DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppr-Y and dnaaf11

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001032332.1	Gene:	dnaaf11 / 394985	XenbaseID:	XB-GENE-946667	Length:	470	Species:	Xenopus tropicalis

Alignment Length:	554	Identity:	121/554 - (21%)
Similarity:	210/554 - (37%)	Gaps:	137/554 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VLEQILTMRLEFNNILRIDHLWILPNLTKLCLNCNKIETIENIE-MLTNLKDLNLSFNFIEKIEN 120
            |.|.::..|.|.||.       .:.:|.::.|:...:|.||.|: ....||.|.|..|.|.||||
Frog     4 VSEDLIRRRAEHNNC-------EIFSLEEISLHQQDLERIEYIDKWCRELKILYLQNNLIGKIEN 61

  Fly   121 LDTLVNLEVLSLFSNKIEAIENIDMLTMLVIISLGNNLIDTVEGIERFRFMNNLKIINLEGNPIA 185
            :..|..||.|:|..|.||.|||::....|..:.|..|.:..:..|...:....|:...|.|||.|
Frog    62 VSKLKKLEYLNLALNNIEKIENLEGCESLQKLDLTVNFVGDLSSINSLQENRQLREFYLVGNPCA 126

  Fly   186 KRTNFCLLKYISAILPKLNYYEYTFIKSELRAEACNLYYREIREIEDKQEKEIQARKFLEREQSE 250
            :...:  .:|:.|.||:|.:.:...|:...|.:|...|.:...:|::::|..::.|. .|||::.
Frog   127 EYEGY--RQYVVATLPQLKWLDGKEIERSERIQAAQDYPQVQGKIKEQEEAYLRKRA-AEREKAT 188

  Fly   251 AKRLASSFVEHLDGHQLFDSLWRGDEDGRVLMLVGTQAQELADEYDK-----------DIFELTQ 304
                              ::|.:..::||       :|||....:|:           |..|.|.
Frog   189 ------------------NNLQQKQKEGR-------KAQEKKPGFDRRWYTDINNTIPDPVEKTD 228

  Fly   305 EIYKLGLERFTER---DEEIRDFFNNLFDGQEELQILGQNEIEWFLQFREIIFEEARIRLLKLEQ 366
            .:.:|.::....|   :||.::|:|      :..|...::.:|     .....||.|    |.::
Frog   229 TVAQLNVDETALRNDDEEEEKEFWN------QPSQYTPESRLE-----THRYLEEKR----KSKE 278

  Fly   367 NSMHGEDEDTPENLKLSDALDKLNIQFEDAINDLWQALMAQELYLHESIQESTINFHRKIAELMS 431
            |....|.:..|....::.....||                        :.||.::|     .|:.
Frog   279 NRSEEELKKKPPRTLITAEGRVLN------------------------VNESKLDF-----SLVD 314

  Fly   432 KFVEQSQAFFVQLREITLHFSENMTEILTRFISTKFALQDFDDVPIELRVCVDDRDAILNLIAGM 496
            .  |::..|.:.|             .:.|.:.|  :|.|.|..|..::|.|.::...|.|.|.:
Frog   315 D--EENNQFVLDL-------------AIYRHLDT--SLLDVDVQPGYIKVLVKEKPFQLVLPAEV 362

  Fly   497 K-DYHTLRLDE---------------------REDTIATRTKEFVDNMIDQLNSNEVERHRSKIL 539
            | |....:..:                     :...||.||.:.....:......||:.....|.
Frog   363 KPDSSAAKRSQTTGHLVVTMPKATEMIQTKRAKSPAIAERTCKNPQKCLKTHEKLEVDPKARSIP 427

  Fly   540 EI-NFFVEMMTDAMTSL---PHDVRDELIAEDYV 569
            :: |...|..|.|...|   .:..||...:||::
Frog   428 DVANIVQEKKTWAQGPLRLHRNSARDTADSEDFI 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	4/18 (22%)
		LRR_8	81..137	CDD:290566	22/56 (39%)
		LRR_4	81..121	CDD:289563	15/40 (38%)
		leucine-rich repeat	83..104	CDD:275378	6/21 (29%)
		LRR_4	103..143	CDD:289563	20/39 (51%)
		leucine-rich repeat	105..126	CDD:275378	11/20 (55%)
		LRR_8	126..184	CDD:290566	18/57 (32%)
		LRR_4	126..166	CDD:289563	13/39 (33%)
		leucine-rich repeat	127..148	CDD:275378	10/20 (50%)
		leucine-rich repeat	149..162	CDD:275378	3/12 (25%)
dnaaf11	NP_001032332.1	LRR_9	1..175	CDD:373143	53/179 (30%)
		LRR 1	20..43		6/22 (27%)
		leucine-rich repeat	23..45	CDD:275378	6/21 (29%)
		LRR 2	44..65		10/20 (50%)
		leucine-rich repeat	46..67	CDD:275378	11/20 (55%)
		LRR 3	66..89		10/22 (45%)
		leucine-rich repeat	68..89	CDD:275378	10/20 (50%)
		leucine-rich repeat	90..114	CDD:275378	4/23 (17%)
		LRR 4	90..110		4/19 (21%)
		PTZ00121	<148..>287	CDD:173412	34/179 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..265		20/113 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..470		4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910