Protein Alignment Ppr-Y and T05H4.3

DIOPT Version :10

• Sequence 1: NP_001015502.3
• Gene: Ppr-Y / 3355180
• FlyBaseID: FBgn0046697
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_001343670.1
• Gene: T05H4.3 / 188149
• WormBaseID: WBGene00020266
• Length: 1150
• Species: Caenorhabditis elegans
• Alignment Length: 698
• Identity: 127/698 - (18%)
• Similarity: 251/698 - (35%)
• Gaps: 248/698 - (35%)

  Fly    33 LIESSYLKHVH--RGEGRRLHQLEPV-----VLEQILTMRLEFNNILRIDHLWILPNLTKLCLNC 90
            |:...|..|:.  |..|:::..|:|:     .||::........::..:||   ...|.||.|..
 Worm    60 LVGLKYFSHLSTLRLFGQQITCLKPLGEVAPTLEELWVCEGAVKDLAGVDH---CIRLKKLFLYD 121

  Fly    91 NKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLFSNKI-----------EAIENID 144
            |.||....:..||||:.||::.|.::.:..|..:.:|..|||..||:           |:|:::|
 Worm   122 NAIEDASCLCALTNLQYLNIASNKLKSLTFLRDMKDLTNLSLADNKMKDSVVATAIWPESIQHLD 186

  Fly   145 MLTMLVIISLGNNLIDTVEGIERFRFMNNLKIINLEGNPIAKRTNFCLLKYISAILPKLNY---- 205
                     :..|...:...:.....:::|:.:||:  |:..:         |.:.|.|.:
 Worm   187 ---------ISANCFSSNRALFSLTILSSLRSLNLD--PVISK---------STVAPNLFFAWIA 231

  Fly   206 YEYTFIKS------------ELRAEACNLYYREIREIEDKQEKEIQARKFLER------------ 246
            :.:.||:|            ..|..|..:|..::.::....||.::..:..|:
 Worm   232 HSFRFIESLDDDPITESFVPTYRPMADTIYAEKLAKLAKADEKYLKDLRMAEKHSGKIENRLACL 296

  Fly   247 -----------EQSEAKR-------------------------LASSFVEHLDGHQLFDSLWRGD 275
                       :..:||:                         :.|.::..|..:|:...:
 Worm   297 AEALTAYKDAMQTKDAKKEIVKRVHEICVSNSKAVKNIKKNYTVLSEYIRSLSKYQISSDM---- 357

  Fly   276 EDGRVLMLVGTQAQELA-------------DEY------------------------DKD----I 299
            |..:...|....|:|:|             :.|                        :||    :
 Worm   358 ESCQTFQLRDGTAEEIAFITQTLNYSCSMKNSYEIIVKSCSVLGNITKNETDRLFILEKDSNEKL 422

  Fly   300 FELTQEIYKLGLERFTERD------EEIRDFFNNLFDGQEELQILGQNEIEWFLQFREIIFEEAR 358
            |:| :.|:.| |:|||.:|      ..||||           :::.:.|.:     |.|||
 Worm   423 FDL-RTIFNL-LDRFTRKDYTKHAVRLIRDF-----------EVIKKQEKD-----RTIIF---- 465

  Fly   359 IRLLKLEQNSMHGE-------DED----TPENLKLSD-----------------ALDKLN--IQF 393
              .|.|..:.|...       ||:    :.:||..||                 ..|:|.  .||
 Worm   466 --FLPLVLSKMAAARGATKFIDEEGVSSSNDNLSWSDIRLLAVLAVEVQPIGQLTTDQLRHMDQF 528

  Fly   394 EDAINDLWQALMAQELYLHESIQESTINFHRKIAELMSKFVEQSQAFFVQLREITLHFSENMT-- 456
            |::.|:  |.....::.:...::|.....:.:.||...:.|...|:...::.::..:.| |:|
 Worm   529 EESYNE--QLKKLNDMNIKLDVKEERHRRNEEPAETSIEAVSNQQSKIRKVSDVLANIS-NLTGR 590

  Fly   457 --------EILTRFISTKFALQDFDDVPIE-----------LRVCVDDRDAILNLIAGMKDYHTL 502
                    :..|.....:.||..||..||:           |.:|    |..|..:.|:::..:|
 Worm   591 ACDEKLPFDWFTMRNPLEIALAYFDFRPIKEVSDLMTRLTALELC----DQKLTKLTGIQELVSL 651

  Fly   503 R-LDEREDTIATRTK-------EFVDNMIDQLNSNEVERHRSKILEIN 542
            : |..|::.:.:..|       :.:|...:.:  :::|:..|.:|.::
 Worm   652 QFLSVRKNKLTSLKKLNRLPCLKLLDASFNHI--SKIEQLPSSLLHVD 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	2/18 (11%)
		LRR	<80..313	CDD:443914	59/348 (17%)
		PPP1R42	82..>176	CDD:455733	26/104 (25%)
		leucine-rich repeat	83..104	CDD:275378	8/20 (40%)
		leucine-rich repeat	105..126	CDD:275378	5/20 (25%)
		leucine-rich repeat	127..148	CDD:275378	9/31 (29%)
		leucine-rich repeat	149..162	CDD:275378	1/12 (8%)
T05H4.3	NP_001343670.1	LRR	<62..>213	CDD:443914	37/162 (23%)
		leucine-rich repeat	69..91	CDD:275380	4/21 (19%)
		leucine-rich repeat	92..113	CDD:275380	4/23 (17%)
		leucine-rich repeat	114..135	CDD:275380	8/20 (40%)
		leucine-rich repeat	136..157	CDD:275380	5/20 (25%)
		leucine-rich repeat	158..181	CDD:275380	6/22 (27%)
		leucine-rich repeat	182..206	CDD:275380	3/32 (9%)
		PPP1R42	626..793	CDD:455733	13/78 (17%)
		leucine-rich repeat	629..650	CDD:275380	5/24 (21%)
		leucine-rich repeat	651..672	CDD:275380	4/20 (20%)
		leucine-rich repeat	673..692	CDD:275380	2/20 (10%)
		leucine-rich repeat	693..714	CDD:275380	1/5 (20%)
		leucine-rich repeat	715..761	CDD:275380
		LRR	742..>1032	CDD:443914
		leucine-rich repeat	762..815	CDD:275380
		leucine-rich repeat	816..851	CDD:275380
		leucine-rich repeat	855..875	CDD:275380
		leucine-rich repeat	876..903	CDD:275380
		leucine-rich repeat	904..952	CDD:275380
		leucine-rich repeat	953..973	CDD:275380
		leucine-rich repeat	974..994	CDD:275380
		leucine-rich repeat	995..1019	CDD:275380