DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppr-Y and Lrguk

DIOPT Version :10

Sequence 1:NP_001015502.3 Gene:Ppr-Y / 3355180 FlyBaseID:FBgn0046697 Length:569 Species:Drosophila melanogaster
Sequence 2:XP_006506776.1 Gene:Lrguk / 74354 MGIID:1921604 Length:1341 Species:Mus musculus


Alignment Length:582 Identity:134/582 - (23%)
Similarity:227/582 - (39%) Gaps:173/582 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 EVIYPDIEPGIINRSLIESSYL-KHVHRGE----GRRLHQLE-----PVVLE-----QILTMRLE 67
            |.:|.::  .:.:..|::.|.| .:||..:    |.|:..|.     |.:||     ..||....
Mouse   126 EQVYLNL--NLSHCELVDISILCGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNKLTTFFN 188

  Fly    68 F---NNILRID----------HLWILPNLTKLCLNCNKIETIENIEMLTNLKDLNLSFNFIEKIE 119
            |   .|:.::|          .|.....||:|.|:.|:||.|..:|...:|..|:|:.|.|..|:
Mouse   189 FKPPQNLKKVDFSSNLISEMYDLSAYHTLTQLILDNNEIEEITGLENCISLTHLSLAGNKITTIK 253

  Fly   120 NLDTLVNLEVLSLFSNKIEAIENIDMLTMLVIISLGNNLIDTVEGIERFRFMNNLKIINLEGNPI 184
            .|.|| .::||||.:|.||.|..::.|..|..:.|.:|.|.:::|:|..   :.|::||||.|.|
Mouse   254 GLGTL-PIKVLSLSNNMIETITGLEELKALQNLDLSHNQISSLQGLENH---DLLEVINLEDNKI 314

  Fly   185 AKRTNFCLLKYIS--AILPKLNYY--------EYTF----------------IKSELRAEACNLY 223
            .:.:.   ::||.  .||..||..        ||.|                ||.|.:..|.|.|
Mouse   315 KELSE---IEYIENLPILRVLNLLRNPIQTKPEYWFFVIYMLLRLTELDQQKIKVEEKVFAVNKY 376

  Fly   224 --YREIREIEDKQEKEIQARKFLEREQSEAKRLASSFVEHLD-------------------GHQL 267
              ..|:..::|.....:.:       .|:.:|:..|.:..||                   .|:|
Mouse   377 DPPPEVVAVQDHMTHVVNS-------MSQPQRIWDSTLPSLDAPYPMLILTGPAACGKRELAHRL 434

  Fly   268 ---FDSLWR------------GDEDGRVLMLVGTQAQELADE---YDKDIFELTQEIYKLGLERF 314
               |.:.:|            |:.|......:   :||:.||   ..|.|.......:..||.|.
Mouse   435 CRQFSTYFRYGACHTTRPPYFGEGDRVDYHFI---SQEVFDEMLNMGKFILTFNYGNHNYGLNRD 496

  Fly   315 T----ERD----------EEIRDFFNNLFDGQEELQI-LGQNEIEWFLQFREIIFEEARIRL--- 361
            |    .||          |.:|....:.|:.:..|.: :.:.:.|.:|: |:.:|..|.|.:   
Mouse   497 TIEGIARDGLASCIHMELEGVRSLKYSYFEPRYILVVPMDKEKYEGYLR-RKGLFSRAEIEIAVS 560

  Fly   362 ---LKLEQNSMHGEDEDTPENLKLSDALDKLNIQFEDAINDLWQALMAQELYLHESIQE------ 417
               |.::.|..:....|...|      .|.::|.::..     ..|:.:.|.|.|:..:      
Mouse   561 RVDLYVKVNQKYPGYFDAVIN------ADDMDIAYQKL-----SELIREYLGLTETAAKTLAPTA 614

  Fly   418 ----------STINFH-----RKIAELMS------KFVE-QSQAFFVQLREITLHFSENMTE 457
                      |.:..|     |::|.|.:      .|:| |:||...:.::.||..|:.:||
Mouse   615 AGAPSSKKTASGVPAHLVPSPRRLARLQADGQKTEAFLEVQTQAVVPENQDPTLPQSQELTE 676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ppr-YNP_001015502.3 leucine-rich repeat 63..82 CDD:275378 5/31 (16%)
LRR <80..313 CDD:443914 76/297 (26%)
PPP1R42 82..>176 CDD:455733 34/93 (37%)
leucine-rich repeat 83..104 CDD:275378 9/20 (45%)
leucine-rich repeat 105..126 CDD:275378 9/20 (45%)
leucine-rich repeat 127..148 CDD:275378 9/20 (45%)
leucine-rich repeat 149..162 CDD:275378 4/12 (33%)
LrgukXP_006506776.1 LRR 97..>340 CDD:443914 65/222 (29%)
leucine-rich repeat 131..150 CDD:275380 3/20 (15%)
leucine-rich repeat 151..172 CDD:275380 3/20 (15%)
leucine-rich repeat 173..194 CDD:275380 5/20 (25%)
leucine-rich repeat 195..216 CDD:275380 2/20 (10%)
leucine-rich repeat 217..238 CDD:275380 9/20 (45%)
leucine-rich repeat 258..281 CDD:275380 10/23 (43%)
leucine-rich repeat 282..300 CDD:275380 5/17 (29%)
leucine-rich repeat 304..328 CDD:275380 9/26 (35%)
GMPK 416..537 CDD:238026 22/123 (18%)
PHA03247 <678..1233 CDD:223021
Blue background indicates that the domain is not in the aligned region.

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