DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppr-Y and LRRC49

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001185946.1	Gene:	LRRC49 / 54839	HGNCID:	25965	Length:	691	Species:	Homo sapiens

Alignment Length:	572	Identity:	127/572 - (22%)
Similarity:	231/572 - (40%)	Gaps:	114/572 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 HQLEPV----VLEQILTMRLEFNNILRIDHLWILPNLTKLCLNCNKIETIENIEMLTNLKDLNLS 111
            :|:|.:    .|..:..:.|..|.|.:|.:|..|.:|..|.|:.|:|..||||..|..|:.|||:
Human   149 NQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLA 213

  Fly   112 FNFIEKIENLDTLVNLEVLSLFSNKIEAIENIDMLTMLVIISLGNNLIDTVEGIERFRFMNNLKI 176
            .||:..::||:.|.:|..|:|..|:|..:.::|.|..|..:.|..|.|.:.:.:......::|..
Human   214 RNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSD 278

  Fly   177 INLEGNPIAKRTNFCLLKYISAILPKLNYYEYTFIKSELRAEACNLYYREIREIEDKQ--EKEIQ 239
            |..:|||||:.                ::|::|.:::.:          ::|:::.|:  |:|.:
Human   279 ITFDGNPIAQE----------------SWYKHTVLQNMM----------QLRQLDMKRITEEERR 317

  Fly   240 ARKFLEREQSEAKRLASSFVEHLDGHQLFDSLWRGDED---GRVLMLVGTQAQELA------DEY 295
            ....|.:::.|.||         :.|:  .||.:..:.   ..|......|.|.:|      |..
Human   318 MASVLAKKEEEKKR---------ESHK--QSLLKEKKRLTINNVARQWDLQQQRVANIATNEDRK 371

  Fly   296 DKDIFELTQEIYKLGLERFTERDEEIRDFFNNLFDG------------QEELQILGQNEIE---- 344
            |.|..:...:|....|..|.|....:....||...|            .:.|.:.|...:|
Human   372 DSDSPQDPCQIDGSTLSAFPEETGPLDSGLNNALQGLSVIDTYLVEVDGDTLSLYGSGALESLDR 436

  Fly   345 -WFLQ---------FREIIFEEARIRLLKLE---QNSMHGEDEDTPENLKLSD---------ALD 387
             |.:|         |..|.|:|....|.||:   .||:|.:.::|  ||.:..         .:|
Human   437 NWSVQTAGMITTVSFTFIEFDEIVQVLPKLKIKFPNSLHLKFKET--NLVMLQQFNALAQLRRID 499

  Fly   388 KLNI--QFEDAIN-DLWQALMAQELYLHESIQ-----ESTINFHRKIAELMSKFVEQSQAFFVQL 444
            :|.|  |....:| .||:..:...| .|.|:|     |.|.|.......|.......:.:...|.
Human   500 QLTIDPQGNPVVNFTLWKYYVLFRL-SHFSMQKINGTEVTQNDMIMAERLFGILAHVASSELPQY 563

  Fly   445 REITL--HFSENMTEILTRFISTKFALQDFDDVPIELRVCVDDRDAILNLIAGMKDYHTLRLDER 507
            |.|::  ...:.....|......|..:.:.::...:..|..:...|.||...  :|::..:|:|.
Human   564 RLISILGDARKKQFRYLLESKGKKPGIINEENNDSKRLVGENTNRATLNYTT--RDFYNEKLEEI 626

  Fly   508 EDTIATRTKEFVDNMIDQL--NSNEVERHRSKILEI--NFFVEMMTDAMTSL 555
            ::     .|:|....|:.|  .:.|:......:.::  ..|:|::.||:..:
Human   627 KE-----KKKFCKTYIEDLVKEATEINMKNEALQKLWPQMFIELVRDAVIEI 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	6/18 (33%)
		LRR_8	81..137	CDD:290566	23/55 (42%)
		LRR_4	81..121	CDD:289563	16/39 (41%)
		leucine-rich repeat	83..104	CDD:275378	10/20 (50%)
		LRR_4	103..143	CDD:289563	14/39 (36%)
		leucine-rich repeat	105..126	CDD:275378	9/20 (45%)
		LRR_8	126..184	CDD:290566	15/57 (26%)
		LRR_4	126..166	CDD:289563	11/39 (28%)
		leucine-rich repeat	127..148	CDD:275378	7/20 (35%)
		leucine-rich repeat	149..162	CDD:275378	4/12 (33%)
LRRC49	NP_001185946.1	LRR_8	118..173	CDD:290566	5/23 (22%)
		LRR_4	118..158	CDD:289563	2/8 (25%)
		LRR 1	118..139
		leucine-rich repeat	119..140	CDD:275380
		LRR_4	139..181	CDD:289563	8/31 (26%)
		LRR 2	140..161		2/11 (18%)
		leucine-rich repeat	141..162	CDD:275380	3/12 (25%)
		LRR 3	162..183		5/20 (25%)
		LRR_4	163..203	CDD:289563	15/39 (38%)
		leucine-rich repeat	163..184	CDD:275380	6/20 (30%)
		LRR 4	184..205		9/20 (45%)
		leucine-rich repeat	185..206	CDD:275380	10/20 (50%)
		LRR_4	205..247	CDD:289563	14/41 (34%)
		LRR_8	206..261	CDD:290566	19/54 (35%)
		LRR 5	206..227		8/20 (40%)
		leucine-rich repeat	207..228	CDD:275380	9/20 (45%)
		LRR_4	228..268	CDD:289563	11/39 (28%)
		LRR 6	228..249		6/20 (30%)
		leucine-rich repeat	229..250	CDD:275380	7/20 (35%)
		LRR 7	250..271		4/20 (20%)
		leucine-rich repeat	251..275	CDD:275380	4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..393		6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910