DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppr-Y and Lrrc9

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_038967924.1	Gene:	Lrrc9 / 299129	RGDID:	1565716	Length:	1188	Species:	Rattus norvegicus

Alignment Length:	592	Identity:	148/592 - (25%)
Similarity:	242/592 - (40%)	Gaps:	147/592 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LIESSYLKHVHRGEGRRLHQL--------EPVVLEQILTMRLE--FNNILRIDHLWILPNLTKLC 87
            :|||   :|.:|||  .:.:|        |.|..|...|.:||  |:...||..|.:..||:.|.
  Rat     1 MIES---EHFNRGE--IIKELCLCNGLSYEMVGQEGSDTSKLEMFFSGYPRIVGLSLFHNLSSLT 60

  Fly    88 LNCNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLFSNKIEAIENIDMLTMLVII 152
            :....|:.|..:|....||:|.::...|||||.|....|||.|.|:.|||..|||::.|..|.::
  Rat    61 IVAQDIKEISGLETCLRLKELWIAECCIEKIEGLHGCRNLEKLYLYYNKISKIENLEKLIKLEVL 125

  Fly   153 SLGNNLIDTVEGIERFRFMNNLKIINLEGNPIAKRTNFCLLKYISAILPKLNYYEYTFIKSELRA 217
            .|.:|.|..:||::.   :.|||.:||.||            .||:|...|:..|        :.
  Rat   126 WLNHNTIRNIEGLQT---LKNLKDLNLAGN------------LISSIGRCLDPNE--------QL 167

  Fly   218 EACNLYYREIREIEDKQE-KEIQARKFLEREQSEAK--------RLASSFVEHLDGHQLFDSLWR 273
            |..||...:|...:|... .::...|.|.....:.|        ..::..:.||...|..|:.
  Rat   168 EKLNLSGNQITSFKDLTNLTKLPRLKDLSLNDPQYKSNPVCQLCNYSTHVLYHLPSLQRLDTF-- 230

  Fly   274 GDEDGRVLMLVGTQAQELADE--------YDKDIFELTQEIYKLGLERFTERDEEIRDFFNNLFD 330
             |...:       |.:||||.        |:..|..:.:.:           :||:    ..|.|
  Rat   231 -DVSAK-------QIKELADSTAMKKIMYYNMRIKTVQRHL-----------NEEL----EKLND 272

  Fly   331 GQEELQILGQNEIEWFLQFREIIFEEARIRLLKLEQNSMHGEDEDTPENLKLSDA---------- 385
            .:.:||.|.:..|:.|...::.:  |..:..||:   |..|:.:..||..|..::
  Rat   273 RKCKLQKLPEERIKLFNFAKKTL--ERELAELKI---SGKGQSDTAPEAEKARNSETLTQESVLQ 332

  Fly   386 ---LDKLNIQFEDAIND---LWQALMAQELYLHESIQESTINFHRKIAELMSKFVEQSQAFFVQL 444
               |.|||     |::|   .|.    ::|:..|:|..:.:...:|...|::.|:      ..:|
  Rat   333 QKILTKLN-----ALDDRVMFWN----KKLHEIEAIYRTEVKQKKKSHGLLTPFL------LTEL 382

  Fly   445 REI-TLHFSENMTE----------ILTRFISTKFALQDFDDVPIELRVCVDDRDAILNLIAGMKD 498
            ..: .:||.|....          ||:||.:..|.......|.::..:.|::|  ||.|....|.
  Rat   383 ETVGNIHFEEGTRADEWFNSCYELILSRFCTWDFRAYGITGVKVKRVIKVNNR--ILRLRFEEKF 445

  Fly   499 YHTLRLDEREDTIATRTKEFVDNMIDQL---NSNEV---ERHRSKILEINFFVEMMTDAMTSLPH 557
            ...|.|::.:|:.:.|      .|::.|   ...||   ::|..:|||..|     .|:.||.|
  Rat   446 QKCLDLEDIQDSESYR------KMLECLFYVFDPEVTVKKKHLLQILERGF-----KDSDTSKP- 498

  Fly   558 DVRDELI 564
            .:|.|.:
  Rat   499 PLRKEAV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	7/20 (35%)
		LRR_8	81..137	CDD:290566	21/55 (38%)
		LRR_4	81..121	CDD:289563	14/39 (36%)
		leucine-rich repeat	83..104	CDD:275378	5/20 (25%)
		LRR_4	103..143	CDD:289563	19/39 (49%)
		leucine-rich repeat	105..126	CDD:275378	9/20 (45%)
		LRR_8	126..184	CDD:290566	25/57 (44%)
		LRR_4	126..166	CDD:289563	18/39 (46%)
		leucine-rich repeat	127..148	CDD:275378	11/20 (55%)
		leucine-rich repeat	149..162	CDD:275378	4/12 (33%)
Lrrc9	XP_038967924.1	leucine-rich repeat	47..77	CDD:275380	8/29 (28%)
		leucine-rich repeat	78..99	CDD:275380	9/20 (45%)
		PPP1R42	85..236	CDD:411060	49/183 (27%)
		leucine-rich repeat	100..121	CDD:275380	11/20 (55%)
		leucine-rich repeat	122..143	CDD:275380	6/23 (26%)
		leucine-rich repeat	144..166	CDD:275380	11/41 (27%)
		leucine-rich repeat	167..191	CDD:275380	5/23 (22%)
		leucine-rich repeat	192..223	CDD:275380	5/30 (17%)
		internalin_A	685..>1014	CDD:380193
		leucine-rich repeat	689..708	CDD:275380
		leucine-rich repeat	709..730	CDD:275380
		leucine-rich repeat	731..752	CDD:275380
		leucine-rich repeat	753..779	CDD:275380
		leucine-rich repeat	780..806	CDD:275380
		leucine-rich repeat	807..865	CDD:275380
		leucine-rich repeat	866..901	CDD:275380
		PPP1R42	879..1057	CDD:411060
		leucine-rich repeat	902..923	CDD:275380
		leucine-rich repeat	924..945	CDD:275380
		leucine-rich repeat	946..969	CDD:275380
		leucine-rich repeat	992..1016	CDD:275380
		leucine-rich repeat	1017..1044	CDD:275380
		leucine-rich repeat	1045..1112	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339653
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840