:::.      ....::.::::.||||:......
Human  3945 KDLIAKV-QADEQFGIWLDSSSPEQ-TVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHM 4007

  Fly  3843 FIITKLGPRY---VDPPVLDLKATFDESIS-QTPLIFVLSPGVDPAQSLISLSESVKMAQRMYSL 3903
            |:.|.||..:   ::.| |||.......:. .||::....||.|.:..:..|  :.:...::.|:
Human  4008 FVSTNLGESFMSIMEQP-LDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDL--AAEQNTQITSI 4069

  Fly  3904 SLGQGQA-PIATKLIMDGIKDGNWVFLANCHLSLSWMPTLDKMIATMQSMKLHKKFRLWLSSSPH 3967
            ::|..:. ..|.|.|...:|.|.||.|.|.||:..|:..|:|.:.::|.   |..|||:|:...:
Human  4070 AIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQP---HACFRLFLTMEIN 4131

  Fly  3968 PDFPISILQTSIKMTTEPPRGIKSNMKRLYNNINEANMENCSEPSKYKKLLFALCFFHTVLLERK 4032
            |..|:::|:.......|||.|:|:||.|.:::|..:.:  |..|::..:|.|.|.:||.::.||.
Human  4132 PKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVSRI--CKSPNERARLYFLLAWFHAIIQERL 4194

  Fly  4033 KFLELGWNVIYSFNDSDFEVSEILLLLYLNEY---------EDTPWGALKYLIAGVNYGGHITDD 4088
            ::..|||:..|.|.:||...:...:..:|::.         :..||.|||.|:|...|||.:.::
Human  4195 RYAPLGWSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNE 4259

  Fly  4089 WDRRLLITYINQFFCDQALQTRKFRLSTL----PNYFIPDDGDVQSYLDQIQMFPNFDKPDAFGQ 4149
            :|:|||.|::.:.|..::..: :|:|:..    .:..:||....:.::..:::.|:...|...|.
Human  4260 FDQRLLNTFLERLFTTRSFDS-EFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSWLGL 4323

  Fly  4150 HSNADIASLIGETRMLFEALLSMQV----------------QTNSTSSNENGETK-VFDLAKEIL 4197
            .:||:...|..:...:...:|.||:                :|:|||.......: :...|...|
Human  4324 PNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTLHTTASNWL 4388

  Fly  4198 MNTPDEINY-EQTAKIIGINRTPLEVVLLQEIERYNKLLVDMSTQLRDLRRGIQGLVVMSSDLED 4261
            ...|..::: ::|.:.|   :.||.....:|::...|||.|:...|.|:.:..:|....::.|..
Human  4389 HLIPQTLSHLKRTVENI---KDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRT 4450

  Fly  4262 IYLAVSEGRVPLQWLKAYN--SLKPLAAWARDLIHRVGHF--------NSWAKTLRPPILFWLAA 4316
            :...:.:|.:|..| ..|.  :...:..|..|...|:...        :..||.|: .|...|..
Human  4451 LINELVKGILPRSW-SHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGGAKELK-NIHVCLGG 4513

  Fly  4317 YTFPTGFVTAVLQTSARATKTPIDELSWDFYVFVEEDTAAARIIREGGGVYIRSLFLEGGGWLRK 4381
            ...|..::||..|..|:|....::||..:..|     |.:.....:.....:..|.|:|......
Human  4514 LFVPEAYITATRQYVAQANSWSLEELCLEVNV-----TTSQGATLDACSFGVTGLKLQGATCNNN 4573

  Fly  4382 NQCLQDPLPMELICPLPVIHFKPVENLKKRCRGVYQCPAYYYPVRSGSFVIAVDLK-SGNEKADY 4445
            ...|.:.:...|  ||..:.:....|.:|:. .|...|.|....|: ..:..||.: :..|....
Human  4574 KLSLSNAISTAL--PLTQLRWVKQTNTEKKA-SVVTLPVYLNFTRA-DLIFTVDFEIATKEDPRS 4634

  Fly  4446 WIKRGTALL 4454
            :.:||.|:|
Human  4635 FYERGVAVL 4643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kl-2NP_001015505.5 DHC_N1 178..749 CDD:285571 87/596 (15%)
DHC_N2 1244..1646 CDD:285579 121/411 (29%)
P-loop_NTPase 1785..2015 CDD:304359 119/262 (45%)
P-loop_NTPase 2099..2242 CDD:304359 61/145 (42%)
P-loop_NTPase 2401..2668 CDD:304359 72/277 (26%)
P-loop_NTPase 2752..3030 CDD:304359 86/291 (30%)
MT 3043..3373 CDD:289543 94/341 (28%)
AAA_9 3402..3618 CDD:289547 70/215 (33%)
Dynein_heavy 3760..4447 CDD:281078 165/739 (22%)
DYNC1H1NP_001367.2 Stem. /evidence=ECO:0000250 53..1867 384/1948 (20%)
DHC_N1 242..832 CDD:400611 127/785 (16%)
Interaction with DYNC1I2. /evidence=ECO:0000250 448..703 54/396 (14%)
Interaction with DYNC1LI2. /evidence=ECO:0000250 651..802 31/187 (17%)
DYN1 1046..4329 CDD:227570 945/3431 (28%)
AAA 1. /evidence=ECO:0000250 1868..2099 116/232 (50%)
AAA 2. /evidence=ECO:0000250 2180..2452 86/277 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2390..2411 1/20 (5%)
AAA 3. /evidence=ECO:0000250 2556..2805 68/252 (27%)
AAA 4. /evidence=ECO:0000250 2899..3168 85/286 (30%)
Stalk. /evidence=ECO:0000250 3189..3500 83/320 (26%)
AAA 5. /evidence=ECO:0000250 3553..3782 73/229 (32%)
AAA 6. /evidence=ECO:0000250 4005..4221 64/223 (29%)
Dynein_C 4333..4644 CDD:408026 65/325 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100025
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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