Protein Alignment Ppr-Y and DNAAF11

DIOPT Version :10

• Sequence 1: NP_001015502.3
• Gene: Ppr-Y / 3355180
• FlyBaseID: FBgn0046697
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_006716601.2
• Gene: DNAAF11 / 23639
• HGNCID: 16725
• Length: 472
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 108/456 - (23%)
• Similarity: 178/456 - (39%)
• Gaps: 111/456 - (24%)

  Fly    55 PVVLEQILTMRLEFNNILRIDHLWILPNLTKLCLNCNKIETIENIE-MLTNLKDLNLSFNFIEKI 118
            |.|.|.::....|.|:.       ::.:|.:|.|:..:||.:|:|: ...:||.|.|..|.|.||
Human     8 PHVTEDLIRRNAEHNDC-------VIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKI 65

  Fly   119 ENLDTLVNLEVLSLFSNKIEAIENIDMLTMLVIISLGNNLIDTVEGIERFRFMNNLKIINLEGNP 183
            ||:..|..||.|:|..|.||.|||::....|..:.|..|.|..:..|:..:...:||.:.|.|||
Human    66 ENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNP 130

  Fly   184 IAKRTNFCLLKYISAILPKLNYYEYTFIKSELRAEACNLY---YREIREIED-------KQEKEI 238
            .|...::  .:::.|.||:|.:.:...|:...|.:|...|   ..:|||.|.       |.::|.
Human   131 CASFDHY--REFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEA 193

  Fly   239 QARKFLEREQSEAKRLASSFVEHLDGHQLFDSLWRGDEDGRVLMLVGTQAQELADEYDKDIFELT 303
            | ||..|.:::|.||..:.          ||..|..|.:..:..|......:..|..:.:..:|
Human   194 Q-RKHQEEDKNEDKRSNAG----------FDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKL- 246

  Fly   304 QEIYKLGLERFTERDEEIRDFFNN--LFDGQEELQILGQNEIEWFLQFREIIFEEARIRLLKLEQ 366
                        :..|:..:|:|.  ||..:..|:.|..             .|:.|.:..||.:
Human   247 ------------DNSEDDLEFWNKPCLFTPESRLETLRH-------------MEKQRKKQEKLSE 286

  Fly   367 NSMHGEDEDTPENLKLSDALDKLNIQFEDAINDLWQALMAQELYLHESIQESTINFHRKIAELMS 431
            ..   :....|..|...|.         .|:|                :.|..|:|..|..|
Human   287 KK---KKVKPPRTLITEDG---------KALN----------------VNEPKIDFSLKDNE--- 320

  Fly   432 KFVEQSQAFFVQLREITLHFSENMTEILTRFISTKFALQDFDDVPIELRVCVDDRDAILNLIAGM 496
                         ::|.|..:      :.|::.|  :|.|.|..|..:||.:..:...|.|.|.:
Human   321 -------------KQIILDLA------VYRYMDT--SLIDVDVQPTYVRVMIKGKPFQLVLPAEV 364

  Fly   497 K 497
            |
Human   365 K 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	2/18 (11%)
		LRR	<80..313	CDD:443914	68/243 (28%)
		PPP1R42	82..>176	CDD:455733	34/94 (36%)
		leucine-rich repeat	83..104	CDD:275378	7/21 (33%)
		leucine-rich repeat	105..126	CDD:275378	11/20 (55%)
		leucine-rich repeat	127..148	CDD:275378	10/20 (50%)
		leucine-rich repeat	149..162	CDD:275378	4/12 (33%)
DNAAF11	XP_006716601.2	PPP1R42	<29..161	CDD:455733	45/133 (34%)
		leucine-rich repeat	29..51	CDD:275378	7/21 (33%)
		leucine-rich repeat	52..73	CDD:275378	11/20 (55%)
		leucine-rich repeat	74..95	CDD:275378	10/20 (50%)
		leucine-rich repeat	96..120	CDD:275378	5/23 (22%)