Protein Alignment Ppr-Y and LRRC43

DIOPT Version :10

• Sequence 1: NP_001015502.3
• Gene: Ppr-Y / 3355180
• FlyBaseID: FBgn0046697
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_047284614.1
• Gene: LRRC43 / 254050
• HGNCID: 28562
• Length: 688
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 89/430 - (20%)
• Similarity: 151/430 - (35%)
• Gaps: 120/430 - (27%)

  Fly    14 PLVDEVIYPDIEP---------------GIINRSLIESSYLKHVHRGEGRRLHQLEPVVLEQILT 63
            |..::|:.|..|.               .::|.|..|.|:|        |.|....|:.:..  |
Human    68 PREEDVVSPGEETVEALLGLVRSRHSPWALLNNSNAEDSFL--------RELAIRNPLTITD--T 122

  Fly    64 MRLEFNNILRI----------DHLWILPNLTKLCLNCNKIETIENIEMLTNLKDLNLSFNFIEKI 118
            ....:...||:          |.|..| .|.:|.|:.|:|:.::...:...||.|.|..|.|..:
Human   123 FFYSYFRSLRVIDKKVTLVDKDLLKFL-KLEELVLSANRIKEVDATNLPPTLKVLELYGNEISSM 186

  Fly   119 ENL--DTLVNLEVLSLFSNK-IEAIENI--------------DMLT----------MLVIISLG- 155
            |.|  .....|:.|.|..|| :..:|::              ..||          .||.:.||
Human   187 ECLCAHPPAGLQHLGLGHNKLLGPLESLYVTANHWLLAPCSPGFLTPRRSCSPSRPNLVSLDLGF 251

  Fly   156 NNLIDTVEGIERFRFMNNLKIINLEGNPIA-----------KRTNFCLLKYISAILPKLNYYEYT 209
            |:|.|....:...|.:.:|:::.|:|||:|           .....|:|..|:....:.:.:...
Human   252 NDLTDLQSMVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHLFRGL 316

  Fly   210 FIKSELRAEACNLYYR--EIREIEDKQEKEIQAR--------------KFLEREQSEAKRLASSF 258
            .:..:|.|:.......  .||.:.|....:.:.|              .|::.|:.|....|...
Human   317 SLNGDLLAQEAQFVVTIGNIRGVLDTSVLDPEPRPEGPFITYNYYVTYDFVKDEEGEMNESAGVL 381

  Fly   259 VEHLDGHQLFDSLWRGDEDGRVLMLVGTQAQELADEYDKDIFELTQEIYKLGLERFTERDEEIRD 323
            .|.:......:            :||....:|:.::..:||.|...|..:..||...|.
Human   382 AEIVKPSPSLE------------LLVEESPEEVVEDVIEDIVEEVTEEVEGSLESEVEE------ 428

  Fly   324 FFNNLFDGQEELQIL-GQNEIEWFLQFREIIFEE-ARIRL 361
                  .|:.||.:: |.:.|   ||......|| |::||
Human   429 ------SGESELSVISGPSTI---LQMPRASAEELAKLRL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	6/28 (21%)
		LRR	<80..313	CDD:443914	58/287 (20%)
		PPP1R42	82..>176	CDD:455733	30/121 (25%)
		leucine-rich repeat	83..104	CDD:275378	5/20 (25%)
		leucine-rich repeat	105..126	CDD:275378	8/22 (36%)
		leucine-rich repeat	127..148	CDD:275378	8/45 (18%)
		leucine-rich repeat	149..162	CDD:275378	7/13 (54%)
LRRC43	XP_047284614.1	PPP1R42	156..310	CDD:455733	36/153 (24%)
		leucine-rich repeat	173..196	CDD:275378	8/22 (36%)
		leucine-rich repeat	197..243	CDD:275378	8/45 (18%)