DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppr-Y and DRC3

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_011522320.1	Gene:	DRC3 / 83450	HGNCID:	25384	Length:	562	Species:	Homo sapiens

Alignment Length:	582	Identity:	182/582 - (31%)
Similarity:	299/582 - (51%)	Gaps:	84/582 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IEPGIINRSLIESSYLKHVHRGEGRRLHQLEPVVLEQILTMRLEF-------------------- 68
            :||.:::..:::.:......:.|..:|.:.|.::.:.:|:::|:|
Human     8 MEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRRKTADEPKGEQDDGQEDSQ 72

  Fly    69 NNILRIDHLWILPNLTKLCLNCNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLF 133
            .:|||||:||...||.||.|:.|.||.||.:|.|.:|..|:||||.||.||.||||||||.||||
Human    73 EDILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLF 137

  Fly   134 SNKIEAIENIDMLTMLVIISLGNNLIDTVEGIERFRFMNNLKIINLEGNPIAKRTNFCLLKYISA 198
            :|:|..|:::|.|..|.::|||||.||.:..|...|....|:.::|..|||::..::.:  :|.|
Human   138 NNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKM--FICA 200

  Fly   199 ILPKLNYYEYTFIKSELR---------------------AEACNLYYREIREIEDKQEKEIQARK 242
            .||.|.|.:|..|.....                     |||.:.|  .|.|:: .||..:||:
Human   201 YLPDLMYLDYRRIDDHTASVSLSVSQPCETDSSSPQKKLAEAKHQY--SIDELK-HQENLMQAQ- 261

  Fly   243 FLEREQSEAKRL---ASSFVEHLDGHQLFDSLWRGDEDGRVLML---VGTQAQELADEYDKDIFE 301
             ||.||::.:.|   .::|||||:|..||||::..|.:|..|..   ||    ||.:.|......
Human   262 -LEDEQAQREELEKHKTAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVG----ELLETYKDKFVI 321

  Fly   302 LTQEIYKLGLERFTERDEEIRDFFNNLFDGQEELQILGQNEIEWFLQFREIIFEEARIRLLKLEQ 366
            :...|::.||::..:|..|:..|...:.:..:|.|..|:.:|        ..|||..:..|...:
Human   322 ICVNIFEYGLKQQEKRKTELDTFSECVREAIQENQEQGKRKI--------AKFEEKHLSSLSAIR 378

  Fly   367 NSMHGEDEDTPENLKLSDALDKLNIQFEDAINDLWQALMAQELYLHESIQESTINFHRKIAELMS 431
                       |.|:|.: ::|:.::....|::|:.|||..|:.|.|.::|:...|.|.|.:::.
Human   379 -----------EELELPN-IEKMILECSADISELFDALMTLEMQLVEQLEETINMFERNIVDMVG 431

  Fly   432 KFVEQSQAFFVQLREITLHFSENMTEILTRFIST--KFALQDFD-DVPIELRVCVDDRDAILNLI 493
            .|:|..|:...|.|::..|..|.:.||   .|||  |....|.| |:|.:||....|:|.|:|.:
Human   432 LFIENVQSLMAQCRDLENHHHEKLLEI---SISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAV 493

  Fly   494 AGMKDYHTLRLDEREDTIATRTKEFVDNMIDQLNSNEVERHRSKILEINFFVEMMTDAMTSL 555
            ....|.|.|::|.|||.:.||...:...:||:::.:|:.|:|.::.|||.:::.|...:.:|
Human   494 GASHDIHLLKIDNREDELVTRINSWCTRLIDRIHKDEIMRNRKRVKEINQYIDHMQSELDNL 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	9/38 (24%)
		LRR_8	81..137	CDD:290566	35/55 (64%)
		LRR_4	81..121	CDD:289563	22/39 (56%)
		leucine-rich repeat	83..104	CDD:275378	11/20 (55%)
		LRR_4	103..143	CDD:289563	25/39 (64%)
		leucine-rich repeat	105..126	CDD:275378	14/20 (70%)
		LRR_8	126..184	CDD:290566	25/57 (44%)
		LRR_4	126..166	CDD:289563	20/39 (51%)
		leucine-rich repeat	127..148	CDD:275378	11/20 (55%)
		leucine-rich repeat	149..162	CDD:275378	8/12 (67%)
DRC3	XP_011522320.1	leucine-rich repeat	87..108	CDD:275378	11/20 (55%)
		LRR_9	88..213	CDD:317038	59/126 (47%)
		leucine-rich repeat	109..130	CDD:275378	14/20 (70%)
		leucine-rich repeat	131..152	CDD:275378	11/20 (55%)
		leucine-rich repeat	153..177	CDD:275378	10/23 (43%)
		leucine-rich repeat	178..189	CDD:275378	4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145924
Domainoid	1	1.000	133	1.000	Domainoid score	I5073
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12581
Inparanoid	1	1.050	270	1.000	Inparanoid score	I3012
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56411
OrthoDB	1	1.010	-	-		D259508at33208
OrthoFinder	1	1.000	-	-		FOG0006354
OrthoInspector	1	1.000	-	-		otm41404
orthoMCL	1	0.900	-	-		OOG6_104691
Panther	1	1.100	-	-	O	PTHR45973
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4624
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910