DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppr-Y and Lrrc46

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001004201.1	Gene:	Lrrc46 / 287653	RGDID:	1303311	Length:	323	Species:	Rattus norvegicus

Alignment Length:	233	Identity:	67/233 - (28%)
Similarity:	107/233 - (45%)	Gaps:	36/233 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EGRRLHQLEPVVLEQILTMRLEFNNILRIDHLWILPNLTKLCLNCNKIETIENIEMLTNLKDLNL 110
            ||  :|..|.::.::.||...:.:...::.|  .|.:|..:.|:...|..|.|:|.|.|:..|.|
  Rat    17 EG--VHITEALITKRNLTFPEDEDLSEKMFH--TLDDLETVRLDGEGITCIGNLERLRNIHSLYL 77

  Fly   111 SFNFIEKIENLDTLVNLEVLSLFSNKIEAIENIDMLTMLVIISLGNNLIDTVEGIERFRFMNNLK 175
            ..|.|::||||..:.:|..|||..|:|..:||:..|..|..:.|..|||:|::..|   ...:|.
  Rat    78 QSNKIQRIENLACITSLRFLSLAGNQIRHVENLLDLQYLQFLDLSENLIETLKLDE---LPQSLL 139

  Fly   176 IINLEGNPIAKRTNFCLLKYISAILPKLNYYEYTFIKSELRAEACNLYYREIREIEDK---QEKE 237
            |:||.|||...:..:  .|.:...||.|           |..:...:..|...:.|||   :|:|
  Rat   140 ILNLCGNPCTNQDGY--RKMVIGALPLL-----------LDLDKQPILERWTSDEEDKSSDEEEE 191

  Fly   238 IQAR-----------KFLERE--QSEAKRLASSFVEHL 262
            ....           |.||:|  |.:.:|..::..|||
  Rat   192 FPELNGPFCAERGFFKDLEQELHQHQERRQQAALTEHL 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	3/18 (17%)
		LRR_8	81..137	CDD:290566	21/55 (38%)
		LRR_4	81..121	CDD:289563	14/39 (36%)
		leucine-rich repeat	83..104	CDD:275378	7/20 (35%)
		LRR_4	103..143	CDD:289563	16/39 (41%)
		leucine-rich repeat	105..126	CDD:275378	8/20 (40%)
		LRR_8	126..184	CDD:290566	22/57 (39%)
		LRR_4	126..166	CDD:289563	15/39 (38%)
		leucine-rich repeat	127..148	CDD:275378	9/20 (45%)
		leucine-rich repeat	149..162	CDD:275378	5/12 (42%)
Lrrc46	NP_001004201.1	LRR 1	49..70		6/20 (30%)
		LRR_4	50..89	CDD:289563	15/38 (39%)
		leucine-rich repeat	50..71	CDD:275378	7/20 (35%)
		LRR_8	70..126	CDD:290566	21/55 (38%)
		LRR_4	71..110	CDD:289563	16/38 (42%)
		LRR 2	71..92		9/20 (45%)
		leucine-rich repeat	72..93	CDD:275378	8/20 (40%)
		LRR_4	92..130	CDD:289563	15/37 (41%)
		LRR 3	93..114		8/20 (40%)
		leucine-rich repeat	94..115	CDD:275378	9/20 (45%)
		LRR 4	115..135		7/22 (32%)
		leucine-rich repeat	116..137	CDD:275378	7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840