DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppr-Y and Lrrcc1

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001157051.1	Gene:	Lrrcc1 / 71710	MGIID:	1918960	Length:	1026	Species:	Mus musculus

Alignment Length:	757	Identity:	161/757 - (21%)
Similarity:	264/757 - (34%)	Gaps:	256/757 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IESSYLKHVHRGEG-----------RRLHQLEPVVLE-QILTMRLEFNNILR---IDHLWILPNL 83
            :|::....:.|.:|           :.||.:..:.|: .|..:.|..|||.:   |||:|   ||
Mouse     1 MEAAVCSEIEREDGDSSCGDVCFMDKGLHSISELSLDSSIHAINLHCNNISKISSIDHIW---NL 62

  Fly    84 TKLCLNCNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLFSNKIEAIENI----D 144
            ..|.|:.|:|..||.:..||.|..||||.|.|.::|.|:.||||..|:|..|.|..:..:    .
Mouse    63 RHLDLSSNQISQIEGLNTLTKLCTLNLSCNLITRVEGLEALVNLTKLNLSYNHINDLSGLMPLHG 127

  Fly   145 MLTMLVIISLGNNLIDTVEGIER----FRFMNNLKIINL--EGNPIAKRTNFCLLKYISAI---- 199
            :...|..|.|.:|.||::..:.:    ..|:.|| |:..  |||||      ||:....||
Mouse   128 LKYKLRYIDLHSNYIDSIHHLLQCTVGLHFLTNL-ILEKDGEGNPI------CLIPGYRAIILQT 185

  Fly   200 LPKLNYYEYTFIKSE-LRAEACNLYYREIRE---------------IEDKQEKEIQA-------- 240
            ||:|...:...|..| :..|..|..:.:..|               .||:...::.|
Mouse   186 LPQLRILDCKNIFGEPVSLEEINSSHLQCLEGLLDNLVSSDSPLNISEDEVNDDVSAPPMDVLPS 250

  Fly   241 -RKFLEREQSEAKRLA-------SSFVEHLDGHQLFDSLWRGDE-DGRVLMLVGTQAQELADEY- 295
             ::|  :...|...||       ||..|.::....|.:..:..: |.::|.|:......|.|..
Mouse   251 LKEF--KSTPEDNVLASLLSVCPSSEPEKINQENDFQNEVKLQKLDDQILQLLNETNNSLIDNVP 313

  Fly   296 DKDI-----FELTQE--------------------IYKLGLERFTE---------------RDEE 320
            :||:     .::|.|                    .|...::....               |...
Mouse   314 EKDLRPKRDTDITSESDYGNRRECSRKVPRRTKIPYYSRTIQTIKHHNKNNGAFVSCNRKMRQPY 378

  Fly   321 IRDFF--------NNLFDGQEEL---------------------QILGQNEIEWFLQ-------- 348
            :||.:        |||.|..|:.                     |:..:.|:.|..:
Mouse   379 LRDLYVRSSLVNCNNLRDLDEQKTGVIKVDKNFSDNSTYRSLVEQLDQEREMRWKAEQTEKKLMD 443

  Fly   349 -------------------------FREIIFEEA---------------RIRLLKLEQNSMHGED 373
                                     .::.||:|.               .::.|.:|......:.
Mouse   444 YIDELHKQADEKKDVHSQALITTDRLKDAIFKERHCKAQLEIIVHRLQNEVKKLTIELMKARDQQ 508

  Fly   374 EDTPENLK-LSDALDKLNIQFEDAINDLWQALMAQELYLHESIQESTINFHRKIAELMSKFVEQS 437
            ||...:|: |..||:|:..|  .|.....|..:.||:.|..|..:..||       |:...:.|.
Mouse   509 EDHIRHLRTLERALEKMEKQ--KAQQQAAQIRLIQEVELKASAADREIN-------LLRTSLHQE 564

  Fly   438 QAFFVQLRE-ITLHFSENMTEILTRFISTKFALQDFDDVPIELRVCVDDRDAILNLIAGMKDYHT 501
            :....||.| :.|...|:..||.||...|....||    .:..|:|.::|.....    :|:|..
Mouse   565 KQQVQQLHELLALKEQEHRQEIETRQFFTDAEFQD----ALTKRLCKEERKHEQE----VKEYQE 621

  Fly   502 LRLD---------EREDTI-----ATRTKEFVDNMID---------------QLNSNE------- 530
             ::|         |.|..|     |.|.|:..|...|               |...||
Mouse   622 -KIDILNQQYLDLENEFRIALTVEARRFKDVQDGFEDVATELAKSKHALIWAQRKENESSSLIKD 685

  Fly   531 ----VERHRSKILEINFFVEMMTDAMTSLPHDVRD-ELIAED 567
                |:..::|:.|:   .::..:|..:|.:.:.. |::.||
Mouse   686 LTCMVKEQKTKLSEV---CKLKQEAAANLQNQINTLEILIED 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	8/21 (38%)
		LRR_8	81..137	CDD:290566	26/55 (47%)
		LRR_4	81..121	CDD:289563	18/39 (46%)
		leucine-rich repeat	83..104	CDD:275378	8/20 (40%)
		LRR_4	103..143	CDD:289563	18/39 (46%)
		leucine-rich repeat	105..126	CDD:275378	10/20 (50%)
		LRR_8	126..184	CDD:290566	19/67 (28%)
		LRR_4	126..166	CDD:289563	12/43 (28%)
		leucine-rich repeat	127..148	CDD:275378	5/24 (21%)
		leucine-rich repeat	149..162	CDD:275378	6/12 (50%)
Lrrcc1	NP_001157051.1	LRR	<30..115	CDD:227223	35/87 (40%)
		LRR 1	39..60		8/20 (40%)
		leucine-rich repeat	43..61	CDD:275378	8/20 (40%)
		LRR_4	61..101	CDD:289563	18/39 (46%)
		LRR 2	61..82		8/20 (40%)
		leucine-rich repeat	62..83	CDD:275378	8/20 (40%)
		LRR_8	82..142	CDD:290566	22/59 (37%)
		LRR_4	82..122	CDD:289563	18/39 (46%)
		LRR 3	83..104		9/20 (45%)
		leucine-rich repeat	84..105	CDD:275378	10/20 (50%)
		LRR_4	105..148	CDD:289563	12/42 (29%)
		LRR 4	105..126		6/20 (30%)
		leucine-rich repeat	106..131	CDD:275378	5/24 (21%)
		LRR 5	131..152		6/20 (30%)
		leucine-rich repeat	132..145	CDD:275378	6/12 (50%)
		leucine-rich repeat	158..188	CDD:275380	13/36 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..338		5/27 (19%)
		SbcC	<421..952	CDD:223496	63/325 (19%)
		FAM184	793..1026	CDD:292293
		DUF342	<817..894	CDD:302792
		RRF	<915..969	CDD:294170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930