DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-2 and DNAH6

DIOPT Version :9

Sequence 1:	NP_001015505.5	Gene:	kl-2 / 3355181	FlyBaseID:	FBgn0001313	Length:	4459	Species:	Drosophila melanogaster
Sequence 2:	NP_001361.1	Gene:	DNAH6 / 1768	HGNCID:	2951	Length:	4158	Species:	Homo sapiens

Alignment Length:	4349	Identity:	1398/4349 - (32%)
Similarity:	2234/4349 - (51%)	Gaps:	596/4349 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 MMVFGRLDESESIPKPQFGGTSGTEFEATADNVENEFLVTLTALCTDSKEIILNVHKNEWYEEVI 481
            :|..|.:....||.|..| .||.|:|....|.|:.                 :.:|:.  |.||.
Human    98 LMTAGIIKRPVSIAKKSF-ATSSTQFLEHQDAVKK-----------------MQIHRP--YVEVF 142

  Fly   482 --------------------------KYRRTVQSMEETVQRLMSNVFQHICNVEEALESLNVMIF 520
                                      ||  |....||.|:          .|:.:.|:.:.:
Human   143 SPSPPKLPHTGIGKRGLFGTRSSAYPKY--TFHDREEVVK----------ANIRDPLQIIKI--- 192

  Fly   521 YSYRSTIRKTFLRQVSSAWVFFSNEIDSSVHMLMDRSKMHESWVPY--YASRALGYRVHLDRLVW 583
                  ||:              ||....::|:   ..:..|.:.|  |..:.:.|
Human   193 ------IRE--------------NEHLGFLYMI---PAVPRSSIEYDTYNLKVVSY--------- 225

  Fly   584 LCNRLNSSDWLPNVSEASVV-----------LKKFES---VRREFDK-------EVKKSFDEWQK 627
              ..:|.:|:. .:|:.:|.           :.::|.   ..||..|       ...|:|..|:|
Human   226 --ENINKNDYY-TISQRAVTHIYNEDIEFIEIDRWEQEYLYHRELTKIPIFSLFRKWKAFSVWRK 287

  Fly   628 NCCSLLLNQKLDRYLLIRSKKKKGLIECNIDRTILTICEQAQHFERLGLGVPGMVRKIYEKHETL 692
            |               :||||             :|.|:                 |..:|:
Human   288 N---------------VRSKK-------------ITGCQ-----------------KSLQKN--- 304

  Fly   693 RFVYNSVVQVCLNYNHILSALSEQERKLFRALIQACDRKIAPGVFKLTYGGELSDAYIADCAKHT 757
            .|:.|.         |:..||                .||....:.|::.|.   .||..|  ||
Human   305 LFIVNP---------HLRPAL----------------LKINELCYHLSFMGL---CYIEKC--HT 339

  Fly   758 NKLQETMDIYKRA-IQNIARFCEKICDTPMLKFNFSGAVTISIFENHLSSYLRRVSNI-LRGFYS 820
            ..|||    :|.| :..:|...|::.:                |.|.....:||.... ||....
Human   340 YTLQE----FKAAQVIRLAEVTERLGE----------------FRNEAKYVVRRACRFALRAAGF 384

  Fly   821 TITDLIFAVFKEFQAV---------IEDMPIEWYG----------------------FVNVFDDM 854
            ...|..|..|:::..|         ..::|.  ||                      |:.:.|.:
Human   385 VPDDCAFGPFEDYHKVQSSGSFINTPHELPT--YGDSEKMTYTEQASKRHYCMRLTCFIRLNDYL 447

  Fly   855 LATA--FLT-SSKNS-LNMLTNALHRDP------------------------------DMAAAPI 885
            :...  .|| ::.|| ||.||:.|.|.|                              |.:..|:
Human   448 IENTMHILTVNAVNSLLNHLTDKLKRTPSADVIQKWITEEKPEVPDKKGTLMVEKQEEDESLIPM 512

  Fly   886 LVMESDVRERCIVLTPDIDVIANLLSGYIDRIHNILEQFPRIGIKMKLPKEHQYESFSKAFL--- 947
            .:.|..:..:.::..|.::...:.:.|.::...|.:...|.:     :|..: :::|:..::
Human   513 FLTELMLTVQSLLFEPSLEDFLDGILGAVNHCQNTVLSVPNL-----VPDSY-FDAFTSPYINNK 571

  Fly   948 -----------------EDSESTQLICNIEAEINHEREEIDGYITFWNSHRMLWETTELEFTKRV 995
                             :|.....:|..|:..|....|....|...:...::.::..|....:.:
Human   572 LEGKTCGTGPSLAAVFEDDKNFHTIISQIKETIQAAFESARIYAATFEKFQIFFKENESLDLQAL 636

  Fly   996 KATQMTADIFEASIEYYSAMADDISYVDAITHVYFILMNQNYIKSSI----LDCIEKWQALNIKI 1056
            |..:...:.|...:|.|.....|...:....:|..:|::...::..:    |.|:|   .||. :
Human   637 KLQEPDINFFSEQLEKYHKQHKDAVALRPTRNVGLLLIDTRLLREKLIPSPLRCLE---VLNF-M 697

  Fly  1057 LLSHSFSLIRAIYRYMRKNERKMMMVPRTLKESLLAKQFFERIINEV-PLKQAGFPPTLELFAIL 1120
            |...|...:.||....:..|.|:..||.|..|.:.:..|.:.|...: .|:..|...| :::.::
Human   698 LPRQSKKKVDAIIFEAQDAEYKLEFVPTTTTEYVHSLLFLDEIQERIESLEDEGNIVT-QMYKLM 761

  Fly  1121 DKYQVEIPEE-------IRVKVIGL-----------EAAWHHYLKRLGEADEMLDNNREEFK--- 1164
            ::|||..|.|       ::..::.:           |::...:...||...|.|:|...|.|
Human   762 EQYQVPTPPEDFAVFATMKPSIVAVRNAIDKSVGDRESSIKQFCVHLGSDLEELNNEVNEVKLQA 826

  Fly  1165 ---KILVQQAEKFKIILKEFLDDFFLKLPTSANINPRIALKFLRIIALKIEDCFTFEESLMRDLA 1226
               :||...|::.||                     |:.|..|:.:...::......:|..::..
Human   827 QDPQILDISADQDKI---------------------RLILNNLQSVLADLQKRAFQYKSYQKNFK 870

  Fly  1227 VFNVNQPESIDLRKLDFEVRIVKNIWELIFEWQTNWEGWKKGYFWKMNINEMEDTALNLYKEFTT 1291
            | .|::.|:  |.::..|:::.:.:|:...||....:.|.|..|..:: .|:.:..::.|.:|.|
Human   871 V-EVSKFEA--LEEVSAELKLKQLLWDSFSEWDKLQQEWLKSKFDCLD-PEVLNGQVSKYAKFVT 931

  Fly  1292 LNKKFYDRHWEMLEATTKNVDSFRRTLPLITALKNPCMRERHWNRVRDVIHVNFDENSKNFTLEL 1356
            ..:|....: .::......|:..:..||:|..|:||.::.|||..:...:.....:.....|||.
Human   932 QLEKGLPPN-SVVPQLKYKVEKMKEKLPVIIDLRNPTLKARHWAAIEQTVDATLVDAEIPLTLER 995

  Fly  1357 IINLDFQAFSEDIQDISNPATMELQIENSIKNIATIWKKQSFEMAFYHDG--IYRIKNVEDCFQL 1419
            :..|....|.::|||||..|:.|..:|..:|.:...||...|.:..:.|.  ::.:...:|...|
Human   996 LSQLHVFDFGQEIQDISGQASGEAALEAILKKVEDSWKTTEFVILPHRDSKDVFILGGTDDIQVL 1060

  Fly  1420 LEEHMVQISAMKATRFVEPFITIVDYWEKTLSYISETLEKGLTVQRQWLYLENIFQGDDIRKQLP 1484
            |::..:.::.:.::|::.|..|.||.|:|.|:..::|||:.||.||.|||||:||...||::|||
Human  1061 LDDSTINVATLASSRYLGPLKTRVDEWQKQLALFNQTLEEWLTCQRNWLYLESIFNAPDIQRQLP 1125

  Fly  1485 EEAKRFATITEEFRTISSKMFQAKTAVKATNLRPPPFLLNRFSRMDERLELIQRALEIYLEAKRQ 1549
            .|||.|..:.:.::.|..|:.:...|::|..   .|.||..|...:..|:.||:.||.|||:||.
Human  1126 AEAKMFLQVDKSWKEIMRKVNRLPNALRAAT---QPGLLETFQNNNALLDQIQKCLEAYLESKRV 1187

  Fly  1550 LFPRFYFISNDDLLEILGNSKRPDLVQTHLKKLFDNLYKLELKRV----GK---------TLSRW 1601
            :||||||:|||:|||||..::.|..||.||:|.||::.|||...:    ||         .:...
Human  1188 IFPRFYFLSNDELLEILAQTRNPQAVQPHLRKCFDSISKLEFALMPPAEGKIPGIDGEPEKVYTN 1252

  Fly  1602 QASGMHSDDGEYVEFMMVIYIDGPSERWLKQVEEYMLVVMKEMLKLT----RGSLKKLVGNREKW 1662
            ....|.|.:||.|.....:...|..|.||.:|||.|...::.:.|..    :|.|      |..|
Human  1253 DILAMLSPEGERVSLGKGLKARGNVEEWLGKVEEAMFTSLRRLCKAAIADYQGKL------RTDW 1311

  Fly  1663 -ISLWPGQMVLTTAQIQWTTECTRSLIHCSMVDQKKPLRKLK---KKQIKVLSKLSEMSRKDLTK 1723
             ::..|.|::||.:||.|   | |.|..|...:....::.||   |...:.|:.|:.:.:..|.|
Human  1312 VVAGHPSQVILTVSQIMW---C-RDLTECLETEHSNHIQALKNFEKVNFERLNALAAIVQGSLPK 1372

  Fly  1724 TMRLKVNTLITLEIHGRDVIERMYKSNCKDTGHFEWFSQLRFYWHRESELCVIRQTNTEHWYGYE 1788
            ..|..:..|||:::|.||::..:.:|..:....|:|..|||:||..:.:.||.|...:::.||||
Human  1373 LHRNILTALITIDVHARDIVTELVQSKVETVESFDWQRQLRYYWDIDLDNCVARMALSQYTYGYE 1437

  Fly  1789 YTGNSGRLVITPLTDRCYITLTTALHLHRGGSPKGPAGTGKTETVKDLGKALGIWVIVTNCSEGL 1853
            |.|...||||||||||||:.|..||.|..||:|.||||||||||.|||.|||.|..:|.|||:||
Human  1438 YLGACPRLVITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSDGL 1502

  Fly  1854 DYKSIGKNFSGLAQSGCWGCFDEFNRINIEVLSVVAQQIMSIMAALSTKALELMFEGQMIKLKHT 1918
            |||.:|:.||||||||.|.||||||||:||||||:|||:::|..|.:.|....||||:.|||..|
Human  1503 DYKMMGRFFSGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKAAKLSRFMFEGREIKLVMT 1567

  Fly  1919 VGLFITMNPGYAGRTELPDNLKSMFRPISMMVPDNIIIAENLLFSDGFTNTRNLARKVYTLYELA 1983
            ...|||||||||||||||||||::|||.:||||:..:|||.:|:|:||.:::.||||:..:|:|.
Human  1568 CAAFITMNPGYAGRTELPDNLKALFRPFAMMVPNYALIAEVILYSEGFESSKILARKMTQMYKLC 1632

  Fly  1984 KQQLSKQYHYDFGLRSMVALLRYAGRKRRQLPNTTEEEIVYLAMKDMNVARLTANDLPLFNGIMS 2048
            .:|||:|.|||||:|::.::|..||..:|:.|:..|:.::..|::|.|:.:...:|..||:||:|
Human  1633 SEQLSQQDHYDFGMRAVKSVLVMAGSLKRENPDLNEDVVLIRALQDSNLPKFLTDDALLFSGIIS 1697

  Fly  2049 DIFPGVSLPTIDYSEFNIAIYEEFREAGLQPITIAVKKVIELFETKNSRHSVMIIGDTGTAKSVT 2113
            |:||||.:|..||......|.:......|||....|:|||:.:||...||.||::|.||..|:..
Human  1698 DLFPGVQIPEHDYGILQSTIVDVMNRQNLQPEMCMVRKVIQFYETMLVRHGVMLVGPTGGGKTTV 1762

  Fly  2114 WRTL------------QNCFYRMNSQRFSGWEAVTVYPVNPKALNLAELYGEYNLSTGEWLDGVL 2166
            :|.|            :|.||          :||..|.:|||::.:.|||||.|..|.||.||::
Human  1763 YRILAETLGNLQKLGIENSFY----------QAVKTYVLNPKSITMGELYGEVNNLTLEWKDGLM 1817

  Fly  2167 SSIMRIICGDEEPTQKWLLFDGPVDAVWIENMNSVMDDNKLLTLVNSERITMPVQVSLLFEVGDL 2231
            :..:|....|.....||::.||||||:||||||:|:||||:|.|.|||||.:..|:.:||||.||
Human  1818 ALSVRAAVNDTSEDHKWIISDGPVDALWIENMNTVLDDNKMLCLANSERIKLTPQIHMLFEVQDL 1882

  Fly  2232 AVASPATVSRCGMVYNDYNDWGWKPFVNSWLQRLRIK---EFADFLRIHFDYMVPKILDFKRMRC 2293
            .|||||||||||||:.|..:..|.|:|.:|::.:..|   |..:::...|...|.:.|.|...:|
Human  1883 RVASPATVSRCGMVFVDPEELKWMPYVKTWMKGISKKLTEETQEYILNLFQRYVDEGLHFINKKC 1947

  Fly  2294 KEPVRTNELNGVVSLCKLLEIFGTKVNGINPINLELLEEMTRL------WFMFCLVWSICSSVDE 2352
            .:.:...:::.|.:||.|||......:|:|     |..|.|:|      .|:||.:||:..::.|
Human  1948 SQAIPQVDISKVTTLCCLLESLILGKDGVN-----LAMEQTKLNTILCQTFVFCYLWSLGGNLTE 2007

  Fly  2353 DSRQRLDSFIR-----ELESCFPIKDTVFDYFVDPNERTFLPWDSKLLSSWKCDFESPFYKIIVP 2412
            :.....|:|||     ..::..|....::...:|.:.:...||: :::.::|.:.:.||::::||
Human  2008 NYYDSFDTFIRTQFDDNPDARLPNSGDLWSIHMDFDTKRLDPWE-RIIPTFKYNRDVPFFEMLVP 2071

  Fly  2413 TGDTVRYEYVVSKLLAEEYPVMLVGNVGTGKTSTAISVMEACDKNK-FCILAVNMSAQTTAAGLQ 2476
            |.|||||.|::.||||.::.|:..|..|.||:..|..::....::. :..:.:|.||||::|..|
Human  2072 TTDTVRYGYLMEKLLAVKHSVLFTGITGVGKSVIAKGLLNKIQESAGYVPVYLNFSAQTSSARTQ 2136

  Fly  2477 ESIENRTEKRTKTQFVPIGGKRMICFMDDFNMPAKDIYGSQPPLELIRQWIDYKYWFNRKTQQKI 2541
            |.||::.|::.|......|.||::.|:||.|||..|.||||||:||:||:.|:..:::|   .|:
Human  2137 EIIESKLERKRKNILGAPGNKRIVIFVDDLNMPRLDRYGSQPPIELLRQYQDFGGFYDR---NKL 2198

  Fly  2542 Y---VQNTLLMAAMGPPGGGRQTISSRTQSRFVLLNLTFPSQETIIRIFGTMLCQKLESYPNEVR 2603
            :   :|:..:::|..||||||..::.|....|.:|.|..||:.::.:||..:|...|..:|..|:
Human  2199 FWKEIQDVTIISACAPPGGGRNPVTPRFIRHFSMLCLPMPSEHSLKQIFQAILNGFLSDFPPAVK 2263

  Fly  2604 EMWLPITLCTINLYVSMISKMLPTPNKSHYLFNLRDISKVFQGLLRSEKELQNKKNFFLRLWVHE 2668
            :....|...::.:|..|...:||||.||||:|||||:||..||:|:.:.....::....||:.||
Human  2264 QTASSIVEASVEIYNKMSVDLLPTPAKSHYVFNLRDLSKCVQGILQCDPGTIREEIQIFRLFCHE 2328

  Fly  2669 CFRVFSDRLVDDSDQFWFVNTINDILGKHFEVTFHSLCPSKVPPFFGDFA-----HPQGFYEDL- 2727
            |.|||.|||:::.|:.:|...:.::..|||.:..........|..||||.     .....|:|:
Human  2329 CQRVFHDRLINNEDKHYFHVILTEMANKHFGIAIDLEYFLNKPIIFGDFIKFGADKADRIYDDMP 2393

  Fly  2728 QVDFLRTFMKNQLEEYNNFPGMTRMNLVFFREAIEHIVRILRVISQPRGHILNMGIGGSGRQVLT 2792
            .::.....:::.|::| |......:.||||::||||:.||.|:|.|.||:.|.:|:||:|:|.||
Human  2394 DIEKTANVLQDYLDDY-NLTNPKEVKLVFFQDAIEHVSRIARMIRQERGNALLVGVGGTGKQSLT 2457

  Fly  2793 KLAAFILEMAVFQIEVTKKYKTGDFREDLKNLYKVTGIKQRLTIFIFSSDQIAEVSFLEITNNML 2857
            :|||.|......|||:::.|....|.|||:.|||:.|::.:..:|:|:..||....|||..||:|
Human  2458 RLAAHICGYKCLQIELSRGYNYDSFHEDLRKLYKMAGVEDKNMVFLFTDTQIVVEEFLEDINNIL 2522

  Fly  2858 STGEI-NLFKSDEFDELKPELERPAKKNGVLL-TTEALYSYFILNVRDFLHVALCFSPIGENFRS 2920
            ::||: |||:.||.:::.......||:.|:.. ..:.::.|||..||..||:.||.||:||.|||
Human  2523 NSGEVPNLFEKDELEQVLAATRPRAKEVGISEGNRDEVFQYFISKVRQKLHIVLCMSPVGEAFRS 2587

  Fly  2921 YIRQYPALLSSTTPNWFRFWPQEALLEVASHFLIGFPLNVVVSGKEDEKHRESLVISTEAILQRD 2985
            ..|.:|:|::..|.:||..||:||||.|:..|     .:.|.:|.|:.|.:..|:...
Human  2588 RCRMFPSLVNCCTIDWFVQWPREALLSVSKTF-----FSQVDAGNEELKEKLPLMCVN------- 2640

  Fly  2986 IAYVFSVIHSSVAKMSENMYAEVKRYNYVTSPNYLQLVSGFKKLLEKKRLEVSTASNRLRNGLSK 3050
                   :|.||:.|:|..|.|::|..|.|..:||:|::.:..:|.:||.::.:|.:|::|||:|
Human  2641 -------VHLSVSSMAERYYNELRRRYYTTPTSYLELINLYLSMLSEKRKQIISARDRVKNGLTK 2698

  Fly  3051 ISETQEKVSLMSEELKASSEQVKILARECEDFISMIE---------------IQKSEATEQKEKV 3100
            :.||...|..|..:|.|..   .:|..:.||..:::|               :|:.|||.:.:..
Human  2699 LLETNILVDKMKLDLSALE---PVLLAKSEDVEALMEKLAVDQESADQVRNTVQEDEATAKVKAE 2760

  Fly  3101 DAEAVLIRRDEIICLELAATARADLEVVMPMIDAAVKALDALNKKDISEVKSYGRPPMKIEKVME 3165
            :.:|:            |..|:.||:..:|.:|||.||||:|:|.||||::.:.:||..:..|||
Human  2761 ETQAI------------ADDAQRDLDEALPALDAANKALDSLDKADISEIRVFTKPPDLVMTVME 2813

  Fly  3166 AVLILLGKEPTWENAKKVLSESTFLNDLKNFDRDHISDKTLKRIAIYTKNPELEPDKVAVVSLAC 3230
            |:.|||..:|.|.:||::|.:|.||..|..:|:::|..:.|.::..|..||:..|:||..||.||
Human  2814 AISILLNAKPDWPSAKQLLGDSNFLKRLLEYDKENIKPQILAKLQKYINNPDFVPEKVEKVSKAC 2878

  Fly  3231 KSLMQWIMAIENYGKVYRIVAPKQEK-------LDSAMKSLEEKQAALAAAKKKLEELQVVIEEL 3288
            ||:..|:.|::.|.:|.::|.||::|       ||..|.:|.||||.|...:.:::.||   :|.
Human  2879 KSMCMWVRAMDLYSRVVKVVEPKRQKLRAAQAELDITMATLREKQALLRQVEDQIQALQ---DEY 2940

  Fly  3289 YRQLEEKTNLLNELRAKEERLRK-QLERAIILVESLSGERERWIETVNQLDLSFEKLPGDCLLSV 3352
            .:.:.||.:|     ||...|.| :|.||..|..:|..|:.||.|::.:.:.....:.|:..::.
Human  2941 DKGVNEKESL-----AKTMALTKARLVRAGKLTAALEDEQVRWEESIQKFEEEISNITGNVFIAA 3000

  Fly  3353 AFMSYLGAFDTKYREELLVKWSLLIKDLLIPATLELKVTYFLVDAVSIREWNIQGLPADDLSTEN 3417
            |.::|.|||..:||:.|:..|....:.|.||......:...|.|...||:||..|||.|.:||||
Human  3001 ACVAYYGAFTAQYRQSLIECWIQDCQSLEIPIDPSFSLINILGDPYEIRQWNTDGLPRDLISTEN 3065

  Fly  3418 GVIVTQGSRWPLIIDPQMQANNWIKNMEERNQLMTLDFGMADYLRQLERALKEGLPVLLQNVGEY 3482
            |::||||.||||:||||.|||.||:|.|.::.|..:....:::||.||.:::.||||||:.:.|.
Human  3066 GILVTQGRRWPLMIDPQDQANRWIRNKESKSGLKIIKLTDSNFLRILENSIRLGLPVLLEELKET 3130

  Fly  3483 LDQAINPILRQSFTIQSGERLLKFNDKYISYNNSFRFYITTKISNPHYPPEISSKTTIVNFALKQ 3547
            ||.|:.|||.:...|..|..|::..|..|.|:.:||||:|||:.||||.||:..|.||:||.:.:
Human  3131 LDPALEPILLKQIFISGGRLLIRLGDSDIDYDKNFRFYMTTKMPNPHYLPEVCIKVTIINFTVTK 3195

  Fly  3548 DGLEAQLLGIIVRKEKPALEEQKDELVMTIARNKRTLIDLDNEILRLLNESRGSLLDDDELFSTL 3612
            .|||.|||..:||.|||.||||:.:|::.|..:|..|..::.:|||:|..|.|::||::||..||
Human  3196 SGLEDQLLSDVVRLEKPRLEEQRIKLIVRINTDKNQLKTIEEKILRMLFTSEGNILDNEELIDTL 3260

  Fly  3613 QKSRQTSVLVKESLSIAEVTEVEIDAARQEYKPASERASILFFVLMDMSKIDPMYVFSLAAYILL 3677
            |.|:.||..:|..|..||.||..|:.||::|:|.:.:.|:::||:..:|:|||||.:||..:..|
Human  3261 QDSKITSGAIKTRLEEAESTEQMINVAREKYRPVATQGSVMYFVIASLSEIDPMYQYSLKYFKQL 3325

  Fly  3678 FTQSIERSPRNQLVHERIQNINEYHSYAVYRNTCRGLFERHKLLFSIHMTAKILSNAGKLLEEEY 3742
            |..:||.|.:.:.:.:|:..:.|......|.|..|||||:|||::|..:..:::...|.|.:.|:
Human  3326 FNTTIETSVKTENLQQRLDVLLEQTLLTAYVNVSRGLFEQHKLIYSFMLCVEMMRQQGTLSDAEW 3390

  Fly  3743 DFILKGGIVLDKLGQAPNPAPWWISEQNWDNITELDK-VSGFHGI------------IDSFEQHY 3794
            :|.|:|...|:| .:.|.|...|:....|....:|:: ...|||:            :.|||.:.
Human  3391 NFFLRGSAGLEK-ERPPKPEAPWLPTATWFACCDLEESFPVFHGLTQNILSHPISIRLGSFETYI 3454

  Fly  3795 --KAWNGWYATTFPEQEDLVGE--------WNDKLTDFQKICVLRSLRPDRISFCLTQFIITKLG 3849
              :.|.| |:....|.:.:..|        |:..|:.|.|:.:::..:.:::.|.||.|:|..||
Human  3455 NPQKWEG-YSKMKHEDKHMRQEKEAAHQDPWSAGLSSFHKLILIKCCKEEKVVFALTDFVIENLG 3518

  Fly  3850 PRYVDPPVLDLKATFDESISQTPLIFVLSPGVDPAQSLISLSESVKMAQRMYSLSLGQGQAPIAT 3914
            .::::.|.:||...:.:....|||:|:||.|.||..:....:.....::|:.|:||||||.|||.
Human  3519 KQFIETPPVDLPTLYQDMSCNTPLVFILSTGSDPMGAFQRFARESGYSERVQSISLGQGQGPIAE 3583

  Fly  3915 KLIMDGIKDGNWVFLANCHLSLSWMPTLDKMIATM--QSMKLHKKFRLWLSSSPHPDFPISILQT 3977
            |::.|.:|.||||||.||||::|||..::::|.|.  ....:...|||:|||.|...||:::||.
Human  3584 KMVKDAMKSGNWVFLQNCHLAVSWMLAMEELIKTFTDPDSAIKDTFRLFLSSMPSNTFPVTVLQN 3648

  Fly  3978 SIKMTTEPPRGIKSNMKRLYNNINEANMENCSEPSKYKKLLFALCFFHTVLLERKKFLELGWNVI 4042
            |:|:|.|||:|:::|::|.:..:..:..|......|:::::|.:||||.::.|||||..||||:.
Human  3649 SVKVTNEPPKGLRANIRRAFTEMTPSFFEENILGKKWRQIIFGICFFHAIIQERKKFGPLGWNIC 3713

  Fly  4043 YSFNDSDFEVSEILLLLYLNEYEDTPWGALKYLIAGVNYGGHITDDWDRRLLITYINQFFCDQAL 4107
            |.|||||.|.:.:.|.||..|.: .||.||.|:...:.|||.:||.||:|.|.|.:.:||..:.|
Human  3714 YEFNDSDRECALLNLKLYCKEGK-IPWDALIYITGEITYGGRVTDSWDQRCLRTILKRFFSPETL 3777

  Fly  4108 QTRKFRLSTLPNYFIPDDGDVQSYLDQIQMFPNFDKPDAFGQHSNADIASLIGETRMLFEALLSM 4172
            : ..::.|....||.|....:|.:.|.|:..|..|.|:.||.|.||::.....||..|...:|.:
Human  3778 E-EDYKYSESGIYFAPMADSLQEFKDYIENLPLIDDPEIFGMHENANLVFQYKETSTLINTILEV 3841

  Fly  4173 QVQTNSTSSNENGETKVFDLAKEILMNTPDEINYEQTAKIIGI-----NRTPLEVVLLQEIERYN 4232
            |.::::....::.:..|.:|...:....|:::..|..::.:.:     ....|..||.||::|:|
Human  3842 QPRSSTGGEGKSNDEIVQELVASVQTRVPEKLEMEGASESLFVKDLQGRLNSLTTVLGQEVDRFN 3906

  Fly  4233 KLLVDMSTQLRDLRRGIQGLVVMSSDLEDIYLAVSEGRVPLQWLK-AYNSLKPLAAWARDLIHRV 4296
            .||..:.|.|..|.:.|.|.||||.::|.:|.:....:||..|.. ||.|||||.:|.:|||.|.
Human  3907 NLLKLIHTSLETLNKAIAGFVVMSEEMEKVYNSFLNNQVPALWSNTAYPSLKPLGSWVKDLILRT 3971

  Fly  4297 GHFNSWAKTLRPPILFWLAAYTFPTGFVTAVLQTSARATKTPIDELSWDFYVF-VEEDTA----A 4356
            ...:.|.|..:|. .:|::.:.||.||:|..||..||....||||||:.:.|. ...|.|    |
Human  3972 SFVDLWLKRGQPK-SYWISGFFFPQGFLTGTLQNHARKYNLPIDELSFKYSVIPTYRDQAAVIEA 4035

  Fly  4357 ARIIREG-------------GGVYIRSLFLEGGGWLRKNQCLQDPLPMELICPLPVIHFKPVENL 4408
            |:.::.|             .||.:..:|::...|..|...::|.||.::...|||:||:|.:|.
Human  4036 AKTVQFGQELPMDMELPSPEDGVLVHGMFMDASRWDDKEMVIEDALPGQMNPVLPVVHFEPQQNY 4100

  Fly  4409 KKRCRGVYQCPAYYYPVRSG---------SFVIAVDLKSGNEKADYWIKRGTALLLSLA 4458
            |. ...:|.||.|....|:|         :||:.|.|.|...| ||||.:|:|||..|:
Human  4101 KP-SPTLYHCPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRSK-DYWIAKGSALLCQLS 4157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-2	NP_001015505.5	DHC_N1	178..749	CDD:285571	63/380 (17%)
		DHC_N2	1244..1646	CDD:285579	132/416 (32%)
		P-loop_NTPase	1785..2015	CDD:304359	142/229 (62%)
		P-loop_NTPase	2099..2242	CDD:304359	71/154 (46%)
		P-loop_NTPase	2401..2668	CDD:304359	99/270 (37%)
		P-loop_NTPase	2752..3030	CDD:304359	107/279 (38%)
		MT	3043..3373	CDD:289543	116/352 (33%)
		AAA_9	3402..3618	CDD:289547	105/215 (49%)
		Dynein_heavy	3760..4447	CDD:281078	246/744 (33%)
DNAH6	NP_001361.1	Stem. /evidence=ECO:0000250	1..1433		343/1554 (22%)
		DHC_N2	882..1300	CDD:285579	133/422 (32%)
		P-loop_NTPase	1434..1664	CDD:304359	142/229 (62%)
		AAA 1. /evidence=ECO:0000250	1434..1655		139/220 (63%)
		AAA 2. /evidence=ECO:0000250	1715..1948		99/242 (41%)
		P-loop_NTPase	1748..1893	CDD:304359	71/154 (46%)
		P-loop_NTPase	2057..2328	CDD:304359	100/273 (37%)
		AAA 3. /evidence=ECO:0000250	2058..2306		95/250 (38%)
		AAA 4. /evidence=ECO:0000250	2408..2659		103/270 (38%)
		P-loop_NTPase	2409..2678	CDD:304359	109/288 (38%)
		Stalk. /evidence=ECO:0000250	2676..2961		102/307 (33%)
		MT	2690..3022	CDD:289543	116/354 (33%)
		AAA 5. /evidence=ECO:0000250	3042..3272		111/229 (48%)
		AAA_9	3050..3266	CDD:289547	105/215 (49%)
		Dynein_heavy	3407..4146	CDD:281078	246/744 (33%)
		AAA 6. /evidence=ECO:0000250	3509..3730		91/220 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1492at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820