Protein Alignment Ppr-Y and LRRCC1

DIOPT Version :10

• Sequence 1: NP_001015502.3
• Gene: Ppr-Y / 3355180
• FlyBaseID: FBgn0046697
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_016869409.1
• Gene: LRRCC1 / 85444
• HGNCID: 29373
• Length: 1046
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 144/680 - (21%)
• Similarity: 245/680 - (36%)
• Gaps: 211/680 - (31%)

  Fly    50 LHQLEPVVLEQIL-TMRLEFNNILR---IDHLWILPNLTKLCLNCNKIETIENIEMLTNLKDLNL 110
            |..:..:.|:..| .:.|..|||.:   |||:|   ||..|.|:.|:|..||.:..||.|..|||
Human    33 LQSISELSLDSTLHAVNLHCNNISKIEAIDHIW---NLQHLDLSSNQISRIEGLNTLTKLCTLNL 94

  Fly   111 SFNFIEKIENLDTLVNLEVLSLFSNKIEAIENIDML----TMLVIISLGNNLIDTVEGIER---- 167
            |.|.|.|:|.|:.|:||..|::..|.|:.:..:..|    ..|..|.|.:|.||::..:.:
Human    95 SCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVG 159

  Fly   168 FRFMNNLKIINLEG--NPIAKRTNFCLLKYISAILPKLNYYEYTFIKSELRAEACNLYYREIREI 230
            ..|:.|| |:..:|  ||:.:             ||..:....| :.||||.      ||.: .:
Human   160 LHFLTNL-ILEKDGDDNPVCR-------------LPGTSLNTVT-LPSELRG------YRAV-IL 202

  Fly   231 EDKQEKEIQARKFLEREQSEAKRLASSFVEHLDGHQLFDSLWRGDEDGRVLMLVGTQAQELADEY 295
            :...:..|...|.:..|......:.||.::.|:|  |.|:|...|..      :.....|:.|..
Human   203 QTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEG--LLDNLVSSDSP------LNISEDEIIDRM 259

  Fly   296 DKDIFELTQEIYKL-GLERF--TERDEEIRDFF-----------NNLFDGQEE----------LQ 336
            .    .:|..|.:| .||:|  |..|..:..|.           |:..|.|.|          ||
Human   260 P----VITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQ 320

  Fly   337 ILGQ--NEIEWFLQ--------------------------------------------------- 348
            :|.:  |.|:..|:
Human   321 LLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYN 385

  Fly   349 -------------FREIIF-------------EEARIRLLKLEQNSMHGEDE------------- 374
                         .:|:..             |:.:..::|::|:  |.||.
Human   386 SFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQS--HSEDNTYQSLVEQLDQER 448

  Fly   375 ------DTPENLKLSDALDKL--NIQFEDAINDLWQALMA----QELYLHESIQESTI------- 420
                  :..|| ||.|.:|:|  :...::.|:.|  ||:.    :|:...|...:..:
Human   449 EKRWRAEQAEN-KLMDYIDELHKHANEKEDIHSL--ALLTTDRLKEIIFRERNSKGQLEVMVHKL 510

  Fly   421 -NFHRKIAELMSKFVEQSQAFFVQLREITLHFSENMTEILTRFISTKFALQDFDDVPIELRVCVD 484
             |..:|:...:.|..:|.:.....||.:     |...|.:.|....:.|.|......:||:....
Human   511 QNEIKKLTVELMKAKDQQEDHLKHLRTL-----EKTLEKMERQKRQQQAAQIRLIQEVELKASAA 570

  Fly   485 DRDAILNLIAGMKD-------YHTLRLDEREDTIATRTKEFV------DNMIDQLNSNEVERHRS 536
            ||:..|...:..::       :..|.|.|:|......|:||.      |.:..:: :.|.::|..
Human   571 DREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEI-AKEEKKHEQ 634

  Fly   537 KILEINFFVEMMTDAMTSLPHDVRDELIAE 566
            .|.|....:::::.....|.::.|..|..|
Human   635 MIKEYQEKIDVLSQQYMDLENEFRIALTVE 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	8/21 (38%)
		LRR	<80..313	CDD:443914	66/243 (27%)
		PPP1R42	82..>176	CDD:455733	36/101 (36%)
		leucine-rich repeat	83..104	CDD:275378	8/20 (40%)
		leucine-rich repeat	105..126	CDD:275378	11/20 (55%)
		leucine-rich repeat	127..148	CDD:275378	5/24 (21%)
		leucine-rich repeat	149..162	CDD:275378	6/12 (50%)
LRRCC1	XP_016869409.1	PPP1R42	30..216	CDD:455733	62/207 (30%)
		leucine-rich repeat	45..66	CDD:275378	9/23 (39%)
		leucine-rich repeat	67..88	CDD:275378	8/20 (40%)
		leucine-rich repeat	89..110	CDD:275378	11/20 (55%)
		leucine-rich repeat	111..136	CDD:275378	5/24 (21%)
		leucine-rich repeat	137..150	CDD:275378	6/12 (50%)
		leucine-rich repeat	185..207	CDD:275380	7/29 (24%)
		leucine-rich repeat	223..241	CDD:275380	6/19 (32%)
		SMC_prok_B	<426..>1044	CDD:274008	50/250 (20%)