DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppr-Y and LRRIQ3

DIOPT Version :10

Sequence 1:NP_001015502.3 Gene:Ppr-Y / 3355180 FlyBaseID:FBgn0046697 Length:569 Species:Drosophila melanogaster
Sequence 2:NP_001099129.1 Gene:LRRIQ3 / 127255 HGNCID:28318 Length:624 Species:Homo sapiens


Alignment Length:533 Identity:107/533 - (20%)
Similarity:187/533 - (35%) Gaps:149/533 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 NLKDLNLSFNFI-------EKIENLDTLVNLEVLSLFSNKIEAIENIDMLTMLVIISLGNNLIDT 161
            |:::....|.|:       :.:|||.:.::|.|....:|.|..|..:.....|:.:.|..|.|.:
Human    22 NIREGQKDFVFVKFNGLHLKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKS 86

  Fly   162 VEGIERFRFMNNLKIINLEGNPIAKRTNFCLLK------------------------YISAILPK 202
            :...:.:..:.|||::.|..|..||..|.|:|.                        .:::|.| 
Human    87 LPNTKFWNGLKNLKLLYLHDNGFAKLKNICVLSACPTLIALTMFDCPVSLKKGYRHVLVNSIWP- 150

  Fly   203 LNYYEYTFIKSE---------LRAEACN---------------LYYREIREIEDKQEKEIQA--- 240
            |...::..|..|         .|.:|||               .|..||..|:....| |.|   
Human   151 LKALDHHVISDEEIIQNWHLPERFKACNHRLFFNFCPALRKGTTYEEEINNIKHITSK-INAILA 214

  Fly   241 ------------RKFLEREQSEAKRLASSFVEHLDGHQLFDSLWRGDEDGRVLMLVGTQAQELAD 293
                        |.||.|     |.|:..|. |....|  :.:.||.|...:.:..|.:.:.|.|
Human   215 HNSPVLIVQRWIRGFLVR-----KNLSPVFF-HKKKQQ--EKIIRGYEAKWIYITKGYEDKLLKD 271

  Fly   294 EYDKDIFELTQEI--------YKLGLERFTERDEEIRDFFNNLFDGQEELQILGQNEIEWFLQFR 350
            .:.|....:..::        |.:.|:..:|..:.:......|  ..::|.:..:..       |
Human   272 LFFKPETNIKGKLAYWKHNIYYPVDLKNSSEHRKHVSSILCEL--KPKDLGMKSKTS-------R 327

  Fly   351 EIIFEEARIRLLKLEQNSMHGEDEDTPENLKLSDALD--KLNIQFEDAINDLWQALM-------- 405
            .:|            |.....|||...|.|..|..:.  ||.|....::.:  .|::        
Human   328 HLI------------QKGQESEDEIVDEKLDTSFRISVFKLPIYTSGSLKN--NAVLREKKQHFF 378

  Fly   406 ---AQELY-LH-ESIQESTINFHRKIAELMSKFVEQSQAFFVQLR---EITLHFSENMTEILTRF 462
               .|.:| .| :.|.:..|...|.:.|..:     .|...::||   :|..:::|...:   .:
Human   379 PAYPQPIYTTHPKPIIKKDIRLERSMKEFFA-----PQRAGMKLRTFSDIDKYYTEQKKQ---EY 435

  Fly   463 ISTKFALQDFDDVPIE-LRVCVDDRDAILNLIAGMKDYHTLRL-DEREDTIATRTKEFVDNMIDQ 525
            ...|..:.....|..| :||.|::.   ||    .|.|.|.:| :|.::||....::...|..:.
Human   436 HKEKVRVVAMAQVARERVRVAVNEH---LN----QKKYATQKLIEENKETIQNSLRQVWQNRFNY 493

  Fly   526 LNSNEVERHRSKI 538
            |   |..|.|..:
Human   494 L---EKARERKAL 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ppr-YNP_001015502.3 leucine-rich repeat 63..82 CDD:275378
LRR <80..313 CDD:443914 59/286 (21%)
PPP1R42 82..>176 CDD:455733 17/78 (22%)
leucine-rich repeat 83..104 CDD:275378 107/533 (20%)
leucine-rich repeat 105..126 CDD:275378 5/27 (19%)
leucine-rich repeat 127..148 CDD:275378 5/20 (25%)
leucine-rich repeat 149..162 CDD:275378 4/12 (33%)
LRRIQ3NP_001099129.1 PPP1R42 33..>119 CDD:455733 21/85 (25%)
LRR 1 51..72 5/20 (25%)
leucine-rich repeat 52..73 CDD:275378 5/20 (25%)
LRR 2 73..94 4/20 (20%)
leucine-rich repeat 74..98 CDD:275378 4/23 (17%)
LRR 3 98..119 9/20 (45%)
leucine-rich repeat 99..123 CDD:275378 9/23 (39%)
leucine-rich repeat 124..135 CDD:275378 0/10 (0%)
Blue background indicates that the domain is not in the aligned region.

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