DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppr-Y and PPP1R7

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_002703.1	Gene:	PPP1R7 / 5510	HGNCID:	9295	Length:	360	Species:	Homo sapiens

Alignment Length:	191	Identity:	54/191 - (28%)
Similarity:	102/191 - (53%)	Gaps:	8/191 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IINRSLIESSYLKHVHRGE-----GRRLHQLEPV-VLEQILTMRLEFNNILRIDHLWILPNLTKL 86
            ::|..:.:...|.::|:.:     ..|:..:|.: .|..:.::.|..|.|.::.:|..|.|||.|
Human   171 LVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVL 235

  Fly    87 CLNCNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLFSNKIEAIENIDMLTMLVI 151
            .:..|::..||.::.|.||::|.||.|.||.||.|:....|.:|.:.||:|:.||||..||.|..
Human   236 SMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 300

  Fly   152 ISLGNNLIDTVEGIERFRFMNNLKIINLEGNPIAKRTNFCLLKYISAILPKLNYYEYTFIK 212
            ..:.:||:::...::..:...:|:.:.||.||:.|...:  .:.:...||.:...:.||::
Human   301 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQY--RRKVMLALPSVRQIDATFVR 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	5/18 (28%)
		LRR_8	81..137	CDD:290566	23/55 (42%)
		LRR_4	81..121	CDD:289563	18/39 (46%)
		leucine-rich repeat	83..104	CDD:275378	7/20 (35%)
		LRR_4	103..143	CDD:289563	18/39 (46%)
		leucine-rich repeat	105..126	CDD:275378	10/20 (50%)
		LRR_8	126..184	CDD:290566	18/57 (32%)
		LRR_4	126..166	CDD:289563	14/39 (36%)
		leucine-rich repeat	127..148	CDD:275378	10/20 (50%)
		leucine-rich repeat	149..162	CDD:275378	3/12 (25%)
PPP1R7	NP_002703.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		LRR 1	77..98
		internalin_A	87..>317	CDD:380193	44/145 (30%)
		LRR 2	99..120
		leucine-rich repeat	100..121	CDD:275380
		LRR 3	121..142
		leucine-rich repeat	122..143	CDD:275380
		LRR 4	143..164
		leucine-rich repeat	144..165	CDD:275380
		LRR 5	165..186		2/14 (14%)
		leucine-rich repeat	166..187	CDD:275380	2/15 (13%)
		LRR 6	187..208		2/20 (10%)
		leucine-rich repeat	188..209	CDD:275380	3/20 (15%)
		LRR 7	209..230		4/20 (20%)
		leucine-rich repeat	210..231	CDD:275380	5/20 (25%)
		LRR 8	231..252		7/20 (35%)
		leucine-rich repeat	232..253	CDD:275380	7/20 (35%)
		LRR 9	253..274		11/20 (55%)
		leucine-rich repeat	254..275	CDD:275380	10/20 (50%)
		LRR 10	275..296		9/20 (45%)
		leucine-rich repeat	276..297	CDD:275380	10/20 (50%)
		LRR 11	297..318		3/20 (15%)
		LRRcap	336..354	CDD:197729	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910