DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppr-Y and Lrrc9

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_006516438.1	Gene:	Lrrc9 / 78257	MGIID:	1925507	Length:	1457	Species:	Mus musculus

Alignment Length:	591	Identity:	140/591 - (23%)
Similarity:	235/591 - (39%)	Gaps:	160/591 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LIESSYLKHVHRGEGRRLHQLEPVVLEQIL---------------TMRLE--FNNILRIDHLWIL 80
            :|||   ::::|||         ::.|..|               |.:||  |:...||..|.:.
Mouse     1 MIES---ENLNRGE---------IIKELCLCNGLTYEIVGQEGSDTSKLEMFFSGYPRIVGLSLF 53

  Fly    81 PNLTKLCLNCNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLFSNKIEAIENIDM 145
            .||:.|.:....|..|..:|....||:|.::...|||||.|....|||.|.|:.|||..|||::.
Mouse    54 HNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEK 118

  Fly   146 LTMLVIISLGNNLIDTVEGIERFRFMNNLKIINLEGNPIAKRTNFCLLKYISAILPKLNYYEYTF 210
            |..|.::.|.:|:|..:||::.   :.|||.:||.||            .:|:|...|:..|
Mouse   119 LIKLEVLWLNHNMIKNIEGLQT---LKNLKDLNLAGN------------LVSSIGRCLDPNE--- 165

  Fly   211 IKSELRAEACNLYYREIREIEDKQEKEIQAR---------KFLEREQSEAKRLASSFVEHLDGHQ 266
                 :.|..||...:|...:|........|         ::......:....::..:.||...|
Mouse   166 -----QLEKLNLSGNQITSFKDLTNLTKLTRLKDLCLNDPQYKSNPVCQLCNYSTHVLYHLPSLQ 225

  Fly   267 LFDSLWRGDEDGRVLMLVGTQAQELADE--------YDKDIFELTQEIYKLGLERFTERDEEIRD 323
            ..|:.   |...:       |.:||||.        |:..|..:.:.:           :||:
Mouse   226 RLDTF---DVSAK-------QIKELADSTAMKKIMYYNMRIKTVQRHL-----------NEEL-- 267

  Fly   324 FFNNLFDGQEELQILGQNEIEWFLQFREIIFEEARIRLLKLEQNSMHGEDEDTPENLKLSDA--- 385
              ..|.|.:.:||.|.:..|:.|...::.:  |..:..||:   |..|:.:.|||..|..::
Mouse   268 --EKLNDRKCKLQKLPEERIKLFNFAKKTL--ERELAELKI---SSKGQSDTTPEAEKPRNSEVV 325

  Fly   386 ----------LDKLNIQFEDAIND---LWQALMAQELYLHESIQESTINFHRKIAELMSKFVEQS 437
                      |.||:     |::|   .|.    ::|:..|:|..:.:...:|...|::.|:
Mouse   326 TQESVLQQKILTKLS-----ALDDRVTFWN----KKLHEIEAIYRTEVKQKKKTHGLLTPFL--- 378

  Fly   438 QAFFVQLREI-TLHFSENMTE----------ILTRFISTKFALQDFDDVPIELRVCVDDRDAILN 491
               ..:|..: .:||.|....          ||:||.:..|.......|.::..:.|::|  ||.
Mouse   379 ---LTELETVGNIHFEEGTQADDWFNSCCELILSRFCTWDFRAYGITGVKVKRVIKVNNR--ILR 438

  Fly   492 LIAGMKDYHTLRLDEREDTIATRTKEFVDNMIDQL---NSNEV---ERHRSKILEINFFVEMMTD 550
            |....|....|.|::.:|..:.|      .|::.|   ...||   ::|..:|||..|     .|
Mouse   439 LKFEEKFQKCLDLEDTQDPESYR------KMLECLFYVFDPEVTVKKKHLLQILERGF-----KD 492

  Fly   551 AMTSLP 556
            :.||.|
Mouse   493 SDTSKP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	7/20 (35%)
		LRR_8	81..137	CDD:290566	21/55 (38%)
		LRR_4	81..121	CDD:289563	14/39 (36%)
		leucine-rich repeat	83..104	CDD:275378	5/20 (25%)
		LRR_4	103..143	CDD:289563	19/39 (49%)
		leucine-rich repeat	105..126	CDD:275378	9/20 (45%)
		LRR_8	126..184	CDD:290566	25/57 (44%)
		LRR_4	126..166	CDD:289563	18/39 (46%)
		leucine-rich repeat	127..148	CDD:275378	11/20 (55%)
		leucine-rich repeat	149..162	CDD:275378	4/12 (33%)
Lrrc9	XP_006516438.1	internalin_A	<32..>264	CDD:380193	69/275 (25%)
		leucine-rich repeat	47..77	CDD:275380	8/29 (28%)
		leucine-rich repeat	78..99	CDD:275380	9/20 (45%)
		leucine-rich repeat	100..121	CDD:275380	11/20 (55%)
		leucine-rich repeat	122..143	CDD:275380	6/23 (26%)
		leucine-rich repeat	144..166	CDD:275380	10/41 (24%)
		leucine-rich repeat	167..191	CDD:275380	5/23 (22%)
		leucine-rich repeat	192..223	CDD:275380	2/30 (7%)
		internalin_A	685..>959	CDD:380193
		leucine-rich repeat	689..708	CDD:275380
		leucine-rich repeat	709..730	CDD:275380
		leucine-rich repeat	731..752	CDD:275380
		leucine-rich repeat	753..779	CDD:275380
		leucine-rich repeat	780..806	CDD:275380
		leucine-rich repeat	807..865	CDD:275380
		leucine-rich repeat	866..901	CDD:275380
		internalin_A	879..>1262	CDD:380193
		leucine-rich repeat	902..923	CDD:275380
		leucine-rich repeat	924..945	CDD:275380
		leucine-rich repeat	946..969	CDD:275380
		leucine-rich repeat	992..1016	CDD:275380
		leucine-rich repeat	1017..1044	CDD:275380
		leucine-rich repeat	1132..1157	CDD:275380
		leucine-rich repeat	1158..1194	CDD:275380
		leucine-rich repeat	1195..1218	CDD:275380
		leucine-rich repeat	1219..1240	CDD:275380
		LRR_9	<1227..1366	CDD:373143
		leucine-rich repeat	1241..1264	CDD:275380
		leucine-rich repeat	1265..1286	CDD:275380
		leucine-rich repeat	1287..1311	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836012
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840