DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppr-Y and drc3

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_021327254.1	Gene:	drc3 / 777619	ZFINID:	ZDB-GENE-061103-349	Length:	514	Species:	Danio rerio

Alignment Length:	548	Identity:	165/548 - (30%)
Similarity:	284/548 - (51%)	Gaps:	64/548 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EPGIINRSLIESSYLKHVHRGEGRRLHQLEPVVLEQILTMRLEFNNILRIDHLWILPNLTKLCLN 89
            |||:|:..:::.:.       |.::....|.:.||::|.:||::.|||:|.|||...:||||.|:
Zfish     8 EPGVIDEQMLQRAV-------EEQQTRYTEGIQLEEVLELRLDYRNILKIYHLWSFSSLTKLQLD 65

  Fly    90 CNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLFSNKIEAIENIDMLTMLVIISL 154
            .|.||.||.:|.||||..|:||||.||.||.|.|||.|:.||||:|:|..|||:|.|..|.::||
Zfish    66 NNAIERIEGLENLTNLTWLDLSFNKIEVIEGLQTLVKLQDLSLFNNRISVIENLDTLQRLQVLSL 130

  Fly   155 GNNLIDTVEGIERFRFMNNLKIINLEGNPIAKRTNFCLLKYISAILPKLNYYEYTFIKSELRAEA 219
            |||.|..:|.:...|...:|:.:||.||||.:...:  ..::||.||:|.|.:|..:..:.| |.
Zfish   131 GNNSIAQLENVIYLRRFQSLRTLNLAGNPICEEDRY--KTFVSAYLPELVYLDYRLLDEQTR-ET 192

  Fly   220 CNLYYR----EIREIEDKQEKEIQARKFLEREQSEAKRLASSFVEHLDGHQLFDSLWRGDEDG-R 279
            .|..|:    |:|:.|.::::.::|:|....|....|   .:|||:|:|.|||.|::..|.|. :
Zfish   193 ANAKYQYAIEEMRQNEMQEQQAMEAQKISNEELQLHK---DAFVENLNGAQLFHSMFADDPDAEK 254

  Fly   280 VLMLVGTQAQELADEYDKDIFELTQEIYKLGLERFTERDEEIRDFFNNLFDG-----QEELQILG 339
            :.:|.|..|  |.:|:...:..:..::::.||.:::.|..|:..||:...:.     |:..||..
Zfish   255 LALLPGVDA--LLEEFRSRMEAVCMQMFEAGLSQYSRRSAEVESFFSCSREAVAENKQKAAQIAA 317

  Fly   340 QNEIEWFLQFREIIFEEARIRLLKLEQNSMHGEDEDTPENLKLSDALDKLNIQFE-------DAI 397
            .             ||..|    :|:...||          ::.||     :|.|       ..:
Zfish   318 D-------------FESFR----RLKTAEMH----------QIQDA-----VQLETHLSVCRQQL 350

  Fly   398 NDLWQALMAQELYLHESIQESTINFHRKIAELMSKFVEQSQAFFVQLREITLHFSENMTEILTRF 462
            ....:.||:.||.|.:.:::....|.|.|:|::..|||..|..|.|.|::.....|...||....
Zfish   351 THTSEQLMSLELQLVDQLEDVYKEFERNISEMLGGFVEFVQGMFAQCRDLENQHHEQQLEIGLET 415

  Fly   463 ISTKFALQDFDDVPIELRVCVDDRDAILNLIAGMKDYHTLRLDEREDTIATRTKEFVDNMIDQLN 527
            :......:..:::|.:|.:.:.|:|.::|......|.|.:::|.|||.:.|.|..::.::..::.
Zfish   416 LEKVLKNELEEEIPDDLAMLLVDKDTLINAANASHDTHLMKIDNREDVLRTHTDSWIKHLKTEIQ 480

  Fly   528 SNEVERHRSKILEINFFVEMMTDAMTSL 555
            ..|::|:|.:|.||..::..:.:.:..:
Zfish   481 EEEMKRNRKRISEIQNYIRFVKEELEDM 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	9/18 (50%)
		LRR_8	81..137	CDD:290566	34/55 (62%)
		LRR_4	81..121	CDD:289563	24/39 (62%)
		leucine-rich repeat	83..104	CDD:275378	12/20 (60%)
		LRR_4	103..143	CDD:289563	25/39 (64%)
		leucine-rich repeat	105..126	CDD:275378	13/20 (65%)
		LRR_8	126..184	CDD:290566	26/57 (46%)
		LRR_4	126..166	CDD:289563	20/39 (51%)
		leucine-rich repeat	127..148	CDD:275378	12/20 (60%)
		leucine-rich repeat	149..162	CDD:275378	7/12 (58%)
drc3	XP_021327254.1	leucine-rich repeat	39..58	CDD:275380	9/18 (50%)
		leucine-rich repeat	59..80	CDD:275378	12/20 (60%)
		LRR_9	61..198	CDD:317038	64/139 (46%)
		leucine-rich repeat	81..102	CDD:275378	13/20 (65%)
		leucine-rich repeat	103..124	CDD:275378	12/20 (60%)
		leucine-rich repeat	125..149	CDD:275378	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579412
Domainoid	1	1.000	131	1.000	Domainoid score	I5120
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12581
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2872
OMA	1	1.010	-	-		QHG56411
OrthoDB	1	1.010	-	-		D259508at33208
OrthoFinder	1	1.000	-	-		FOG0006354
OrthoInspector	1	1.000	-	-		otm25486
orthoMCL	1	0.900	-	-		OOG6_104691
Panther	1	1.100	-	-	O	PTHR45973
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4624
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910