DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-2 and Dnah1

DIOPT Version :9

Sequence 1:	NP_001015505.5	Gene:	kl-2 / 3355181	FlyBaseID:	FBgn0001313	Length:	4459	Species:	Drosophila melanogaster
Sequence 2:	NP_001028840.1	Gene:	Dnah1 / 110084	MGIID:	107721	Length:	4250	Species:	Mus musculus

Alignment Length:	4286	Identity:	1411/4286 - (32%)
Similarity:	2155/4286 - (50%)	Gaps:	550/4286 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 FCTE--KVNVEKILSGSS----RFGIKICNMCIDCCLTYKGIYDIMSKTHAKINIRIGWSLD--- 392
            ||.|  :|..::::..::    ...:.:.|:.:||..| :|...|..::.:||.   .|:|.
Mouse   348 FCAEDPRVFTQRVVQANALRKYTEALLMYNLYVDCMPT-EGRRVINEQSLSKIK---QWALSTPR 408

  Fly   393 ---NAMIFNHVDAFMERLNDVIDICESM---------------MVFGRLDESESIPKPQFGGTSG 439
               ...:..|:......:|  :|...||               ..:..|.|.|....|..|..|.
Mouse   409 MRKGQSVLEHLSCLAREVN--LDYERSMNKINFDQIVSSNPETFSYVTLPEKEEEKVPNQGLVSV 471

  Fly   440 TEFEATADNVENEFLVTLTALCTDSKEIILNVHK-----------NEWYEEVIKYRRTVQSMEET 493
            .|:.......:..|:..||     ..|:|..:.|           :.::..:.||.|.     |.
Mouse   472 PEYPFREQKEDFTFVSLLT-----RPEVITALSKVRAECNKVTSMSLFHSSLSKYSRL-----EE 526

  Fly   494 VQRLMSNVFQHICNVEEALESLNVMIFYSYRSTIR---KTFLRQVSSAWVFFSNEIDSSVHMLMD 555
            .:::.|..|..:          .:.:..|:.||::   :..||.:|..|.
Mouse   527 FEQIQSQTFSQV----------QMFLKDSWISTLKVAMRGSLRDMSKGWY--------------- 566

  Fly   556 RSKMHE-SWVPYYASRALGYRVHLDRLVWLCNRLNSSDWLPNVSEASVVLKKFESVRREFDKEVK 619
              .::| :|..|..|:       |.:|:.|...:                  .:...|...::..
Mouse   567 --NLYETNWEVYLMSK-------LRKLMELIKYM------------------LQDTLRFLVQDSL 604

  Fly   620 KSFDEWQKN-CCSLL-----LNQKLDRYLLIRS--KKKKG---LIECNIDRTILTICEQAQHFER 673
            .||.::..: |||:|     ::...|   |:.|  |.:|.   :::..:|.:.:......:|||.
Mouse   605 GSFTQFIGDACCSVLECVDDMDWGED---LVNSPYKPRKNPLFIVDLVLDNSGVHYSTPLEHFEM 666

  Fly   674 LGLGVPGMVRKIYEKHETLRFVYNSVVQVCLNYNHILSALSEQERKLFRALIQACDRKI-----A 733
            :                                                 |:...|:.|     .
Mouse   667 I-------------------------------------------------LLNLFDKGILATHAV 682

  Fly   734 PGVFKLTYGGELSDAYIADCAKHTNKLQETMDIYKRAIQNIARFCEKICDTPMLKFNFSGA---- 794
            |.:.||.    :.|.:|:.     :.|.|::.:::..::.             |:.|.:.|
Mouse   683 PQLEKLV----MEDIFISG-----DPLLESVGLHEPLVEE-------------LRANITNAMHKA 725

  Fly   795 -VTISIFENHLSSYLRRVSNILRGFYST----------ITDLIFAVFKEFQAVIEDMPIEWYGFV 848
             :.:..:......||...:|.:..|..|          :.:::....||.:.:...:|
Mouse   726 MMPLQAYAKEYRKYLELNNNDISTFLKTYQTQCPSAEEVREVVITHLKEKEILDNSLP------- 783

  Fly   849 NVFDDMLATAFLTSSKNSLNMLTNALHRDPDMAAAPILVMESDVRERCIVLTPDIDVIANLLSGY 913
               ..::...|..:..|                     |.:|..::|..:.|..:|::|..|...
Mouse   784 ---SSIIIGPFYINVDN---------------------VKQSLSKKRKALATSMLDILAKNLHKE 824

  Fly   914 IDRIHNILEQFPRIGIKMKLPKEHQYESFSKAFLEDSESTQLICNIEAEINHEREEIDGYITFWN 978
            :|   :|.|:|               .|.|:...|...|.:.:    ||:....:.|...:.|..
Mouse   825 VD---SICEEF---------------RSISRKIYEKPNSIEEL----AELRDWMKGIPEKLVFLE 867

  Fly   979 SHRMLWETTELEFTKRVKATQMTADIFEASIEYYSAMADDISYVDAITHVYFILMNQNYIKSSIL 1043
                       |...:|.:.....|.|     :|:...||.:
Mouse   868 -----------ERIVKVMSDYEVMDEF-----FYNLTTDDFN----------------------- 893

  Fly  1044 DCIEKWQALNIKILLSHSFSLIRAIYRYMRKNERKMMMVPRTLKESLLAKQFFERIINEVPLKQA 1108
               :||.|.|....:.....::|..:....:..||:         .|:.:..|:..:..:.|..|
Mouse   894 ---DKWAANNWPSKILGQIDMVRQQHVEDEEKFRKI---------QLMDQNNFQEKLEGLQLVVA 946

  Fly  1109 GFPPTLELFAILDKYQVEIPEEI-RVKVIGLEAAWHHYLKRLGEADE--MLDNNREEFKKILVQQ 1170
            ||...:|:     ....||..|: |||            |:|.:..:  ||.||||....:.:..
Mouse   947 GFSIHVEI-----ARAHEIANEVRRVK------------KQLKDCQQLAMLYNNRERIFGLPITN 994

  Fly  1171 AEKFKIILKEFLDDFFLKLPTSANINPRIALKFLRIIALKIEDCFTFEESLMRDLAVFNVNQPES 1235
            .:|...::|||                                                  ||
Mouse   995 YDKLSRMVKEF--------------------------------------------------QP-- 1007

  Fly  1236 IDLRKLDFEVRIVKNIWELIFEWQTNWEGWKKGYFWKMNINEMEDTALNLYKEFTTLNKKFYD-- 1298
                .||        :|....:|....|.|.......::..::|...:..:|......|:|.|
Mouse  1008 ----YLD--------LWTTASDWLRWSESWMNDPLSAIDAEQLEKNVIESFKTMHKCVKQFKDIP 1060

  Fly  1299 -RHWEMLEATTKNVDSFRRTLPLITALKNPCMRERHWNRVRDVIHVNFDENSKNFTLELIINLDF 1362
             .....|:..|: ::.|:..:|||..|:||.||.|||..:.:.|::|....: |.|....:.::.
Mouse  1061 ACQEVALDIRTR-IEEFKPYIPLIQGLRNPGMRNRHWEVLSNEININVRPKA-NLTFARCLEMNL 1123

  Fly  1363 QAFSEDIQDISNPATMELQIENSIKNIATIWKKQSFEMAFYHD-GIYRIKNVEDCFQLLEEHMVQ 1426
            |...|.|..::..|..|..||.::..:...|....|.:..|.: ..|.:|:.::..|||::|:|.
Mouse  1124 QDHIESISKVAEVAGKEYAIEQALDKMEKEWSSILFNVLPYKETDTYILKSPDEASQLLDDHIVM 1188

  Fly  1427 ISAMKATRFVEPFITIVDYWEKTLSYISETLEKGLTVQRQWLYLENIFQGDDIRKQLPEEAKRFA 1491
            ..:|..:.:.:||...::.||..|....|.||:.|..||.|||||.||..:||.:|||.|:||:.
Mouse  1189 TQSMSFSPYKKPFEQRINSWETKLKLTQEVLEEWLNCQRAWLYLEPIFSSEDITRQLPVESKRYQ 1253

  Fly  1492 TITEEFRTISSKMFQAKTAVKATNLRPPPFLLNRFSRMDERLELIQRALEIYLEAKRQLFPRFYF 1556
            |:...:|.|....::.:..:   |:.....||:.....::.|:|:|:.|..|||.||..||||||
Mouse  1254 TMERIWRKIMKNAYENREVI---NVCSDQRLLDSLRDCNKLLDLVQKGLSEYLETKRTAFPRFYF 1315

  Fly  1557 ISNDDLLEILGNSKRPDLVQTHLKKLFDNLYKLELKRVGKTLSRWQASGMHSDDGEYVEFMMVIY 1621
            :|:|:|||||..:|.|..||.||:|.|:|:.:|..:      ...:.:.|:|.:||.|:....||
Mouse  1316 LSDDELLEILSQTKDPTAVQPHLRKCFENIARLLFQ------EDLEITHMYSAEGEEVKLSFSIY 1374

  Fly  1622 IDGPSERWLKQVEEYMLVVMKEMLKLTRGSLKKLVGNREKWISLWPGQMVLTTAQIQWTTECTRS 1686
            .....|.||.:||..|...:.:::::...:...::  |.:|:..||||:.:...|..||.|...:
Mouse  1375 PSSNVEDWLLEVERSMKASVHDIIEMAIKAYPTML--RTEWVLNWPGQVTIAGCQTYWTMEVAEA 1437

  Fly  1687 LIHCSMVDQKKPLRKLKKKQIKVLSKLSEMSRKDLTKTMRLKVNTLITLEIHGRDVIERMYKSNC 1751
            |      :......||..:..|.||.|..:.|..|::..|:.::.||.:|:|.:||:.::...|.
Mouse  1438 L------EAGNISSKLFPQLSKQLSDLVALVRGKLSRMQRMVLSALIVIEVHAKDVVSKLIDENV 1496

  Fly  1752 KDTGHFEWFSQLRFYWHRESELCVIRQTNTEHWYGYEYTGNSGRLVITPLTDRCYITLTTALHLH 1816
            .....|||.||||:||.::.  ..||..|.|..|||||.||||||||||||||||:|||.||||.
Mouse  1497 VSVHDFEWISQLRYYWTKDD--LYIRAVNAEFIYGYEYLGNSGRLVITPLTDRCYLTLTGALHLK 1559

  Fly  1817 RGGSPKGPAGTGKTETVKDLGKALGIWVIVTNCSEGLDYKSIGKNFSGLAQSGCWGCFDEFNRIN 1881
            .||:|.||||||||||.|||||||.|..:|.|||:.||:.::||.|.|||.:|.|.||||||||:
Mouse  1560 FGGAPAGPAGTGKTETTKDLGKALAIQTVVFNCSDQLDFMAMGKFFKGLASAGAWACFDEFNRID 1624

  Fly  1882 IEVLSVVAQQIMSIMAALSTKALELMFEGQMIKLKHTVGLFITMNPGYAGRTELPDNLKSMFRPI 1946
            |||||||||||.:|..|...:....||||..|.|..:..:|||||||||||||||||||::|||:
Mouse  1625 IEVLSVVAQQITTIQKAQQQRVERFMFEGVEIPLVPSCAVFITMNPGYAGRTELPDNLKALFRPV 1689

  Fly  1947 SMMVPDNIIIAENLLFSDGFTNTRNLARKVYTLYELAKQQLSKQYHYDFGLRSMVALLRYAGRKR 2011
            :|||||..:|||..|:|.||.....||:|:.|.::|:.:|||.|.|||||:|::..::..||..:
Mouse  1690 AMMVPDYAMIAEISLYSFGFNEANVLAKKITTTFKLSSEQLSSQDHYDFGMRAVKTVISAAGNLK 1754

  Fly  2012 RQLPNTTEEEIVYLAMKDMNVARLTANDLPLFNGIMSDIFPGVSLPTIDYSEFNIAIYEEFREAG 2076
            |:.|...||.|...|::|:||.:....||.||:||:||:||.:.....||...:.||.....:..
Mouse  1755 RENPTMNEELICLRAIRDVNVPKFLQEDLKLFSGIVSDLFPTIKEEETDYGILDQAIRRSCEKNN 1819

  Fly  2077 LQPITIAVKKVIELFETKNSRHSVMIIGDTGTAKSVTWRTLQNCFYRMNSQ-RFSG--WEAVTVY 2138
            |:.:...:.|.|:|:||...||.:|::|.||:.||..:|.|......:..: ..||  :|||..|
Mouse  1820 LKDVEGFLIKCIQLYETTVVRHGLMLVGPTGSGKSNCYRVLAAAMTLLKGKPSISGGVYEAVNYY 1884

  Fly  2139 PVNPKALNLAELYGEYNLSTGEWLDGVLSSIMRIICGDEEPTQKWLLFDGPVDAVWIENMNSVMD 2203
            .:|||::.:.:||||::|.|.||.||:.||::|......:..:||.:||||||||||||||:|:|
Mouse  1885 VLNPKSITMGQLYGEFDLLTHEWTDGIFSSLIRAGAIASDTNKKWYMFDGPVDAVWIENMNTVLD 1949

  Fly  2204 DNKLLTLVNSERITMPVQVSLLFEVGDLAVASPATVSRCGMVYNDYNDWGWKPFVNSWLQRLR-- 2266
            |||.|.|.:.|.|.:...::::|||.|||||||||||||||||.:.:..|..|||..||:||.
Mouse  1950 DNKKLCLSSGEIIKLTEAMTMMFEVQDLAVASPATVSRCGMVYLEPSILGLMPFVECWLKRLPAI 2014

  Fly  2267 IKEFADFLRIHFDYMVPKILDFKRMRCKEPVRTNELNGVVSLCKLLEIFGTKV---NGINPINLE 2328
            ||.:.:..:..|...:...::|.|...||.:.:...|..:||.|||:.|....   .|:..|..|
Mouse  2015 IKPYEEQFKSLFTKYLENSINFVRNTVKEVIASTNSNLTMSLLKLLDCFFRPFLPREGLKKIPSE 2079

  Fly  2329 LLEEMTRL---WFMFCLVWSICSSVDEDSR------QRLDSFIRELESCFPIKDTVFDYFVD--- 2381
            .|..:..|   ||:|.||||:.::.|..||      .||...:.:::..||....|:||.:|
Mouse  2080 KLSHIPELIEPWFIFSLVWSVGATGDHTSRISFSQWLRLKMRLEQVKLGFPEDGLVYDYRLDDAG 2144

  Fly  2382 ----------PNERTFLPWDSKLLSSWKCDFESPF--------YKIIVPTGDTVRYEYVVSKLLA 2428
                      .:|...:.|     ..| .|:.:||        ..|||||.|||:..|::..||.
Mouse  2145 ISSTEDDDEEEDENKQVSW-----VKW-MDYSAPFTMMPDTNYCNIIVPTMDTVQMSYLLGMLLT 2203

  Fly  2429 EEYPVMLVGNVGTGKTSTAISVMEACDKNKFCILAVNMSAQTTAAGLQESIENRTEKRTKTQFVP 2493
            ...||:.:|..|||||.|..:.:......::....:..||:|:|...|:.|:::.:||.|..|.|
Mouse  2204 NHKPVLCIGPTGTGKTLTVSNKLLKYLPLEYISHFLTFSARTSANQTQDLIDSKLDKRRKGVFGP 2268

  Fly  2494 IGGKRMICFMDDFNMPAKDIYGSQPPLELIRQWIDYKYWFNRKTQQKIYVQNTLL----MAAMGP 2554
            ..|:..|.|:||.||||.:.||:|||:||:|||:|:..|::||.   |.....|:    :.||||
Mouse  2269 PLGRNFIFFIDDLNMPALETYGAQPPIELLRQWMDHGGWYDRKV---IGAFKNLVDINFVCAMGP 2330

  Fly  2555 PGGGRQTISSRTQSRFVLLNLTFPSQETIIRIFGTML-C------------QKLESYPNEVREMW 2606
            |||||..|:.|....|..|:.....:.:..|||..:| |            :.:...|| :.::.
Mouse  2331 PGGGRNAITPRLTRHFNYLSFIEMDEVSKKRIFSIILECWMDGLLGEKSYREPVPGAPN-IDDLT 2394

  Fly  2607 LPITLCTINLYVSMISKMLPTPNKSHYLFNLRDISKVFQGLLRSEKELQNKKNFFLRLWVHECFR 2671
            .|:...|||:|..:.|::||||.||||.|||||:||||||:|.:|......|...||||.||..|
Mouse  2395 EPLVDATINVYGIITSQLLPTPAKSHYTFNLRDLSKVFQGMLMAEPSKVEDKVQLLRLWYHENCR 2459

  Fly  2672 VFSDRLVDDSDQFWFVNTINDILGKHFEVTFHSLCPSKVPPFFGDFAHPQGFYEDLQVDFLRTFM 2736
            ||.||||::.|:.|| :.:.:...:.|.|.|:.:||.: |..:|||..|....:..::....:.|
Mouse  2460 VFRDRLVNEEDRSWF-DELLEAQMEEFGVAFNKVCPFQ-PILYGDFMSPGSDVKSYELITSESKM 2522

  Fly  2737 KNQLEEY---NNFPGMTRMNLVFFREAIEHIVRILRVISQPRGHILNMGIGGSGRQVLTKLAAFI 2798
            ...:|||   .|.....::.||.|.:|:.||.||.|.:.|..|:.|.:|:|||||..||:||:.:
Mouse  2523 MQVIEEYMEDYNQINTAKLRLVLFVDAMSHICRISRTLRQALGNALLLGVGGSGRSSLTRLASHM 2587

  Fly  2799 LEMAVFQIEVTKKYKTGDFREDLKNLYKVTGIKQRLTIFIFSSDQIAEVSFLEITNNMLSTGEI- 2862
            .|...||||::|.|...::|||:|.:....|::.....|:||..||...||||..||:|::|:|
Mouse  2588 AEYECFQIELSKNYGMSEWREDVKKVLLKAGLQNLPITFLFSDTQIKNESFLEDINNVLNSGDIP 2652

  Fly  2863 NLFKSDEFDELKPELERPAKKNGVLLTTEALYSYFILNVRDFLHVALCFSPIGENFRSYIRQYPA 2927
            |::.:||.|::...:....::.|:..|...|.:.:...||..:|:.||.|||||.||:.:||:|:
Mouse  2653 NIYSADEQDQIINTMRPYIQEQGLQPTKANLMAAYTGRVRSNIHMVLCMSPIGEVFRARLRQFPS 2717

  Fly  2928 LLSSTTPNWFRFWPQEALLEVASHFLIGFPLNVVVSGKEDEKHRESLVISTEAILQRDIAYVFSV 2992
            |::..|.:||..||.|||..||:.||...|               .|..|.|.|  :.:..|...
Mouse  2718 LVNCCTIDWFNEWPAEALKSVATTFLSEIP---------------ELECSEEVI--QGLIQVCVF 2765

  Fly  2993 IHSSVAKMSENMYAEVKRYNYVTSPNYLQLVSGFKKLLEKKRLEVSTASNRLRNGLSKISETQEK 3057
            ||.|||.......||:.|:||||..:||:|::.|..|:.:|::|:.||.||:::||.|:..|.|.
Mouse  2766 IHQSVASKCVEYLAELARHNYVTPKSYLELLNIFSILIGQKKMELKTAKNRMKSGLDKLLRTSED 2830

  Fly  3058 VSLMSEELKASSEQVKILARECEDFISMIEIQKSEATEQKEKVDAEAVLIRRDEIICLELAATAR 3122
            |:.|.|||:.....::..|::....:..|::..:.|.|.::.|.||.:...........:|..|:
Mouse  2831 VAKMQEELEIMRPLLEEAAKDTMLTMEQIKVDTAIAEETRKSVQAEEIKANEKANKAQAIADDAQ 2895

  Fly  3123 ADLEVVMPMIDAAVKALDALNKKDISEVKSYGRPPMKIEKVMEAVLILLGKEPT----------- 3176
            .||:..:|.:|||:.:|..|||.|::||::..|||..::.|:|||.|:.|.:|.
Mouse  2896 KDLDEALPALDAALASLRNLNKNDVTEVRAMQRPPPGVKLVIEAVCIMKGIKPKKVPGEKPGSKV 2960

  Fly  3177 ---WENAKKVLSE-STFLNDLKNFDRDHISDKTLKRIAIYTKNPELEPDKVAVVSLACKSLMQWI 3237
               ||..|.:|.: ..||..|..||:|:|.:..:|.|..|..|.|.:|..:|.||.||.|:.||:
Mouse  2961 DDYWEPGKGLLQDPGRFLESLFKFDKDNIGEAVIKAIQPYIDNEEFQPAAIAKVSKACTSICQWV 3025

  Fly  3238 MAIENYGKVYRIVAPKQEKLDSAMKSLEEKQAALAAAKKKLEELQVVIEELYRQLEEKTNLLNEL 3302
            .|:..|..|.:.|.||::.|..|...||..|..|..||..|.|::..|..:..:..|......||
Mouse  3026 RAMHKYHFVAKAVEPKRQALREAQDDLEVTQRILEEAKHHLHEVEDGIATMQAKYRECVAKKEEL 3090

  Fly  3303 RAKEERLRKQLERAIILVESLSGERERWIETVNQLDLSFEKLPGDCLLSVAFMSYLGAFDTKYRE 3367
            ..|.|:..::|.||..|:..|:.|:.||.|||..|:...:.:.||.|::..|::|||.|..:||.
Mouse  3091 EMKCEQCEQRLGRADKLINGLADEKVRWQETVENLENMLDNIFGDVLVAAGFVAYLGPFTGQYRT 3155

  Fly  3368 ELLVKWSLLIKDLLIPATLELKVTYFLVDAVSIREWNIQGLPADDLSTENGVIVTQGSRWPLIID 3432
            .|...|...:....:|.|.:..:...|.:.|.||.|.|.|||.|.||.|||||.....||...||
Mouse  3156 TLYEYWVNQLTVHHVPHTSKPTLITTLGNPVKIRSWQIAGLPNDTLSVENGVINQFSQRWTHFID 3220

  Fly  3433 PQMQANNWIKNMEERNQLMTLDFGMADYLRQLERALKEGLPVLLQNVGEYLDQAINPILRQSFTI 3497
            ||.|||.||||||..:.|........|:||.:|.|::.|.|.||:||||.||.|:.|:|.:....
Mouse  3221 PQGQANKWIKNMERESGLDVFKLSDRDFLRSMENAIRFGKPCLLENVGEELDPALEPVLLKQTYK 3285

  Fly  3498 QSGERLLKFNDKYISYNNSFRFYITTKISNPHYPPEISSKTTIVNFALKQDGLEAQLLGIIVRKE 3562
            |.|..:||..|..|.|:..||.|||||:.||||.||||:|.|::||.|...|||.||||.:|.:|
Mouse  3286 QQGNIVLKLGDTVIPYHEDFRMYITTKLPNPHYSPEISTKLTLINFTLSPSGLEDQLLGQVVAEE 3350

  Fly  3563 KPALEEQKDELVMTIARNKRTLIDLDNEILRLLNESRGSLLDDDELFSTLQKSRQTSVLVKESLS 3627
            :|.|||.|::|:::.|:.::.|.|::::||..|:.|.|:.:||.||...|:.|:..:..::..:.
Mouse  3351 RPDLEEAKNQLIVSNAKMRQELKDIEDQILYRLSSSEGNPVDDMELIKVLEASKMKAAEIQAKVR 3415

  Fly  3628 IAEVTEVEIDAARQEYKPASERASILFFVLMDMSKIDPMYVFSLAAYILLFTQSIERSPRNQLVH 3692
            |||.||.:||..|.||.|.:.|..||||.:.|::.:||||.:||..::.:|...|..|.|...:.
Mouse  3416 IAEQTEKDIDLTRMEYIPVAVRTQILFFCVSDLANVDPMYQYSLEWFLNIFLSGIANSERADNLK 3480

  Fly  3693 ERIQNINEYHSYAVYRNTCRGLFERHKLLFSIHMTAKILSNAGKLLEEEYDFILKGGIVLDKLGQ 3757
            :||.|||.|.::::|.|.||.|||:|||:|:..:..:|:.|.||:.:.|:.::|.||.:....
Mouse  3481 KRIVNINRYLTFSLYSNVCRSLFEKHKLMFAFLLCVRIMMNEGKINQAEWRYLLSGGSIQTMF-- 3543

  Fly  3758 APNPAPWWISEQNWDNITELDKVSGFHGIIDSFEQHYKAWNGWYATTFPEQEDLVGEWNDKLTDF 3822
             .||||.|:|::.|.:|..|..:..|....:.|..:...:...:.:..|.:|.|.|.||..|.:|
Mouse  3544 -ENPAPQWLSDRAWRDILALSNLPTFATFSNDFVMYLSEFQAIFDSAEPHRELLPGIWNAYLDEF 3607

  Fly  3823 QKICVLRSLRPDRISFCLTQFIITKLGPRYVDPPVLDLKATFDESISQTPLIFVLSPGVDPAQSL 3887
            ||:.:||.||.|:::..:..|:.|.|.||:::|...:|.|.|.||.|.||||||||||.|||..|
Mouse  3608 QKLLILRCLRGDKVTNAMQDFVATHLEPRFIEPQTANLSAVFKESNSTTPLIFVLSPGTDPAADL 3672

  Fly  3888 ISLSESVKMAQRMYSLSLGQGQAPIATKLIMDGIKDGNWVFLANCHLSLSWMPTLDKMIATMQSM 3952
            ...:|.:|.:::..::||||||.|.|..::.:.|:.|.|||..||||:.||||.|:::|..:...
Mouse  3673 YKFAEEMKFSKKFSAISLGQGQGPRAEAMMRNSIERGKWVFFQNCHLAPSWMPALERLIEHINPD 3737

  Fly  3953 KLHKKFRLWLSSSPHPDFPISILQTSIKMTTEPPRGIKSNMKRLYNNINEANMENCSEPSKYKKL 4017
            |:|:.|||||:|.|...||:||||...|||.|||||:|:|:.:.||::::..:.:|.:..::|.|
Mouse  3738 KVHRDFRLWLTSLPSNKFPVSILQNGSKMTIEPPRGVKANLLKSYNSLSDDFLHSCQKVVEFKSL 3802

  Fly  4018 LFALCFFHTVLLERKKFLELGWNVIYSFNDSDFEVSEILLLLYLNEYEDTPWGALKYLIAGVNYG 4082
            |.:||.||...|||:||..||:|:.|.|.|.|..:....|.::|:||||.|:..|||....:|||
Mouse  3803 LLSLCLFHGNALERRKFGPLGFNIPYEFTDGDLRICISQLKMFLDEYEDIPYKVLKYTAGEINYG 3867

  Fly  4083 GHITDDWDRRLLITYINQFFCDQALQTRKFRLSTLPNYFIPDDGDVQSYLDQIQMFPNFDKPDAF 4147
            |.:|||||||.::..:..|:....|.:.....::...:.||...|:..||..|:..|..|.|:.|
Mouse  3868 GRVTDDWDRRCVMNILEDFYNPAVLSSEHSYSNSGIYHQIPPTYDLNGYLSYIKSLPLNDMPEIF 3932

  Fly  4148 GQHSNADIASLIGETRMLFEALLSMQVQTNSTSSNENGETKVFDLAKEILMNTPDEINYEQ-TAK 4211
            |.|.||:|.....||..||.|:|.:|.: :|:...::.|..|.|:|:.||:..|..|..:: |.|
Mouse  3933 GLHDNANITFAQNETFALFNAILQLQPK-SSSMGGQSREELVEDVAENILLQVPGPIELQEVTKK 3996

  Fly  4212 IIGINRTPLEVVLLQEIERYNKLLVDMSTQLRDLRRGIQGLVVMSSDLEDIYLAVSEGRVPLQW- 4275
            ...:....:..||:||:.||||||..::..|.|:.:.|:||||||.:||.:.:::....||..|
Mouse  3997 FPVLYEESMNTVLVQEVIRYNKLLEVITQTLSDMLKAIKGLVVMSLELELMSISLYNNTVPELWK 4061

  Fly  4276 LKAYNSLKPLAAWARDLIHRVGHFNSWAKTLRPPILFWLAAYTFPTGFVTAVLQTSARATKTPID 4340
            .|||.||||||:|..||:.|:...:||.....||: ||::.:.||..|:|..||..||.....||
Mouse  4062 SKAYPSLKPLASWIMDLLLRLDFMHSWINDGIPPV-FWISGFFFPQAFLTGTLQNFARKFVISID 4125

  Fly  4341 ELSWDFYVFVEEDTAAARIIREGGGVYIRSLFLEGGGWLRKNQCLQDPLPMELICPLPVIHFKPV 4405
            .:::||.|..|..:....  |...|.||..|||||..|...|..|.:..|.||...:.||...|.
Mouse  4126 TITFDFKVLPEASSEIKE--RPQTGCYIHGLFLEGARWDSMNFQLAESRPKELYTEMAVIWLLPE 4188

  Fly  4406 ENLKKRCRGVYQCPAYYYPVRSG---------SFVIAVDLKSGNEKADYWIKRGTALLLSL 4457
            .|.|.:.:..|.||.|....|:|         ::||||::.| |:...:|||||.||:.:|
Mouse  4189 ANRKVQNQDFYLCPIYKTLTRAGTLSTTGHSTNYVIAVEIPS-NQPQRHWIKRGVALICAL 4248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-2	NP_001015505.5	DHC_N1	178..749	CDD:285571	75/469 (16%)
		DHC_N2	1244..1646	CDD:285579	122/405 (30%)
		P-loop_NTPase	1785..2015	CDD:304359	142/229 (62%)
		P-loop_NTPase	2099..2242	CDD:304359	69/145 (48%)
		P-loop_NTPase	2401..2668	CDD:304359	111/291 (38%)
		P-loop_NTPase	2752..3030	CDD:304359	105/278 (38%)
		MT	3043..3373	CDD:289543	113/344 (33%)
		AAA_9	3402..3618	CDD:289547	103/215 (48%)
		Dynein_heavy	3760..4447	CDD:281078	269/697 (39%)
Dnah1	NP_001028840.1	Stem. /evidence=ECO:0000250	1..1527		315/1526 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		DHC_N2	998..1401	CDD:369852	129/477 (27%)
		DYN1	<1237..3883	CDD:227570	1063/2696 (39%)
		AAA_6	1528..1854	CDD:372306	176/325 (54%)
		AAA 1. /evidence=ECO:0000250	1528..1749		139/220 (63%)
		GPAGTGKT motif	1566..1573		6/6 (100%)
		CFDEFNR motif	1616..1622		5/5 (100%)
		AAA 2. /evidence=ECO:0000250	1809..2042		98/232 (42%)
		AAA 3. /evidence=ECO:0000250	2174..2434		99/263 (38%)
		AAA 4. /evidence=ECO:0000250	2532..2784		97/268 (36%)
		AAA_8	2541..2799	CDD:372310	104/274 (38%)
		Stalk. /evidence=ECO:0000250	2799..3097		97/297 (33%)
		AAA 5. /evidence=ECO:0000250	3182..3412		107/229 (47%)
		AAA 6. /evidence=ECO:0000250	3625..3844		99/218 (45%)
		Dynein_C	3944..4246	CDD:375627	114/306 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D2450at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820